Neurodevelopmental disorder

This study tests whether a small social robot named Tessa can help people with disabilities who have trouble planning and remembering daily tasks. Participants use the robot in their home, and researchers track how much professional caregiver support they need. The goal is to see…

This study tests whether a wide-spectrum nutritional supplement can improve mitochondrial function in children with autism spectrum disorder (ASD). Mitochondria are the energy factories in cells, and some children with ASD have abnormal mitochondrial activity. The trial enrolls c…

This phase 2 trial tested sodium valproate, a drug used for seizures, in 41 children with Rubinstein-Taybi syndrome (RTS), a rare genetic condition causing intellectual disability. Participants aged 6 to 21 received either the drug or a placebo for one year. Researchers measured …

This study tested an oral drug called ADX-629 in 8 people with Sjögren-Larsson syndrome, a rare inherited disorder that causes harmful fatty substances to build up in the skin, brain, and eyes. The main goals were to see if the drug is safe and can reduce these fatty aldehydes. P…

This study tested a computer program called Work Chat that helps young adults with autism practice conversations with coworkers, customers, and supervisors in a virtual workplace. 44 participants used the tool to improve social skills needed for jobs. The goal is to help more peo…

This study tested whether a 16-week lifestyle program delivered through WeChat could help children with autism (ages 8-12) manage their weight. 276 families were split into three groups: usual care, the WeChat program alone, or the program plus weekly group coaching. The main goa…

This study compared two FDA-approved medications, risperidone and aripiprazole, used to treat irritability in children with autism. The goal was to see which one causes more weight gain. Thirty children under 18 who had never taken these drugs before were followed during routine …

This phase 3 study looked at what happens when males with MCT8 deficiency (a rare genetic condition affecting thyroid hormone transport) stop taking tiratricol. Twenty participants who had been stable on tiratricol were randomly assigned to either continue the drug or receive a p…

This study tested two teaching methods—watching a peer brush teeth in a video or using a 3D jaw model—to improve toothbrushing in 120 children with autism aged 6-12. Children who watched the peer video had less plaque and better brushing skills over six months compared to those u…

This study tested a drug called clomastine fumarate in 28 children aged 3-12 with Williams syndrome, a genetic condition that causes developmental delays. The goal was to see if the drug could improve thinking, movement, and social skills by repairing brain myelin. The study used…

This study tested the drug allopurinol in 8 children and adults with adenylosuccinate lyase deficiency (ADSL), a rare genetic disorder that can cause autism, seizures, and developmental delays. Researchers measured changes in thinking, daily skills, and seizure control over 12 mo…

This study tested a program called PR-ESSENCE, which teaches teens and staff how to solve problems together. Twenty youth aged 12-17 with behavior issues in special treatment homes took part. The goal was to see if this approach reduces problem behaviors and improves daily life c…

This pilot trial tested whether taking oral zinc every day for 6 months is safe and doable for people with GNAO1 disorders, a rare genetic condition that causes movement problems, seizures, and developmental delays. 13 participants aged 6 months to 30 years took zinc acetate. The…

This study tested whether a child's own bone marrow stem cells, combined with educational therapy, can safely reduce autism symptoms. 54 children aged 3-7 with moderate to severe autism took part. Researchers measured changes in behavior, social skills, and quality of life. The g…

This completed Phase 3 study tested somatropin, a synthetic growth hormone, in 33 Japanese children and adults with Prader-Willi syndrome. The goal was to see if it safely improves body composition by increasing lean body mass and reducing fat. Participants were divided into thre…

This pilot study tested whether triheptanoin oil, a special fat taken by mouth, can reduce the number of sudden paralytic attacks in children with Alternating Hemiplegia of Childhood (AHC), a rare genetic disorder. Ten participants aged 15 and older with confirmed ATP1A3 mutation…

This study tested the long-term safety of a drug called LP352 (bexicaserin) in 41 people aged 12 to 65 with severe epilepsy syndromes like Dravet or Lennox-Gastaut. Participants took the drug three times daily for up to 52 weeks. The main goal was to check for side effects, while…

This study looked at the long-term safety of a drug called fenfluramine (ZX008) for people with rare seizure disorders like Dravet syndrome and Lennox-Gastaut syndrome. A total of 412 participants who had completed earlier studies took the drug and were monitored for side effects…

This study looked at whether parent-child co-exercise helps children with autism become more active and improve their motor skills. Forty children aged 4 to 11 were split into three groups: one where parents and children exercised together, one where children exercised with peers…

This study tested a program called Autism Eats, designed to help children with autism spectrum disorder (ASD) eat more fruits and vegetables and try new foods. The program was offered through early intervention services for children up to 36 months old. Researchers compared the p…

This study looked at the long-term safety of cariprazine, a medication, in 310 children and teens with schizophrenia, bipolar I disorder, or autism spectrum disorder. Over 52 weeks, researchers monitored side effects, vital signs, lab results, and movement disorders. The goal was…

This study tested a drug called troriluzole in 141 adults with spinocerebellar ataxia, a rare disease that affects balance and coordination. Participants took either the drug or a placebo daily for 8 weeks. The main goal was to see if troriluzole could improve symptoms like walki…

This completed trial tested a personalized program of physical activity, nutrition guidance, and education for 128 adults with Prader-Willi syndrome. Participants followed the program during a 5-week hospital stay, with the goal of stabilizing or reducing their body mass index (B…

This study tested whether minoxidil, a blood pressure medicine, can improve blood vessel health in children with Williams-Beuren syndrome. The condition causes weak blood vessels due to a missing gene. 21 children took minoxidil or a placebo for 12 months, and researchers measure…

This study tested whether stem cells taken from a child's own bone marrow could improve autism symptoms. Thirty children aged 5 to 15 received an injection of their own stem cells into the spinal fluid. Researchers measured changes in behavior and social skills over six months us…

This study tested a combination therapy—including antibiotics, a bowel cleanse, stomach acid suppressants, and beneficial bacteria from human feces—to treat gastrointestinal problems in 18 children with autism. The goal was to see if the treatment could reduce gut symptoms like p…

This completed study tested whether a special diet plus a nutritional supplement called T-2 could improve thinking skills, sleep, and overall health in 76 people with Down syndrome, autism, or ADHD, aged 2 to 35. Participants followed either the diet alone, the diet plus suppleme…

This study tested a drug called NBI-827104 in 24 children with a rare epilepsy that causes constant brain spikes during sleep. The drug is a calcium channel blocker given daily for 13 weeks. The main goal was to see if it reduces abnormal brain activity measured by EEG.

