Connective tissue disorder

This trial tests a treatment strategy for adults with acute myeloid leukemia (AML) that did not respond to standard induction chemotherapy. Participants receive clofarabine and intermediate-dose Ara-C chemotherapy, followed by a reduced-intensity allogeneic stem cell transplant u…

Researchers test a reduced-intensity conditioning regimen before allogeneic stem cell transplant in adults with high-risk AML, MDS, or ALL who cannot tolerate standard intensive treatment. The regimen combines clofarabine, busulfan, and thymoglobulin. The trial measures relapse r…

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study looked at how safe and effective two shingles vaccines (Zostavax and Shingrix) are in people with rheumatoid arthritis who are taking the drug abatacept. About 154 adults took part, and researchers measured their immune response and any side effects. The goal was to se…

Researchers at Yale University are testing whether abrocitinib, an oral JAK1 inhibitor already approved for atopic dermatitis, can reduce inflammation in people with moderate to severe cutaneous sarcoidosis. The trial enrolls adults with a confirmed skin biopsy and a CSAMI activi…

This trial tests whether efgartigimod, an injected drug that blocks certain immune antibodies, can improve muscle strength and function in adults with active idiopathic inflammatory myopathy — a group of rare autoimmune diseases that cause muscle inflammation and weakness. About …

Researchers are testing a drug called APR-246 combined with azacitidine in people with myeloid blood cancers that carry a TP53 mutation, including myelodysplastic syndrome, acute myeloid leukemia, myeloproliferative neoplasms, and chronic myelomonocytic leukemia. The trial aims t…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) to bone tumors before surgery is safe and can prevent the cancer from returning. About 39 adults with cancer that has spread to their bones and who need surgery to stabilize a fracture risk will recei…

This early-phase trial tested two cancer drugs—imatinib mesylate and cyclophosphamide—given daily by mouth to 26 people with rare, advanced tumors that had no standard treatment. The main goal was to find the safest dose of imatinib when combined with a fixed dose of cyclophospha…

This early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take pa…

This study tests whether a substance produced by umbilical cord cells can help control moderate rheumatoid arthritis. Participants receive weekly injections of either the cell substance or a placebo for six weeks, alongside their usual medication. The goal is to see if it improve…

This phase 3 trial tests an oral drug called brepocitinib in 241 adults with dermatomyositis, a rare disease causing muscle weakness and skin rash. Participants receive either the drug or a placebo for 52 weeks to see if it improves symptoms. The study is active but no longer rec…

This trial investigates whether using a socket sealing abutment, with or without bone graft material, helps preserve bone and soft tissue after immediate molar implant placement. Adults aged 18-45 with non-restorable molars will receive the implant right after extraction, and the…

Researchers are testing whether adding tocilizumab, a drug that blocks an inflammation signal called IL-6, to standard chemotherapy helps adults with high-risk acute myeloid leukemia. Participants receive idarubicin and cytarabine, the usual induction chemotherapy, plus a single …

Researchers are testing a combination of the experimental antibody MEDI5752 and stereotactic body radiotherapy in people with metastatic soft tissue sarcoma that has spread to the lungs. MEDI5752 targets two immune checkpoints, PD-1 and CTLA-4, and the radiation is aimed at one l…

Researchers are testing whether apremilast helps people with early psoriatic arthritis that affects only a few joints. Participants have had symptoms for five years or less and still have joint pain and swelling despite stable treatment with NSAIDs or one conventional DMARD. The …

Researchers are testing whether giving radiation therapy before sipuleucel-T, a personalized immunotherapy vaccine, works better than the vaccine alone in men with hormone-resistant prostate cancer that has spread. The trial enrolls about 51 participants and randomly assigns them…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

Researchers are testing whether a liposomal chemotherapy drug called CPX-351 works better than standard chemotherapy before an allogeneic stem cell transplant in adults with higher-risk myelodysplastic syndromes (MDS) or oligoblastic acute myeloid leukemia (AML). The trial enroll…

This study is testing the long-term safety and effectiveness of bimekizumab, a drug that reduces inflammation, in 508 adults with active axial spondyloarthritis (including ankylosing spondylitis). Participants who completed earlier trials will receive the drug for an extended per…

Researchers are testing an experimental drug called sonelokimab in adults with active psoriatic arthritis, a condition that causes painful, swollen joints along with skin psoriasis. The trial compares sonelokimab injections with placebo injections, and also includes a third group…

This study tests whether adding metformin, a diabetes drug, to standard methotrexate therapy helps more people with rheumatoid arthritis achieve disease control. About 128 adults with active RA who have not recently taken methotrexate will receive either methotrexate plus metform…

This trial tests whether patient-specific PEEK implants, custom-made plastic pieces, can rebuild the bone under the eye after surgery to remove part of the upper jaw due to tumors. The goal is to keep the eye in its natural position and avoid a sunken appearance or vision problem…

Researchers are testing whether a combination of venetoclax and a three-day course of decitabine works better than the standard pairing of venetoclax and azacitidine for older or unfit adults newly diagnosed with acute myeloid leukemia. The trial enrolls 154 participants and comp…

This trial tests whether adding tofacitinib to a standard steroid treatment can better control polymyalgia rheumatica, a condition causing pain and stiffness in the shoulders and hips. Adults aged 50 to 88 with active disease will receive either tofacitinib plus a tapering course…

This study tests a chemotherapy drug called CPX-351 in people under 60 with secondary acute myeloid leukemia (AML), a type of leukemia that develops after other blood disorders or cancer treatments. The goal is to see how well the drug can make the cancer disappear or improve blo…

This study looked at the long-term safety and effectiveness of bimekizumab in adults with active psoriatic arthritis. Over 1,100 people who completed earlier studies received the drug and were monitored for side effects and disease symptoms. The goal was to see if bimekizumab rem…

This early-stage trial evaluates an experimental drug called ZB002, given as an injection under the skin. In the first part, healthy volunteers receive a single dose to check safety and how the drug moves through the body. In the second part, people with rheumatoid arthritis rece…

This early-phase trial tested the drug enasidenib in 17 people with low-risk myelodysplastic syndrome or a related leukemia who had anemia and did not have a specific gene mutation. The goal was to see if the drug could safely improve red blood cell counts and reduce the need for…

This study tests whether bimekizumab works better than risankizumab for adults with active psoriatic arthritis (PsA), a condition causing joint pain and skin lesions. About 684 participants will receive one of the two drugs for 16 weeks. The main goal is to see who gets at least …

This pilot study tested whether a butyrate supplement, a type of short-chain fatty acid, could change the gut microbiome and immune responses in people with rheumatoid arthritis who didn't respond well to methotrexate. Twenty participants took the supplement for up to two months.…

This phase 2 trial tests a personalized cell therapy called Lete-Cel in 7 people with advanced synovial sarcoma or myxoid/round cell liposarcoma that has not been treated before. Participants receive their own immune cells that have been engineered to recognize and attack their c…

This early-stage trial tests the safety and tolerability of SOF-SKN, a cream applied to the skin, in healthy volunteers aged 18 to 64. The study has two parts: one applies a single dose, and the other applies daily doses for two weeks, with escalating strengths. Researchers monit…

This trial tests whether adding venetoclax to a standard chemotherapy pair (cytarabine and mitoxantrone) can help adults with acute myeloid leukemia that has relapsed or not responded to initial treatment. In the first phase, researchers find the highest safe dose of cytarabine w…

This study tested the drug RINVOQ in 69 adults with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Participants took RINVOQ as prescribed by their doctor and were followed for up to a year. The goal was to see how safe and effective the drug is in real…

This trial tests whether placing a graft made from the patient's own tooth and blood components into an extraction socket improves bone healing compared with letting the socket heal on its own. Adults with non-restorable teeth will receive either the graft or no graft, and resear…

This study tests whether avatrombopag, a pill that boosts platelet production, can help people with gastrointestinal cancer who develop low platelets from chemotherapy. About 60 participants will receive either avatrombopag or a placebo. The goal is to see if the drug can raise p…

This study tested a drug called emapalumab in 33 children and adults with macrophage activation syndrome (MAS), a life-threatening immune overreaction, linked to Still's disease or lupus. The goal was to see if the drug could safely control the condition and reduce the need for h…

This trial is testing whether combining certolizumab pegol, an injectable biologic, with methotrexate, a standard oral medication, can help adults with early active rheumatoid arthritis achieve and maintain remission. Participants are newly diagnosed, have not yet taken disease-m…

This trial tests whether combining certolizumab pegol (Cimzia) with methotrexate can help adults with early, active rheumatoid arthritis achieve and maintain low disease activity without flare-ups. Participants who already responded well to this combination in a prior study conti…

This study tests the drug regorafenib in 30 patients aged 9 to 21 with bone cancers (osteosarcoma or Ewing sarcoma) that have not responded to standard therapy. The goal is to see if the drug can help control the disease and improve survival, while also checking its safety. The a…

This phase 3 study tests guselkumab (Tremfya) in 453 adults with active psoriatic arthritis who did not respond to or could not tolerate a prior anti-TNF drug. Participants receive either guselkumab or a placebo injection. The main goal is to see if guselkumab reduces joint swell…

This phase 3 trial investigates whether nirogacestat, an oral drug, can slow the growth of desmoid tumors (also called aggressive fibromatosis) in adults whose tumors are progressing. Half the participants receive nirogacestat, while the other half receive a placebo, in a double-…

This phase 2 trial is testing whether adding venetoclax, a pill taken daily for 12 months, can reduce the number of leukemia stem cells that remain in the bone marrow of people with chronic myeloid leukemia (CML) who are already in deep molecular remission on standard TKI therapy…

This phase III trial is testing whether taking oral azacitidine as a maintenance therapy after an allogeneic stem cell transplant can help prevent relapse in people with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Participants are randomly assigned to receive…

This study looked at whether people with chronic myeloid leukemia (CML) who have done very well on the drug nilotinib can safely stop taking it. 215 patients who had been on nilotinib for at least two years and had very low levels of cancer cells were enrolled. The main goal was …

This study looked at whether people with chronic myeloid leukemia (CML) who had very low levels of cancer cells could safely stop taking the drug nilotinib (Tasigna). Participants had already been treated with imatinib (Gleevec) and then nilotinib for at least 3 years. The main g…

This early-phase trial tests a new type of immunotherapy for people who develop a rare blood cancer called post-transplant lymphoproliferative disease (PTLD) after a solid organ transplant. The treatment uses the patient's own immune cells (T-cells) that are engineered to resist …

This trial looks at whether children with juvenile spondyloarthritis who have stable, inactive disease can safely reduce or stop their TNFi medication without causing a flare. Participants are randomly assigned to continue their usual TNFi dose, take it less frequently, or stop i…

This study looked at 220 adults with chronic myeloid leukemia who had been in deep remission for at least two years while taking imatinib. Researchers wanted to see if stopping the drug would cause the cancer to come back. They found that many patients stayed in remission after s…

