Gastroenteritis

This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Dif…

This study tested a new vaccine designed to protect against severe diarrhea caused by Shigella bacteria. The vaccine was first given to adults in Europe, then to adults, children, and infants in Africa. Researchers checked for side effects and measured immune responses to find th…

This early-stage trial tested a new vaccine (CJCV2) designed to protect against Campylobacter infection, a leading cause of foodborne illness. Fifty-nine healthy adults received three different doses of the vaccine, with or without an immune-boosting adjuvant (ALFQ). The main goa…

This phase 2 trial tested the oral cholera vaccine Vaxchora in 34 healthy adults to see how well it triggers protective antibodies and immune cells. Participants received a single dose, and researchers measured antibody levels, B cells, and T cell responses. The goal is to unders…

This study tested a new vaccine called Shigella4V2 to protect infants against shigellosis, a severe diarrheal disease. Researchers gave the vaccine to 110 healthy 9-month-old babies to check its safety and how well it triggers an immune response. The goal is to find the best dose…

This early-stage study tested a new oral vaccine designed to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Fifty-three healthy adults received the vaccine to check for side effects and to see if it triggers an immune response. The goal is to develop …

This study tested a new Shigella vaccine in 200 healthy African infants to see if it can prevent severe diarrhea. The vaccine was given in two doses, and researchers measured immune responses and safety. The trial is now complete, and results will show whether this approach is pr…

This study looked at how effective the Rotarix vaccine is at preventing severe rotavirus infections in children under 6 years old. Researchers enrolled 362 children with acute gastroenteritis at two U.S. hospitals, comparing those who tested positive for rotavirus (cases) with th…

This study tested a new vaccine called ShigETEC in healthy adults and children in Bangladesh. The vaccine aims to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Researchers gave three doses of the vaccine or a placebo to 196 participants to check if i…

This study tested whether giving the polio vaccine (IPV) at the same time as a rotavirus vaccine (Rotarix PCV-free) is safe and works well in healthy Chinese infants aged 6-10 weeks. About 400 infants received the vaccines either together or a few weeks apart. The main goal was t…

This study tested a Novavax COVID-19 booster vaccine in 21 people with weakened immune systems due to inflammatory bowel disease or organ transplants. The goal was to see if the booster improved antibody levels and immune protection against COVID-19. Participants had already rece…

This study tested fecal microbiota transplantation (FMT) from different donors to treat ulcerative colitis, a type of inflammatory bowel disease. Researchers gave 102 patients a one-time colonoscopic infusion of fresh fecal bacteria from healthy donors. The goal was to see if don…

This study investigates whether giving vitamin D supplements to adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who also have low vitamin D levels can improve their iron status. Participants take high-dose vitamin D3 weekly for 8 weeks, then a lower…

This study tests whether giving patients their own stool bacteria through a temporary stoma can reduce inflammation in the unused part of the colon, a condition called diversion colitis. Sixty-six people with rectal cancer who have a temporary ileostomy will receive either a dail…

This phase 2 trial tests whether OSE-127, an antibody that blocks a key immune signal, can reduce disease activity in people with moderate to severe ulcerative colitis who have not responded to or cannot tolerate previous treatments. Participants are randomly assigned to receive …

This trial tests whether a nurse-led education program, based on the Health Belief Model, can improve treatment adherence in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are receiving anti-TNF therapy. The program aims to address patients' co…

This study tested whether taking tempeh powder (a source of isoflavones) and vitamin D3 daily for 8 weeks could improve vitamin D levels, reduce inflammation, and boost quality of life in people with inflammatory bowel disease (IBD). Fifty adults with ulcerative colitis or Crohn'…

This early-stage study tested a new treatment called MB310 in 29 adults with mild-to-moderate ulcerative colitis. The main goal was to see if it is safe and how well it takes hold in the body. Participants received either MB310 or a placebo, and researchers monitored side effects…

This study tested whether a daily dose of Travelan (IMM-124E) tablets could prevent moderate-to-severe diarrhea in healthy adults deliberately infected with ETEC bacteria, a common cause of travelers' diarrhea. Sixty-three volunteers took either Travelan or a placebo for 7 days. …

This study tested the drug mirikizumab in 172 adults with moderate-to-severe ulcerative colitis who still had bowel urgency despite other treatments. The main goal was to see if the drug reduces the sudden, urgent need to use the bathroom. Participants were followed for 36 weeks …

This study tested whether a seaweed-derived supplement called Aquamin® can reduce gut permeability (often called 'leaky gut') in people with ulcerative colitis, irritable bowel syndrome with diarrhea, and healthy volunteers. Thirty-five adults took Aquamin capsules for 90 days. R…

This study tested a new drug called VR-AD-1005 for treating severe diarrhea caused by cholera. The drug aims to reduce fluid loss and the need for antibiotics, which could help fight antibiotic resistance. 150 adults with cholera took part, and researchers measured stool output a…

This completed observational study looked at how well the drug tofacitinib works for people with ulcerative colitis in everyday Swedish clinics. Researchers used a national registry to track disease remission and whether patients stayed on the medication. The study included 102 p…

