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Hunting for the first clues of a devastating brain disease

NCT ID NCT01037777

Knowledge-focused Sponsor: Institut National de la Santé Et de la Recherche Médicale, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This study follows people who have a 50% chance of inheriting a gene for spinocerebellar ataxia, a group of progressive brain disorders that affect movement and coordination. The goal is to identify the earliest clinical signs and biological markers that appear before the disease fully develops. Participants will undergo regular check-ups, including movement tests, sleep and mood questionnaires, and some will have MRI scans. The findings could help design future treatments to delay or prevent the onset of ataxia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could reveal the earliest warning signs of spinocerebellar ataxia, helping future treatments delay or prevent the disease from starting.
What could go wrong
This is an observational study, so it won't test any treatment. It may not find clear early markers, and results may not apply to all types of ataxia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

37 people

The number who actually took part.

Started

May 2009

Finished

Dec 2017

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

French population

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * individuals at risk for spinocerebellar ataxia type 1, type 2, type 3, type 6 and type 7 (SCA1, SCA2, SCA3, SCA6 and SCA7) * age between 18 and 50 years old for SCA1, SCA2, SCA3 or SCA7 * age between 35 and 70 years old for SCA6 * no clinical sign of ataxia (SARA \< 3) Exclusion Criteria: * no writing consent * no family members affected * presence of clinical sign of ataxia (SARA \> 3)

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Conditions

The condition(s) this trial relates to.

Machado-Joseph disease spinocerebellar ataxia 7 spinocerebellar ataxia type 1 spinocerebellar ataxia type 2 spinocerebellar ataxia type 6 Spinocerebellar Ataxias

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spinocerebellar ataxias

Contacts and locations

Locations

  • Pitié Salpêtrière Hospital

    Paris, 75013, France

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