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Brushing teeth during aplasia: safe or risky?

NCT ID NCT03879252

Disease control Sponsor: University Hospital, Angers Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether brushing teeth is safe for patients with prolonged aplasia (low blood cell counts) after intensive chemotherapy. Currently, many hospitals only allow mouthwash to avoid bleeding and infection. The trial compared brushing with an extra-soft toothbrush plus mouthwash versus mouthwash alone in 76 patients. The goal was to see if brushing improves oral health without increasing risks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Toothbrush and mouthwash solution
What this could lead to
If successful, this could allow patients with aplasia to brush their teeth safely, improving comfort and well-being during hospital stays.
What could go wrong
This is a small, completed Phase 3 trial with 76 participants, so results may not apply to all patients. There is still a risk of bleeding or infection from brushing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

76 people

The number who actually took part.

Started

Jul 2019

Finished

Feb 2023

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Hospitalized Patients in protected area of the Blood Disease Service with predictable prolonged aplasia and risk of mucite * Acute myeloblastic leukemia undergoing induction or consolidation treatment * Acute lymphoblastic leukemia under induction treatment * Patients affiliated or beneficiaries of a social security * Written inform consent Exclusion Criteria: * Patients with removable complete dentures * Constitutional disorder of coagulation * Hematopoietic stem cell allogreffe * Therapeutic intensification with autograft of haematopoietic stem cells * Patient unable to provide oral care alone (brushing teeth or mouthwash) * Already included in the study * Pregnant women, lactating mothers * Persons deprived of liberty by an administrative or judicial decision * Persons undergoing psychiatric care under duress * Adults who are subject to a legal or non-state protection measure to express their consent

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aplasia

Contacts and locations

Locations

  • CHU Angers

    Angers, France

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Other studies related to the condition(s) this trial covers.