This study tested the drug mirikizumab in 63 children aged 2 to 17 with moderate-to-severe ulcerative colitis, a chronic bowel disease. The goal was to see if the drug could help control the disease and improve symptoms. All children received the drug, and researchers measured re…

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study looked at the long-term safety of vedolizumab, a biologic drug given by IV, in 59 children with ulcerative colitis or Crohn's disease. Participants had already completed a previous study and continued treatment to monitor for side effects. The goal was to see if the dr…

This study tested whether mirikizumab can help people with moderate to severe ulcerative colitis stay in remission (symptom-free) after they had already responded to an initial treatment. About 1,300 adults who completed a prior induction study were randomly assigned to receive m…

This study tested a drug called ustekinumab in 112 children with moderate-to-severe ulcerative colitis, a condition causing inflammation in the colon. The goal was to see if the drug could reduce symptoms like diarrhea and bleeding and help the colon heal. Children first received…

This study tested the drug tofacitinib (Xeljanz) in 10 adults with chronic granulomatous disease (CGD) who had ongoing inflammation in the gut, skin, or lungs. Participants took the pill daily for 3 months to see if it was safe and could help control symptoms. The goal was to fin…

This study tested whether adding fenofibrate, a drug typically used for high cholesterol, to the standard treatment mesalamine can improve symptoms and quality of life in people with mild-to-moderate ulcerative colitis. The trial enrolled 60 adults and measured changes in disease…

This study tested a daily pill called ABX464 (obefazimod) as a long-term maintenance therapy for people with moderate to severe ulcerative colitis. 217 patients who completed a prior 16-week induction study took the drug for up to 96 weeks. The main goal was to see how many patie…

This study tested whether cleaning therapy dogs with a special disinfectant (chlorhexidine) before hospital visits could reduce the spread of harmful germs to children. The trial involved 45 children aged 3 to 17 who interacted with therapy dogs. Researchers checked if the cleani…

This study tested whether people with ulcerative colitis can use a home stool test to catch inflammation early and prevent symptom flares. Over 700 adults in remission used a smartphone-based test kit to measure calprotectin levels. The goal was to see if this proactive monitorin…

This study tested a medicine called vedolizumab in 121 children with moderate to severe ulcerative colitis, a condition causing inflammation and pain in the gut. The goal was to see if the drug could help children achieve remission, meaning their symptoms improve and tests show l…

This study looked at whether adding mesalazine (a standard anti-inflammatory drug) to biologic treatments like infliximab or vedolizumab helps people with moderate to severe ulcerative colitis achieve endoscopic remission (healing of the gut lining). The trial enrolled 438 adults…

This study tested a treatment called RBX2660 (REBYOTA) for people with recurrent Clostridioides difficile infection. The treatment is made from healthy human stool bacteria and was given during a colonoscopy. The goal was to see if this delivery method is safe and works well. For…

This study looked at whether giving the antibiotic vancomycin helps cancer patients who have diarrhea and a positive screening test for C. difficile but a negative toxin test. Only 9 patients were enrolled, far fewer than planned. Researchers measured changes in C. difficile leve…

This study tested whether an oral rehydration solution (ORS) with added calcium works better than standard ORS for adults with severe watery diarrhea, including cholera. Researchers measured stool output, diarrhea duration, and other symptoms in 396 adults. The goal is to find a …

This completed Phase 2b trial tested an oral tablet called JNJ-77242113 against placebo in 252 adults with moderate-to-severe ulcerative colitis. The goal was to see if the drug could reduce symptoms and inflammation better than a dummy pill. Researchers measured clinical respons…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

This study looks at the long-term safety of a drug called CC-93538 (cendakimab) for people with eosinophilic esophagitis, a condition that causes inflammation in the esophagus. It enrolled 367 adults and teens who had already taken part in earlier studies of the same drug. The ma…

This phase 2b trial tested a new drug called TEV-48574 (duvakitug) in 290 adults with moderate to severe ulcerative colitis or Crohn's disease. The study aimed to see if the drug could help patients achieve clinical remission (for UC) or an endoscopic response (for CD) after 14 w…

This study tested whether taking capsules containing healthy gut bacteria could help clear drug-resistant germs (including C. difficile) from the intestines of 42 hospitalized adults who needed at least 7 days of antibiotics. Participants received either the bacteria capsules or …

This phase 2 study tested an experimental antibiotic called CRS3123 against the standard treatment vancomycin for Clostridioides difficile infection (C. diff). 43 adults with a first episode or first recurrence of C. diff took either CRS3123 or vancomycin for 10 days. The main go…

This study tested fecal microbiota transplant (FMT) in 24 adults with recurrent Clostridium difficile infection (C. diff) that didn't get better with standard antibiotics. FMT involves placing healthy donor stool into the patient's colon to restore good bacteria. The goal was to …

This study tested whether fecal transplants from healthy donors could help people with ulcerative colitis, a chronic condition causing inflammation in the colon. 85 participants received either donor or their own stool via tubes and enemas. The goal was to see if donor transplant…

