Diabetes drug metformin tested for fragile x symptoms
NCT ID NCT03862950
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether metformin, a common diabetes medication, can help improve language, behavior, and weight problems in people with fragile X syndrome. 125 participants aged 6 to 35 took either metformin or a placebo for 4 months. Researchers measured changes in language skills and behavior to see if the drug made a difference.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Metformin
- What this could lead to
- If it works, this could point toward a treatment to improve language and behavior and reduce obesity in people with fragile X syndrome.
- What could go wrong
- This is a phase 2 trial with only 125 participants, so results may not be conclusive. Metformin is a diabetes drug, and its benefits for fragile X syndrome are not yet proven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU Sainte-Justine
Montreal, Quebec, H3T 1C5, Canada
-
University of Alberta
Edmonton, Alberta, T6G 2E1, Canada
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