This study tracks about 450 adults with active psoriatic arthritis who are prescribed upadacitinib (RINVOQ) by their doctor. Researchers will follow participants for up to 24 months to see how well the drug controls joint and skin symptoms when used alone or with methotrexate in …

This trial is testing the long-term safety and tolerability of the drug filgotinib in people with rheumatoid arthritis who have already completed an earlier filgotinib study. Researchers are monitoring side effects, lab abnormalities, and vital signs over an extended period. The …

This study tested whether combining two drugs (guselkumab and golimumab) works better than one drug alone for people with active psoriatic arthritis who didn't get enough relief from previous TNF-alpha blockers. 91 adults took part. The goal was to see if the combo could help mor…

This trial investigates whether a single injection of platelet-rich plasma (PRP), made from a person's own blood, can reduce pain and improve function in chronic patellar tendinopathy (knee tendon pain). The study includes 29 adults aged 18–65 who have had tendon pain for over th…

This Phase 3 trial tested bimekizumab, a drug given by injection, against a placebo in 400 adults with active psoriatic arthritis who had not responded well to TNF-alpha inhibitors. The study aimed to see if bimekizumab could reduce joint pain and swelling and improve daily funct…

This study tested a drug called bimekizumab in 852 adults with active psoriatic arthritis, a condition causing joint pain, swelling, and skin patches. Participants received either bimekizumab, a placebo, or an existing treatment (adalimumab). The main goal was to see if bimekizum…

This phase 3 trial tests whether risankizumab, an injectable biologic, can reduce joint pain and swelling in adults with moderately to severely active psoriatic arthritis who have not responded to or cannot tolerate other biologic treatments. Participants receive either risankizu…

This study tests whether adding the targeted drug venetoclax to standard chemotherapy helps more adults with acute myeloid leukemia (AML) achieve remission. It enrolls people aged 18 to 65 with intermediate- or high-risk AML who have not yet been treated. The main goal is to see …

This study tests whether a peer coaching program delivered by phone and text can help adolescents and young adults (ages 16–22) with chronic conditions like sickle cell disease, diabetes, or cystic fibrosis improve their self-management skills. Participants are paired with a trai…

This study tests whether extracorporeal shock wave therapy can reduce the thickness of fibrous tissue in the hand caused by palmar fibromatosis (Dupuytren's contracture). Adults aged 18 to 70 with nodules, cords, or contractures will receive either shock wave therapy plus standar…

This study tracks the safety and effectiveness of bosutinib (Bosulif) in people with chronic myelogenous leukemia (CML) who are either newly diagnosed or have not responded to or tolerated prior treatments. Researchers will monitor side effects and how well the drug controls the …

This study compares the safety of baricitinib, an oral medication, against TNF inhibitors (injectable drugs like etanercept and adalimumab) in people with rheumatoid arthritis. The main focus is on the risk of venous thromboembolism (blood clots in veins). Participants include th…

This study follows 36 Italian patients with Polycythemia Vera who responded well to Ropeginterferon alfa-2b in an earlier trial. Researchers will check every 6 months whether the treatment continues to keep their red blood cell levels normal and prevent the disease from getting w…

This study investigates whether a passive stretching program can reduce muscle and tendon stiffness in people with type 2 diabetes. Diabetes can cause muscles and tendons to become stiffer, making walking harder and increasing energy use. The trial compares stiffness in people wi…

This phase 2 trial is testing whether combining two drugs, ponatinib and 5-azacitidine, can improve survival in people with advanced chronic myeloid leukemia (CML). The study includes adults whose CML has progressed to an accelerated phase or a more aggressive blast crisis. Parti…

This study tests whether adjusting the daily dose of the leukemia drug dasatinib based on a patient's blood levels can improve safety and effectiveness. Adults newly diagnosed with chronic phase chronic myeloid leukemia (CML) will receive either standard dosing or a dose tailored…

This phase 2 trial tests whether adding pioglitazone (a diabetes drug) to the standard leukemia medication imatinib can eliminate remaining cancer cells in people with chronic-phase chronic myeloid leukemia (CML). Participants must have been on imatinib for at least two years and…

This trial tests whether adding the targeted drug ponatinib to standard chemotherapy (cytarabine) can help prevent relapse in adults with a specific, high-risk genetic form of acute myeloid leukemia (FLT3-ITD AML) who are already in first remission. The study includes two age gro…

This trial investigates whether adjusting the dose of imatinib (Gleevec) based on the drug's level in the blood can improve outcomes for people newly diagnosed with chronic phase chronic myeloid leukemia (CML). Participants whose imatinib blood level is low after 28 days are rand…

This study investigates whether changing diet can reduce disease activity in people with psoriatic arthritis. Participants are randomly assigned to one of two diets: one focusing on which foods are eaten, and another limiting daily calorie intake. The trial lasts 24 weeks and inc…

This study looked at whether taking oral azacitidine (Onureg) as maintenance therapy can help older adults with acute myeloid leukemia (AML) stay in remission longer after treatment with CPX-351 chemotherapy. The study included 100 patients aged 65 and older who had achieved remi…

This study tested a chemotherapy drug called CPX-351 in 59 adults aged 60 to 75 with a high-risk form of acute myeloid leukemia (AML). The goal was to see how well it could put the cancer into remission. Participants received the drug through an IV, and some also had a stem cell …

This completed Phase 4 study compared the safety of baricitinib (a daily pill) to TNF inhibitors (injections) in over 2,600 adults with rheumatoid arthritis. The main goal was to see if baricitinib had a higher risk of blood clots. Participants had to be at least 60, have a histo…

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This study tested a drug called SB-UF, which combines hormones and a plant extract, to see if it can shrink uterine fibroids in pregnant women. 66 women took the drug or a placebo throughout their pregnancy. The goal was to reduce fibroid size and help them disappear, which could…

This phase 3 trial tested whether abatacept, a drug that calms the immune system, can control polymyalgia rheumatica (a painful inflammatory condition) without the need for long-term steroids. Thirty-four adults with early disease received either abatacept or a placebo for 12 wee…

This study looked at the safety and effectiveness of a drug called asciminib in 85 Indian adults with a specific type of leukemia (Ph+ CML-CP). Some participants had a genetic mutation (T315I) that can make treatment harder, while others had already tried two or more other drugs.…

This early-stage trial tested a drug called itolizumab (EQ001) in 52 adults with lupus, some of whom also had active kidney inflammation. The main goal was to check safety and find the right dose. Researchers also looked at how the drug behaves in the body and how it affects immu…

This study looked at 152 adults with systemic lupus erythematosus (SLE) who started taking anifrolumab during its first year on the market in Spain. Researchers tracked their disease activity, flare-ups, and remission rates using standard medical records. The goal was to see how …

This study tested the drug bosentan in 18 adults with systemic sclerosis who had reduced blood flow in their hands and a history of digital ulcers. The goal was to see if bosentan could improve hand blood flow measured by laser imaging and how blood flow relates to ulcer severity…

This study tested a new way to treat blood cancers like leukemia in 16 adults who did not have a standard bone marrow donor. Doctors used a single unit of cord blood that was grown in a lab to increase the number of stem cells before transplant. The goal was to see if this method…

This study tested a new treatment for adults with a high-risk form of acute promyelocytic leukemia (APL). The experimental therapy combined arsenic trioxide, ATRA, and a low dose of idarubicin, aiming to improve survival and reduce side effects compared to the standard chemothera…

This phase 2 trial tests whether a combination of clofarabine and intermediate-dose cytarabine (CLARA) works better than high-dose cytarabine (HDAC) alone as consolidation therapy for younger adults (18-60) with newly diagnosed acute myeloid leukemia (AML). After initial remissio…

This study tested a program to help veterans with heart disease or rheumatic conditions take their medications as prescribed. Over 5,000 participants received reminders via text or phone calls, with extra support if needed. The goal was to improve medication adherence and reduce …

This study looked at 31 adults with chronic myeloid leukemia (CML) whose cancer came back after they stopped taking imatinib. They were given nilotinib, a more powerful targeted therapy, to see if it could make their cancer undetectable again and allow them to stop treatment once…

This study tested whether exenatide, a diabetes drug, plus lifestyle changes helps adults with severe weight gain after treatment for a rare brain tumor (craniopharyngioma). 42 adults aged 18-75 took either exenatide or a placebo for 6 months. The main goal was to see if they los…

This study followed 155 French adults with moderate-to-severe rheumatoid arthritis who were prescribed filgotinib (Jyseleca) for the first time. Over two years, researchers measured how many patients stayed on the drug and how well it controlled their disease activity. The goal w…

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This study looked at whether taking NSAIDs every day, instead of only when needed, can prevent spine damage in people with ankylosing spondylitis who are also receiving anti-TNF therapy. 188 adults participated in this Phase 3 trial. The goal was to see if continuous NSAID use re…

This study tested an oral medication called GLPG3667 in 186 adults with active systemic lupus erythematosus (SLE). Participants took the drug or a placebo once daily for 48 weeks. The goal was to see if the drug could reduce lupus disease activity and improve symptoms, while moni…

This study tested whether a daily combination pill (relugolix, estradiol, and norethindrone acetate) can prevent pregnancy in women aged 18 to 50 who have uterine fibroids or endometriosis. Over 1,100 women took the pill for up to a year, and researchers counted how many became p…

This study tested whether imatinib, a drug used for certain cancers, can reduce skin hardening in people with severe scleroderma. 28 adults received either imatinib or a placebo for 6 months. The main goal was to see if the drug improved skin thickness and quality of life.

This study tested an oral drug called GLPG3667 (Cadefrecitinib) in 40 adults with dermatomyositis, a rare disease causing muscle weakness and skin rash. Participants took the drug or a placebo daily for 24 weeks to see if it improves symptoms. The trial is complete, and results w…

This study tested whether sildenafil (the drug in Viagra) can help heal painful finger ulcers in people with scleroderma, a disease that damages blood vessels. 84 participants took either sildenafil or a placebo three times daily for 90 days. The main goal was to see if the ulcer…

This study tested whether an oral medication (CC-486) could help elderly patients with a serious blood disorder called myelodysplastic syndrome (MDS) maintain their improvement after initial injectable treatment. Eleven patients who had responded to injectable azacitidine switche…

This study tested a triple therapy—surgery, stem cells, and hyperbaric oxygen—in 24 patients with early-stage osteonecrosis (bone death) of the hip. After two years, patients reported better hip function and fewer needed a hip replacement. The approach aims to stop the bone from …

This study tested a drug called bosentan in 16 adults with scleroderma who had a serious kidney complication called scleroderma renal crisis. The goal was to see if bosentan could help protect kidney function and improve survival over 6 months to a year. The drug works by blockin…

This study looked at how well a special knee replacement (MUTARS) works after removing bone cancer. Nine patients were checked to see if they could lock their new knee and walk actively. The goal was to understand if the prosthesis helps with daily movement and walking.

