ATRIAL FIBRILLATION

This study tests whether a catheter-based procedure to close a small pouch in the heart (the left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4,000 participants with a high risk of stroke wil…

This study tests whether people with atrial fibrillation (AFib) can use a smartwatch to guide when they take blood thinners, instead of taking them every day. About 5,350 adults with AFib and low-to-moderate stroke risk will either follow standard daily blood thinner use or take …

This study tests a new device called CLAAS that closes a small pouch in the heart to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 1,600 participants will be randomly assigned to get either the new device or an already-approved device. The goa…

This study compares two methods for treating atrial fibrillation (AFib) using a balloon-based ablation system. About 96 adults with AFib will be randomly assigned to have the procedure guided either by X-ray alone or with additional 3D heart mapping. The goal is to see if the ext…

This study is for people with atrial fibrillation (an irregular heartbeat) who are at high risk of stroke but cannot take blood thinners. The LambrE device is implanted to close off a small pouch in the heart where clots often form. Researchers will track 220 patients to see how …

This study is testing a new device called the Volt PFA System, which uses balloon-based energy to treat atrial fibrillation (AF), a common heart rhythm problem. Researchers will enroll 300 people with paroxysmal or persistent AF to see how safe and effective the procedure is in r…

This study looks at whether doing a heart procedure called ablation early after diagnosis can help prevent strokes, heart-related deaths, and heart failure hospitalizations in people with atrial fibrillation (an irregular heartbeat) who also have other health problems like high b…

This study looks at the best time to start blood thinners after emergency stroke treatment in people with atrial fibrillation (an irregular heartbeat). About 438 adults who had a stroke caused by a blocked large artery and received emergency clot removal will be randomly assigned…

This study compares two types of heart procedures—convergent hybrid ablation and standard catheter ablation—in 120 adults with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. The goal is to see which approach better controls heart rhythm without …

This study tests whether a pacemaker plus a small heart procedure works better than standard medications for controlling heart rate in 600 people with atrial fibrillation and heart failure. The pacemaker uses a newer method called conduction system pacing to regulate the heartbea…

This study tests an oral drug called PKN605 in people with atrial fibrillation (an irregular heart rhythm). The goal is to see if it can reduce the total time a person spends in this abnormal rhythm. About 165 adults with a history of atrial fibrillation will receive either PKN60…

This study is testing a new system (VARIPULSE catheter and TRUPULSE generator) with updated software to treat atrial fibrillation, a condition where the heart beats irregularly. About 50 adults with either short-lasting (paroxysmal) or longer-lasting (persistent) atrial fibrillat…

This study tests whether ondansetron, a drug usually used to prevent nausea in cancer patients, can help people with atrial fibrillation (Afib). Afib is a common irregular heartbeat that can lead to stroke or death. The researchers believe ondansetron may block a specific heart c…

This study is testing a new device that uses pulsed fields to map and treat atrial fibrillation (AF), a common heart rhythm problem. About 175 adults with AF will receive this procedure to see if it is safe and works well. The goal is to restore a normal heart rhythm without the …

This study looks at whether a structured program to find and treat obstructive sleep apnea can reduce the amount of time people with atrial fibrillation spend in an irregular heart rhythm. About 209 adults with AF will use a home sleep test and a Fitbit smartwatch to monitor thei…

This study compares two catheter ablation approaches for people with persistent atrial fibrillation (AF), a type of irregular heartbeat. The standard method isolates the pulmonary veins, while the experimental method also targets scarred areas in the left atrium. The goal is to s…

This study looks at 300 adults with atrial fibrillation (an irregular heartbeat) who have had a brain bleed. It compares three approaches to prevent future strokes: restarting blood thinners, using a device to close a part of the heart (left atrial appendage closure), or avoiding…

This study is a global registry that will follow about 1,950 people with atrial fibrillation who are treated with the PulseSelect PFA system. The goal is to see how well the procedure prevents irregular heart rhythms and to track any serious side effects. Participants will be tre…

This study compares two blood thinners, apixaban and aspirin, in 700 people who have had a brain bleed (intracerebral hemorrhage) and also have an irregular heartbeat (atrial fibrillation). The goal is to see which drug better prevents another stroke or death. Participants will t…

This study tests whether a drug called Enavogliflozin, currently used for diabetes, can prevent atrial fibrillation (an irregular heartbeat) from returning after a catheter ablation procedure in people who also have heart failure. About 390 adults will be randomly assigned to rec…

