Warm baths tested as seizure treatment for rare childhood disorder

NCT ID NCT06447675

Completed Symptom relief Sponsor: Xuanwu Hospital, Beijing Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether daily 20-minute warm baths could safely reduce seizures in 8 children (ages 6 months to 6 years) with CDKL5 deficiency, a rare genetic disorder causing hard-to-control seizures. The treatment was added to their usual medications for 12 weeks. The goal was to see if seizure frequency dropped by at least half. Because the trial was small and had no comparison group, the results are preliminary.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyperthermic baths
What this could lead to: If effective, daily warm baths could offer a simple, drug-free way to help reduce seizures in children with CDKL5 deficiency.
What could go wrong: This is a very small trial (8 children) with no control group, so results may not be reliable or apply to others. The treatment is not a cure and only aims to ease symptoms.

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Conditions

The condition(s) this trial relates to.

CDKL5 disorder developmental and epileptic encephalopathy, 2 Drug Resistant Epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CDKL5 DEFICIENCY DISORDER

Contacts and locations

Locations

Xuanwu Hospital,Capital Medical University

Beijing, Beijing Municipality, 100053, China

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