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Can a depression drug ease bladder pain? new study says maybe

NCT ID NCT00124306

First seen Nov 01, 2025 · Last updated May 24, 2026 · Updated 27 times

Summary

This study tested whether amitriptyline, a drug typically used for depression, can reduce pain and frequent urination in people newly diagnosed with painful bladder syndrome. About 271 adults took part. The goal was to see if the drug improves overall symptoms after 12 weeks compared to a placebo.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Henry Ford Hospital

    Detroit, Michigan, 48202, United States

  • Loyola University Medical Center

    Maywood, Illinois, 60153, United States

  • Queen's University

    Kingston, Ontario, K7L 2Y7, Canada

  • Stanford University Medical Center

    Stanford, California, 94305, United States

  • University of Iowa Hospitals and Clinic

    Iowa City, Iowa, 52242, United States

  • University of Maryland

    Baltimore, Maryland, 21201, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Rochester Medical Center

    Rochester, New York, 14642, United States

  • University of Washington

    Seattle, Washington, 98195, United States

  • William Beaumont Hospital

    Royal Oak, Michigan, 48073, United States

Conditions

Explore the condition pages connected to this study.