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Lupus Patients' exercise response under the microscope

NCT ID NCT05478018

Knowledge-focused Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at how a 12-week program of high-intensity interval training (HIIT) affects fitness and fatigue in 55 people with lupus. Researchers wanted to understand if certain immune system signals (interferons) change how the body adapts to exercise. Participants were randomly assigned to supervised exercise or usual care, and their aerobic capacity and fatigue levels were measured.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High Intensity Interval Training (HIIT) - supervised aerobic exercise
What this could lead to
If successful, this could help design better exercise programs tailored for people with lupus to improve fitness and reduce fatigue.
What could go wrong
This is a small, completed study (55 participants) that looks at biological responses, not a treatment. Results may not apply to all lupus patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

55 people

The number who actually took part.

Started

Apr 2022

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years by inclusion. * Able to provide informed consent. * Diagnosed SLE and fulfilling the classification criteria for SLE based on the American College of Rheumatology/EULAR criteria (SLICC) Exclusion Criteria: * Health conditions that prevent participating in the exercise intervention determined by the Research Coordinator these include but are not limited to * Major bone fracture at inclusion * Significant myalgias exacerbated by physical exercise * Active infectious disease such as Covid-19 * Severe symptomatic pleuritis or pericarditis * Corticosteroid use \> 10mg/day at baseline * Diagnosed with diabetes mellitus by physician * Pregnancy * SLEDAI-2k (with the SELENA modifications to Proteinuria changes so as to not exclude patients with chronic proteinuria) \> 10 * Contraindications to 82Rb-PET with adenosine stress (according to local guidelines at the Dept. of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, which are in accordance with the recommendations of the European Association of Nuclear Medicine) * Fever, myocarditis or endocarditis * Previous heart transplantation * Dysregulated atrial or ventricular tachyarrhythmias * Severe chronic obstructive pulmonary disease with a FEV1 of less than 50% of predicted * Second or third degree sinoatrial or atrioventricular block * Active bronchospasm at the time of the scan * Systolic blood pressure \<90 or \>200 mmHg at the time of the scan * Treatment with theophyllin within 7 days of the scan

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Conditions

The condition(s) this trial relates to.

systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Interferon deficiency Systemic lupus erythematosus

Contacts and locations

Locations

  • Center for Physical Activity Research

    Copenhagen, 2200, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.