This study looks at 70 people with heart failure, an irregular heartbeat (atrial fibrillation), and a special pacemaker (CRT) that isn't pacing enough. It compares two procedures: one that fixes the irregular heartbeat (AF ablation) and one that slows the heart's electrical signa…

This study tests whether semaglutide, a medication used for weight loss, can help control atrial fibrillation (AF) in overweight or obese adults. About 200 people aged 18-75 with AF and a BMI of 30 or higher will receive semaglutide alongside standard AF care. The goal is to see …

This study compares a new catheter (VARIPULSE) to an approved one (FARAWAVE) for treating persistent atrial fibrillation, a condition where the heart beats irregularly for over a week. About 466 adults with this condition will be randomly assigned to one of the two procedures. Th…

This study tests a new device called FARAFLEX that uses pulsed field ablation to treat people with persistent or occasional atrial fibrillation (an irregular heartbeat). About 250 adults will receive either the new catheter or a standard one to see if it safely and effectively cr…

This study compares two types of ablation (pulsed field vs cryoballoon) for people with atrial fibrillation, a heart rhythm problem. About 104 participants will be randomly assigned to one of the two methods. The main goal is to see which technique creates better scar tissue arou…

This study looks at whether taking blood thinners can prevent strokes in people who have brief episodes of atrial fibrillation (irregular heartbeat) triggered by stress, such as after surgery or a serious illness. About 2,270 participants with additional stroke risk factors will …

This study looks at whether people with atrial fibrillation can safely take a lower dose of the blood thinner apixaban for just 3 months after a procedure to close a part of the heart (left atrial appendage), then stop all blood thinners. The goal is to see if this approach reduc…

This study tests a new device that uses electrical pulses to treat atrial fibrillation (an irregular heartbeat) while patients are already having heart surgery for other reasons. About 135 adults aged 18 to 85 with a history of atrial fibrillation will take part. The goal is to s…

This study tests if a newer pacing method (left bundle branch area pacing) is better than standard pacing at preventing heart muscle weakening after a procedure to control atrial fibrillation. About 86 adults with normal heart function will be randomly assigned to one of the two …

This study compares two common blood thinners, rivaroxaban and apixaban, to see which causes less bleeding in people with atrial fibrillation (an irregular heartbeat). About 3,000 adults with newly diagnosed AF will be randomly assigned to one of the two drugs. The goal is to hel…

This study tests whether closing a small heart pouch (left atrial appendage) with a device, along with continuing blood thinners, can reduce the risk of another stroke in people with atrial fibrillation who already had a stroke while on blood thinners. About 482 participants will…

This study tests a new device called the SpherePVI catheter for people with atrial fibrillation (an irregular heartbeat). About 100 adults who have not gotten better with medication will receive this treatment. The goal is to safely isolate the veins that trigger the irregular rh…

This study tests if a small filter placed in the neck arteries can catch blood clots before they reach the brain, preventing strokes in people with atrial fibrillation who already had a stroke. About 2,000 participants will either get the implant plus blood thinners or just blood…

This study looks at whether adding a blood thinner to standard aspirin therapy helps prevent strokes and blood clots in people who develop a new irregular heartbeat after coronary bypass surgery. About 3,200 adults who had bypass surgery and then had a short-lasting or repeated i…

This study tests whether doing two heart procedures at once—fixing faulty electrical signals and closing a small heart pouch—can prevent strokes better than standard blood thinners or closing the pouch alone. About 240 people who recently had a stroke and have atrial fibrillation…

This study tests whether the weight-loss medication tirzepatide can improve control of atrial fibrillation (an irregular heartbeat) in people with obesity. About 100 adults with a BMI of 27 or higher and symptomatic AFib will receive either tirzepatide or a placebo. The main goal…

This study tests a new system that uses heat to destroy tiny areas of heart tissue causing irregular heartbeats (atrial fibrillation). About 150 adults who have not responded to medication will receive this procedure. The goal is to safely restore a normal heart rhythm and reduce…

This study tests whether adding a kidney nerve procedure (renal denervation) to the standard heart ablation can better control atrial fibrillation (AF) in people with controlled or no high blood pressure. About 50 adults with persistent AF will be randomly assigned to get either …

This study tracks 580 adults with atrial fibrillation (an irregular heartbeat) who receive a procedure using the PulseSelect PFA system. The goal is to see how well the procedure prevents heart rhythm problems and how safe it is over 3 years. Participants must have tried at least…

This study follows 250 people with atrial fibrillation who had a procedure to close a small heart pouch (left atrial appendage) to prevent strokes. The goal is to see how well the procedure works over 5 years, especially for those who cannot take long-term blood thinners. Researc…

