Engineered immune cells take aim at HPV-Positive cancers
NCT ID NCT03578406
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial tested a new type of cell therapy for people with HPV-positive head & neck or cervical cancer. The treatment uses a patient's own immune cells, engineered to recognize and attack HPV-infected cancer cells. Some patients also received cells that produce an anti-PD1 molecule to help the immune cells work better. The main goal was to find a safe dose, and only 9 people took part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- HPV E6-specific TCR-T cells
- What this could lead to
- If it works, this could point toward a new treatment option for HPV-positive head & neck or cervical cancers that have not responded to standard therapies.
- What could go wrong
- This is a very early Phase 1 trial with only 9 participants, so it is too small to prove effectiveness. The approach may not work well in solid tumors, and there are risks from the cell therapy itself.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Qingzhu Jia
Chongqing, Chongqing Municipality, 400037, China
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