This study tested the drug baricitinib, given with steroids, in 16 children aged 3-18 with newly diagnosed juvenile dermatomyositis, a rare disease causing muscle weakness and skin rashes. The goal was to see if baricitinib works better than the standard treatment (methotrexate p…

This study looked at whether the drug anifrolumab, when added to standard lupus treatments, can reduce long-term organ damage compared to standard care alone. Researchers analyzed data from 561 adults with active lupus, comparing those who took anifrolumab in earlier trials to si…

This study tested the drug belimumab in children aged 5 to 17 with active lupus. Participants received either belimumab or a placebo alongside their usual treatments. The goal was to see if belimumab could safely reduce lupus disease activity over 52 weeks.

This study tested a new drug called bimekizumab in 567 adults with moderate to severe plaque psoriasis. Participants received either bimekizumab, a placebo, or another active drug. The main goal was to see how well bimekizumab cleared skin lesions after 16 weeks. Results showed s…

This phase 3 study tested bimekizumab, a drug given by injection, against a placebo in 435 adults with moderate to severe plaque psoriasis. The main goal was to see how many people achieved at least 90% skin clearing after 16 weeks. The trial also looked at complete clearing and …

This study tested whether ultrasound could detect signs of rheumatoid arthritis (RA) relapse before symptoms appear in patients treated with rituximab. Thirty adults with RA who had not responded to at least one TNF-blocking drug were included. Researchers used ultrasound to meas…

This study tested whether people with rheumatoid arthritis, psoriatic arthritis, or spine arthritis could safely switch from receiving infliximab through an IV infusion at a clinic to giving themselves a simple shot under the skin at home. 22 adults who were already stable on IV …

This study tested whether a combination of two drugs, venetoclax and azacitidine, can help adults with acute myeloid leukemia (AML) stay in remission after initial chemotherapy. The goal was to find the right dose and see if it safely delays the cancer from coming back. The study…

This study tested whether taking a probiotic called VSL#3, alongside standard treatment, can reduce disease activity in children with juvenile idiopathic arthritis (JIA). Fifty-one children aged 1 to 7 with specific types of JIA took either the probiotic or a placebo. Researchers…

This study looked at whether adding methotrexate to adalimumab (a biologic drug) reduces the chance that the body makes antibodies against adalimumab in people with ankylosing spondylitis. About 110 adults with active disease who did not respond well to NSAIDs took part. The goal…

This study tested a new way of delivering radiation for people with non-secreting pituitary adenomas that came back or remained after surgery. Instead of a single high dose, the radiation was given in five smaller daily doses. The goal was to see if this approach could control tu…

This study compared two treatment strategies for people with early, severe scleroderma: a stem cell transplant using their own cells versus standard immunosuppressive drugs. The trial enrolled 60 adults with diffuse cutaneous systemic sclerosis. The goal was to see which approach…

This study looked at how well upadacitinib, an anti-inflammatory pill, controls pain in people with axial spondylarthritis (axSpA), a condition causing chronic back pain. Over 700 adults from 19 countries took the drug as prescribed by their doctors and were followed for 12 month…

This study looked at 62 children with juvenile idiopathic arthritis whose disease was inactive. Researchers tested whether slowly reducing and then stopping their biologic medication was as safe and effective as staying on the full dose for 24 weeks. The goal was to see if taperi…

This study tested whether adding the experimental drug navitoclax to the standard drug ruxolitinib works better than ruxolitinib alone for people with myelofibrosis, a type of bone marrow cancer. The main goal was to see if the combination could shrink an enlarged spleen by at le…

This study looked at whether children with cancer and a fever caused by low white blood cells can safely stop antibiotics earlier than usual. 55 children took part, and half stopped antibiotics once their fever was gone for 48 hours, while the other half continued until their whi…

This study tested a medicine called Avenciguat (BI 685509) in 214 adults with scleroderma, a disease that can cause skin hardening and lung or blood vessel damage. Participants took either the study drug or a placebo three times daily for at least 11 months. Researchers measured …

This study tested three different starting doses (45 mg, 30 mg, and 15 mg daily) of the drug ponatinib in 283 adults with chronic phase chronic myeloid leukemia (CML) that had stopped responding to other treatments or had a specific genetic mutation (T315I). The main goal was to …

This early-phase study tested a combination of two drugs, venetoclax and omacetaxine, in 6 adults with acute myeloid leukemia (AML) whose cancer had stopped responding to venetoclax-based treatments. The main goal was to find the safest dose of omacetaxine when given with venetoc…

This early-phase trial tested a new type of stem cell transplant called a microtransplant in 25 people with myeloid blood cancers (like leukemia) who were too old or frail for a standard transplant. Unlike a regular transplant, this one used stem cells from a partially matched fa…

This pilot study tested a combined bone marrow and kidney transplant from a partially matched family donor in 10 people with both a blood disorder and chronic kidney disease. The goal was to treat both conditions at once and possibly reduce the need for lifelong anti-rejection dr…

This study tested the drug secukinumab (Cosentyx) in 151 adults with newly diagnosed giant cell arteritis, a condition causing inflamed blood vessels. Participants were in remission and received either secukinumab or a placebo, along with a steroid taper. The goal was to see if s…

This study tested a daily pill called upadacitinib in 734 adults with axial spondyloarthritis, a type of arthritis that causes pain and stiffness in the spine. The drug was compared to a placebo to see if it could reduce symptoms and control the disease. Results showed that upada…

This study tested whether adding leflunomide to standard methotrexate treatment helps children with polyarticular juvenile idiopathic arthritis (JIA) that did not improve with methotrexate alone. Fifty children were randomly assigned to receive either the combination or methotrex…

This study tested a radioactive drug called radium-223 in 921 men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The goal was to see if it helps them live longer and controls the cancer. Participants received either the drug …

This phase 2 study tested whether adding pioglitazone (a diabetes drug) to trabectedin (a chemotherapy) could help shrink or control liposarcoma, a rare cancer of fat tissue. The study included 10 patients whose tumors had stopped growing but not shrunk with trabectedin alone. Re…

This early-phase study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine) is safe for people with two rare types of soft tissue sarcoma (leiomyosarcoma and undifferentiated pleomorphic sarcoma). Twenty-five adults with advanced or in…

This study looked at how adults with a specific type of acute myeloid leukemia (AML) who cannot receive standard chemotherapy feel and function while taking a combination of ivosidenib and azacitidine. The main goal was to measure quality of life using questionnaires, along with …

This study tested an inhaled medication called treprostinil in 5 people with sarcoidosis who also have lung scarring and high blood pressure in the lungs. The goal was to see if the drug could improve blood flow and heart function. Participants took the drug and were monitored wi…

This study tested whether rituximab, a drug that calms the immune system, can help people with polymyalgia rheumatica (PMR) stop taking steroids sooner. PMR causes pain and stiffness, and steroids are the main treatment but have side effects. The trial included 114 newly diagnose…

This study looked at 70 people with psoriatic arthritis to compare two drug types: upadacitinib and IL-17 inhibitors. Researchers tracked joint and skin symptoms over 24 weeks in routine care. The goal is to see which works better in real life, helping doctors personalize treatme…

This study tested a three-drug chemotherapy combination (cladribine, homoharringtonine, and cytarabine) in 65 adults under 60 with newly diagnosed acute myeloid leukemia (AML). The goal was to see how well it wiped out leukemia cells and how safe it was. Results tracked complete …

This study tested whether a weekly injection of abatacept (Orencia) plus usual care could prevent juvenile idiopathic arthritis (JIA) from spreading to more joints or causing eye inflammation. 121 children with recent-onset JIA affecting 4 or fewer joints took part. The goal was …

This study tested a freezing technique called cryoablation on 50 adults with desmoid tumors that had grown despite medical treatment. The goal was to stop tumor growth and ease symptoms without surgery. Researchers used MRI to guide the freezing and check results one year later.

This study looked at 300 adults with active rheumatoid arthritis whose first anti-TNF treatment stopped working. Researchers compared two strategies: switching to a different type of biologic drug or trying a second anti-TNF. The goal was to see which approach better controls the…

This study tested a drug called navitoclax, either alone or added to the standard drug ruxolitinib, in 191 people with myelofibrosis. The main goal was to see if the treatment could shrink the spleen by at least 35% after 24 weeks. The trial also looked at whether it could reduce…

This study tested a new bone graft material, ZetaMet, in 10 women with breast cancer that spread to their spine, causing bone defects. The graft was implanted into the damaged vertebra to see if it could safely stabilize the spine and reduce pain. The main goals were to track com…

This study tested what happens when patients with rheumatoid arthritis, Crohn's disease, or eye inflammation switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Over 260 adults who had been on Remicade for at least 4 months were switched. The main goal …

This early study tested a new drug called EF-M2 (Immutalon) in 48 adults with moderate-to-severe rheumatoid arthritis. The drug is designed to shift immune cells from a pro-inflammatory to an anti-inflammatory state. Participants received injections for 4 weeks, and researchers m…

This Phase 2 trial tested Proximod, a daily pill that calms the immune system, in 179 adults with moderate-to-severe rheumatoid arthritis who had not responded well to standard treatments. Participants took either 5 mg, 10 mg, or a placebo daily for three months, with one month o…

This study tested whether the antibiotic levofloxacin can prevent fevers and infections in people with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) who are receiving the chemotherapy drug azacitidine. Infections are a major risk for these patients. The trial ran…

This study tested whether adding rituximab (a drug that calms certain immune cells) to standard mycophenolate mofetil treatment helps people with interstitial lung disease whose lungs are not responding to initial therapy. 122 adults with various ILD types received either rituxim…

This study tested whether brushing teeth is safe for patients with prolonged aplasia (low blood cell counts) after intensive chemotherapy. Currently, many hospitals only allow mouthwash to avoid bleeding and infection. The trial compared brushing with an extra-soft toothbrush plu…

This early-phase trial tested a new approach for osteosarcoma (bone cancer) in 10 patients aged 12-40. The treatment combined standard chemotherapy with a targeted drug (Endostar) and cisplatin delivered directly into the artery supplying the tumor. The goal was to see if this me…

This study tested a drug called bimekizumab in 332 adults with active ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. Participants received either the drug or a placebo injection. The goal was to see if the drug could reduce symptoms like pain and…

This study tested a new shoulder implant called PyroTITAN HRA in 156 people with arthritis. The implant resurfaces the ball part of the shoulder joint to relieve pain and improve function. Researchers tracked how long the device lasted and whether it caused problems, aiming to se…

This study looked at whether treating gum disease (periodontitis) can reduce the severity of rheumatoid arthritis (RA) in people who have both conditions. Researchers enrolled 22 adults with RA and gum disease, providing periodontal treatment and measuring changes in RA activity …

