Could a new pill calm Autism-Related irritability?

NCT ID NCT04895215

Completed Symptom relief Sponsor: Vertero Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called AB-2004 to see if it can safely reduce irritability in people with autism spectrum disorder. 156 participants received either the drug or a placebo for 8 weeks. The main goal was to measure changes in irritability scores and check for side effects.

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Conditions

The condition(s) this trial relates to.

anxiety disorder autism spectrum disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTISM SPECTRUM DISORDER (ASD

Contacts and locations

Locations

Baber Research

Naperville, Illinois, 60563, United States
Brain Mind Centre

Sydney, New South Wales, 2050, Australia
CNS Solutions

Jacksonville, Florida, 32256, United States
CNS Solutions

Orlando, Florida, 32801, United States
Children's Health Queensland Hospital

South Brisbane, Queensland, 4101, Australia
Clinical Research of Southern Nevada

Las Vegas, Nevada, 89128, United States
Cortica Marin

San Rafael, California, 94903, United States
Cortica Westlake

Westlake Village, California, 91361, United States
Harmonex Neuroscience Research

Dothan, Alabama, 36303, United States
IMMUNOe Research Centers

Centennial, Colorado, 80112, United States
Monash Kids Research

Clayton, Victoria, 3186, Australia
Murdoch Children's Research Institute

Parkville, Victoria, 3052, Australia
Nathan S. Kline Institute for Psychiatric Research

Orangeburg, New York, 10962, United States
Ohio State University

Columbus, Ohio, 43210, United States
Optimal Clinical Trials

Grafton, Auckland, 1010, New Zealand
Relaro Medical Trials

Dallas, Texas, 75243, United States
Southwestern Autism Research and Resource Center

Phoenix, Arizona, 85006, United States
Spectrum Neuroscience and Treatment Institute

New York, New York, 10021, United States
University of Arizona

Tucson, Arizona, 85724, United States
University of Missouri, Thompson Center for Autism and Neurodevelopmental Disorders

Columbia, Missouri, 65201, United States
University of South Florida

Tampa, Florida, 33613, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37212, United States
Westmead Children's Hospital

Sydney, New South Wales, 2145, Australia
Yale University

New Haven, Connecticut, 06519, United States

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