Which autism drug causes less weight gain? small study aims to find out
NCT ID NCT04903353
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study compared two FDA-approved medications, risperidone and aripiprazole, used to treat irritability in children with autism. The goal was to see which one causes more weight gain. Thirty children under 18 who had never taken these drugs before were followed during routine care. Results could help doctors choose the better option for managing behavior problems with fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
risperidone and aripiprazole
What this could lead to
If this trial succeeds, it could help doctors choose which medication causes less weight gain in children with autism.
What could go wrong
This is a small, completed Phase 4 trial with only 30 children, so results may not apply to all kids. Weight gain is a known side effect of both drugs.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Division of Developmental Medicine
Nashville, Tennessee, 37212, United States