This study looked at how well the drug Venetoclax works for adults with acute myeloid leukemia (AML) who are not healthy enough for intensive chemotherapy. About 120 patients in Switzerland and Austria took Venetoclax pills daily as part of their normal care. Researchers tracked …

This study tested a combination of two drugs—pembrolizumab (an immunotherapy) and cyclophosphamide (a chemotherapy)—in 129 people with advanced sarcomas that had spread or could not be removed by surgery. The goal was to see if the combination could shrink tumors or stop them fro…

This study tested a combination of two drugs, lenvatinib and eribulin, in 30 people with advanced soft tissue sarcomas (liposarcoma or leiomyosarcoma) that could not be removed by surgery or had spread. The goal was to see if the combo could shrink tumors or slow their growth. Th…

This study tested whether adding GOLimumab to methotrexate works better than methotrexate alone for people with very early psoriatic arthritis (PsA). 84 adults with active PsA diagnosed within the last 2 years took part. The main goal was to see if the combination improved diseas…

This large study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of developing autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or …

This study tested two methods to help people with rheumatoid arthritis stop taking steroids (prednisone) safely. 102 adults with low disease activity or remission were given either a gradual dose reduction or a replacement with hydrocortisone. The goal was to see which approach a…

This study compared two types of knee implants—the Vanguard Cruciate Retaining and the AGC Total Condylar—in 150 patients with knee arthritis. The goal was to see which implant provides better pain relief and function after knee replacement surgery. Patients were followed for sev…

This completed trial tested whether starting stronger medications early helps people with moderate to severe psoriatic arthritis more than the usual step-up approach. 192 adults were randomly assigned to standard care, early combination disease-modifying drugs, or early TNF inhib…

This study tested whether rituximab, a drug used for certain cancers and autoimmune diseases, can reduce joint pain and swelling in people with systemic sclerosis (scleroderma). Twenty-two adults with active arthritis took rituximab or a placebo, plus standard care. Researchers c…

This study looked at how well flu vaccines (seasonal and H1N1) work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or immunosuppressants. Researchers measured antibody levels three weeks after each shot to see if the vaccine provide…

This study compared two treatments for symptomatic uterine fibroids—surgery (myomectomy) and a minimally invasive procedure (uterine artery embolization)—to see which one better helps women get pregnant and have a live birth. It included 9 women aged 18 to 43 with fibroids larger…

This study tested a new drug called KZR-616 (zetomipzomib) in 69 people with lupus, some of whom also had kidney inflammation (lupus nephritis). Participants received weekly injections for 13 or 24 weeks. The main goals were to check safety and see if the drug could reduce protei…

This Phase 2 trial tested a drug called KZR-616 (zetomipzomib) in 25 adults with active polymyositis or dermatomyositis, two rare diseases that cause muscle inflammation and weakness. Participants received either the drug or a placebo for 16 weeks, then switched to the other trea…

This study tested an intravenous drug called golimumab in 130 children with active juvenile idiopathic arthritis that did not improve with methotrexate. The main goal was to measure how the drug moves through the body over time. The study was completed and provides information on…

This study tested a smartphone app to help young adult cancer survivors (ages 18-39) lose weight. The app tracked diet and activity as part of a behavioral weight loss program. The goal was to see if this approach was practical and well-liked by participants. The study involved 6…

This study tested a program to help people with rheumatoid arthritis (RA) get their cholesterol checked and treated. Many RA patients are at higher risk for heart attacks and strokes but often miss out on proper screening. The program used peer coaches and educational materials t…

This study tested whether adding a drug called pevonedistat to the standard two-drug combination (venetoclax and azacitidine) helps adults recently diagnosed with acute myeloid leukemia (AML) who are too frail for intensive chemotherapy. About 164 participants received either the…

This study tested two biologic drugs, secukinumab and ustekinumab, in 119 adults with active psoriatic arthritis who had not responded to or could not tolerate TNFα-inhibitor treatment. The main goal was to see which drug better improved physical function over 28 weeks. Researche…

This study tested an experimental drug called SPI-62 in 26 adults with Cushing's syndrome caused by a non-adrenal tumor. The goal was to see if SPI-62 could lower cortisol levels safely. Participants received either SPI-62 or a placebo for 24 weeks, with an option to continue lon…

This study tested whether adding a second drug (pegylated interferon) to the standard leukemia medication nilotinib helps people with newly diagnosed chronic myeloid leukemia (CML) achieve a deeper molecular response faster. About 200 adults under 65 with early-stage CML took par…

This study tested a nurse-led care management program for lupus patients at high risk of missing appointments or ending up in the emergency room. Nurses received special training on lupus and social barriers to care, then reached out to patients to help them attend rheumatology v…

This early-phase trial tested a single infusion of stem cells taken from the patient's own belly fat in 15 adults with active rheumatoid arthritis. The main goal was to see if the treatment is safe over 12 months. Researchers also looked at whether it could lower inflammation mar…

This study tested a robotic system called EPIONE that helps doctors guide needles into bones during CT scans. The robot is used for procedures like biopsies, tumor treatments, and bone repairs. Researchers wanted to see if the robot could make these procedures safer and more accu…

This phase 3 study tested upadacitinib, an oral anti-inflammatory drug, in 642 adults with active psoriatic arthritis who had not responded well to at least one biologic treatment. Participants received either 15 mg or 30 mg of upadacitinib daily or a placebo. The main goal was t…

This study tested whether a combination of the chemotherapy drug cyclophosphamide and the steroid prednisone could help people with scleroderma-related lung disease. Forty adults whose lung function had worsened in the past year received either the drug combo or a placebo plus pr…

This study tested the drug adalimumab against a placebo in 34 children with juvenile arthritis and active eye inflammation (uveitis) that wasn't controlled by steroid drops or methotrexate. The goal was to see if adalimumab could reduce eye inflammation after two months. After th…

This study followed over 1,500 women with moderate to severe uterine fibroids who were taking Esmya (ulipristal acetate) long-term. Researchers tracked side effects, especially those affecting the uterus, and how doctors prescribed the drug in everyday practice. The goal was to b…

This study tested whether using a special bag during laparoscopic fibroid removal (myomectomy or hysterectomy) can prevent the spread of cells that might be cancerous. Forty-eight women were randomly assigned to have the procedure with or without the bag. Researchers then checked…

Researchers at Emory University are testing whether shear wave elastography, an ultrasound technique that measures tissue stiffness, can tell the difference between healthy tendons and painful ones. The study enrolls about 56 people, some with tendinopathy and some without, and s…

This study is working to create a reliable imaging test to find and measure problem areas in muscle and fascia tissue, known as myofascial pain. Researchers will use ultrasound and MRI to identify unique 'biosignatures' in 120 people with plantar fasciitis, Achilles tendinopathy,…

This study tested a new 3D bone scan camera (VERITON-CT) that takes only 25 minutes and uses less radiation than standard scans. Researchers compared it to conventional 2D scans in 146 people with suspected or known bone metastases. The goal was to see if the new method could acc…

This study tested a new structured reporting system called BTI-RADS to help doctors better assess bone tumors from X-rays, CT, and MRI scans. Researchers analyzed images from 1,100 patients to see if the tool could more accurately tell which tumors are likely cancerous. The goal …

This study tested whether a special lung MRI can replace CT scans for diagnosing idiopathic pulmonary fibrosis (IPF), a scarring lung disease. Researchers compared MRI to standard CT in 60 patients to see if MRI could spot the same key signs of IPF without using radiation. The go…

This study looked at whether whole body MRI can accurately diagnose inflammatory myopathies—a group of muscle diseases causing weakness and damage. Researchers compared MRI results with muscle biopsies in 139 people suspected of having these conditions. If MRI proves reliable, it…

This study tested whether a painless, non-radiation ultrasound of the chest can find early signs of lung scarring in people with scleroderma. Thirty patients without known lung disease on CT scans underwent thoracic ultrasound. The goal was to see how often ultrasound detects hid…

Researchers are testing whether giving azacitidine, a chemotherapy drug, together with donor lymphocyte infusions after a stem cell transplant can prevent relapse in people with high-risk acute myeloid leukemia or myelodysplastic syndrome. About 30 patients will receive the combi…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This trial tests whether giving azithromycin—a common antibiotic—twice a year to young children in Niger can reduce deaths. It compares giving the drug to all children aged 1-59 months versus only to infants 1-11 months, who are at highest risk. The study also checks how these ap…

Researchers are testing whether a topical melatonin gel helps dental implants stay stable when placed immediately into tooth sockets that had chronic infection. Sixty adults with non-restorable teeth and long-standing apical lesions will receive either standard implant placement …

This study tested whether wet cupping therapy, an ancient practice where small cuts are made on the skin and cups are used to draw out a small amount of blood, can help people with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Half of the 100 particip…

Researchers are testing whether a 12-week Taekwondo training program can help adults with ankylosing spondylitis and axial spondyloarthritis. The trial enrolls 21 adults aged 19 to 59 who have stable treatment or no medication for at least three months. Participants join either a…

This study tests whether adding an injection called Tropho Tend to standard physical therapy helps reduce pain and improve shoulder function in people with rotator cuff tendinopathy. Sixty adults with shoulder pain lasting at least six weeks will be randomly assigned to receive e…

This trial compares two ultrasound-guided pain-relief techniques for children aged 1 to 12 undergoing surgery on the front or side of the thigh. One group receives a fascia iliaca nerve block, while the other gets caudal analgesia, both given after general anesthesia. The goal is…

Plantar fasciitis causes heel pain from irritation of the thick band of tissue on the bottom of the foot. This trial compares two common treatments: kinesiotaping, where a flexible tape is applied to the foot, and lower limb stretching exercises that target the calf and hamstring…

Calcific tendinitis of the rotator cuff causes long-lasting shoulder pain when calcium builds up in the tendon. Standard treatment flushes the deposit with fluid, but the calcium often dissolves slowly. Researchers are testing whether injecting sodium thiosulfate, a chemical that…

Calcific tendinitis of the rotator cuff causes long-lasting shoulder pain when calcium builds up in a tendon. A common treatment is ultrasound-guided needling and lavage to break up and flush out the deposit, often followed by a corticosteroid injection to prevent a pain flare. R…

Researchers compare two treatments for long head of the biceps brachii tendinopathy, a common cause of shoulder pain. One group receives a single ultrasound-guided injection of triamcinolone acetonide and lidocaine around the tendon. The other group receives transcutaneous electr…

Boys with hemophilia often miss out on games and activities because of concerns about bleeding and joint damage. Researchers developed a 12-week muscle-strengthening exercise programme with input from children, parents, and physiotherapists. The DOLPHIN-II trial compares this pro…

This small pilot study is testing whether using heat (radiofrequency ablation) to disable a nerve in the heel can relieve chronic pain from plantar fasciitis or heel spurs. The 31 participants have had pain for over 6 months and tried at least four other treatments without succes…

