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Which donor search strategy saves more lives?

NCT ID NCT03904134

Knowledge-focused Sponsor: Center for International Blood and Marrow Transplant Research Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 1,753 patients needing a stem cell transplant for blood cancers or other serious blood disorders. Researchers compared two strategies: first searching for a matched unrelated donor, then trying an alternative donor if needed, versus going straight to an alternative donor. The goal was to see which approach leads to better survival within two years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,753 people

The number who actually took part.

Started

Jun 2019

Finished

Jan 2025

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients fulfilling the inclusion criteria will be eligible for enrollment in this study. Of those who consent, only patients who lack a suitable HLA-identical or 1 allele or antigen mismatched related donors are evaluable. Patients with an HLA-identical sibling or 1 allele or antigen mismatched family member donor are evaluable as long as the center deems the family member donor as unsuitable for other reasons. Patients may co-enroll with other interventional or observational studies. 1. Patients of all ages with AML, ALL, MDS, NHL, HL, AA, or SCD are eligible. 2. Any planned conditioning regimen and GVHD prophylaxis approach is eligible. 3. Patients must be considered suitable allogeneic transplant candidates at the time of enrollment based on medical history, physical examination, and available laboratory tests. Specific testing for organ function is not required for eligibility but, if available, these tests should be used by the treating physician to judge transplant suitability. 4. Patient and physician must intend to proceed with allogeneic HCT within the next 6 months if a suitable donor is identified. 5. Center plans to follow the algorithm for alternative donor identification: (a) for subjects who are Very Likely to find a MUD, attempt to identify a matched unrelated donor; (b) for a subjects who are Very Unlikely to find a MUD, proceed expeditiously to a haploidentical, cord blood or mismatched unrelated donor. 6. Signed informed consent, and assent if applicable. Consent may be signed prior to completion of family typing but patients will only be considered evaluable upon confirmation that there is no suitable HLA-identical or 1 allele or antigen mismatched related donor available. Exclusion Criteria: 1. Prior allogeneic HCT (prior autologous transplant is allowed) 2. Previous formal unrelated donor search

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Conditions

The condition(s) this trial relates to.

acquired aplastic anemia acute lymphoblastic leukemia acute myeloid leukemia Hodgkins lymphoma myelodysplastic syndrome Myelodysplastic Syndromes non-Hodgkin lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acquired aplastic anemia Acute lymphoblastic leukemia Acute myeloid leukemia Hodgkin lymphoma Myelodysplastic syndromes Non-Hodgkin lymphoma Sickle cell disease

Contacts and locations

Locations

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Children's Healthcare of Atlanta

    Atlanta, Georgia, 30322, United States

  • Children's Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Children's Hospital of Philadelphia

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Medical Center Dallas

    Dallas, Texas, 75235, United States

  • Children's Mercy Hospital

    Kansas City, Missouri, 64108, United States

  • Children's National Medical Center

    Washington D.C., District of Columbia, 20010, United States

  • City of Hope

    Duarte, California, 91010, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Cook Children's Medical Center

    Fort Worth, Texas, 76104, United States

  • Dana Farber Cancer Institute

    Boston, Massachusetts, 02215, United States

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Emory University

    Atlanta, Georgia, 30322, United States

  • Fred Hutchinson Cancer Research Center

    Seattle, Washington, 98109, United States

  • H. Lee Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Levine Cancer Institute

    Charlotte, North Carolina, 28204, United States

  • Loyola University

    Maywood, Illinois, 60153, United States

  • M.D. Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Mayo Clinic Rochester

    Rochester, Minnesota, 55905, United States

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Memorial Healthcare System

    Pembroke Pines, Florida, 33028, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Mount Sinai Medical Center

    New York, New York, 10029, United States

  • Nationwide Children's Hospital

    Columbus, Ohio, 43205, United States

  • Northside Hospital

    Atlanta, Georgia, 30342, United States

  • Oregon Health and Science University

    Portland, Oregon, 97239, United States

  • Rosewell Park Cancer Institute

    Buffalo, New York, 14263, United States

  • St. Louis Children's Hospital

    St Louis, Missouri, 63110, United States

  • Stanford Hospitals and Clinics

    Stanford, California, 94305, United States

  • The Ohio State University

    Columbus, Ohio, 43210, United States

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of California, San Diego Medical Center

    La Jolla, California, 92093, United States

  • University of Florida

    Gainesville, Florida, 32610, United States

  • University of Maryland

    Baltimore, Maryland, 21201, United States

  • University of Miami

    Miami, Florida, 33136, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55414, United States

  • University of Mississippi

    Jackson, Mississippi, 39216, United States

  • University of Nebraska Medical Center - Adults

    Omaha, Nebraska, 68105, United States

  • University of Nebraska Medical Center - Pediatrics

    Omaha, Nebraska, 68105, United States

  • University of North Carolina

    Chapel Hill, North Carolina, 27599, United States

  • University of Oklahoma

    Oklahoma City, Oklahoma, 73104, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Utah

    Salt Lake City, Utah, 84113, United States

  • University of Virginia

    Charlottesville, Virginia, 22903, United States

  • University of Wisconsin

    Madison, Wisconsin, 53792, United States

  • Virginia Commonwealth University

    Richmond, Virginia, 23298, United States

  • Wake Forest Baptist Health

    Winston-Salem, North Carolina, 27157, United States

  • Washington University in St. Louis

    St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.