This study looked back at medical records of 81 people with severe ulcerative colitis to see if starting upadacitinib early works better than using it after other treatments fail. Researchers checked how many avoided surgery and achieved remission within 12 weeks. The goal is to …

This study tested a probiotic called INF108F in 20 breastfed infants with a food allergy that causes blood in their stool. The goal was to see if the probiotic could improve the balance of gut bacteria and reduce symptoms like reflux and fussiness. While the treatment aims to con…

This study tested an experimental pill called MORF-057 in 39 adults with moderate to severe ulcerative colitis. The drug aims to reduce gut inflammation by blocking a specific protein. Researchers measured changes in colon tissue health and symptom scores after 12 weeks of treatm…

This study tested a 15-day diet called UC-TREAT, rich in high-fiber foods, fermented foods, and berries, in 36 adults—some healthy and some with quiescent (inactive) ulcerative colitis. Researchers measured changes in gut bacteria, digestive symptoms, and diet acceptability. The …

This study tested whether adding the drug bezlotoxumab to standard treatment could prevent serious outcomes in people with a severe C. diff infection. Researchers used a special score to identify 44 high-risk patients. The goal was to see if the drug reduced organ failure, infect…

This study tested whether physiotherapist-led pelvic floor and bowel training could improve bowel function in people who had ileo-anal pouch surgery for ulcerative colitis or familial adenomatous polyposis. Fifty-three participants were randomly assigned to either the behavioural…

This phase 2 trial tested the safety of P28GST, a protein from a parasite, in 10 adults with moderate Crohn's disease. Participants received three injections over three months. The goal was to see if the protein could safely control inflammation, especially after intestinal surge…

This study tested whether a prebiotic called 2'-fucosyllactose can help people with mild-to-moderate ulcerative colitis. 38 adults took the prebiotic or a placebo for four weeks, then switched. Researchers measured symptoms, gut bacteria, and inflammation markers. The goal was to…

This study tested a web-based telemonitoring system called TECCU for people with moderate-to-severe inflammatory bowel disease (Crohn's disease or ulcerative colitis). 290 participants in Spain were randomly assigned to use the app or receive usual care. The goal was to see if th…

This study tested whether rutin, a natural compound found in plants, can help people with ulcerative colitis. 60 adults took rutin tablets or a placebo for 30 days. The goal was to see if rutin reduces gut inflammation and improves symptoms like diarrhea and abdominal pain.

This study followed 152 adults with moderate to severe ulcerative colitis who were prescribed tofacitinib by their doctors in France. Researchers tracked how many patients felt better after one and two years of treatment, using symptom scores and noting if they needed other medic…

This completed study looked at how safe and effective upadacitinib (RINVOQ) is for Korean adults with moderate to severe ulcerative colitis or Crohn's disease. About 600 participants were followed for up to 52 weeks while taking the drug as prescribed by their doctor. The main go…

This study tested switching 38 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) from intravenous infliximab to a subcutaneous (under-the-skin) injection. Researchers measured drug levels, quality of life, and patient satisfaction over 24 weeks. The goal was …

This study tested a drug called TA-650 in 21 children with moderate to severe ulcerative colitis, a condition causing inflammation and sores in the colon. The goal was to see if the drug could reduce disease activity and improve symptoms. Children received the drug by infusion at…

This study looked at the long-term safety and effectiveness of an oral medication called RPC1063 for people with moderate to severe ulcerative colitis. It included 877 adults who had already taken part in earlier RPC1063 trials. The goal was to see how well the drug controls the …

This study looked at how safe and effective the drug Rinvoq is for adults with moderate to severe ulcerative colitis. About 300 people in Japan took Rinvoq as part of their normal care and were followed for up to 60 weeks. The main goal was to track serious infections and other s…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study monitored 688 people in South Korea with ulcerative colitis, Crohn's disease, or pouchitis who were treated with Kynteles (vedolizumab) as part of their normal care. The main goal was to track side effects, and researchers also looked at how many patients saw symptom i…

This study tested an experimental drug called ABBV-668 in 30 adults with moderate to severe ulcerative colitis, a condition that causes inflammation and bleeding in the colon. Participants took the drug twice daily for 16 weeks, and researchers checked for side effects and signs …

This study tested a new drug called PF-06480605 in 246 adults with moderate to severe ulcerative colitis. Participants received different doses of the drug or a placebo for 12 weeks, then everyone received the active drug for 40 more weeks. The goal was to see if the drug could h…

This study tested whether adding a transanal (through the anus) approach to standard laparoscopic pelvic pouch surgery could improve outcomes for patients with ulcerative colitis or familial adenomatous polyposis. The transanal method may give surgeons better control and visibili…

This study followed 150 people with inflammatory bowel disease (ulcerative colitis or Crohn's disease) who were given VedAryo (vedolizumab) to see if it helps control their condition and is safe. Participants received the drug by IV at the start, after 2 weeks, after 6 weeks, and…

This study tested whether a blood test measuring proteins can help doctors choose the best treatment for people newly diagnosed with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. 300 patients were split into two groups: one where doctors had …