This study tested whether whole genome sequencing (WGS) can find more genetic causes of intellectual disability than current standard tests. Researchers compared WGS to usual methods in 3825 children and adults with unexplained intellectual disability. The goal was to see if WGS …

This study tested two new technologies—optical genome mapping and long-read DNA sequencing—against standard chromosome tests in 350 people with infertility, intellectual disability, birth defects, or miscarriage. The goal was to see if these newer methods can find more chromosome…

This study tested whether a blood test called exome sequencing can find genetic causes of autism better than standard care. Researchers studied 300 people with autism to see if the test could identify risk genes. The goal is to improve diagnosis and help families understand the b…

This study tested whether an iPad game (Play.Care) could help diagnose autism spectrum disorder (ASD) in children aged 2.5 to 5 years. The game measures how children move while playing, since movement differences may be early signs of autism. Researchers compared the game's resul…

This study tested whether a special MRI technique called ASL-MRI can measure blood flow in the brains of children with autism. The goal was to see if this could be used as a non-invasive diagnostic tool, similar to PET scans but without radiation. Researchers studied 115 children…

This study tested whether a powerful genetic test called exome sequencing can find the cause of severe epilepsy in children when standard tests fail. Researchers studied 15 children with epileptic encephalopathy of unknown genetic origin. The goal was to see if this test could im…

This study tested whether a portable eye-tracking device can help diagnose autism in young children in Kenya. 27 children aged 14-72 months watched pictures and videos while the device measured their eye movements. The goal was to see if these eye-tracking patterns match a clinic…

This study tested a device called EarliPoint that tracks where children look while watching short videos. The goal was to see if it could help diagnose autism spectrum disorder (ASD) in children ages 2.5 to 7. Nearly 1,000 children participated, and the device's results were comp…

This study tests a program called 'Thoughts and Health' designed to prevent depression in adolescents. The program is delivered in 12 sessions in a school setting. Researchers will see if it helps students' mental health and their ability to finish junior high with passing grades…

This study tested a school-based program called Preventure in 3,900 Canadian teens. The program targets four personality traits linked to substance misuse, aiming to delay or prevent alcohol and drug use. Researchers also measured whether delaying substance use helps protect cogn…

This study tested a training program called SAFE for people with intellectual or developmental disabilities who are working or looking for work. The program taught them about COVID-19, how to use protective gear, social distancing, and self-advocacy. 67 young adults took part, an…

This study tests whether a brief, telehealth-delivered therapy called Written Exposure Therapy (WET) can help autistic adults who have experienced trauma. Participants complete five weekly writing sessions and wear a Fitbit to track sleep, activity, and heart rate. The goal is to…

This pilot study in Pakistan tests a culturally adapted psychological therapy (Y-CMAP) for autistic young people aged 14-24 who have a history of self-harm. The therapy is based on cognitive behavioral therapy and includes 8-10 sessions over three months. The study will check if …

This trial tests whether a program called MyRAKAN Autism, which combines video modeling with virtual reality, can help autistic young adults improve their social communication skills. Participants attend eight sessions over five weeks, practicing skills like eye contact, conversa…

This study tested whether a single infusion of stem cells from donated umbilical cord tissue could improve social communication in children with autism. 137 children aged 4 to 12 took part. The main goal was to see if their socialization and communication scores improved after si…

This study tested whether adding group music therapy to standard speech therapy helps autistic children aged 3-5 improve their language and social skills. Forty children were split into two groups: one got music therapy plus usual speech therapy, the other only speech therapy. Af…

This study tested whether an intensive, center-based version of Pivotal Response Treatment (PRT) can improve social communication in preschoolers with autism. 75 children aged 2 to 4 years participated. The therapy combined weekly parent training with center-based sessions for a …

This study tested a special spatula designed to help dentists examine the teeth of people with mental disabilities who have behavioral issues. The goal was to see if the spatula makes it easier and safer to look inside the mouth. Two hundred participants were included, and the st…

This study tests whether a smartphone app called 'Compra con-Migo' (Shop with Me) can help adults with intellectual disabilities learn how to shop at a supermarket. The app uses NFC technology to guide users through tasks like planning a shopping list, finding products, and payin…

This study tested a swimming and water safety program designed for children with autism spectrum disorder. The program uses individualized teaching methods and sensory modifications to help kids learn to swim and stay safe around water. Over 350 children with autism took part, an…

This study tested two ways to improve dental care for children with autism. One group received a dental toolkit with tips and resources. The other group got the toolkit plus special parent training to help with brushing and dentist visits. The goal was to see if the extra trainin…

This study looked at whether a recreational ballet program called Ballet for all Kids can help children with autism spectrum disorder (ASD) improve their motor skills. 32 children aged 6-12 with ASD participated in the program for 12 weeks. Researchers measured changes in coordin…

This study tested a structured online program for parents of children with autism or ADHD. 90 families took part to see if the program could lower parental stress, improve coping skills, and boost social support. Researchers compared parents who received the program to those who …

This study tests a 10-week visual rehabilitation program for children with autism spectrum disorder who also have vision problems. The program uses games and activities to improve how children use their eyes and process visual information. Researchers want to see if better vision…

This study tested a new behavior therapy for teens with autism who struggle with irritability and aggression. The therapy teaches emotion regulation and coping skills for the challenges of growing up. 65 adolescents participated, and researchers measured changes in aggressive beh…

This study tested a program called ASPEN, which coaches parents of young children with autism in low-resource communities. The program includes 12 sessions teaching parents strategies to improve their child's social communication and play skills, while also reducing parenting str…

This study tests whether pediatric massage can improve behavior and social skills in children aged 3 to 10 with autism spectrum disorder (ASD). Children receive massage twice a week for 12 weeks from a professional, plus at-home massage from trained parents. Researchers also use …

This study tested whether a natural supplement called ultramicronized palmitoylethanolamide (umPEA) can improve smell, taste, and other sensory issues in children with autism. Eighty children took either umPEA or a standard treatment (probiotics plus omega-3) for six months. Rese…

This study looked at whether adding game elements to tai chi can improve thinking skills and reduce challenging behaviors in children with autism. About 100 children aged 9 to 12 took part. They were split into three groups: one did gamified tai chi, one did regular tai chi, and …

This study looked at whether a 10-week supervised physical activity program is practical and well-liked by mothers of children with developmental disabilities. Nineteen mothers were enrolled to attend three 60-minute group exercise sessions per week. The goal was to see if the pr…

This study tested a program called the Westmead Feelings Program 2 for Chinese children with autism in Hong Kong primary schools. The goal was to help them better understand and manage emotions. 85 children took part, and researchers measured changes in emotional skills and behav…

This study tested whether a nasal spray containing vasopressin, a natural hormone, can improve social functioning in children with autism. 157 children aged 6 to 17 took part. Researchers measured changes in social responsiveness and overall symptoms over 8 weeks.

This study tested whether playing virtual reality games (like Nintendo Switch Sports) could improve balance and walking in young people with autism, compared to standard physical therapy exercises. Thirteen participants aged 7-22 did six sessions over two weeks at home via Zoom. …

This study tested a 10-week progressive adapted physical education program for 46 adolescents with mild intellectual disability. Half did the special program plus regular school activities, while the other half stuck to their usual curriculum. Researchers measured upper-body stre…

This study tested a psycho-educational program designed to help family caregivers of children with autism become more aware of their own needs and better at seeking support. Fifty caregivers of children aged 6 to 12 took part. The program involved teaching coping strategies and w…

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve core symptoms in 200 children with autism spectrum disorder. Children received either real or sham stimulation over five days, with multiple…

This study tested an experimental drug called ML-004 in 168 adolescents and adults with autism spectrum disorder to see if it could improve social communication skills. Participants were randomly assigned to receive either the drug or a placebo for several weeks. The main goal wa…

This study tested whether remote occupational therapy could help children and teens (ages 7-18) with Dravet syndrome improve their daily living skills and satisfaction. 14 families participated in online sessions where a therapist coached the child or parent. The goal was to see …

This study tested whether a virtual reality (VR) social skills program works as well as an in-person group program for preschool children with autism. Thirty-two children aged 4 to 6 were randomly assigned to either VR or in-person sessions over 8 weeks. Researchers measured soci…

This study tested a home-based brain-training program in 12 autistic adults who also had insomnia. Participants played cognitive games for 18 hours over 6 weeks while wearing a sleep tracker and filling out sleep diaries. The goal was to see if the training was usable and could i…

This study tested whether aripiprazole (Abilify) can reduce serious behavioral problems in children and teens aged 6 to 17 with autistic disorder. 98 participants received either the drug or a placebo for 8 weeks. Researchers measured changes in irritability and overall improveme…

This early study tested esketamine, a form of ketamine, in 3 girls with Rett syndrome. The goal was to see if weekly infusions over five weeks could improve symptoms and be safe. The trial is complete, but with only 3 participants, it's too small to draw firm conclusions.

