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Leukemia drug holiday: study finds many can stop imatinib without relapse

NCT ID NCT01343173

First seen May 21, 2026 · Last updated Jun 19, 2026 · Updated 4 times

Summary

This study looked at 220 adults with chronic myeloid leukemia who had been in deep remission for at least two years while taking imatinib. Researchers wanted to see if stopping the drug would cause the cancer to come back. They found that many patients stayed in remission after stopping, and they identified factors that help predict who can safely stop treatment without relapse.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • C.H.U. Brabois

    Vandœuvre-lès-Nancy, 54500, France

  • CH Annecy

    Annecy, France

  • CH Bretagne Atlantique

    Vannes, France

  • CH Régional de l'ILE DE LA REUNION/ Groupe Hospitalier Sud

    Saint-Pierre, France

  • CH Sud Francilien

    Corbeil-Essonnes, France

  • CH Valence

    Valence, France

  • CH Yves Le Foll

    Saint-Brieuc, France

  • CHR La Réunion

    Saint-Denis, 97405, France

  • CHU Bensançon

    Besançon, France

  • CHU Caen

    Caen, France

  • CHU Dupuytren

    Limoges, France

  • CHU Grenoble

    Grenoble, 38043, France

  • CHU Hôtel-Dieu

    Nantes, 44035, France

  • CHU de Nice - Hôpital Archet 1

    Nice, 06202, France

  • Centre Henri Becquerel

    Rouen, France

  • Centre Hospitalier - La Roche sur Yon

    La Roche-sur-Yon, 85025, France

  • Centre Hospitalier de Nevers

    Nevers, 58033, France

  • Centre Hospitalier de Versailles - Hôpital André Mignot

    Versailles, 78157, France

  • Hôpital Edouard Herriot

    Lyon, 69374, France

  • Hôpital Henri-Mondor

    Créteil, 94000, France

  • Hôpital Morvan

    Brest, 29285, France

  • Hôpital Necker-Enfants Malades

    Paris, 75743, France

  • Hôpital Pontchaillou

    Rennes, 35033, France

  • Hôpital Purpan

    Toulouse, 31059, France

  • Hôpital Saint Louis

    Paris, 75475, France

  • Hôpitaux civils de Colmar

    Colmar, 68000, France

  • Institut Bergonié

    Bordeaux, 33076, France

  • Institut Paoli Calmette

    Marseille, 13273, France

  • Lille University hospital - Hôpital Claude Huriez

    Lille, 59037, France

  • University Hospital Angers

    Angers, 49033, France

  • University Hospital Bordeaux, Hôpital du Haut Lévêque

    Pessac, 33604, France

  • University Hospital Poitiers - Hôpital Jean Bernard

    Poitiers, 86021, France

Conditions

The condition(s) this trial relates to.

Bronchiolitis Obliterans Syndrome chronic myelogenous leukemia, BCR-ABL1 positive leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.