This study tests whether custom-made 3D-printed masks fit children better than standard commercial masks for non-invasive ventilation (NIV). Fifteen children aged 8-12 who already use NIV but have poor adherence will try a custom mask made from a 3D facial scan. Researchers will …

Researchers at Rigshospitalet in Denmark are testing whether adults newly diagnosed with acute myeloid leukemia can safely measure their own blood counts and give themselves blood and platelet transfusions at home. The study trains and certifies 22 participants to use a home bloo…

This study tests whether a 5-minute educational video about uterine fibroids and their treatments can help patients feel less conflicted when deciding on a treatment plan. About 154 women with fibroids will be randomly assigned to watch the video before their appointment or recei…

Researchers are testing a six-week online program called Learning to THRIVE for women with interstitial cystitis, also known as bladder pain syndrome. The program combines self-paced online lessons with weekly live virtual group meetings to teach pain management, self-care, commu…

This trial tests two types of custom-made insoles for people with plantar fasciitis, a common cause of heel pain. One insole is milled from EVA foam, the other is 3D-printed from TPU plastic. Over 12 weeks, researchers measure calf muscle activity during walking, foot pressure, p…

This trial tests a new 24-week program called COMFI that combines a cognitive behavioral approach with physical activity to help people with inflammatory arthritis manage fatigue. Participants attend group sessions, an optional individual session, and a booster session, and they …

This study tests if a biceps tendon cutting procedure (tenotomy) done in the doctor's office with a tiny camera and local anesthesia works as well as the same surgery in an operating room. 14 adults with shoulder pain from biceps or rotator cuff problems will be enrolled. The mai…

This study tests whether blood flow restriction training (BFRT) — using pressure cuffs during low-load exercise — can help people with rheumatoid or psoriatic arthritis build muscle with less joint strain than conventional strength training. Adults with these conditions will be r…

This study looked at how satisfied people were with three different types of mouthguards (occlusal splints) for jaw joint and muscle pain (TMD). 27 adults who had jaw pain for at least 3 months and had never been treated for it tried one of the splints. The main goal was to see w…

This study tests whether learning Argentine tango can increase overall physical activity in people with chronic inflammatory arthritis, such as rheumatoid arthritis or spondyloarthritis. Participants will take tango sessions that focus on body awareness, movement, and connection …

This trial investigates whether eccentric isokinetic exercise — a type of controlled, lengthening muscle contraction performed on a special machine — can reduce pain and improve shoulder function in people with rotator cuff tendinopathy. Fifty adults aged 20 to 50 with confirmed …

This study compared two procedures for treating painful calcium buildup in the shoulder: barbotage (a needle-guided washout) and shock wave therapy. Sixty-three adults aged 30–60 with chronic shoulder pain were randomly assigned to one treatment. Researchers tracked pain levels a…

This trial investigates whether histotripsy, a focused ultrasound technique, can reduce pain in people with plantar fasciitis that has not responded to standard treatments like shock waves, orthotics, or steroid injections. Participants receive two ultrasound sessions and report …

This study tested whether a mobile health program—including a Fitbit with movement reminders, coaching sessions, and a WhatsApp peer support group—could help 20 adolescents and young adults with acute lymphoblastic leukemia (ALL) reduce the time they spend sitting or lying down d…

This study tests whether adding neural gliding exercises—gentle movements that help nerves slide smoothly—to standard shock wave therapy and home exercises can further reduce pain and improve foot function in people with plantar fasciitis. About 56 adults with this common cause o…

This study tested two device-based treatments—high-intensity laser and high-power ultrasound—against standard care for plantar fasciitis. 51 adults with heel pain for at least a month received one of the therapies three times a week for a month. Researchers measured pain levels a…

This study tested whether nurse-led consultations can help people with rheumatoid arthritis become more independent in managing their subcutaneous biotherapy. Many patients struggle to recognize warning signs and delay seeking help. The study enrolled 71 adults with rheumatoid ar…

This study tested whether practicing Qi Gong, a gentle mind-body exercise, could improve quality of life in people with systemic lupus erythematosus (SLE). Thirty-three participants took part in weekly Qi Gong sessions for six months. Researchers measured changes in physical func…

This study tested whether a small, at-home device that stimulates a nerve in the ear can improve symptoms like pain, fatigue, sleep, and mood in people with hypermobile Ehlers-Danlos syndrome (hEDS). Twenty-five adults with hEDS used the device daily for two weeks, with some rece…

This study tested two simple, non-invasive treatments for plantar fasciitis, a common cause of heel pain. Eighty adults aged 20–50 with heel pain lasting over 4 weeks were split into two groups: one received Bowen therapy (a gentle hands-on technique) twice weekly for 12 weeks, w…

This completed pilot study tested an 8-week online mindfulness course in 38 people with rheumatoid arthritis. The goal was to see if patients liked the program, what barriers they faced, and how it might affect symptoms. Half the group took the course while the other half receive…

This study tested two physical therapy approaches for people with painful heel spurs. 38 adults received either myofascial release alone or myofascial release plus taping over several weeks. The goal was to see which method better reduces pain and improves foot function. Results …

This study tested whether applying antibiotics directly into the tooth socket after wisdom tooth removal works as well as taking antibiotic pills. 90 adults having their lower wisdom teeth taken out were split into two groups: one got antibiotic gel at the surgery site, the other…

This study tested a 3-month treatment with a combination of vitamin D, green tea extract (EGCG), vitamin B6, and D-Chiro-inositol in 108 women with uterine fibroids who were planning surgery. The goal was to see if the supplement could ease symptoms and possibly help some women a…

This study tested whether a personalized home respiratory rehabilitation program is feasible for people with systemic sclerosis (scleroderma) who have early lung disease. Fifteen participants completed a 3-month program with one supervised session followed by home exercises. The …

This early-phase study tested whether a drug used for lymphoma, brentuximab vedotin, is safe for people with a severe form of scleroderma (diffuse cutaneous systemic sclerosis). The drug targets overactive immune cells that may drive the disease. Only 17 people took part, and the…

This study tested whether surgery (radiofrequency microtenotomy) or non-surgical treatment (strength training) works better for chronic plantar fasciitis—a common cause of heel pain. 70 adults with heel pain lasting over 7 months took part. The main goal was to see which approach…

This study tested a smartphone app called RENEW designed to help people with scleroderma manage fatigue and build resilience. Over 12 weeks, 43 participants used the app to set and track weekly healthy goals. The main goal was to see if people would actually use the app and compl…

This study tested a device called AVELI to safely reduce cellulite and fibrous tissue in 130 people undergoing body contouring surgery. Researchers measured safety, patient satisfaction, and appearance improvements over 9 months. The goal was to see if adding AVELI to standard li…

This study tested whether memantine, a drug used for Alzheimer's, can help with thinking and memory problems in people with lupus. About 111 adults with lupus and cognitive issues took either memantine or a placebo for 14 weeks. The goal was to see if the drug safely improves bra…

This study tested whether a program called PRISM (Promoting Resilience in Stress Management) could help young adults aged 18-39 who have cancer or desmoid tumors manage anxiety and depression. The program teaches skills like stress management, goal setting, and positive thinking.…

This study tested whether a food formula containing medium-chain triglycerides (MCTs) and vegetable fibers could improve quality of life in 72 adults with psoriatic arthritis and low disease activity. Participants took the formula for 3 months while continuing their usual medicat…

This study compared two types of minimally invasive hysterectomy: vNOTES (done through the vagina) and conventional laparoscopic hysterectomy (done through small belly cuts). About 90 women having hysterectomy for non-cancer reasons took part. The goal was to see which method cau…

This study tested whether a simple walking program using a pedometer could help reduce fatigue and improve quality of life in people with lupus. 101 participants were randomly assigned to either a walking group with personalized step goals or a wait-list control group. The progra…

This study tested a mobile app designed to help people with rheumatoid arthritis manage their condition. 90 adults with stable treatment used the app for 12 weeks, while a control group received usual care. Researchers measured changes in disease activity and quality of life to s…

This study tested a pulsed dye laser to reduce red veins (telangiectasias) on the face and neck in 21 people with scleroderma. Participants received four laser sessions, and the researchers checked how many veins disappeared, how patients felt about the results, and any side effe…

This small pilot study looked at whether acupuncture given twice before surgery could help stabilize blood pressure in women having their uterus removed (total laparoscopic hysterectomy) for fibroids. Thirty-five adult patients received acupuncture before the operation, and resea…

This study tested two hands-on treatments for chronic plantar fasciitis, a common cause of heel pain. Fifty-six adults received either instrument-assisted soft tissue mobilization or foam rolling, plus exercises. The goal was to see which approach better reduces pain, improves an…

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This study looked at 53 patients with cancer that spread to the upper arm bone, causing pain and limited movement. Researchers compared older and younger patients who had shoulder replacement surgery to see if age affected recovery. The goal was to find out if this surgery is saf…

This study tested whether a personalized rehabilitation program could improve quality of life for people with systemic sclerosis, a disease that causes skin and joint stiffness. 220 adults with the condition were randomly assigned to either the rehab program or usual care. The pr…

This study tested whether eye drops made from a patient's own blood (autologous serum) can relieve severe dry eye better than standard artificial tears. 46 adults with severe dry eye tried both diluted (20%) and full-strength (100%) serum drops, as well as artificial tears. The m…

This study tested whether two structured telemedicine visits, added between regular doctor appointments, could help people with psoriatic arthritis improve their quality of life and reduce disease impact. 101 adults with active symptoms took part. The visits focused on lifestyle …

This study tested a program called OPERAS that includes a web app for tracking symptoms and a physiotherapist who gives activity advice using a Fitbit. The goal was to see if it helps people with rheumatoid arthritis feel more confident managing their disease. 132 adults with rhe…

This study tested whether an herbal supplement could reduce fatigue in people with lupus. 59 adults with lupus and significant tiredness took either the supplement or a placebo for 8 weeks. The main goal was to see if fatigue and disease activity improved. The results may offer a…

This study tested a personalized exercise program for 28 children and young adults with Marfan syndrome, a rare genetic condition affecting the heart, eyes, and bones. The program aimed to improve endurance, muscle strength, and quality of life. Researchers measured changes in fi…

This study tested whether a nerve block (stellate ganglion block) combined with standard anesthesia could help women with uterine fibroids sleep better and feel less anxious after laparoscopic surgery. 233 women aged 35-55 took part. Results aim to show if this approach reduces s…

This study tested whether secukinumab, an anti-inflammatory drug, can reduce pain and improve function in adults with moderate to severe rotator cuff tendinopathy (shoulder tendon pain) that didn't get better with standard treatments. 62 participants received either the drug or a…

This study looked at whether providing free blood transfusions to blood cancer patients would encourage them to enroll in hospice care earlier. Many patients delay hospice because they need transfusions for symptom relief, but hospices often cannot afford to provide them. The stu…