This study tested a program where mothers and their children with intellectual disabilities (ages 6-12) did art activities together to improve their relationship and well-being. 157 mother-child pairs took part, with some receiving the art program and others continuing usual care…

This study tested whether Acceptance and Commitment Therapy (ACT) can improve the well-being of parents caring for children with autism. Thirty parents in Saudi Arabia took part in online ACT sessions over five weeks. Researchers measured changes in stigma, mindfulness, and stres…

This pilot study tested whether a nurse-led community sailing program could improve resilience, quality of life, and mood in 36 school-aged children with autism. Children in the sailing group took part in 24 hours of sailing over six days, while a control group did simple crafts.…

This study tested whether aripiprazole (Abilify) can reduce serious behavioral problems in children and adolescents with autistic disorder. 218 participants aged 6 to 17 received either a fixed dose of aripiprazole or a placebo daily for 8 weeks. The main goal was to see if the d…

This phase 2 study tested whether pitolisant, a drug that promotes wakefulness, can safely reduce excessive daytime sleepiness in people with Prader-Willi syndrome. The trial enrolled 65 participants aged 6 to 65 and compared pitolisant to a placebo over 11 weeks, followed by an …

This study tested a probiotic (BB-12 with LGG) in 123 children with autism and stomach problems. The goal was to see if different doses are safe and can improve behavior and gut health. Researchers tracked side effects, behavior changes, and gut bacteria over 56 days of treatment…

This study adapted a behavioral activation treatment called BeatIt-MV to help improve mood in minimally verbal autistic adults with depression. Nine adults took part, along with a caregiver. The therapy focused on increasing meaningful activities like recreation and social time. …

This study tested a 12-session outdoor group training program where children interacted with animals to build resilience. It included 107 children aged 2-4 or 8-12 who had either autism or a history of stressful life events. The goal was to see if this approach could help them be…

This study tested a Spanish-language program called Unstuck and On Target with 20 families in Ecuador. Children aged 8-11 with autism or ADHD took part in an 8-week program to improve flexibility and problem-solving. The goal was to see if the program was practical and helpful fo…

This study tested a non-invasive brain stimulation technique called TMS in 20 young adults with autism. The goal was to see if stimulating a specific brain area could improve how they look at faces and interact socially. Participants received 10 daily sessions, and researchers me…

This study tested whether bumetanide, a diuretic, can improve social skills in children with autism. Researchers used a blood test and machine learning to pick children likely to respond. 66 children aged 3-6 took bumetanide or standard behavioral therapy for three months. The go…

This pilot study tested whether electromagnetic therapy (EMT) can help improve autism symptoms in children. Thirty children aged 3-12 with mild to moderate autism were randomly assigned to receive either their usual care plus EMT or usual care alone. The treatment involved 30 ses…

This study tested whether an adapted form of Narrative Exposure Therapy (NET) is acceptable and helpful for adults with mild learning disabilities who have experienced trauma. Thirteen participants completed the therapy, which involved talking through their life events in a struc…

This study tested a special light helmet (called tPBM) on 6 autistic children aged 4–12 who also had abnormal brain activity or epilepsy. The helmet delivered near-infrared light to specific brain areas twice a week for 10 weeks. The goal was to see if it could safely improve foc…

This study looked at whether teaching parents to use Reciprocal Imitation Training (RIT) at home helps young children with autism improve their imitation and social skills more than therapist-only sessions. Eighteen children aged 2 to 5 years participated. The goal was to see if …

This study tested whether wrapping children with autism in sheets (wet or dry) can reduce severe injurious behaviors like self-harm or aggression. 48 children took part, and researchers compared wet wraps to dry wraps. The goal was to see if this gentle, drug-free approach could …

This study tested whether a mix of vitamins and supplements could ease autism symptoms in 88 children aged 2.5 to 6 years. Half received the supplements plus behavioral therapy, the other half only behavioral therapy. After three months, researchers measured changes in social ski…

This completed study tested whether Vita 6 (a vitamin supplement) or zinc, each given alongside behavioral therapy, could reduce autism severity in children aged 3-12. Sixty-four newly diagnosed children who were not on any other treatment took part. The goal was to see if either…

This study tested whether daily 20-minute warm baths could safely reduce seizures in 8 children (ages 6 months to 6 years) with CDKL5 deficiency, a rare genetic disorder causing hard-to-control seizures. The treatment was added to their usual medications for 12 weeks. The goal wa…

This study tested a new psychological treatment for autistic young people who struggle with overwhelming sensory experiences, like sounds or lights. Twenty-five participants completed a group therapy program and did tasks before and after to see if their brain responses and anxie…

This study tested a digital aftercare program for 60 children and teens leaving psychiatric hospital care. The program used regular video calls and a secure smartphone messenger to connect patients, parents, and teachers with their hospital therapist. The goal was to ease the ret…

This study tested whether breathing high-flow oxygen for 15 minutes can stop dystonic or plegic attacks in children with Alternating Hemiplegia of Childhood (AHC), a rare genetic disorder causing temporary paralysis and muscle spasms. 24 participants used oxygen or a placebo (med…

This pilot study tested a community-based group programme called 'Encompass' for parents of children under 5 with complex neurodisability. Fifteen parents in East London attended ten group sessions over six months. The study aimed to see if the programme was feasible and acceptab…

This small pilot study tested a structured plate with separate compartments to help children aged 5 to 7 with autism and feeding difficulties eat more easily. Six children used the plate during school lunch three times a week for two months, guided by an occupational therapist. R…

This study tested a therapy called Sentido's Model in 24 children aged 3 to 7 with autism or other neurodevelopmental challenges. The therapy combines behavior analysis, sensory integration, and stress science to help children improve adaptive behaviors like communication and dai…

This study tested a custom probiotic blend in 296 children and adults with autism spectrum disorder. The goal was to see if the supplement could improve autism symptoms and gastrointestinal issues. Participants took a personalized mix of probiotics, prebiotics, and botanicals, an…

This study tested whether a virtual reality (VR) product called Floreo can help autistic children improve their social skills. 117 children aged 5 to 18 used the VR program twice a week for 12 weeks. Researchers compared the Floreo VR group to a control VR group to see if there w…

This small pilot study tested whether a non-invasive brain stimulation technique called TMS, guided by each person's unique brain map, could help improve language and social skills in 22 children and young adults with autism and language delay. The treatment targeted a specific b…

This pilot study tested whether a 12-week course of a synbiotic supplement (probiotics plus prebiotics) could help reduce anxiety in 30 children with autism spectrum disorder. The main goals were to see if the treatment was safe and tolerable, and to measure any changes in anxiet…

This study looked at whether adding Ayres Sensory Integration therapy to usual education helps preschool children with autism. 63 children aged 4 to 5 years took part. The therapy focused on improving daily skills and sensory processing over 12 weeks.

