Lupus patients get custom steroid tapering plan in new study
NCT ID NCT03187743
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a personalized way to reduce steroid doses in 72 lupus patients. Doctors used blood tests and regular check-ups over 3 months to safely lower prednisone. The goal was to find the best tapering schedule for each person, minimizing side effects while controlling the disease.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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72 people
The number who actually took part.
- Started
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Apr 2018
- Finished
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Apr 2022
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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6 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient aged ≥ 6 years * Patient who met the American College of Rheumatology criteria (ACR) or the Systemic Lupus International Collaborating Clinics Classification (SLICC) for systemic lupus erythematosus. * Patients needs (re)initiation of oral prednisone regimen at least at 0.5 mg/Kg/d(or \>30mg/d for patients \>60 kg) in combination with mycophenolate mofetyl or mycofenolic acid or cyclophosphamide at usual dose including : i) patient who receives bolus of methylprednisolone the week before and/or the week after inclusion for treating the lupus flare ii) patient who was previously treated by a low-prednisone dose (≤ 7.5 mg/d in patients ≥ 60 kg and ≤ 0.1 mg/kd/d in patient \< 60 kg). iii) patient who was previously treated by prednisone ≥ 0,5 mg/kg/d (or \>30mg/d for patients \>60 kg) but stopped since at least one month before inclusion * Patient with stable doses of other immunosuppressive or biological drugs before inclusion (at least 15 days for Imurel, Methotrexate, Tacrolimus ; at least 6 months for Rituximab, Belimumab) and during the 3 months of patient participation in the study. * Signed informed consent form by the patient (if aged ≥ 18 years), or by the parents / legal guardian and patient's agreement (if aged \< 18 years) * Patient affiliated to the health insurance system Exclusion Criteria: * Patient presents contraindications to corticosteroids * Patient presents contraindications to MMF, mycofenolic acid or cyclophosphamide for patient receiving immunosupressor * Patient cannot be treated by oral way * Patient whose physician has planned to stop prednisone in less than 3 months * Patient (or parents for minor) are unable to give a written informed consent for physical or psychical reasons * Patient disagrees with the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hospital Necker Enfants Malades
Paris, Paris, 75015, France
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Other studies related to the condition(s) this trial covers.
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