This study tested an experimental drug called ABX464 in 355 adults with moderate to severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could reduce symptoms like diarrhea, bleeding, and colon inflammation. Participants receiv…

This study tests a new delayed-release metronidazole capsule designed to release the drug directly in the colon, where C. diff bacteria live. 18 healthy adults will receive a single dose of either the new capsule or the standard tablet to compare how much drug reaches the colon v…

This study tested whether adding the antibiotic minocycline to standard mesalamine treatment helps control mild-to-moderate ulcerative colitis. 46 adults took part. Researchers measured disease activity using a symptom score. The trial is complete, but results are not yet publish…

This study tested whether adding atorvastatin (a cholesterol-lowering drug) to standard mesalamine treatment improves quality of life and reduces inflammation in adults with ulcerative colitis. 54 participants completed the trial. The goal was to see if the drug's anti-inflammato…

This study tested a new drug called IBI112 in 150 people with moderate to severe ulcerative colitis, a condition that causes inflammation and sores in the colon. The goal was to see if IBI112 could help patients achieve remission (no symptoms) after 12 weeks of treatment. Partici…

This study tested dupilumab, a drug that calms certain immune reactions, in 41 people aged 12-70 with eosinophilic gastritis, a condition where too many immune cells build up in the stomach lining. Participants received either dupilumab or a placebo injection every two weeks for …

This study looked at whether giving fewer antibiotics after appendix removal is safe and effective. 268 adults who had surgery for simple or complicated appendicitis took part. The goal was to see if a short course of antibiotics could reduce side effects without increasing compl…

This study tested a once-daily pill called ABX464 (obefazimod) in 639 people with moderate-to-severe ulcerative colitis who had not responded well to other treatments. The goal was to see if the drug could help bring about remission and improve bowel inflammation within 8 weeks. …

This study tested a new daily pill, ABX464, for people with moderate to severe ulcerative colitis who did not get better with other treatments. About 636 adults and teens took either 25 mg, 50 mg, or a placebo for 8 weeks. The main goal was to see if the drug could help achieve r…

This study tested a drug called CC-93538 (Cendakimab) in 48 Japanese adults and adolescents with eosinophilic gastroenteritis, a condition where certain white blood cells build up in the digestive tract causing pain and other symptoms. The trial was randomized and placebo-control…

This study looked at the long-term safety of a drug called spesolimab in adults with moderate to severe ulcerative colitis who had already finished earlier trials. Researchers tracked side effects and checked if patients achieved remission over about 6.5 years. The goal was to se…

This study tested whether mirikizumab, a biologic drug, can improve symptoms and gut healing in 100 people with moderate-to-severe ulcerative colitis who had a specific type of inflammation seen on biopsy. Participants received either mirikizumab or vedolizumab, and doctors track…

This study tested two doses of a daily pill called ozanimod in 198 Japanese adults with moderate to severe ulcerative colitis. The goal was to see if it could reduce symptoms and inflammation better than a placebo. The trial also checked long-term safety. Ozanimod works by calmin…

This study tested a new drug called spesolimab in 98 adults with moderate-to-severe ulcerative colitis who did not get better with other biologic treatments. The goal was to see if the drug could safely reduce symptoms and help the colon heal. The trial was completed and looked a…

This phase 2 study tested whether adding spesolimab to standard TNF inhibitor therapy could help heal the gut lining in people with mild-to-moderate ulcerative colitis. Twenty-two adults who still had active disease despite TNF inhibitor treatment received spesolimab or a placebo…

This phase 2 trial tested a drug called spesolimab in 8 adults with moderate to severe ulcerative colitis. The main goal was to understand how the drug works in the body, while also checking for safety and any signs of improvement. Participants received the drug for 12 weeks, and…

This study looked at the long-term safety and effectiveness of adalimumab (Humira) in 59 children with ulcerative colitis who had already completed a previous trial. The children received injections every other week or weekly. Researchers tracked side effects and how well the dru…

This study looked at 73 adults with Crohn's disease who needed surgery to remove a diseased part of the bowel. Researchers compared two different ways to reconnect the healthy ends: one that removes the fatty tissue around the bowel (mesentery) and one that keeps it (Kono-S). The…

This study looked at whether regularly measuring levels of anti-TNF drugs and antibodies in the blood can help doctors better manage inflammatory bowel disease (Crohn's and ulcerative colitis). 260 patients were split into two groups: one where doctors used these test results to …

This study tested a new oral treatment called LMN-101, made from spirulina, to see if it can prevent or control Campylobacter infection. Healthy volunteers took LMN-101 or a placebo for two days, then were exposed to the bacteria. The goal was to check safety and how well the tre…

This study looked at whether adding probiotics (Bacillus Clausii) to standard mesalamine treatment helps people with ulcerative colitis stay in remission. 70 adults in remission were split into groups: mesalamine alone, probiotics alone, or both. Researchers tracked disease activ…

