Rotarix vaccine shows strong protection against severe rotavirus in kids
NCT ID NCT01871038
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at how effective the Rotarix vaccine is at preventing severe rotavirus infections in children under 6 years old. Researchers enrolled 362 children with acute gastroenteritis at two U.S. hospitals, comparing those who tested positive for rotavirus (cases) with those who tested negative (controls). By analyzing vaccination records, they estimated the vaccine's effectiveness in real-world conditions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Rotarix (RV1) vaccine
What this could lead to
If successful, this study confirms that Rotarix effectively prevents severe rotavirus infections in young children, supporting continued vaccine use.
What could go wrong
This is an observational case-control study, not a randomized trial, so results may be influenced by unmeasured factors. Vaccine effectiveness can vary by region and circulating strains.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States