Brushing teeth during aplasia: safe or risky?
NCT ID NCT03879252
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether brushing teeth is safe for patients with prolonged aplasia (low blood cell counts) after intensive chemotherapy. Currently, many hospitals only allow mouthwash to avoid bleeding and infection. The trial compared brushing with an extra-soft toothbrush plus mouthwash versus mouthwash alone in 76 patients. The goal was to see if brushing improves oral health without increasing risks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Toothbrush and mouthwash solution
What this could lead to
If successful, this could allow patients with aplasia to brush their teeth safely, improving comfort and well-being during hospital stays.
What could go wrong
This is a small, completed Phase 3 trial with 76 participants, so results may not apply to all patients. There is still a risk of bleeding or infection from brushing.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CHU Angers
Angers, France