10-Year study checks if HPV test alone can replace pap smear

NCT ID NCT04185389

Completed Knowledge-focused Sponsor: University of British Columbia Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows over 1,700 women who previously took part in a cervical cancer screening trial. Researchers want to see if testing for HPV alone is as safe and effective as combining it with a Pap smear over 10 years. Participants provide a cervical sample for both tests, and the study tracks rates of abnormal cell changes. The goal is to improve screening guidelines and reduce unnecessary procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could confirm that HPV testing alone is a safe and effective way to screen for cervical cancer, potentially simplifying screening guidelines.
What could go wrong: This is an observational follow-up study, not a new treatment trial. It cannot prove that HPV testing alone prevents cancer better than current methods, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cervical cancer Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL CANCER

Contacts and locations

Locations

Women's Health Research Institute

Vancouver, British Columbia, V6H3N1, Canada

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