Which autism drug causes less weight gain? small study aims to find out

NCT ID NCT04903353

Completed Disease control Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study compared two FDA-approved medications, risperidone and aripiprazole, used to treat irritability in children with autism. The goal was to see which one causes more weight gain. Thirty children under 18 who had never taken these drugs before were followed during routine care. Results could help doctors choose the better option for managing behavior problems with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: risperidone and aripiprazole
What this could lead to: If this trial succeeds, it could help doctors choose which medication causes less weight gain in children with autism.
What could go wrong: This is a small, completed Phase 4 trial with only 30 children, so results may not apply to all kids. Weight gain is a known side effect of both drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autism spectrum disorder Drug-Related Side Effects and Adverse Reactions Weight Gain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTISM SPECTRUM DISORDER MEDICATION SIDE EFFECT WEIGHT GAIN

Contacts and locations

Locations

Division of Developmental Medicine

Nashville, Tennessee, 37212, United States

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