Freezing out tumors: new hope for rare desmoid disease

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Extra-abdominal desmoid tumor (confirmed by prior biopsy) * 18 years of age or older * Tumor deemed accessible for cryoablation procedure by the operator in the investigator center * At least one measurable lesion (RECIST v1.1) using MRI (gadolinium injection mandatory) * 90 % of destruction of the tumor achievable in one procedure of cryoablation with a possible second cryoablation procedure (if a complete treatment must be achieved). * Progressive disease under standard treatment (after at least two lines of adequate medical therapy, including tamoxifen, non-steroid anti-inflamatory or chemotherapy), with presence of functional symptoms and/or pain The definition of progressing tumors also involves patients with RECIST stable disease, but with persistent functional disability or tumor-induced pain not controlled by adequate pain medication including narcotics. * Unresectable tumor or tumor amenable only to mutilating surgery, deemed inappropriate, and discussed in multidisciplinary meeting (RCP) * ECOG performance status 0-2 * Biological and hematological parameters: * neutrophils 1,5.109/L * platelet count 100.109/L * No significant hemostatic abnormalities * Subject affiliated to social security * Signed informed consent Exclusion Criteria: * Any contra-indication for the procedure as stated by the radiologist in terms of tumor size, proximity to neural/vascular structures making the procedure at unacceptable risk * Impaired hemostasis, that may interfere with the conduct of the cryoablation * Concurrent participation in other experimental studies that could affect endpoints of this study * Contraindication to any form of sedation * Contraindication to MRI or gadolinium injection (proven allergy, subject with impaired renal function (defined by a creatinine clearance below 30 ml/min by MDRD formula)) * Psychiatric disorders and adults under guardianship * Pregnancy or breastfeeding * Patients under judicial protection