This study tested whether amitriptyline, a drug already used for depression and some chronic pain conditions, can relieve symptoms of painful bladder syndrome (PBS) in people newly diagnosed with the condition. PBS causes frequent urination and increasing pain as the bladder fill…

This study tested a gel called Cystistat (sodium hyaluronate) placed directly into the bladder to treat women with interstitial cystitis, a condition causing long-term bladder pain. Researchers tracked 74 women to see if the gel improved their symptoms and was safe. The goal was …

This pilot study tested whether gentle yoga and breathing exercises are feasible for people with scleroderma, a condition that can limit movement. Thirty participants learned chair-based yoga and breathing techniques, then practiced twice daily at home for 10 weeks. Researchers m…

This study tested whether giving an anti-inflammatory steroid directly into the uterine arteries during a non-surgical fibroid treatment can lessen pain, nausea, vomiting, and tiredness afterward. Forty-two women with symptomatic fibroids took part. The goal was to see if this si…

This study tested whether injecting the numbing drug ropivacaine into the belly and around a nerve cluster before surgery can lower pain after laparoscopic fibroid removal. 207 women having fibroid surgery were randomly assigned to get either ropivacaine or a placebo. The main go…

This study tested two ways of using high-intensity laser therapy to relieve pain from plantar fasciitis, a common cause of heel pain. 24 adults with the condition received either a static (pointed) or scanning (sweeping) laser application. Researchers measured pain levels and fas…

This completed Phase 3 trial tested whether a fentanyl spray (Pecfent) could prevent pain when moving patients with bone metastases during radiotherapy. 39 adults with cancer that spread to bone and who had pain during positioning for radiation took part. The study compared fenta…

This study tested a 6-week stress management program for 30 African American adults with lupus. Half took part in group sessions while the other half received usual care. Researchers measured stress levels, saliva stress hormones, and quality of life to see if the program helped.

This study looked at adding tramadol, nefopam, or opioids to standard painkillers (paracetamol and ketoprofene) for adults recovering from shoulder surgery. 92 patients were enrolled, and their recovery quality was measured using a survey. The goal was to find the best oral pain …

This study tested whether a 6-week self-management workshop, called the Chronic Disease Self-Management Program, could improve health and reduce healthcare use in African American women with lupus. Nearly 700 women from the GOAL study took part. The program covers topics like dea…

This study tested two local anesthesia methods for hand, wrist, or elbow surgery. One used lidocaine alone, the other added ropivacaine for longer pain relief. 91 adults participated. Researchers measured pain and recovery quality 48 hours after surgery to see if the combination …

This study tested whether a 9-week personalized physical training program using an exercise bike could help people with ankylosing spondylitis, a type of arthritis that affects the spine. Fifty-six patients participated, and researchers measured how many achieved a meaningful imp…

This study tested two oral medications, aprepitant and hydroxyzine, to see which better reduces severe itching triggered by water contact in people with myeloproliferative neoplasms (a type of blood cancer). 63 participants who had persistent itching rated 5 or higher on a 10-poi…

This pilot study tested whether taking a combination of EGCG (from green tea), vitamin D, and D-chiro-inositol for three months before hysteroscopic myomectomy improves surgical outcomes. 90 women with uterine fibroids were divided into two groups: one received the supplements be…

This study tested a new device called Spinery® that uses radio-frequency energy to treat painful tumors that have spread to the spine or nearby bones. 52 adults who could not have or did not benefit from standard treatments received the procedure. The goal was to see if the devic…

This completed trial tested whether kinesiologic taping (a special elastic tape) applied to the knee can reduce pain, improve mobility, and lessen fear of movement in people with rheumatoid arthritis. Thirty adults aged 45 to 60 were randomly assigned to receive either real kines…

This study tested whether a procedure called percutaneous needle electrolysis can help people with posterior tibial tendinopathy, a common cause of foot pain. 46 adults with pain for at least 3 months were split into two groups to compare the treatment against a control. Research…

This study tested a web-based program to help children aged 8-17 with cancer adjust to returning to school. The program included modules for children, parents, teachers, and peers, focusing on communication, coping, and social skills. Twenty children participated, and researchers…

This pilot study tested a procedure that combines a needle tenotomy (breaking up scar tissue with a needle) with an injection of platelet-rich plasma (PRP) for people with chronic plantar fasciitis that didn't improve with standard treatments like physical therapy or steroid shot…

This study looked at whether early, regular visits from a palliative care team can improve quality of life for adults with acute leukemia that has returned. 49 patients were assigned to either receive this extra support or standard care. The team addressed physical, emotional, an…

Researchers are studying whether certain immune substances in the blood are linked to physical and mental abilities in people with relapsing-remitting multiple sclerosis. The study includes 20 adults aged 19 to 45 with mild disability. Participants give blood samples, and researc…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This study investigated whether environmental exposures during military service increase the risk of developing myositis, a rare autoimmune disease that attacks muscles. Researchers compared 37 military personnel with and without myositis using questionnaires and blood samples. N…

Researchers at Giresun University are studying whether a blood protein called calprotectin changes in people with axial spondyloarthritis who complete a four-week pulmonary rehabilitation program. Thirty patients aged 25 to 65 will take part. The team will measure calprotectin al…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

Researchers are studying whether the lining of the small intestine shows signs of inflammation in people with Familial Mediterranean Fever (FMF), a genetic condition that causes recurring fevers and pain. The study compares intestinal biopsy samples from about 30 adults with FMF …

This study collects tissue and blood samples from 300 people with autoimmune diseases like Crohn's, multiple sclerosis, and celiac disease. Researchers aim to identify the specific targets of immune cells (T cells) that cause inflammation. The goal is to discover new targets for …

Researchers are studying natural killer (NK) cells in people who receive stem cell transplants for leukemia. The study follows 92 patients and their donors, looking at genes called KIR and HLA that control how NK cells work. By tracking NK cells during immune recovery, researcher…

Researchers want to learn what causes myeloproliferative neoplasms, a group of rare blood cancers. They are testing whether small incentives like pens, trolley tokens, or a £10 reimbursement encourage more people to join a case-control study. The trial includes about 100 patients…

This registry study follows 400 patients with a specific type of leukemia (non-high-risk APL) who are 70 or younger. It compares two standard treatments: ATRA plus chemotherapy versus ATRA plus arsenic trioxide. The goal is to see which approach leads to better long-term outcomes…

This study aims to find the best way to share research results with people who have scleroderma, a rare autoimmune disease. About 128 participants will be randomly assigned to receive either an infographic or a plain-language summary of a study. They will then rate how complete, …

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study checks whether the Four Square Step Test (FSST) is a good way to measure balance in people with rheumatoid arthritis. Researchers will test 50 adults aged 18-65 with RA, comparing FSST results to other measures like disease activity, pain, and muscle strength. The goal…

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study tests a program called HOP-STEP that helps doctors talk about pregnancy planning with women who have lupus. The goal is to make sure doctors document contraception use and pregnancy intentions during visits. The study involves 14 participants and is being tested at two…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This trial investigates whether combining group and individual educational sessions helps patients with chronic inflammatory rheumatism (like rheumatoid arthritis or spondyloarthritis) learn safety skills better than individual sessions alone. Participants are starting their firs…

This study aims to understand how inflammation and the dominance of mutant blood cells drive VEXAS syndrome, a rare and severe autoinflammatory disease. Researchers will analyze blood and bone marrow samples from VEXAS patients and healthy controls to identify key mechanisms and …

This study tests whether a smartphone-based digital assessment can measure rheumatoid arthritis activity as well as a standard doctor-performed exam. Adults with rheumatoid arthritis will complete a digital questionnaire, record guided videos of their joint movements, and then ha…

This completed study looked at 621 people with moderate to severe systemic lupus erythematosus (SLE) in Russia. Researchers collected information about their disease activity and background to better understand the condition. The study did not test any new treatment, but aimed to…

This study tests three different force levels (2 kg, 5 kg, and 11 kg) of the 'crossed hands' myofascial release technique on healthy adults. The goal is to see how each force affects muscle stiffness, thickness, pain sensitivity, and lower back and hip mobility. By finding the mo…

This completed study examined 22 adolescents with idiopathic scoliosis to see if joint hypermobility (flexibility) and foot posture are linked to the severity of their spinal curve. Researchers measured hypermobility with the Beighton Score, foot posture with the Foot Posture Ind…

This completed study enrolled 6 adults with systemic lupus erythematosus (SLE) to collect blood, urine, saliva, stool, and tissue samples over time. The goal was to find biological markers that could predict when a patient's disease might flare up or how they might respond to tre…

This early-phase trial tested whether adding atovaquone (a drug usually used to prevent pneumonia) to standard chemotherapy is safe and reaches effective levels in the blood. It involved 26 children and young adults (ages 1 month to 21 years) newly diagnosed with acute myeloid le…

This study follows people newly diagnosed with psoriatic arthritis (PsA) to see how a 'treat to target' approach works in everyday clinics. Participants receive standard care, often starting with methotrexate, and their disease activity is tracked over time. The goal is to unders…

This study looked at a type of immune cell called B regulatory cells in 100 people—some healthy and some with rheumatoid arthritis (RA). The goal was to understand how these cells differ between the two groups and how they might help control the disease. By identifying unique fea…

This completed study from France examined whether a specific type of immune cell (innate CD8+ T cells) is linked to how quickly resistance mutations develop in patients with chronic myeloid leukemia or Philadelphia-positive acute lymphoblastic leukemia. Researchers analyzed blood…

This study looked at three ways to help people with rheumatoid arthritis take their methotrexate medication as prescribed: usual doctor visits, text message reminders, or a chat with a pharmacist. The goal was to see which method works best to improve adherence. The study include…

This study looks at whether people with chronic inflammatory rheumatism (like spondyloarthritis) or lupus who still have pain despite treatment have low vitamin C levels. Researchers will measure vitamin C in the blood and ask about pain, fatigue, and quality of life. The goal is…

This completed study looked at 340 people to understand how certain proteins in the lungs, called autoantibodies, might be linked to the start of rheumatoid arthritis (RA). Researchers collected sputum (mucus from the lungs) from people at risk for RA, those already diagnosed, an…

This study tested whether a new version of the arthritis drug abatacept (called KSHB002) works similarly to the approved drug Orencia. Three hundred healthy adults received a single injection of either the new drug or Orencia. Researchers measured drug levels in the blood, checke…

This study tested whether wearable motion sensors can accurately measure spinal movement in people with ankylosing spondylitis (AS), a condition that causes back pain and stiffness. Forty participants (20 with AS and 20 healthy volunteers) wore sensors while performing everyday m…

This study followed 150 adults with systemic sclerosis (scleroderma) for two years to track their nutritional health. Researchers measured weight, diet, and disease severity every six months. If malnutrition was found, patients received dietary advice or supplements. The goal was…