This completed study looked at the long-term safety and effectiveness of vedolizumab (Entyvio) in over 1,100 people with moderate to severe ulcerative colitis who had not responded well to other treatments. Researchers tracked side effects and how well the drug controlled disease…

This study tested an oral drug called amiselimod (MT-1303) in 322 adults with mild to moderate ulcerative colitis. Participants received either a low dose, high dose, or placebo for 12 weeks, with an optional 36-week open-label period. The goal was to see if the drug could reduce…

This study tested two team-based care models for 657 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) who also had mild to severe behavioral health symptoms. One model used in-person visits with a team including a gastroenterologist, nurse, nutritionist, and…

This study looked at whether measuring a protein called calprotectin in the blood can help diagnose acute appendicitis. Researchers compared 74 patients with abdominal pain, some with confirmed appendicitis and others with non-specific pain. They measured calprotectin levels and …

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study tested whether simple blood test ratios, like CRP-to-albumin, can help monitor disease activity in people with ulcerative colitis. Researchers compared these blood markers to standard colonoscopy and symptom scores in 80 patients. The goal was to find a less invasive, …

This study looked at four substances in the blood (Osteoprotegerin, sRANKL, NFkB, and TFF3) to see if they could help diagnose inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. Researchers measured these markers in 70 newly diagnosed patient…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This study looked at whether the Appendistat Score (APS) can accurately identify patients with complicated appendicitis who need urgent surgery. Researchers reviewed records of 592 patients who had their appendix removed. They compared the APS score to the final lab results to se…

This observational study followed 145 adults who received REBYOTA™ to prevent another Clostridioides difficile infection (CDI) after completing antibiotics. Researchers collected information from medical records over 6 months to see how many people stayed infection-free. The goal…

This study tested whether extending standard vancomycin treatment for C. diff infection with a 2-week taper (lowering the dose gradually) reduces the chance of the infection returning. 263 adults who had a first episode or first recurrence of C. diff were randomly assigned to rec…

This study tested whether combining a fecal microbiota transplant (FMT) with the drug bezlotoxumab could prevent repeat Clostridium difficile infections in people with inflammatory bowel disease (IBD). Sixty-one adults with at least two prior C. diff infections were randomly assi…

This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenterit…

This study looked at whether giving fewer antibiotics after appendicitis surgery could lower the risk of antibiotic side effects without compromising patient safety. Over 650 adults who had surgery for simple or complicated appendicitis took part. The goal was to find the right b…

This study tested a 21-step enhanced recovery protocol for children aged 10-18 undergoing elective gastrointestinal surgery. The protocol included things like shorter fasting times, early eating and moving, and less use of opioids. The goal was to see if it could shorten hospital…

This study tests whether cognitive behavioral therapy (CBT) can reduce anxiety and depression in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis). Participants receive either psychologist-led or self-administered CBT over 8 weeks. The goal is to see …

This study tested whether a numbing injection into the abdominal wall muscles (called a TAP block) can reduce pain for people with acute appendicitis waiting for emergency surgery. 105 adults in the emergency department received the block, and researchers measured how much pain m…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study compared two types of nerve blocks—erector spinae plane (ESP) and quadratus lumborum (QL)—to see which provides better pain relief after appendix surgery in children aged 3-13. Sixty children received one of the blocks along with general anesthesia. Researchers measure…

This study tested whether using a cold therapy device on the belly after appendix removal helps control pain in children ages 7 and older. Half the kids got the cold pack plus usual care, the other half got usual care alone. Researchers measured pain scores, morphine use, and hos…

This study tested a newer, gentler type of keyhole surgery for removing the appendix. It uses lower gas pressure and smaller instruments than standard laparoscopy. Fifty adults with uncomplicated appendicitis took part, and the researchers measured their pain, recovery time, and …

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This early-phase study tested whether TUDCA, a bile acid supplement, is safe and can reduce stress in gut cells of people with active ulcerative colitis. Fourteen adults took TUDCA for 6 weeks while researchers measured changes in cell stress markers from colon biopsies. The goal…

This study compared two types of nerve blocks (TAP and ESPB) to standard pain medication (tramadol) for people with acute appendicitis in the emergency department. The goal was to see if these blocks could reduce pain before surgery and lower the need for opioids. The trial inclu…

This study looked at 250 children having laparoscopic surgery for appendicitis. It compared using low versus medium gas pressure in the belly during the operation to see if it affects pain the next day. The goal is to find ways to make children more comfortable after surgery.