This study compares a new, personalized ablation method to the standard approach for treating atrial fibrillation (AFib), a common heart rhythm problem. About 556 adults with paroxysmal AFib will be randomly assigned to either standard treatment or a tailored procedure that targe…

This study combines two heart procedures into one session for people with atrial fibrillation (AFib). The first uses pulsed field energy to fix the irregular heartbeat, and the second closes a small pouch in the heart to lower stroke risk. About 433 adults who need both treatment…

This study tests whether the drug colchicine can prevent atrial fibrillation (a type of irregular heartbeat) after heart bypass surgery. Researchers will compare 70 patients who receive colchicine plus a special surgical technique with 70 patients who receive standard care. The g…

This study compares a new pacing method (His bundle pacing) to the standard right ventricular pacing in 100 adults with atrial fibrillation and heart failure who need AV node ablation. The goal is to see if the new method improves walking distance, daily activity, and quality of …

This study tests whether dapagliflozin, a diabetes medication, can reduce the amount of time people with diabetes spend in atrial fibrillation (AF). About 28 adults with paroxysmal AF and diabetes will receive either dapagliflozin or a placebo for 3 months. Researchers will measu…

This study tests if a special heart pacing method followed by a targeted ablation (a procedure to destroy a small area of heart tissue) can help people with both heart failure and a type of irregular heartbeat called permanent atrial fibrillation. The goal is to see if this appro…

This early study tests a new device that uses short electrical pulses to treat atrial fibrillation (an irregular heartbeat) during heart surgery. About 30 adults aged 18-85 with a history of atrial fibrillation will receive the treatment. The goal is to see if the device safely c…

This study looks at two approaches to blood thinners after a common heart procedure for atrial fibrillation. One group takes blood thinners every day as usual, while the other takes them only when a small implanted monitor detects the heart rhythm problem returning. The goal is t…

This study looks at 240 adults with atrial fibrillation who had a stroke and then a procedure to remove a clot. Some will start blood thinners early (within 3 days) and others later (after 7-14 days) to see which timing is safer and prevents another stroke. The goal is to find th…

This study tests a new device that uses quick electric pulses to fix faulty heart signals in people with a type of irregular heartbeat called paroxysmal atrial fibrillation. About 440 adults who have not gotten relief from medication will receive the procedure. The goal is to see…

This study looks at the long-term safety and effectiveness of the VARIPULSE catheter, a device already approved by the FDA, for treating people with a type of irregular heartbeat called paroxysmal atrial fibrillation. About 276 participants will undergo a procedure to isolate the…

This early-phase study tests a new radioactive tracer called 64Cu-FBP8 that lights up blood clots on PET-MR scans. Researchers want to see if it can safely and accurately detect clots in people with atrial fibrillation, cancer, COVID-19, or other clot risks. About 165 participant…

This study tests whether a smartwatch can find hidden atrial fibrillation (an irregular heartbeat) in people who have had heart surgery. About 30% of patients develop this condition after surgery, but many have no symptoms and it can lead to strokes. The trial will compare standa…

This study tests whether placing the heart medication amiodarone directly into the sac around the heart during bypass or valve surgery can prevent a common complication called atrial fibrillation (irregular heartbeat) after the operation. About 63 adults aged 20-85 having open-ch…

This study tests whether the heart medication amiodarone can prevent atrial fibrillation (a fast, irregular heartbeat) in people recovering from minimally invasive esophageal cancer surgery. Atrial fibrillation is a common complication after this surgery, and there is no standard…

This study tests whether giving magnesium through an IV can safely lower a dangerously fast heart rate in people with atrial fibrillation or flutter. About 153 adults will receive either a low dose (2g), a higher dose (4g), or a placebo. The main goal is to see if magnesium helps…

This study compares two defibrillators to see which one is better at restoring normal heart rhythm in people with atrial fibrillation (AF). About 376 adults with persistent AF will receive an electrical shock from either a 360-joule or a 200-joule device. The goal is to find out …

This study compares two types of exercise training—high-intensity interval training (HIIT) and moderate-intensity continuous exercise—against usual care in 132 adults with persistent or permanent atrial fibrillation. The goal is to see which approach best improves exercise capaci…

This study tests whether a personalized, sensor-based exercise program can reduce symptoms in 120 adults with atrial fibrillation (AFib). Participants will use a digital tool to guide their activity over several weeks. The goal is to see if this approach improves how patients fee…