This study tested a 6-week mobile app designed to support Chinese parents of children with autism. The app provided knowledge, skills, and mindfulness training. 852 parents took part to see if the app could reduce anxiety, depression, and stress while boosting parenting confidenc…

This pilot study tested a wearable device that gently stimulates a nerve in the ear to help manage anxiety in teenagers with autism. Ten participants used the device at home twice daily for four weeks. The goal was to see if it was safe and easy to use, not yet to prove it works.…

This pilot study tested a 4-week laughter yoga program (8 sessions, 15 minutes each) in 45 adolescents with intellectual or physical disabilities at a special school in Hong Kong. Half did laughter yoga, half got routine care. The goal was to see if laughter yoga could improve mo…

This completed trial tested whether LEGO therapy can improve social skills in 50 adolescents aged 10–14 with high-functioning autism. Participants attended 12 weekly 90-minute group LEGO sessions over 3 months. Researchers compared their social skills to a control group who conti…

This study tested whether pregnenolone, a natural hormone in the brain, can help reduce irritability and improve social communication in people with autism. 40 participants aged 14 to 25 took either pregnenolone or a placebo for several weeks. Researchers measured changes in beha…

This study tested an in-person mindfulness program for adolescents with autism and their caregivers. The goal was to help reduce stress, anxiety, and depression. 28 teens and their caregivers took part in group sessions. The program aimed to improve mental health and well-being.

This study tested a school-based program where teachers were trained to use special techniques to help preschoolers with autism improve their social and communication skills. 700 children aged 3 to 6 took part. The goal was to see if this approach works in real classrooms and can…

This study tested whether a gentle, non-invasive brain stimulation technique could safely improve social symptoms in children with autism. 36 children aged 4-10 received either real stimulation or routine rehabilitation for 5 days. The goal was to see if the treatment is safe and…

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This study looked at whether a 16-week swimming and water exercise program could improve behavior and physical skills in 35 boys aged 6 to 12 with mild autism. Half the boys did the water exercises twice a week, while the other half continued their usual school routine. The resul…

This study tested a structured movement program (Sherborne Developmental Movement) in 30 children aged 8-12 with autism. The program aimed to improve how they process sensory information, move their bodies, and perform everyday tasks. Results were measured using motor skill tests…

This study tested whether having a therapy dog present during dental visits could reduce anxiety and improve cooperation in autistic children aged 6 to 17. Fifty children received two sessions with a dog and one without. The goal was to see if the dog's presence made later visits…

This study tested a structured program to help children and teens with autism, developmental delays, or intellectual disabilities cooperate during eye exams. Twenty participants attended six training sessions that used practice in a mock clinic, rewards like snacks or toys, and o…

This study tested a new anxiety program designed for autistic youth ages 7 to 17. The program was delivered in community care centers to make it more accessible. Researchers wanted to see if it was practical and helpful for reducing anxiety symptoms. The study involved 32 partici…

This study tested two ways of using action observation therapy to help children with cerebral palsy improve their balance, walking, and daily movement. Twenty-two children aged 6 to 18 watched videos of motor tasks either in real time (synchronous) or with a delay (asynchronous) …

This study tested a video-based therapy called Focused Acceptance and Commitment Therapy (FACT) for parents of children with special health needs, like ADHD or autism. The goal was to see if it could reduce stress, anxiety, and depression. 104 parents took part, and the therapy w…

This study tested whether adapted judo training plus nutritional counseling could improve physical fitness, body composition, and stability in children and adolescents with autism spectrum disorder (ASD). One hundred participants aged 7–14, with and without ASD, took part in 10 m…

This study tested an 8-week virtual reality program based on cognitive-behavior therapy to help adults with autism spectrum disorder handle sensory sensitivities. 90 participants practiced relaxation, ranked scary situations, and faced them gradually in VR. The goal was to reduce…

This study tested whether a physical activity program delivered via telehealth could improve sleep in children with autism spectrum disorder (ASD) and reduce stress for their parents. 160 children aged 8-12 and their caregivers took part from home, using activity trackers and que…

This study looked at whether circuit aerobic training (like walking and stepping) or circuit resistance training (like hand grip exercises) can improve heart and lung fitness in children with autism aged 7 to 17. Thirty-two children took part, and researchers measured their breat…

This study tested a 40-week music program using bone conduction headphones in 8 children with autism who are overly sensitive to sound. The goal was to see if the program could reduce their discomfort with noise and improve their daily living skills. Researchers measured changes …

This study tested whether gabapentin, a medication that boosts a calming brain chemical called GABA, could improve social thinking in teens with autism. Sixteen adolescents aged 13-17 took gabapentin for 8 weeks while researchers measured brain GABA levels and social abilities. T…

This study looked at how 10 months of judo training affects physical fitness and anxiety in children with autism. Ninety kids aged 7 to 14, with and without autism, trained together. Researchers measured fitness with standard tests and anxiety with questionnaires. The goal was to…

This study tested a school-based program called Unstuck & On Target: High School for autistic teens. The program teaches skills like flexibility, planning, and self-advocacy through 25 lessons led by school staff. Researchers measured changes in classroom behavior and daily livin…

This study tested whether an 8-week mindfulness-based stress reduction program could lower depression, anxiety, stress, and hopelessness in parents of children with autism. 96 parents took part in weekly 60-minute group sessions. The goal is to see if this simple, non-drug approa…

This study tested whether a mild electrical stimulation to the ear (taVNS) can help manage symptoms of autism spectrum disorder in teens aged 12-17. Sixteen participants used the device at home for one month and had MRI brain scans before and after to track changes. The goal was …

This study looked at whether a 12-week structured movement program could help young children (ages 4-6) with autism improve their motor skills and daily functioning. Twenty-eight children participated; some did the movement program twice a week plus their usual education, while o…

This phase 3 trial tested an experimental drug called AST-001 in 169 children with autism spectrum disorder. The goal was to see if it improves core symptoms like social communication and repetitive behaviors better than a placebo. The study is already completed, and results will…

This study tested a device called transcranial photobiomodulation (tPBM), which shines invisible light on the front of the brain through a headband. Researchers wanted to see if it is safe and can improve social and behavioral symptoms in adults with autism. Forty-one adults took…

This study tested whether adding fully immersive virtual reality (VR) training to standard psychological and behavioral therapy helps children with autism. 120 children aged 2 to 12 took part; 62 received VR plus therapy, and 58 received therapy alone. The goal was to see if VR c…

This study tested a theatre-based program called SENSE Theatre for adults with autism. 72 participants took part in 10 sessions of role-play and peer interaction, ending with a public performance. The goal was to see if this approach could improve social skills like reading faces…

This early-phase trial tested the safety of nabilone, a synthetic cannabinoid, in 20 adults with intellectual and developmental disabilities who have severe aggression. The goal was to see if the drug is well-tolerated and to gather initial data on whether it might reduce aggress…

This study tested whether a 5-month program of dialectical behavior therapy (DBT) can help adults with autism who struggle with self-harm or suicidal thoughts. Researchers enrolled 92 adults with autism and no intellectual disability. The goal was to see if DBT reduces emotional …

This study tested whether metformin, a common diabetes medication, can help improve language, behavior, and weight problems in people with fragile X syndrome. 125 participants aged 6 to 35 took either metformin or a placebo for 4 months. Researchers measured changes in language s…

This study tested a 12-week motor support program in 28 children aged 4-6 with autism. The program added 40-minute sessions twice a week to regular special education. Researchers measured changes in gross motor skills, sensory processing, and autism symptoms using standard tests.…

This study tested a flexible, play-based program to improve social communication and language in toddlers (ages 2-3) with autism. 199 children took part in community early-intervention settings. The program adjusted the type and amount of one-on-one play coaching based on each ch…

This study tested whether a daily routine of gentle massage and deep breathing, called qigong sensory training, could help children with autism who have trouble processing sensory information. Twenty-six children aged 4 to 12 received 15-minute sessions twice a day, five days a w…

This study tested whether short, structured physical activity breaks or free play in the classroom can improve gross motor skills, endurance, and behavior in children with mild intellectual disability. Twenty-two children from a special education center took part, with one group …