This study followed 163 people with chronic inflammatory rheumatism (like rheumatoid arthritis) who had a recent COVID-19 infection. Researchers measured their antibody levels over two years to see how immunosuppressive drugs affect antibody persistence. The goal was to better un…

This study looked at whether healthcare professionals in Saudi Arabia are aware of and follow safety measures for the drug leflunomide, used for rheumatoid and psoriatic arthritis. Researchers surveyed 302 doctors and pharmacists to see if they received and read safety materials,…

This study enrolled 200 adults with lung adenocarcinoma that has spread to the bones. Researchers took bone biopsies, scans, and blood tests to measure bone and metabolic markers. The goal is to see if these markers are linked to how long patients live. This is an observational s…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study tested whether giving general practitioners a simple, evidence-based guideline improves care for people with shoulder pain. 160 adults with shoulder pain took part in Norwegian GP clinics. Researchers measured pain, disability, and quality of life to see if the guideli…

This study used a special MRI technique to create detailed maps of the Achilles tendon in 121 adults. Researchers compared healthy volunteers to people with a type of arthritis called spondyloarthropathy, both with and without tendon pain. The goal was to better understand tendon…

This study looked at whether measuring the stiffness of uterine fibroids can help predict how well they respond to a non-invasive treatment called MR-HIFU. Forty women with symptomatic fibroids were enrolled. The goal was to improve patient selection so that only those likely to …

This study examined spinal fluid from 32 children with tethered spinal cord to see if inflammation plays a role in the condition. Researchers collected fluid samples during surgery and looked for markers of inflammation. The goal was to better understand how the spinal cord gets …

This study looked at 29 people who had ACL surgery using their own hamstring tendons. Researchers used a special ultrasound to check how stretchy the healed tendons were and compared them to the healthy leg. They also tested leg muscle strength to see if tendon quality affects re…

This study aimed to find blood markers that can predict whether the drug adalimumab will successfully treat ankylosing spondylitis after 6 months. Researchers analyzed blood samples from 50 adults starting adalimumab for the first time. The goal was to create an algorithm to help…

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This study looked at tiny particles called microparticles in the blood and urine of people with lupus or scleroderma. Researchers wanted to see if these particles could help explain how these diseases work and possibly lead to better diagnosis or treatment. Over 200 adults partic…

This study looks at how radiation therapy for brain tumors like meningioma or pituitary adenoma might affect autobiographical memory—the memories of your life events. Researchers will ask 17 patients to complete memory tests one and two years after treatment. The goal is to see i…

This small pilot study looked at whether clopidogrel, a drug that stops blood clots, could lower a substance called sCD40L in people with lupus. Lupus is an autoimmune disease where the body attacks itself. The study involved 18 adults with lupus and measured sCD40L levels in the…

This study looked at 40 women with symptomatic uterine fibroids to understand why MR-guided focused ultrasound (HIFU) works better for some than others. Researchers used MRI and contrast-enhanced ultrasound to measure fibroid blood flow, stiffness, and other features before treat…

This study looked at how blood vessel cells and immune cells talk to each other in people with systemic sclerosis, a rare autoimmune disease that causes skin hardening and organ damage. Researchers collected blood samples and skin biopsies from 350 participants to measure a speci…

This study measured phytoestrogens (plant-based compounds) in the blood and urine of 63 premenopausal women with active lupus, other autoimmune diseases, or no disease. Researchers also asked about diet and measured estradiol levels. The goal was to see if these dietary compounds…

This study looked at 202 adults with cutaneous lupus to see how well they follow their treatment plans and how satisfied they are with their care. Researchers used questionnaires to measure adherence, beliefs about medicine, anxiety, depression, and quality of life. The goal is t…

This study looked at whether measuring drug levels and anti-drug antibodies in the blood of rheumatoid arthritis patients can help doctors make better treatment decisions. 52 patients starting adalimumab or certolizumab were randomly assigned to have their test results shared wit…

This study looked at DNA methylation patterns in stored samples from 90 patients with rare skeletal disorders, sarcomas, or inflammatory arthritis. The goal was to better understand these patterns and explore their potential for diagnosis and treatment. The research aimed to impr…

This study looked at blood samples from 24 people with axial spondyloarthritis (a type of inflammatory arthritis) and 12 healthy volunteers to understand how a receptor called KIR3DL2 contributes to inflammation. Researchers also tested whether a drug called IPH4102 could reduce …

This study looked at how skin changes from systemic sclerosis affect a person's feelings about their appearance. Researchers compared 170 patients with the disease to healthy people using surveys about body image and emotional distress. The goal was to understand the burden of th…

This completed study used artificial intelligence to examine electronic health records from 10,000 head and neck cancer patients. The goal was to create models that can predict the risk of cancer coming back or progressing, and to identify which patients might live longer after i…

This early-stage study tested the safety and tolerability of a new drug called RAB001 in 16 healthy adults. Researchers gave single and multiple injections at two dose levels to see how the body handles the drug and if it causes side effects. This is a first step before testing t…

This study collected blood, bone marrow, skin, and cheek cell samples from 650 adults with acute leukemia, myelodysplastic syndromes, or myeloproliferative disorders. Researchers analyzed the samples to find genetic, epigenetic, and drug sensitivity patterns that might predict ho…

This completed study looked at how tofacitinib, a rheumatoid arthritis drug, changes body fat, muscle, and bone density in 10 patients. Researchers measured visceral fat, lean mass, and bone marrow fat before and after treatment. The goal was to gather early data, not to prove th…

This study tested whether a smartphone app and a wearable activity tracker are practical and acceptable for people with inflammatory rheumatic diseases like rheumatoid arthritis and spondyloarthritis. Over 14 days, 50 participants answered short surveys on their phone and wore a …

This study looked at bone tissue from 34 men who had hip replacement surgery due to femoral head necrosis (bone death in the hip joint). Researchers used advanced imaging and spectroscopy to identify changes in bone structure and composition. The goal was to better understand wha…

This pilot study tested a communication tool called UR-GOAL in 15 older adults (age 60+) with newly diagnosed acute myeloid leukemia (AML), along with their caregivers and doctors. The tool helps patients share their preferences and goals, so treatment decisions better match what…

This study looked at whether regular nurse check-ins could spot the return of rheumatoid arthritis symptoms sooner than standard doctor visits. 51 adults with controlled arthritis on rituximab took part. The goal was to see if nurses could detect early signs of a flare, potential…

This study tested whether holding a newborn skin-to-skin right after a C-section (within 5 minutes) or within the first hour helps with breastfeeding, reduces anxiety, and keeps mom and baby healthy. 92 mothers and their newborns took part. The results showed that early contact c…

This study tests whether measuring two substances in the blood—FLT3L and IL-6—during chemotherapy can help predict survival in people with acute myeloid leukemia (AML). Researchers will track 201 newly diagnosed AML patients across 25 French hospitals. The goal is to confirm that…

This study looked at how often people with active lupus take their medication as prescribed. Researchers measured blood levels of hydroxychloroquine in 307 patients to find out who was skipping doses. The goal was to understand how common non-adherence is, especially in those wit…

This study looked back at 46 women who had a procedure called uterine artery embolization to treat fibroids. The goal was to see how often women later had a baby and what pregnancy complications occurred. The researchers reviewed medical records from one hospital in France to gat…

This study followed 100 adults with a rare, non-cancerous tumor called peripheral primitive fibromatosis. Instead of treating everyone right away, doctors monitored patients closely to see how the tumors behaved over three years. The goal was to learn which factors might predict …

This study followed 80 people with newly diagnosed Cushing's disease for three years to see how the disease affects the heart, bones, metabolism, and quality of life. Researchers used blood tests, heart scans, bone density tests, and questionnaires to track complications before a…

This study tested whether a telehealth program could help older patients (60+) with acute myeloid leukemia or myelodysplastic syndrome discuss and document their future medical wishes. Researchers enrolled 36 patients, caregivers, and clinicians to see if the program was easy to …

This study looked at 30 adults with scleroderma, an autoimmune disease that often causes hand stiffness and disability. Researchers measured how much movement was limited in each hand to compare the dominant and non-dominant sides. The goal was to better understand hand function …

This completed study surveyed 121 adults with autoimmune diseases like lupus, Sjögren's syndrome, or scleroderma. Participants filled out a questionnaire about their use of alternative medicines. The goal was to find out how common these practices are in this patient group.

This study aimed to create a standard set of items, called an ICF core set, to describe the health and functioning of people with systemic sclerosis (scleroderma). Researchers gathered input from 100 patients and experts to identify the most important aspects of the disease. The …

This study tested whether a type of eye scan called OCT-angiography can predict how well vision will recover after surgery to remove a pituitary tumor. Researchers compared the scan results with standard vision tests in 21 patients. The goal was to see if the scan could serve as …

This 5-year study tracked over 3,000 adults with active lupus to see how safe and effective Benlysta (belimumab) is compared to standard care alone. Researchers monitored serious infections, cancers, and other side effects. The goal was to gather real-world data to help doctors a…

This pilot study tested whether a transition coach can help 16-17 year olds with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease move from pediatric to adult care. The coach met with each teen for 8 one-hour sessions covering self-advocacy, medication management, and …

This study looked at 28 women with breast cancer that spread to their bones. Researchers compared two types of scans—PET-CT and whole-body MRI—to see if they agree on whether the bone tumors are stable, improving, or getting worse. The goal is to find a reliable way to monitor tr…

This study followed 356 adults with lupus over time to see how the disease impacts their quality of life. Participants filled out questionnaires about their symptoms, fatigue, mood, and daily activities. The goal was to better understand what factors affect well-being in lupus, w…

This study compared 243 people with and without Dupuytren disease to see if having the palmaris longus tendon (a small hand tendon not everyone has) is linked to the condition. Researchers used simple hand tests and ultrasound to check for the tendon. The goal is to understand if…

This study aims to find biological markers that can predict whether the drug trabectedin will work in patients with certain types of soft-tissue sarcoma. Researchers will collect tumor biopsies and blood samples from 29 participants before and during treatment. The goal is to use…

This study tested a personalized way to reduce steroid doses in 72 lupus patients. Doctors used blood tests and regular check-ups over 3 months to safely lower prednisone. The goal was to find the best tapering schedule for each person, minimizing side effects while controlling t…

This completed study tested whether training rheumatology clinicians in shared decision making helps veterans with rheumatoid arthritis. About 900 patients from VA clinics took part. The training taught doctors to acknowledge treatment options and involve patients in choices. Res…

This study looked at how heart surgery impacts the mental health, well-being, and quality of life of adults with Marfan Syndrome. Researchers asked 28 patients to fill out questionnaires about depression, fatigue, pain, and self-esteem before surgery and at several points after. …

This study aimed to create and test a decision aid for people with psoriasis or psoriatic arthritis who are starting or switching treatments. Researchers worked with 37 patients and their doctors to design a tool that supports shared decision-making. The goal was to help patients…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This completed study collected real-world data from 112 adults in France with acute myeloid leukemia (AML) who were in remission and taking oral azacitidine as maintenance therapy. The goal was to describe patient characteristics, treatment patterns, and outcomes like relapse and…

This study tested whether coaching sessions are practical for young people with rheumatic diseases moving from pediatric to adult care. 26 participants received up to 8 coaching sessions covering self-advocacy, medication management, and future planning. The main goal was to see …

This completed study enrolled over 2,100 people with or suspected of having myelodysplastic syndromes (MDS), a group of blood disorders. Researchers collected medical data, blood, and tissue samples over time to track how the disease develops and progresses. The goal was to creat…

This study looked at how small molecules called microRNAs change during pregnancy in women with rheumatoid arthritis or lupus. Researchers collected blood and urine samples before and after pregnancy from 50 women to see if these changes relate to disease activity. The goal is to…

This study followed 100 people who had surgery to remove bone or soft tissue tumors in their leg or pelvis. Researchers measured how independent they became in daily activities and how well their joints moved during the first six months after surgery. The goal was simply to descr…

This completed study tracked 132 children with obstructive sleep apnea who had their tonsils removed. Researchers recorded how many had breathing problems after surgery, especially those with other health issues. The goal was to create a simple flowchart to help doctors decide wh…

This study looked at how the drug methotrexate and its main byproduct leave the body in people with rheumatoid arthritis. Researchers measured levels in urine to create a reference range. This could help doctors identify patients who are not taking their medication as prescribed.

