Rotarix vaccine shows strong protection against severe rotavirus in kids
NCT ID NCT01871038
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at how effective the Rotarix vaccine is at preventing severe rotavirus infections in children under 6 years old. Researchers enrolled 362 children with acute gastroenteritis at two U.S. hospitals, comparing those who tested positive for rotavirus (cases) with those who tested negative (controls). By analyzing vaccination records, they estimated the vaccine's effectiveness in real-world conditions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Rotarix (RV1) vaccine
- What this could lead to
- If successful, this study confirms that Rotarix effectively prevents severe rotavirus infections in young children, supporting continued vaccine use.
- What could go wrong
- This is an observational case-control study, not a randomized trial, so results may be influenced by unmeasured factors. Vaccine effectiveness can vary by region and circulating strains.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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