This study tested a tablet application called Mental Imagery Therapy for Autism (MITA) in 150 children aged 2 to 8 with autism. The goal was to see if using the app could improve their language, sociability, and cognitive awareness. Researchers measured changes using standard che…

This study tested whether taking creatine supplements could improve brain health and reduce symptoms in people with autism spectrum disorder (ASD). Twenty participants aged 10 and older took creatine or a placebo for a period. Researchers measured changes in brain creatine levels…

This study tested a mobile app called TRIP designed to support Chinese parents of children with autism. The app provides mindfulness training and parenting tips over 6 weeks. Researchers measured if parents found the app useful and if it helped reduce their stress and anxiety. Th…

This study tested whether baby SPA (hydrotherapy) and massage can reduce colic symptoms in infants. 72 babies aged 40 days to 4 months with diagnosed colic were enrolled. The intervention involved weekly SPA and massage sessions for four weeks, with symptoms tracked using a colic…

This study tested whether occupational therapy that includes horseback riding can help autistic youth improve self-regulation, compared to standard clinic-based therapy. 73 participants received 10 weeks of therapy and provided weekly saliva samples. The goal was to see if the ho…

This study tested a 16-week sensory-friendly physical activity program for autistic children aged 7-12 in special education schools. The program included predictable routines and calming cool-downs to help with sleep. Researchers measured sleep quality using wrist monitors and pa…

This study looked at whether a structured physical activity program could improve motor skills and social abilities in autistic children aged 8 to 12. Forty children from a special education school took part. The program focused on exercises to boost physical fitness and daily li…

This study tested a 22-week online parenting program (Incredible Years) for families of children aged 3-7 with genetic abnormalities and mental health or developmental problems. 53 families were randomly assigned to the program or usual care. The goal was to see if parents would …

This study looked at whether a gluten-free and casein-free diet affects certain blood markers and symptoms in children with autism spectrum disorder. Twenty-one children aged 3-6 were randomly assigned to either the special diet or a normal diet for 12 weeks. Researchers measured…

This study tested a light therapy called transcranial photobiomodulation (tPBM) to see if it could safely reduce autistic traits and ADHD symptoms in children and teens. 38 participants aged 9 to 17 with ADHD and at least moderate autism symptoms received the treatment. The goal …

This study looked at whether aquatic (water) training or land exercises better improve motor function in children with autism. Forty children aged 3 to 5 with mild to moderate autism took part. Researchers measured changes in motor skills, autism severity, and quality of life aft…

This study tested whether oxytocin nasal spray, sometimes called the 'love hormone,' can improve behavior and eating problems in adults with Prader-Willi syndrome. Fifty participants received either oxytocin or a placebo daily or every three days for 28 days. Researchers measured…

This study tested an online sleep program for preschool-aged children with autism who have trouble sleeping. 20 children participated to see if the program was easy to use and helped improve sleep. The goal was to make sleep help more accessible for families.

This study tested whether wearing a virtual reality headset during dental treatment could reduce anxiety in children aged 11-15 with mild intellectual disability. Fifty-six children with moderate dental anxiety were randomly assigned to either VR distraction or watching a cartoon…

This pilot study tested a 14-week Independent Life Skills Program (ILSP) for adults with autism. The program covers personal management, home skills, and community integration through group sessions led by occupational therapists. Thirty adults aged 18 and older with autism and b…

This study tested a new card game called 'Wai Ji Match Fun' designed for adults with mild to moderate intellectual disabilities. 60 participants played the game in weekly group sessions for 8 weeks. Researchers measured how feasible and acceptable the game was, and whether it imp…

This completed study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) could improve social awareness and reduce repetitive behaviors in 16 adults with autism spectrum disorder. rTMS uses magnetic pulses to gently…

This study tested an experimental drug called AB-2004 to see if it can safely reduce irritability in people with autism spectrum disorder. 156 participants received either the drug or a placebo for 8 weeks. The main goal was to measure changes in irritability scores and check for…

This study tested whether parents can learn a proven autism therapy called Pivotal Response Treatment (PRT) through secure video calls. 101 children aged 2-5 with autism and language delays took part. Parents received weekly 60-minute training for 12 weeks. The goal was to see if…

This study tested whether adding homeopathic treatment to standard therapies (speech, occupational therapy) helps children with autism. 54 kids aged 3–12 were randomly given either individualized homeopathic medicines or a placebo. Researchers tracked changes in communication, be…

This study tested whether a structured program of therapeutic play activities could improve motor adaptive behavior in 20 Egyptian children aged 5-9 with mild intellectual disability. The children took part in 24 play sessions over 2 months, focusing on core strength, coordinatio…

This study tested whether a structured physiotherapy program—including breathing exercises, balance training, and relaxation techniques—could reduce stress, anxiety, and depression in 117 children aged 6 to 18 with autism or ADHD. Participants were randomly assigned to either the…

This study tested a coaching program for families of young children (ages 1.5 to 4.5 years) with suspected or confirmed developmental delays. The program included regular coaching sessions, online education, and peer support over 18 months. Researchers measured whether this appro…

This study tested a time-limited version of Parent-Child Interaction Therapy (PCIT) delivered via telehealth for young children (ages 2-6) with autism and disruptive behavior problems. 80 families were randomly assigned to receive 10 sessions of Tele-PCIT or continue with their u…

This study tested the drug atomoxetine in 60 children with autism who also had significant hyperactivity, inattention, or impulsivity. Over 8 weeks, researchers measured changes in ADHD symptoms using a standard rating scale. The goal was to see if atomoxetine could safely reduce…

This study tested whether omega-3 and omega-6 supplements could improve behavior and reduce inflammation in 98 children aged 2-6 with autism. Researchers measured changes in autism symptoms and certain blood markers over 90 days. The goal was to see if these natural supplements c…

This study tested special safety kits for children with autism who tend to wander away from safe places. Caregivers of 65 children aged 4 to 11 rated how useful each kit item was and how the kits affected their stress and ability to go out in the community. The goal is to use thi…

This small study tested a cognitive training app called D-kit/EF1 in 11 children aged 4-8 with borderline or mild intellectual disability. Children used the app for 30 minutes a day, 5 times a week for 12 weeks, while a comparison group watched educational videos. The goal was to…

This study tested whether teaching social skills to autistic children and educating their classmates can improve social relationships at school. Sixty children in kindergarten through 5th grade took part in 30-minute sessions twice a week for six weeks. The goal was to see if the…

This study tested whether therapeutic horseback riding can improve behavior, social skills, and emotional control in 250 autistic youth who also have a mental health condition. Participants were randomly assigned to riding, barn activities without riding, or a hybrid group. Resea…

This study tested whether a biofeedback video game called Mightier can help children aged 8-12 with emotional dysregulation. 183 kids were randomly assigned to play the game at home or receive usual care for 6 months. Researchers tracked symptoms, parent stress, and healthcare co…

This study tested whether a noninvasive technique called repetitive transcranial magnetic stimulation (rTMS) could improve cognitive functions and behavior in 35 children with autism spectrum disorder (ASD), aged 5 to 11. The treatment uses magnetic pulses to gently stimulate bra…

This study looked at whether a 5-week parenting training program could improve the quality of life and parenting skills for parents of children with intellectual disabilities. 141 parents from 11 special schools took part, with 71 receiving the training and 70 in a control group.…

This pilot study tested whether lithium can improve social communication in children with autism spectrum disorder who also have a SHANK3 gene mutation (Phelan-McDermid syndrome). 22 children took either lithium or a placebo for 12 weeks. Researchers measured changes in social re…