This study tests a special device to close the leg puncture site after a common heart procedure for atrial fibrillation. The goal is to see if it helps patients get up and walk sooner compared to the standard method of pressing on the leg and using a stitch. About 100 adults havi…

This study tests a digital toolkit (smartphone app) designed to help people with atrial fibrillation (AFib) learn about their condition, stick to treatments, and manage episodes. Researchers want to see if using the app improves quality of life and reduces AFib episodes. The stud…

This study tests if using a small ultrasound probe inside the heart (ICE) is as good as the standard throat ultrasound (TEE) for placing a Watchman device. The Watchman is a device that helps prevent strokes in people with atrial fibrillation. About 100 adults who qualify for the…

This study looks at whether helping patients understand what to expect before a procedure for atrial fibrillation (an irregular heartbeat) can improve their quality of life. About 60 adults with symptomatic atrial fibrillation will be split into two groups: one gets extra expecta…

This study looks at whether combining a heart procedure (ablation) with a 12-week exercise program helps people with heart failure and atrial fibrillation use oxygen better. About 40 adults with both conditions will take part. The goal is to see if the combo improves how well the…

This study aims to find out if a procedure called cardioversion, which uses a mild electric shock to restore a normal heart rhythm, truly improves quality of life in people with persistent atrial fibrillation (a type of irregular heartbeat). About 100 adults with this condition w…

This study tests a new device (TS-RF system) against a standard needle used to access the left atrium of the heart during treatment for arrhythmia (irregular heartbeat) and mitral stenosis (narrowed heart valve). About 70 adults will be randomly assigned to receive either the new…

This study is a large registry that will collect data from 10,000 people with atrial fibrillation who are scheduled for or have had a heart ablation procedure. The goal is to track how well the procedure controls the heart rhythm and to monitor any side effects. The study does no…

This study looks at whether a simple ECG test can tell which patients are at risk of forming dangerous blood clots that lead to stroke. Researchers will study the heart's small pouch (left atrial appendage) and blood samples from 1000 people having open-heart surgery. The goal is…

This study observes what happens when a single doctor schedules eight or more left atrial appendage occlusion (LAAO) device implants in one day. Researchers will track complications, device leaks, and late problems in 678 adults with atrial fibrillation. The goal is to see if hig…

This study tests a new imaging system called VERAFEYE that helps doctors see inside the heart during a common procedure called catheter ablation. The procedure treats irregular heartbeats like atrial fibrillation. The study will enroll 50 adults and focus on how well the system w…

This study looks at 350 people with beta-thalassemia to find out what makes some develop atrial fibrillation (an irregular heartbeat) while others do not. Researchers will compare medical tests and lab results between the two groups. The goal is to better understand the condition…

This study is a registry that collects information on 2,000 people with atrial fibrillation who undergo heart surgery to treat it. Researchers want to see how well the surgery works in everyday medical practice and track complications like bleeding or heart problems. The goal is …

This study follows 750 people with atrial fibrillation (AF) who are getting a catheter ablation procedure. The main goal is to find out which factors predict whether AF will return within 3 years. Researchers will also track serious heart problems and major bleeding. The results …

This study follows 1,125 adults who have had or will have a heart procedure called catheter ablation for atrial fibrillation (AFib). Over one year, participants use a mobile app to answer surveys about their lifestyle, symptoms, and quality of life. The goal is to find out what f…

This study looks at whether a special heart ultrasound done before cardiovascular surgery can help predict which patients will develop atrial fibrillation (an irregular heartbeat) after their operation. Researchers will follow 138 adults who are in normal rhythm before surgery an…

This study aims to find out how common atrial fibrillation (an irregular heartbeat) is after heart surgery and what makes some people more likely to get it. About 150 adults having planned open-heart surgery will wear a small EKG patch to track their heart rhythm. The results cou…

This study is watching 400 people in the US who have a heart condition called atrial fibrillation (AF). Doctors use a special AI system during a procedure to fix the heart's rhythm. The goal is to see how well the AI helps prevent the heart problem from coming back.

