ATRIAL FIBRILLATION

This study tests a new approach for people with end-stage heart failure and a fast, irregular heartbeat (atrial fibrillation). Participants will get a special pacemaker and a small procedure to control the heart's rhythm, plus an implantable defibrillator (ICD). The goal is to se…

This study tests if metabolic (weight-loss) surgery can reduce the severity of atrial fibrillation (AF), a common heart rhythm disorder, in people with obesity. About 100 adults with AF and a BMI of 35-65 will be randomly assigned to surgery or standard care. The main goal is to …

This study looks at 900 adults with atrial fibrillation (an irregular heartbeat) and a type of heart failure where the heart's pumping ability is mildly reduced or preserved. It compares a procedure called catheter ablation (which destroys tiny areas of heart tissue causing the i…

This study tests a new pulsed field ablation system (VARIPULSE catheter and TRUPULSE generator) with updated software in 50 adults with persistent atrial fibrillation (an irregular heart rhythm lasting over 7 days). The goal is to see how well the system works during the procedur…

This study compares two ablation procedures for people with persistent atrial fibrillation (AFib). The standard method isolates the pulmonary veins, while the experimental method also looks for and burns extra triggers outside those veins. About 406 adults having their first AFib…

This study will compare two widely used blood thinners, apixaban (Eliquis) and rivaroxaban (Xarelto), in about 10,000 veterans with atrial fibrillation (an irregular heartbeat). The goal is to see which drug better prevents strokes, major bleeding, and death. Participants must al…

This study tests a procedure called left atrial appendage occlusion (LAAO) in 40 dialysis patients with atrial fibrillation to prevent strokes. The goal is to see if it is safe and effective, allowing patients to avoid long-term blood thinners that raise bleeding risks. Participa…

This study tests a new catheter device to treat a type of irregular heartbeat called paroxysmal atrial fibrillation, which comes and goes. The procedure aims to isolate the veins that trigger the abnormal rhythm. Researchers will check if the treatment works well over time and if…

This study tests a telemedicine program for older adults (ages 65-80) with both atrial fibrillation and heart failure in rural China. Village doctors use a digital platform with remote expert support to guide medication and lifestyle changes, including group exercise and wearable…

This study tests a procedure called pulsed field ablation (PFA) in 70 adults who have atrial fibrillation (AFib) and already received a left atrial appendage closure device. The goal is to see if PFA can safely stop AFib from coming back for at least 12 months. Participants must …

This study tests a new device called the VARIPULSE catheter for people with a type of irregular heartbeat called persistent atrial fibrillation. The procedure uses heat energy to isolate certain veins in the heart to restore normal rhythm. The trial will check how safe the device…

This study compares different standard methods for a heart procedure called pulmonary vein isolation, used to treat atrial fibrillation (an irregular heartbeat). About 1,125 adults will receive one of the standard treatments, and researchers will track which method best prevents …

This study tests a device called CLAAS that is implanted to close off a part of the heart (the left atrial appendage) in people with atrial fibrillation. The goal is to reduce stroke risk and allow patients to stop taking long-term blood thinners. About 300 adults at high risk fo…

This study will test a small, single-lead ECG patch that sticks to the chest and sends heart rhythm data to a central monitoring system. It aims to help doctors spot serious heart rhythm problems like atrial fibrillation or ventricular tachycardia faster in hospitalized patients.…

This study tests whether an artificial intelligence (AI) tool can improve detection of atrial fibrillation (an irregular heartbeat) in adults who have symptoms like palpitations or dizziness but have not been diagnosed before. About 1,230 participants will be randomly assigned to…

This study aims to see if artificial intelligence (AI) can predict which patients will develop dangerous irregular heartbeats during or after high-risk surgery. Researchers will analyze simple heart monitor recordings from 300 patients before their operations. The goal is to crea…

This study tests if a numbing injection near certain neck nerves, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (an irregular heartbeat). About 450 adults having bypass surgery will be randomly assigned to get either the nerv…