This study tested different doses of melatonin to see which one best improves sleep quality in autistic children aged 3 to 12 who have trouble sleeping. Researchers measured things like how long it takes to fall asleep, total sleep time, and number of night awakenings using sleep…

This study tested whether taking part in art activities (like painting, music, or dance) can improve mental well-being. 382 people with mental health issues such as anxiety, depression, or emotional disorders were randomly assigned to either an art program or a waitlist. The stud…

This study tested whether a specialized swim program (Sensory Enhanced Aquatics) helps autistic children aged 5-9 learn swimming and water safety better than standard lessons. Fifty-one children participated in 16 half-hour lessons. Researchers measured swimming skills before and…

This study tested whether a robot program can help children with autism spectrum disorder (ASD) better understand emotions and social cues. Forty children aged 4 to 8 were split into two groups: one used the robot program for 8-14 weeks, the other received no extra help. Research…

This completed trial tested a 5-session group program for siblings and parents of children with chronic illness. The goal was to improve sibling mental health, family communication, and quality of life. 288 families participated, with some receiving the program immediately and ot…

This study tested whether listening to white noise or seeing visual pixel noise can improve attention in children with ADHD. Sixty children, some with ADHD and some without, completed eye-tracking tasks while exposed to these noises. The goal was to see if the noise could help th…

This study tested whether a 12-session program combining yoga and support groups could reduce stress for caregivers of young adults with intellectual and developmental disabilities. Twenty caregivers participated, and researchers measured stress levels, cortisol, and how many ses…

This study looked at whether a special type of counseling, called the Tidal Model, could help mothers of children with autism. The mothers attended 8 weekly one-on-one sessions. The goal was to reduce feelings of internalized stigma (blaming themselves) and improve their overall …

This study tested whether cannabidiol (CBD) oil can reduce severe behavioral problems in children aged 6-18 with intellectual disability. 132 participants received either CBD or a placebo for 8 weeks. The main goal was to see if CBD improves irritability and other challenging beh…

This study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70. The goal was to learn how these tissues change over tim…

This study used PET scans to measure blood flow in the frontal lobe while participants performed thinking tasks. It included healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to understand how the frontal lobe works during cognitive activities …

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This study adapts an existing advocacy program, called ASSIST, for Latinx families of autistic youth aged 12 and older. The program teaches parents how to advocate for adult disability services, aiming to improve access to care. Researchers will test the adapted program with 48 S…

This study looked at how adults with autism spectrum disorder (ASD) form emotional attachments to others. Researchers used questionnaires to measure social responsiveness and attachment styles in 32 adults with ASD. The goal was to better understand the link between autism and at…

This completed study looked for genetic changes linked to autism spectrum disorder in over 1,600 participants. Researchers focused on genes involved in brain cell communication, hoping to understand which biological pathways are involved. The goal was to gather knowledge that cou…

This study investigates why people develop obstructive sleep apnea (OSA) and whether the underlying cause affects how they respond to different treatments. Researchers will test three approaches—CPAP, a sleep medication (eszopiclone), and supplemental oxygen—in adults with OSA. T…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study tested a digital app called CICADAS, designed to improve thinking skills in teenagers with autism. Sixty-eight teens aged 11-18 used the app for up to 40 hours, doing exercises that adapt to their ability. The goal was to see if the app is acceptable and easy to use, n…

This study looked at how adults with autism spectrum disorder (ASD) and bipolar disorder (BD) experience and show emotions. Researchers measured things like heart rate, pupil size, and facial expressions in a lab, and also tracked emotions in daily life for a week. The goal was t…

This study tested a mixed reality app designed to help students aged 10-20 with mild-to-moderate intellectual disabilities learn digital skills like online safety and independence. The app adapts to each student's responses, providing visual cues and Arabic voice prompts. Researc…

This completed study looked at how adults with autism spectrum disorder (ASD) process emotions in moral situations, compared to people without autism. Researchers used stories about harm and accidents, then asked participants to quickly identify faces or judge if facial expressio…

This study looked for hidden genetic changes in 10 children with developmental delays who had a balanced chromosomal translocation (a rearrangement of DNA that appears normal under a microscope). Researchers used high-resolution DNA microarrays to check for tiny missing or extra …

This study tested whether a 6-session online class called HEARTS helps autistic adults feel more satisfied with their friendships and dating relationships, compared to a 6-week online discussion group. Ninety-two autistic adults took part over three months, completing surveys abo…

This study tested a family navigator program and a smartphone app to help low-resourced families of young children (ages 3-5) with autism find and access services. 52 families took part. The program aimed to improve parents' knowledge, skills, and confidence in getting support fo…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This study collected DNA, tissue, and medical history from 305 people with Williams syndrome or supravalvar aortic stenosis (SVAS), as well as their family members and healthy volunteers. The goal was to create a resource for future research to understand why symptoms vary so muc…

This study looked at 8500 people with intellectual disability to find new genes that might cause it. Researchers used advanced DNA tools to compare patients and their healthy siblings. The goal was to identify unknown genetic causes and improve future diagnosis.

This study looked at how children with autism (without intellectual disability) form and recall paired memories, like linking a face to a name. Researchers used EEG brain scans and memory tests to compare 74 right-handed children aged 10-18, half with autism and half without. The…

This study compared how 59 children with and without autism look at videos of people interacting. Researchers measured where children focused their eyes—on faces, objects, or the background—to understand differences in social attention. The goal was to learn more about how autism…

This study used eye-tracking to see how emotional expressions (low, medium, or high intensity) influence how children with autism understand intentions. Researchers watched where 80 children looked during a puzzle task. The goal was to learn more about attention patterns, not to …

This completed study used eye-tracking technology to understand how children with autism spectrum disorder (ASD), intellectual disability (ID), and typically developing children process visual cues. Researchers showed 80 children videos of a model choosing objects and recorded th…

This study looked at how children with autism pay attention to social threats compared to non-social threats. Using eye-tracking and brain imaging, researchers measured eye movements and brain activity in 56 children while they watched videos. The goal was to understand joint att…

This study used eye-tracking to see how children with autism spectrum disorder (ASD) and typically developing children look at faces during social interactions. Researchers measured where and how long children focused on faces versus objects. The goal was to understand when diffe…

This study screened 233 children aged 6 to 66 months with congenital heart disease for neurodevelopmental disorders like delays in communication, movement, and problem-solving. Researchers used a parent questionnaire to identify children at risk. The goal is to better understand …

This study examined 90 children with obesity and additional features like intellectual disability or birth defects, whose genetic cause was unknown. Researchers used a special DNA test to look for tiny missing or extra pieces of chromosomes. The goal was to find new genes that ma…

This study looked at how 30 children aged 12-18 with mild intellectual disabilities learn tennis. One group used real-time pose recognition technology, while the other had standard instructor-led lessons. Over 14 weeks, researchers compared their learning experiences and motor sk…

This study looked at whether a special walking test (3D gait analysis) can help identify movement problems in people with rare genetic diseases like Tuberous Sclerosis and STXBP1. About 40 participants aged 6 and older who could walk without help took part. The goal was to see if…

This study looked at 60 teens ages 12 to 18 to see if those with Avoidant and Restrictive Food Intake Disorder (ARFID) had more feeding problems before age 4 compared to healthy teens. Researchers used questionnaires to check early feeding history, growth, and sensory sensitiviti…

This study explored why some children with autism respond better to parent-led therapies than others. Researchers tested different sequences of parent education and child coaching in 81 toddlers (12-36 months) to see which approach worked best for which families. The goal was to …

This completed study at Rutgers University looked at how the brain and body communicate in 30 people with conditions like autism, ADHD, Alzheimer's, and Parkinson's. Participants performed natural movements like walking and pointing while their brain, heart, and motion signals we…

This study used brain scans like MEG, EEG, and MRI to learn how the brains of people with autism spectrum disorder process sensory information. 85 people between the ages of 14 and 32 took part. The goal was to better understand the condition, not to test a new treatment.