This study compared two types of nerve blocks (erector spinae plane block vs. transversus abdominis plane block) for pain relief after laparoscopic appendix removal. 72 adults aged 18-50 participated. The goal was to see which block provides better pain control and fewer complica…

This study tested whether eating steamed broccoli sprouts daily for 28 days could increase anti-inflammatory compounds in the blood and stool of people with mild ulcerative colitis. 23 participants took either 1 or 3 servings of sprouts per day. The goal was to see if this diet i…

This study tested whether a mix of two probiotics (Lactobacillus acidophilus and Limosilactobacillus reuteri) could shorten diarrhea in children aged 1 to 6 with acute infectious diarrhea. 145 children were randomly assigned to receive the probiotics or a placebo. Researchers mea…

This study tested whether eating gluten-free for one week reduces gut symptoms and fatigue in people with ulcerative colitis. Fifteen participants followed both a high-gluten and a gluten-free diet in random order, with symptom questionnaires and samples collected. The goal is to…

This study tested a comprehensive self-management program for people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Research…

This completed trial tested whether four free self-help resources—a symptom-tracking app, a cognitive behavioral therapy workbook, a helpline, and a peer mentor—can reduce disability in people with moderate-to-severe Crohn's disease or ulcerative colitis. Over 800 adults particip…

This study tested a new anesthesia drug called ciprofol in 86 children having laparoscopic surgery (like hernia repair or appendix removal). The goal was to see if it works as well as standard anesthesia for helping kids wake up and recover. Researchers measured how fast children…

This study looked at whether a tailored physical activity program could improve bone density in 15 children and teens with inflammatory bowel disease (IBD). Kids with IBD often have weaker bones due to inflammation, medication, and lower activity levels. The program focused on mo…

This study tested whether a liquid diet called Neocate Splash could change gut bacteria and ease stomach symptoms in people with chronic granulomatous disease (CGD) and inflammatory bowel disease (IBD). Three participants followed the diet for up to 4 weeks, with hospital stays a…

This small study tested whether an AI-powered virtual reality app could safely provide mental health support to 22 adults with inflammatory bowel disease (IBD) who also had mild anxiety or depression. The goal was to see if the digital session was practical and acceptable, not to…

This pilot study tested whether giving ondansetron (Zofran) before drinking bowel-cleansing liquid helps children have a cleaner colon and feel less sick. 41 kids aged 2 to 20 took either ondansetron or a placebo before their colonoscopy. The study measured bowel cleanliness and …

This study tested a set of care steps called Enhanced Recovery After Surgery (ERAS) in 82 children who had their appendix removed. The steps included teaching families what to expect, avoiding tubes, and helping kids eat and move early after surgery. The goal was to see if this p…

This early-stage trial tested whether an oral biologic drug called MB-001 is safe in 48 healthy adults. Participants received either a single dose or five daily doses of the drug or a placebo. The main goal was to check for side effects and see how the body processes the drug. Th…

This study looked at whether people with simple appendicitis can safely go home within 12 hours after surgery instead of staying overnight. Researchers followed 120 adults who had their appendix removed and checked if they were discharged quickly. The goal was to see if same-day …

This study tested whether a low-calorie, plant-based diet that mimics fasting could reduce depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with mild-to-moderate depression and IBD followed either the fasting-mimicking diet or a calorie-sufficient pl…

This study tested whether aromatherapy (breathing lavender oil) or acupressure (gentle thumb pressure on specific points) could reduce pain and improve sleep in 100 children aged 6-12 after abdominal surgeries like appendix or hernia repair. The goal was to find simple, non-drug …

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study looked at how a protein called IL-22 binding protein (IL-22BP) affects gut healing in people with Crohn's disease or ulcerative colitis. Researchers compared samples from 52 patients and healthy volunteers to understand how IL-22BP is regulated during disease flares. T…

This completed study surveyed over 2,500 appendicitis patients to understand their satisfaction and regret after choosing either surgery or antibiotics. Researchers aim to use this information to design decision-support tools that help future patients make choices aligned with th…

This study looks at how being physically fit changes the bacteria in your gut. Researchers will compare the gut microbes of 30 healthy men, from inactive to elite athletes, by testing their exercise capacity and analyzing stool samples. The goal is to find connections between fit…

This study investigates whether gut microorganisms and their byproducts play a role in triggering severe flare-ups of ulcerative colitis. Researchers will compare patients hospitalized with severe colitis to those with milder symptoms, analyzing stool and blood samples over three…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study measured how often adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) show signs of eating disorders, including avoidant/restrictive food intake disorder (ARFID). Researchers used questionnaires to assess eating habits and nutritional status…

This study tested a new scoring system called CAT-DESIRE to evaluate ulcerative colitis severity using colonoscopy images. Researchers reviewed images from 235 patients to see if the new score is reliable and can predict long-term outcomes. The goal is to provide a simple, accura…

This study looked at 343 adults who were diagnosed with inflammatory bowel disease (Crohn's disease or ulcerative colitis) before age 17. Researchers compared their employment rates and education levels to the general population to understand how the disease may affect long-term …

This study looked at antibodies in the intestines of 160 people: 80 with Crohn's disease, 40 with ulcerative colitis, and 40 without inflammatory bowel disease. Researchers took blood samples and intestinal biopsies to compare antibody levels in the gut versus the blood. The goal…

This study looked at 366 adults referred for suspected inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The goal was to find simple, non-invasive markers that can help doctors diagnose IBD more accurately and predict how the disease will progres…

This study examined how differences in the BAFF gene might affect a person's risk of developing ulcerative colitis and how well they respond to the drug vedolizumab. Researchers analyzed genetic samples from 841 people with ulcerative colitis. The goal was to better understand th…

