Gene sequencing breakthrough could solve mystery of intellectual disability

NCT ID NCT04154891

Completed Diagnosis Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether whole genome sequencing (WGS) can find more genetic causes of intellectual disability than current standard tests. Researchers compared WGS to usual methods in 3825 children and adults with unexplained intellectual disability. The goal was to see if WGS gives a diagnosis more often and more cost-effectively.

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Conditions

The condition(s) this trial relates to.

disease intellectual disability Rare Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTELLECTUAL DISABILITY

Contacts and locations

Locations

Assistance publique - Hôpitaux de Marseille

Marseille, France
Assistance publique - Hôpitaux de Paris - Groupe Hospitalier Pitié Salpétrière

Paris, France
Assistance publique - Hôpitaux de Paris - Hôpital Necker - Enfants malades

Paris, France
CHRU Lille

Lille, France
CHU Bordeaux

Bordeaux, France
CHU Dijon

Dijon, France
CHU Montpellier

Montpellier, France
CHU Nantes

Nantes, France
CHU Rennes

Rennes, France
CHU Rouen

Rouen, France
CHU Strasbourg

Strasbourg, France
CHU d'Angers

Angers, 49000, France
CHU de Grenoble-Alpes

La Tronche, 38700, France
Hospices Civil de Lyon

Bron, France

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