This study created a database of 40 people, including healthy volunteers and those with autism spectrum disorder, to make it easier to recruit for future research. Participants were between 14 and 32 years old. The goal was to build a pool of willing volunteers for upcoming studi…

This study tested a training program for teachers of preschool children with autism. Forty teachers from mainstream schools in Barcelona took part. The program aimed to give teachers practical tools to support children with autism in the classroom. The main goal was to see if tea…

This study looked at the types of bacteria in the mouth and the levels of a protective antibody in the saliva of children with autism, aged 6 to 18. Researchers collected dental plaque and saliva samples to compare with dental health. The goal was to learn more about oral health …

This completed study followed over 1,100 pregnant women in Guangzhou to see how their diet and nutrition during and after pregnancy relate to blood sugar problems like gestational diabetes. Researchers also tracked the children's growth, brain development, and allergies up to age…

This study looked at how fever changes seizure patterns in people with CDKL5 deficiency disorder, a rare genetic condition that causes hard-to-control seizures. Researchers surveyed parents of 131 affected individuals to collect information on fever history and seizure frequency.…

This study followed 344 infants with a sibling diagnosed with autism from birth to age three. Researchers collected blood, stool, urine, and saliva samples to find early biological markers that might predict autism. The goal is to better understand how autism develops and eventua…

This study looked at 15 people with a rare genetic condition called DDX3X syndrome, which can cause intellectual disability and sometimes autism. Researchers used interviews, play-based assessments, and genetic tests to better understand the condition. The goal was to describe th…

This study looked at why girls with Rett syndrome often develop weak bones (osteoporosis) at a very young age. Researchers checked bone density, looked at medical history, and measured certain proteins in the blood. The goal was to find risk factors and understand the biological …

This completed study looked at how appetite-regulating hormones change in infants with Prader-Willi syndrome during the first four years of life. Researchers collected blood samples from 215 infants to understand why they switch from poor feeding to severe overeating and obesity.…

This study looked at whether teenagers with autism spectrum disorder can comfortably wear different types of wearable devices—like wristbands, headbands, patches, or rings—for two weeks. Forty teens and their caregivers participated, answering questions and wearing the device as …

This completed study followed 509 children aged 3 to 18 who were taking risperidone or aripiprazole for conditions like schizophrenia or bipolar disorder. Researchers measured weight changes over up to 50 months to understand long-term risks. The goal was to provide better safety…

This study tested a falls management tool adapted for adults with intellectual disabilities. 13 participants, including adults with intellectual disabilities, carers, and clinicians, tried the program and gave feedback on how easy it was to use. The goal was to see if the tool is…

This study looked at whether children with autism spectrum disorder (ASD) can learn new words by overhearing conversations, compared to being directly taught. Researchers tested 342 children aged 18 to 71 months, both with and without ASD, using video sessions. They measured lear…

This completed study looked at how teenagers with autism or schizophrenia understand emotions, metaphors, and social situations compared to healthy teens. Researchers tested 60 participants using facial emotion recognition and other tasks. The goal was to find out if social diffi…

This completed study tested a 16-hour training program called SPECTROM for staff and caregivers who work with adults with developmental disabilities and co-occurring mental health disorders. The training focused on managing challenging behaviors. Researchers measured changes in p…

This study looked at whether a program called Movement Matters is practical and acceptable for children aged 7-11 with intellectual disabilities or autism. The program includes teacher training, school activities, family involvement, and role models. Researchers worked with 43 ch…

This study looked at new ways to help children with autism who also have severe destructive behaviors, like aggression or self-harm. The goal was to make communication therapy more flexible and prevent bad behaviors from coming back when therapy is interrupted. Nine children aged…

This completed study looked at whether giving doctors access to genetic tests called FirstStepDx PLUS and NextStepDx PLUS helps them diagnose intellectual disability and developmental delay more accurately and cost-effectively. The study involved 217 pediatric neurologists, devel…

This study looked at the best ways to encourage COVID-19 testing for children with intellectual and developmental disabilities and their teachers. Over 1,100 participants from two special school districts took part. The goal was to find what messages and strategies work best to k…

This early-stage study tested a new oral drug called IAMA-6 in 72 healthy adults to see if it is safe and how the body processes it. The drug is being developed for neurodevelopmental disorders, but this trial did not treat any disease. Researchers monitored side effects, vital s…

This study tested a 10-week group education program for parents of autistic preschoolers in Türkiye. The program taught naturalistic teaching strategies to help parents support their child's development. Researchers measured changes in parents' confidence and tracked how many fam…

This study created and tested a program called Families FORWARD to help parents of autistic teens (ages 14-21) plan for their child's future. 27 families in Massachusetts took part. The program focused on improving family readiness for the teen's transition to adulthood. Research…

This study looked at gut bacteria in children with autism and their neurotypical siblings who live together. Researchers collected stool samples from 20 children aged 3 to 10. The goal was to compare the types of bacteria and other substances in the gut. This was an observational…

This study followed 188 children who had seizures shortly after birth to see how they develop over time. Researchers measured thinking skills, behavior, and daily function. The goal is to understand which children are at higher risk for conditions like cerebral palsy or intellect…

This completed study looked at 500 children aged 5 to 18 to understand how factors around birth, thinking abilities, and social-emotional skills are linked to learning difficulties and developmental disorders like ADHD or autism. Researchers compared children with and without the…

This study looked at how children with autism and typically developing children perform physical tasks like standing still or walking when they also have to do a thinking task at the same time. Researchers tested 90 children aged 5 to 16 using a balance board and a walking app. T…

This study tested JASPER, a play-based therapy for autism, in 84 toddlers aged 18 months to 5 years. Children were randomly assigned to receive JASPER from a clinician or their parent. The goal was to see if two new measurement tools (BOSCC and ELSA-T) could track changes in soci…

This study looked for early signs of epilepsy in children with autism and tested whether a structured exercise program could influence those signs. Fifty children aged 10-15 with autism, epilepsy, or both took part. Researchers analyzed blood, sleep, brain activity, and thinking …

This study tested a virtual educational program called FLAPS, designed to help members of organizations learn how to support suicide prevention for autistic people. Fifty-one participants completed surveys before, after, and three months after the program, and some gave interview…

This study looked at 227 orphaned children aged 6-12 with severe intellectual disability to see if their gross motor skills (like running and throwing) are linked to everyday abilities such as dressing, communicating, and socializing. Researchers tested motor skills with a standa…

This study looked at how stress-reduction classes affect brain function in adults with autism. 108 participants were randomly assigned to either an 8-week mindfulness program or a relaxation and social support group. Researchers used brain scans and questionnaires to see if chang…

This study tested a reading program for 55 young adults with intellectual or developmental disabilities. Participants learned strategies to understand everyday texts like emails and messages during 45-minute sessions twice a week for three months. The goal was to see if the progr…

This study explores whether a single general anesthesia before age 4 can affect thinking skills like memory, attention, and flexibility in children aged 9-10. Researchers compared 80 children—half had anesthesia, half did not—using computer tasks. The goal is to understand if ear…

This study tested a program that uses technology and trained family navigators to help children with autism and their families get connected to mental health services more quickly. The program was used in primary care clinics. Researchers measured how acceptable, feasible, and he…