This study looked at whether a specific antibody, called anti-GBM, could be a useful marker for lupus nephritis—a serious kidney complication of lupus. Researchers tested stored blood samples from 100 people with lupus (some with kidney issues, some without) and compared them to …

This study looked at how reducing inflammation might lower heart disease risk in people with rheumatoid arthritis. Researchers measured heart blood flow in 74 patients before and after treatment with certolizumab, a drug that fights inflammation. The goal was to see if better con…

This study measured two newer blood markers (calprotectin and serum amyloid protein) alongside standard tests in 20 children with juvenile arthritis and related conditions. The goal was to see if these markers could better track disease flare-ups in everyday clinic visits. The st…

This study looked at fatigue in 33 adults with psoriatic arthritis or psoriasis. Researchers used questionnaires to measure tiredness and see how it relates to disease severity and treatments. The goal was to better understand fatigue and its impact on quality of life.

This study looked at 43 adults with scleroderma or unexplained pulmonary arterial hypertension (PAH) to understand why the right side of the heart weakens. Researchers collected blood and tissue samples during routine procedures and measured heart function over 6 months. The goal…

This study looked at 1,753 patients needing a stem cell transplant for blood cancers or other serious blood disorders. Researchers compared two strategies: first searching for a matched unrelated donor, then trying an alternative donor if needed, versus going straight to an alter…

This study looked at how faithfully people with lupus take their hydroxychloroquine (Plaquenil). Researchers used a simple questionnaire to measure compliance in 102 patients. The goal was to find which questions best identify those who skip doses, so doctors can catch problems e…

This study used a very powerful 7 Tesla MRI to look at the hands of 50 people with systemic sclerosis (scleroderma), a rare autoimmune disease. The goal was to see bone, joint, and blood vessel problems in detail. Researchers hope this will help them understand how the disease af…

This completed study surveyed 229 people with chronic inflammatory rheumatism (like rheumatoid arthritis) and their doctors to find out what makes it hard to follow care recommendations after a hospital visit. The goal was to identify barriers to good outpatient management. No tr…

This study looked at 69 adults with rheumatoid arthritis who were taking the drug adalimumab (Humira). Researchers measured drug levels in the blood over 6 months to see if they could predict who would respond well to treatment. The goal was to find a way to adjust doses early, i…

This pilot study looked at ovarian tissue from 9 young women with acute myeloid leukemia who had it frozen to preserve fertility before a stem cell transplant. Researchers checked the frozen tissue for any leftover leukemia cells. The goal was to see if the tissue might be safe t…

This study looked at whether people with systemic sclerosis (scleroderma) have higher levels of the hormone prolactin in their blood. Researchers measured prolactin in 71 patients and compared them to healthy volunteers. The goal was to understand if prolactin plays a role in the…

This study collected information from 2,200 people with sarcoidosis around the world using online surveys. The goal was to learn more about how the disease affects different people, not just those seen at major medical centers. Participants also had the option to provide a DNA sa…

This study looked at how B cells, a type of immune cell, may contribute to scarring in people with systemic sclerosis (scleroderma). Researchers compared skin and blood samples from 71 participants, including patients and healthy volunteers. The goal was to understand the disease…

This completed study examined whether eosinophils, a type of white blood cell, contribute to fibrosis (scarring) in systemic sclerosis, an autoimmune disease. Researchers compared blood samples from 40 patients with systemic sclerosis and 30 healthy volunteers, with optional skin…

This study followed 56 adults with systemic sclerosis (scleroderma) who also had a serious lung complication called diffuse infiltrating pneumonia. Researchers measured lung function at 12 and 24 months to see how it changed and to identify factors that might predict faster decli…

This study looked at genetic and immune system differences in children with lupus, a chronic autoimmune disease. Researchers collected blood samples from 271 participants to search for mutations in known lupus genes and discover new ones. The goal is to better understand what cau…

This study tested whether a special laser technique called Raman spectroscopy can measure skin fibrosis (hardening) in people with systemic sclerosis, a rare autoimmune disease. Twenty-six adults with the condition had their skin scanned with the laser. The goal was to see if thi…

This pilot study looked at 20 adults with acute myeloid leukemia (AML) who were not healthy enough for strong chemotherapy. They received a standard combination of azacitidine and venetoclax. Researchers measured venetoclax levels in the blood at several time points to see if tho…

This completed study looked at data from 1,000 lupus patients and gathered expert opinions to find where diagnosis and treatment fall short. Researchers reviewed existing information, discussed with doctors, and built consensus on unmet needs. The goal is to publish findings that…

This study looked at how children with Noonan syndrome process energy and sugar. Researchers measured insulin sensitivity in 20 children with the condition to see if they have unique metabolic traits. The goal was to better understand the disease, not to test a new treatment.

This study looked at 183 women with menstrual pain to understand why it happens and how naproxen (a common painkiller) relieves it. Using MRI scans, researchers measured uterine activity, blood flow, and oxygen levels before and after taking naproxen or a placebo. The goal is to …

This study looked back at the medical records of 545 patients with bone tumors that had spread (metastatic). The goal was to see how these patients were treated in real life and what their outcomes were. The study focused on three types of bone tumors: osteosarcoma, Ewing sarcoma…

This completed study looked at the safety of the arthritis drug abatacept in over 38,000 people with rheumatoid or psoriatic arthritis in Denmark. Researchers used a national health registry to track rates of cancers and other side effects. The goal was to better understand the d…

This completed study involved 214 people with systemic sclerosis (scleroderma) to find out how often calcium deposits form in the hands and feet. Researchers used X-rays to detect these deposits and checked if they were linked to damage in organs like the lungs or heart. The goal…

This study tested whether PET scans can detect early response to chemotherapy in people with retroperitoneal sarcoma, a rare cancer in the abdomen. 18 participants received extra PET scans before and after their first chemo cycle. The goal was to see if PET could predict tumor sh…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This completed study reviewed the medical charts of 32 people with Still's disease who developed a serious complication called macrophage activation syndrome (MAS). The goal was to learn more about their symptoms, how long it took for lab values to return to normal, and what trea…

This study created a registry and biobank for people with osteosarcoma, a rare bone cancer, and their family members. Researchers collected genetic samples from 362 participants to compare genes of those with and without the disease. The goal is to better understand what causes o…

This study looked at whether people who have been cured of Cushing's disease for at least a year still have memory problems. Researchers used a special virtual reality test to check memory, along with standard tests. The goal was to better understand these lasting effects and imp…

This completed study followed 127 adults with moderate to severe plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, or non-radiographic axial spondyloarthritis who were already taking or starting secukinumab. Researchers observed them for two years to see how long the…

This study looked at the gut bacteria of 55 people—some newly diagnosed with rheumatoid arthritis and some without the disease. Researchers wanted to see if certain bacteria are more common in arthritis patients. The goal is to better understand how gut health might be linked to …

This completed study looked at 126 children with juvenile idiopathic arthritis to find the best dose of the drug etanercept. Researchers measured drug levels in the blood and checked how well the disease was controlled. The goal is to help doctors give each child the right amount…

This study followed 133 people with PPNAD (a rare adrenal gland disorder) or Carney Complex (a related genetic condition) for three years. The goal was to better understand the symptoms and genetic causes of these diseases, not to test a new treatment. Participants had yearly che…

This study looked at 192 people aged 50-85 with knee arthritis who needed knee replacement surgery. Half had computer-navigated surgery and half had the traditional technique. The goal was to see if computer guidance helps the new knee last longer, improves function, or reduces c…

This study looked at whether the seasonal flu vaccine works as well in people with sarcoidosis as it does in healthy people. Researchers gave the flu shot to 190 adults with sarcoidosis and compared their immune response to a group of healthy volunteers. The goal was to see if th…

This study tested whether artificial intelligence (AI) can help doctors diagnose a rare blood cancer called acute promyelocytic leukemia (APL) more quickly and accurately. Ten doctors reviewed bone marrow samples with and without AI assistance. The goal was to see if AI improves …

This study looked at 126 people aged 60 and older who had a bone marrow transplant for blood cancers like leukemia or lymphoma. Researchers measured physical abilities, mental health, and stress levels before and after transplant to find traits that help people recover better. Th…

This study tested a computerized decision-aid called SMILE that gives lupus patients information about their disease and treatment options. Nearly 1,900 adults with lupus from multiple clinics used the tool during their visits. The main goal was to see how many eligible patients …

This study involved 39 adults and children with autoinflammatory diseases like FMF and Still's disease. Researchers conducted interviews to understand how these conditions affect quality of life. The goal was to create a tool that doctors can use to better assess and address pati…

This study looked at specific cells in the blood of 40 women with either Sjögren's syndrome or systemic sclerosis. The goal was to see if counting these cells could help understand the diseases better. No treatment was given; it was purely an observational study to explore potent…

This study tested whether a questionnaire called the Rheumatoid Arthritis Impact of Disease (RAID) could help doctors make better decisions during virtual consultations. 70 patients with rheumatoid arthritis participated. The goal was to see if using this tool reduced the need fo…

This study looked at how a 12-week program of high-intensity interval training (HIIT) affects fitness and fatigue in 55 people with lupus. Researchers wanted to understand if certain immune system signals (interferons) change how the body adapts to exercise. Participants were ran…