This study is a registry that will follow 2000 people with atrial fibrillation (an irregular heartbeat) who are taking long-term blood thinners. The goal is to track how often serious bleeding or heart problems like stroke or heart attack occur. Researchers hope to better underst…

This study is creating a large collection of blood and DNA samples from 1,000 people with atrial fibrillation (an irregular heartbeat) and stroke. Researchers will use these samples to investigate the genetic causes of these conditions and find better treatment targets. Participa…

This study at Stanford University is observing 200 people with persistent atrial fibrillation (AF) who are already scheduled for a heart procedure. Researchers will map the heart's electrical signals to see if the size of organized areas predicts success from ablation. No new tre…

This study looks at whether obstructive sleep apnea (OSA) causes scarring (fibrosis) in the heart's upper chambers, even in people without atrial fibrillation. Researchers will use special MRI scans to measure scarring in 60 adults with different severities of OSA. The goal is to…

This study aims to see if certain blood markers that indicate clotting are linked to how much atrial fibrillation (AFib) a person has after a catheter ablation procedure. Researchers will collect blood samples from 20 adults with AFib before, during, and up to 90 days after their…

This study looks at whether it's possible to run a larger trial comparing how different types of exercise (moderate or high intensity) affect symptoms of atrial fibrillation (AFib) compared to a week of rest. About 36 adults with AFib who have symptoms will try each approach. The…

This study tests a new 3D imaging system (VERAFEYE) that helps doctors see inside the heart during a procedure called catheter ablation. The procedure treats common heart rhythm problems like atrial flutter and atrial fibrillation. About 50 adults will take part to see if the sys…

This study aims to improve how we detect and understand heart disease using advanced MRI scans. Researchers will compare new MRI techniques with standard tests in 1,000 adults, both healthy volunteers and those with various heart conditions. The goal is to find better ways to see…

This study enrolls 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Researchers want to understand why some strokes happen even when patients take blood thinners. They will collect blood samples and heart ultrasound images, then follow …

This study enrolls 300 people with heart failure who do not have standard heart devices like ICDs or CRTs. Researchers use the BIOMONITOR IV, a small implant that tracks heart activity, breathing, and fluid levels remotely. The goal is to learn how often irregular heartbeats occu…

This study at Stanford University is testing whether a computer program can help doctors better treat atrial fibrillation, a common heart rhythm problem. About 120 adults with AF who are scheduled for a procedure called ablation will take part. The researchers will use machine le…

This study looks at whether a telemedicine program can help heart failure patients who often end up back in the hospital. Researchers will track 300 patients, their doctors, and home caregivers as they use video calls and chat to manage care. The goal is to see if this approach r…

This study tests whether a connected watch can better detect returning atrial fibrillation (an irregular heartbeat) in 106 adults who had heart surgery and developed a temporary irregular rhythm. Participants will wear the watch for 12 months, and doctors will compare the watch's…

This study enrolls 1,000 adults with atrial fibrillation who are already scheduled for a heart procedure. Researchers will test different computer programs that analyze heart signals and images to see which ones best identify problem areas. The goal is to improve future treatment…

This study looks at whether a special CT scan can measure scarring in the heart muscle of people with atrial fibrillation (AF) before they have a procedure called ablation. The goal is to see if more scarring leads to worse outcomes, like the AF coming back or needing hospital vi…

This study is a global registry that will follow 540 people with atrial fibrillation who are treated with the Affera ablation system. The goal is to see how well the procedure controls heart rhythm problems and how safe it is in routine medical practice. Participants will be obse…

This study looks at 200 adults with early-onset atrial fibrillation (before age 60) who have certain genetic heart conditions. Researchers will use cardiac MRI and electrical mapping during a scheduled procedure to see who is at high risk for ventricular tachycardia, a dangerous …

This study follows 24 people who had a stroke and were recently diagnosed with atrial fibrillation (AF), a heart rhythm problem. Researchers will monitor how AF changes over 24 months using heart monitors and blood tests. The goal is to better understand AF progression in stroke …

This study follows 141 adults with atrial fibrillation and moderate-to-severe leakage of the mitral or tricuspid heart valves. Researchers will use echocardiograms and exercise tests to track how the valve disease changes over one year. The goal is to identify patterns and risk f…

This study is looking at 50 adults without prior irregular heartbeat who are scheduled for heart surgery. Researchers want to see if scarring (fibrosis) in the heart's upper chambers before surgery can predict who will develop a temporary irregular heartbeat after the operation. …

This study follows 1,400 people who receive a small heart monitor implanted under the skin to track heart rhythms. Researchers want to see how quickly the device finds rare but serious heart issues like atrial fibrillation or fainting spells. The goal is to learn how well the mon…

This study is testing a digital app called VIRTUES to help people with heart conditions manage their health at home. The app provides personalized recommendations on medications, diet, exercise, and more. Researchers will enroll 2000 participants to use the app for one month and …

This study is for people starting a type of blood cancer medication called BTK inhibitors. Researchers want to see if a small heart monitor (implanted under the skin) can detect irregular heartbeats that these drugs might cause. The goal is to catch problems early and guide treat…