This study looked for brain markers of catatonia (a condition causing movement and behavior problems) in people with autism. Researchers used MRI scans to target a brain area with magnetic stimulation and measured brain activity and symptoms. The goal was to see if overactive bra…

This study used special PET and MRI scans to look at brain activity in 27 men with autism, Fragile X syndrome, or no condition. The goal was to measure a brain chemical called glutamate, which helps nerve cells communicate. Researchers hope this will reveal how brain signaling di…

This study looked at whether the ability to learn patterns (called statistical learning) can predict how well first-graders with autism and their non-autistic peers improve their language and reading skills over three months. Forty-one children completed language tests and comput…

This study looked at whether learning to ride a bike improves planning, memory, and self-control in children aged 8-10 with autism. Sixty-two children tried different cycling exercises for two weeks. Researchers measured changes in thinking skills and a brain chemical called BDNF…

This study followed 132 children and teens aged 7-18 with severe intellectual disabilities living in Chinese orphanages for three years. Researchers measured their physical fitness every three months using simple tests like throwing a beanbag, doing sit-ups, and standing on one l…

This study tested two types of early help for infants who may develop autism. About 269 families with a baby at higher risk (because an older sibling has autism) took part. Some parents got a web-based guide to support their baby's social communication, and later, some received e…

This study looked at how autism affects personal identity in adults without intellectual disability. Researchers compared 102 autistic adults to healthy controls using memory tests and questionnaires about self-concept. The goal was to understand how autism influences the way peo…

This study tested a new parent questionnaire called ORALQUEST to assess feeding and eating disorders in children aged 9 months to 6 years. Researchers included 338 children with chronic conditions like heart defects or autism, as well as those with picky eating. The goal was to s…

This study tested whether an online program called Work Chat could be delivered entirely over the internet to autistic adults. Researchers wanted to see if it was practical and if it helped with social skills like understanding hints and emotions. 234 employed or job-seeking auti…

This study looked at whether a physical therapy program based on the Bobath concept can help very preterm babies (born between 24 and 32 weeks) improve their motor skills and overall development after leaving the hospital. Sixty infants took part, with some receiving the therapy …

This study measured how children with and without autism look at faces, body movements, and objects using eye-tracking technology. Researchers wanted to see if visual patterns could help understand social differences in autism. 150 children took part, including those with autism …

This completed study at the NIH enrolled 96 children with known or suspected genetic disorders, including autism and Fragile X syndrome. The main goal was to give clinic staff hands-on experience and explore new research ideas. Participants received medical exams, lab tests, and …

This completed study observed nearly 27,000 pregnant women in French Caribbean departments during the 2016 Zika epidemic. Researchers tracked Zika infections and their impact on pregnancy, including rates of microcephaly and other fetal abnormalities. The goal was to better under…

This completed study looked at whether children with neurodevelopmental disorders (like mitochondrial disease, cerebral palsy, or developmental delay) have fewer small nerve fibers in their skin, which could cause pain. Researchers took small skin biopsies from 203 children—some …

This study tested a training program to help autistic adults learn to use rideshare services like Uber or Lyft. 13 autistic adults took part to see if the training was acceptable and helpful. The goal was to give them more freedom to travel independently for work, social events, …

This completed study looked at how people with autism spectrum disorder (ASD) pay attention to emotional cues and changes in their environment, compared to people without ASD. Researchers used brain imaging (fMRI, DTI) and EEG to measure brain activity in 120 children and adults.…

This study tested a French version of the PEERS social skills program for 64 adolescents and young adults with rare neurodevelopmental disorders. The goal was to see if improving social skills could lower their risk of anxiety and depression. Participants attended the program wit…

This study tested whether a 6-session psychoeducation program could improve autism knowledge, sibling relationships, well-being, and resilience in 88 adult siblings of people with autism. Participants were all neurotypical adults living in Greece. The program was designed to prov…

This pilot study looked at how routine occupational therapy changes brain activity and behavior in children with autism. Two children received weekly one-hour therapy sessions for 6-8 weeks. Researchers used EEG to measure brain responses and parent questionnaires to track social…

This study explores how parents' own language skills influence the quality of early language interactions with their children, especially those with language delays or autism. Researchers trained 156 parents using a program called Enhanced Milieu Teaching, which teaches responsiv…

This study looked at whether whole genome sequencing (a complete read of a person's DNA) can help diagnose leukodystrophies, a group of rare brain diseases that are hard to identify. Researchers enrolled 236 children with white matter abnormalities on brain scans but no known gen…

This completed study followed 126 babies born at 35 weeks or later who were at risk for low blood sugar (hypoglycemia). Researchers compared those who had low blood sugar in their first day of life with those who did not, testing their thinking, movement, and language skills at 1…

This completed study looked at how the body processes certain amino acids in people with autism compared to healthy volunteers. Researchers gave participants a special infusion of stable isotopes to track metabolism, and also tested their thinking and mood. The goal was to find l…

This study tested a set of questions to better identify suicide risk in young people aged 8–17 with autism or other neurodevelopmental disorders. Researchers asked 278 participants and their parents about thoughts of self-harm and understanding of death. The goal was to create a …

This study looked at 40 children with autism and 40 healthy children, ages 5 to 10, to see how posture, hand function, and sensory processing affect nutrition. Researchers measured head posture, balance, hand strength, and feeding behaviors. They found that children with autism h…

This study looked at 25 people with FOXP1 syndrome, a rare genetic condition, to better understand their psychiatric symptoms. Researchers used interviews and questionnaires with families to assess hyperactivity, attention, anxiety, autism traits, and more. The goal is to improve…

This study tested two versions of the seizure medication stiripentol (Diacomit®) in 24 healthy adults: a capsule and a liquid suspension. The goal was to see if the liquid form is absorbed by the body in a similar way to the capsule. If so, it could provide a more convenient opti…

This study looked at 29 boys with autism, aged 6 to 8, to see if brain scans could reveal how sensory-based occupational therapy changes the brain. Half received a customized 16-week sensory enrichment program, while the other half served as controls. Researchers used MRI before …

This completed study from Yale University enrolled 565 children aged 6-11, both with and without autism, to confirm whether certain brain wave and eye-tracking measures can serve as reliable biomarkers. The goal is to provide objective tools for future clinical trials to measure …

This completed study tested a device called EarliPoint that uses eye-tracking to monitor changes in children with autism spectrum disorder (ASD) or developmental delays. Researchers followed 325 children aged 15-84 months over 180 days to see if the device could detect improvemen…

This study examined 22 deaf infants under 10 months old to find factors linked to early signs of neurodevelopmental disorders like autism. Researchers filmed psychiatric consultations and used a special scoring system to assess the babies' interaction and movement skills. By comp…

This completed study used a non-invasive brain stimulation technique called rTMS to investigate how a specific brain area (the superior temporal sulcus) influences social perception in people with autism and healthy controls. Researchers measured changes in eye-gaze patterns and …

This study looked at 558 people with congenital hypothyroidism, a rare thyroid condition found in newborns. Researchers examined their genes, medical images, and health records to find links between genetic changes and the type or severity of the disease. The goal is to improve e…

This study looked at how foot posture and body measurements relate to balance in 22 children with autism spectrum disorder, aged 5 to 18. The children performed simple balance and walking tests while researchers measured their feet. The goal was to understand if foot structure af…

This completed study followed 477 women in Denmark who had a planned cesarean delivery. Researchers used text-message surveys to track pain levels, medication use, and how pain affected daily life over several months. The goal was to better understand how common persistent pain i…