This study observed 165 people with inflammatory bowel disease (Crohn's or ulcerative colitis) in Poland who were already taking or starting vedolizumab. Researchers tracked whether patients chose intravenous or subcutaneous (under-the-skin) injections, and how long they stayed o…

This completed Italian study looked at how often children with inactive inflammatory bowel disease (IBD) also have disorders of gut-brain interaction (DGBIs), like irritable bowel syndrome. Researchers used the Rome IV questionnaire to compare 220 children with quiescent IBD to h…

This study measured calprotectin, a protein in stool that signals gut inflammation, in 121 healthy adults aged 22 and older. Participants collected a single stool sample at home and mailed it in. The goal is to establish what level is normal, helping doctors better tell apart inf…

This study reviewed medical records of 966 children diagnosed with Crohn's disease or ulcerative colitis between 1988 and 2011. Researchers looked at how often children needed surgery and how treatments like immunosuppressants and anti-TNF drugs were used over time. The goal was …

This completed study from China looked at 50 adults with Crohn's disease who were treated with two newer biologic drugs, Ustekinumab and Vedolizumab. The goal was to see how well these drugs control the disease and what factors might predict a good response. By analyzing past med…

This study looked at physical fitness in 100 children and teens (ages 10-17) with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or unclassified colitis) and compared them to healthy kids of the same age, weight, and sex. Researchers measured cardiorespi…

This study looked at how much of the drug risankizumab (Skyrizi) passes into the breast milk of women with inflammatory bowel disease (IBD). Ten breastfeeding mothers who were already taking the drug provided milk samples over several weeks. The goal is to understand potential ex…

This study looked at 120 adults with inflammatory bowel disease (IBD) to see if simple stool tests can tell if the disease is active or in remission, just like a colonoscopy does. Colonoscopy is the current gold standard but is expensive, invasive, and not ideal for frequent chec…

This study looked at whether adding walnuts to your diet can change the bacteria in your gut and reduce signs of colon cancer risk. About 140 people at higher risk for colorectal cancer ate walnuts for a month. Researchers measured changes in gut bacteria, blood markers, and colo…

This study looked at how hormonal birth control might help manage inflammatory bowel disease (IBD) symptoms that get worse during a woman's period. Researchers surveyed 50 women with IBD to understand their preferences for birth control and whether they would join a future trial.…

This study aims to create a tool that helps nurses better assess and care for the sexual health needs of men with inflammatory bowel disease (IBD). The research involved 792 participants, including men with IBD and their partners, as well as healthcare professionals. The goal is …

This study looked at how emergency general surgery affects pregnant women and their unborn babies. Researchers planned to follow pregnant women who needed surgery for problems like appendicitis or gallbladder disease. The goal was to learn more about the safety of these surgeries…

This study looked at how a short course of antibiotics changes the nerve and glia cells in the lower gut of 10 healthy adults. Researchers took colon tissue samples before and after antibiotic treatment to count these cells and measure gene activity. The goal was to understand if…

This study analyzed data from over 8,700 pregnant women with inflammatory bowel disease (Crohn's or ulcerative colitis) to see how well doctors follow guidelines when prescribing antiTNFα drugs and whether the benefits outweigh the risks for both mother and baby. Researchers look…

This study looked at how sustainable laparoscopic appendectomy is by measuring its environmental impact (carbon emissions), cost, and health benefits. Researchers followed 63 patients in Chile who had surgery for acute appendicitis. The goal was to create a single score that comb…

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds precancerous growths better: high-definition white light or dye spraying. Participants had IBD for at least eight years. The goal was to improve cancer screen…

This study tested a mobile app called OASES that guides nurses and clinical officers in rural Uganda through emergency care steps for severe diarrhea, breathing problems, and seizures. About 15 clinicians used the app during simulated patient scenarios to see if it helped them fo…

This study tested a new way to deliver the drug ozanimod using a skin patch instead of oral capsules. 24 healthy adults either took one capsule or wore a patch for 7 days. Researchers measured drug levels in the blood and checked for skin reactions to see if the patch works well …

This study looked at 139 children having a colonoscopy to see how often the CMV virus is found in their gut tissue and blood. Some children had inflammatory bowel disease (Crohn's or colitis) and some did not. The goal was to learn which tests best detect CMV in the gut, helping …

This completed study examined whether differences in the IL-7 receptor gene are linked to the risk of developing ulcerative colitis and how well patients respond to the drug vedolizumab. Researchers enrolled 898 people, including those with UC and healthy controls, and analyzed t…

This study observed 193 adults who had emergency laparoscopic appendix surgery for uncomplicated appendicitis. Researchers wanted to see how closely hospitals followed a specific recovery plan called RICA (an ERAS pathway) and whether early discharge within 24 hours was safe and …

This study looked back at 765 children with complicated appendicitis treated over ten years. Researchers wanted to see how well laparoscopic surgery works for different types of the condition, including cases with abscess or mass. The goal is to help doctors decide the best treat…