This study tests whether two heart medications, amiodarone and metoprolol, can prevent new-onset atrial fibrillation (a type of irregular heartbeat) in people who have just had a heart valve replacement (TAVR). About 198 participants with certain early warning signs after TAVR wi…

This study tests whether a sedative drug called dexmedetomidine can prevent a common heart rhythm problem (atrial fibrillation) that often occurs after mitral valve surgery. About 140 adults undergoing this surgery will receive the drug or a placebo. The goal is to see if the dru…

This study compares two treatments to prevent another stroke in people who have both atrial fibrillation (an irregular heartbeat) and hardened brain arteries. About 586 participants will receive either the blood thinner apixaban alone or apixaban plus clopidogrel for 30 days. The…

This study tests whether a telemedicine program led by village doctors can prevent heart failure in older adults (ages 65-80) in rural China who have atrial fibrillation but not yet heart failure. Participants use wearable devices, get lifestyle coaching, and receive remote speci…

This study tests whether electronic alerts in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goal …

This study tests whether having a trained peer mentor—someone who also has atrial fibrillation—can help reduce anxiety in vulnerable patients. About 290 adults with AF and low socioeconomic status will either receive usual care or be matched with a mentor for 16 weeks. The goal i…

This study tests whether using a brain-activity monitor (BIS) to guide sedation during electrical cardioversion for atrial fibrillation leads to faster recovery and fewer side effects compared to standard clinical checks. Sixty adults will be randomly assigned to either BIS-guide…

This study tests whether a nasal spray called etripamil can safely and quickly slow a rapid heart rate during episodes of atrial fibrillation. About 750 adults with AFib will use the spray at home when they feel symptoms. The goal is to see if it works better than a placebo spray…

This study tests a new way to treat a common heart rhythm problem called atrial fibrillation (AFib). Instead of using heat or cold, doctors will use a special energy called pulsed field ablation (PFA) to fix the heart's electrical signals. They will also use a 3D ultrasound map t…

This study looks at how often a newer heart procedure for atrial fibrillation (called pulsed field ablation) causes temporary or permanent paralysis of the diaphragm, the main muscle used for breathing. Researchers will use a special X-ray video (fluoroscopy) to check diaphragm m…

This study will collect information from 50 people having standard heart procedures for atrial fibrillation or left atrial appendage closure. Doctors will use a new imaging system called VERAFEYE to help guide the procedure. The goal is to see how well the system works in everyda…

This study follows 1100 people with atrial fibrillation who are getting a standard heart procedure called pulsed field ablation. Researchers want to find out which patients and which procedure details make it more likely that someone will need a second ablation later. The goal is…

This study compares a new heart monitoring technique called magnetocardiography (MCG) to the standard ECG in 100 adults with atrial fibrillation and Long QT syndrome who are starting a heart rhythm medication. The goal is to see if MCG can better predict who will have a safe resp…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and remote monitoring to understand why some patients respond well to treatment while others do not. The goal is to id…

This study will collect heart recordings from 600 people using the HeartBeam 3-Lead ECG recorder. The recordings will be used to create a de-identified database for future research and regulatory submissions. Participants must already be scheduled for an ECG as part of their regu…

This study will test a new type of heart MRI that can see tiny details in heart muscle, like early damage or healing. Researchers will compare these images with standard tests in 1000 adults with and without heart disease. The goal is to learn which markers are best for spotting …

This study tests whether an artificial intelligence (AI) system can help doctors find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 400 participants will be randomly assigned to either AI-guided monitoring with wearable devices or stan…

This pilot study tests whether a decision support tool helps Black and White patients with atrial fibrillation make informed choices about blood thinners to prevent strokes. Researchers will enroll 40 adults to see if the tool is easy to use and improves decision quality. The goa…

This study is testing a new software tool that helps doctors check if they have successfully treated the heart tissue causing atrial fibrillation (AFib) during a procedure called pulsed field ablation. About 100 adults with AFib having their first ablation will take part. The too…

This study follows 500 people with dual-chamber pacemakers to see how the pacemaker's programming affects the development of permanent atrial fibrillation (an irregular heartbeat). Researchers will track heart rhythm, quality of life, hospital visits, and deaths over time. The go…