This early-stage study tested a single dose of AZD5148, a potential treatment for C. difficile infection, in 16 healthy Japanese adults. The main goal was to see if the drug is safe and how the body processes it. Participants received either the drug or a placebo by injection and…

This study looked at how often emergency room doctors in Villavicencio, Colombia, use a tool called the Alvarado score to help diagnose appendicitis. The researchers surveyed 125 doctors to see if they knew about the score, used it, and wrote it down for patients with belly pain.…

This study looked at whether high bilirubin levels in the blood can help doctors quickly tell if appendicitis is complicated. Researchers studied 400 people who had their appendix removed. The goal was to see if this cheap, fast test could help doctors make better decisions about…

This study observed 92 adults with Crohn's disease or ulcerative colitis who were receiving vedolizumab either as an intravenous infusion or a subcutaneous injection. Researchers tracked treatment patterns, such as whether patients stayed on their current form or switched, over 1…

This study looked at whether having better sanitation helps the oral rotavirus vaccine work better in babies. Researchers followed 261 infants in low-income areas of Maputo, Mozambique, comparing those with improved sanitation to those without. They measured immune response and c…

This study looked at how inflammatory bowel disease (IBD) affects oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to understand which factors, like medic…

This study tested whether the Capillary Leak Index (CLI), a score based on routine blood tests, can predict which patients are at higher risk of dying after developing a serious abdominal infection following surgery. Researchers followed 100 critically ill adults in the ICU for 2…

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (Crohn's or ulcerative colitis) to understand how DNA that escapes from cells might make inflammation worse. Researchers analyzed blood, stool, and gut tissue samples to see if a specific pathway (cGAS-…

This study looked at how the immune system responds to Clostridium difficile infection in hospitalized patients. Researchers took blood samples every two days to measure immune markers. The goal was to find out why some patients have repeat infections. The study involved 56 parti…

This study looked at how well stool and blood samples could be collected from 7 adults with an active C. diff infection. Researchers wanted to see if the collection, shipping, and testing methods worked smoothly. Participants also filled out questionnaires about their symptoms. T…

This completed trial looked at 190 people having laparoscopic appendix removal. It compared closing the appendix stump with a hand-tied knot versus a plastic clip. The goal was to see which method leads to fewer problems like infection or slow bowel recovery within 15 days after …

This study looked at 818 people with Crohn's disease to see if variations in the TNFSF4 gene are linked to the disease and how well patients respond to the drug ustekinumab. Researchers analyzed blood samples to find genetic patterns. The goal is to better understand why some pat…

This study looked at 234 adults with ulcerative colitis whose gut lining had healed (Mayo 0 or 1). Researchers tracked how increasing, decreasing, or switching treatments affected patients' quality of life over 6 and 12 months. They also measured inflammation markers like fecal c…

This study looked at tiny, lab-grown versions of the intestine called organoids, made from tissue samples of people with inflammatory bowel disease (Crohn's or ulcerative colitis), a genetic polyp condition (FAP), and healthy volunteers. The goal was to understand how intestinal …

This completed study from Xijing Hospital looked at 180 adults with mild-to-moderate ulcerative colitis starting 5-ASA therapy. Researchers compared checking symptoms at 4, 8, or 12 weeks to see which timing best predicted treatment success at 48 weeks. The goal was to help docto…

This study tested how well the flu vaccine works and if it's safe for people with inflammatory bowel disease (IBD). Researchers compared 228 adults with IBD who were either taking immunosuppressive drugs or not. The goal was to see if the vaccine triggers a strong immune response…

This study looked at different methods for closing the appendix stump after surgery for complicated appendicitis. Researchers compared how often leaks happened with each technique. The study included 666 adults aged 18 and older with complicated appendicitis.

This study looked at whether two blood-based scores (CALLY and HAALP) can help doctors tell when ulcerative colitis is active. Researchers measured these scores in 100 patients and compared them to standard inflammation markers. The goal was to see if these scores could be a simp…

This study looked at 159 people with ulcerative colitis who started a new advanced therapy. Researchers examined tissue samples from the colon to see if microscopic signs of inflammation could predict future problems like hospital stays or surgery. The goal is to help doctors dec…

This study looked at whether certain proteins in the blood can predict if the drug vedolizumab (Entyvio) will reduce inflammation in the small bowel of people with Crohn's disease. Researchers used MRI scans to measure changes in the bowel wall after treatment. The goal is to hel…

This study takes small tissue samples from people with inflammatory bowel disease (IBD) and healthy volunteers to grow 'mini guts' (organoids) in the lab. Researchers will then expose these organoids to radiation to mimic radiation enteritis and test potential treatments. The goa…

This completed study looked at 100 people who reported a suspected chemical submission (being secretly given drugs). Researchers performed detailed toxicology tests on blood and urine samples to find out which substances were present. The goal was to confirm how many cases involv…

This completed study looked at how a special form of vitamin B3 (nicotinamide) is processed in 28 patients with low tryptophan levels due to respiratory infections or inflammatory bowel disease. Participants took either 500 mg or 1000 mg of the supplement daily for four weeks. Th…