ATRIAL FIBRILLATION

This study aimed to see if a short course of the heart medication amiodarone could prevent atrial fibrillation (an irregular heartbeat) in adults after heart surgery. About 1 in 3 patients experience this complication. However, the study was withdrawn before enrolling any partici…

This registry will follow 500 people with symptomatic atrial fibrillation who are scheduled for a heart ablation using the Globe Pulsed Field System. The goal is to see how well the device controls the heart rhythm over 12 months and to track any major side effects within the fir…

This study compares a heart procedure called catheter ablation to standard medical treatment for people with atrial fibrillation (an irregular heartbeat) and heart failure with preserved ejection fraction (a type of heart failure where the heart pumps normally but is stiff). The …

This study tests whether a non-invasive ear stimulation, called low-level tragus stimulation, can reduce inflammation and early heart rhythm problems after pulsed field ablation for atrial fibrillation. Forty-six adults with atrial fibrillation will receive either active or sham …

This study tests whether the diabetes and weight-loss drug tirzepatide (Mounjaro) can reduce the chance of atrial fibrillation coming back after a heart procedure called catheter ablation. About 602 adults with obesity and a type of heart failure (HFpEF) will get either tirzepati…

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This study tests a catheter-based procedure called Varipulse to treat paroxysmal atrial fibrillation (irregular heartbeat that comes and goes). Researchers want to see how well it works long-term when combined with different types of sedation. About 300 adults aged 18-80 with sym…

This study will enroll 30,000 adults in China with atrial fibrillation (a type of irregular heartbeat) that hasn't improved with medication. They will receive a new type of catheter treatment called pulse-field ablation. Researchers will track their health for up to 10 years to s…

This study tests a procedure called pulsed field ablation (PFA) for people with early-stage atrial fibrillation (AFib) diagnosed within the last 3 years. The procedure uses a balloon to deliver energy that isolates the pulmonary veins, aiming to stop abnormal heart rhythms. Resea…

This study tests whether a wearable monitoring system (ECG patch, temperature patch, and pulse oximeter) can reduce major heart complications in hospitalized patients with heart disease. About 1500 adults will be monitored either with standard care (vital signs every 4-8 hours) o…

This study tests whether a newer drug, Vernakalant, works better than the standard Amiodarone for treating atrial fibrillation (irregular heartbeat) that often occurs after heart surgery. About 50 adults who recently had heart surgery will receive one of the two drugs. The main g…

This study tests a new way to treat atrial fibrillation (AFib), a condition where the heart beats irregularly. Doctors will use pulsed field ablation (PFA) instead of heat or cold to create scars in the heart and block bad signals. They will also use a special 3D ultrasound syste…

This clinical trial tests whether giving two electrical shocks at once (dual shock) is better than the standard single shock for restoring normal heart rhythm in people with persistent atrial fibrillation. About 177 participants will be randomly assigned to receive either a stand…

This study looks at whether metabolic surgery (like gastric bypass) can reduce the severity of atrial fibrillation (AF), a common heart rhythm problem, in people with obesity. About 100 adults with AF and a BMI between 35 and 65 will be randomly assigned to either surgery or medi…

This study tests a telemedicine program for people aged 65-80 with both atrial fibrillation and heart failure living in rural China. Village clinics are randomly assigned to offer either standard care or a program that includes a digital health system, a smartwatch for monitoring…

This study tests a device called CLAAS that closes a small pouch in the heart (left atrial appendage) to prevent strokes in people with atrial fibrillation. About 300 adults at high risk of stroke will get the device under conscious sedation (awake but relaxed). The goal is to se…

This study will compare different pulse field ablation systems used to treat atrial fibrillation (AF), a common heart rhythm problem. Over 1,100 patients will receive one of the standard treatments depending on the time period they are treated. Researchers will track whether AF r…

This trial tests two different heart pacing leads—one without a hollow core (lumenless) and one with a stylet—to see which works better for left bundle branch pacing. About 288 people with slow heart rhythms will take part. Doctors will use continuous monitoring to guide the lead…

This study tests a new approach for people with end-stage heart failure and permanent atrial fibrillation who are waiting for a heart transplant or heart pump. Participants will receive either a standard implantable defibrillator (ICD) alone or an ICD plus a special pacing lead a…

This study tests a procedure called pulsed field ablation in 70 people with atrial fibrillation who have already had a left atrial appendage occlusion to prevent stroke. The procedure uses electric pulses to destroy small areas of heart tissue causing the irregular rhythm. Resear…

This pilot study tests a procedure called left atrial appendage occlusion (LAAO) using the Watchman Flx PRO device in 40 dialysis patients with atrial fibrillation. The goal is to see if it safely reduces stroke and major bleeding compared to standard care. Participants will be f…

This study tests a temporary pacing technique to slow dangerously fast heart rates in people with atrial fibrillation who cannot use standard medications. Researchers will pace specific nerve fibers near the heart to see if it safely controls heart rate without permanent procedur…

This study tests if burning extra spots outside the main heart veins can better control persistent atrial fibrillation (a type of irregular heartbeat). About 406 adults having their first ablation will be split into two groups: one gets standard vein isolation, the other gets add…

This study will test whether a small, wearable patch that records heart activity for 7 days can find undiagnosed atrial fibrillation (a common heart rhythm problem) in 30,000 Chinese adults aged 60 and older. Participants will wear the patch and then be followed for up to 10 year…

This study tests whether using artificial intelligence (AI) along with a smartwatch and a heart monitor patch can find a hidden heart rhythm problem called atrial fibrillation (AF) in people who have had a stroke. AF can cause strokes, but it often comes and goes without symptoms…

This study at Mayo Clinic will enroll 100 adults with atrial fibrillation who are taking the drug dofetilide. Researchers will compare a non-invasive magnetic heart scan (magnetocardiography, or MCG) with the standard ECG to see which better predicts safe drug dosing and heart co…

This study tests whether an artificial intelligence-enhanced ECG (SmartECG-AFrisk) can detect atrial fibrillation (AF) earlier than usual care in 1,230 adults with symptoms like palpitations or dizziness but no prior AF diagnosis. Participants are randomly assigned to either stan…

This study investigates whether screening older veterans (age 65 and older) who have a higher risk of atrial fibrillation—a condition where the heart beats irregularly—can reduce their chances of stroke, heart failure, or death. Participants selected for screening wear a small, w…

This study tests whether a numbing injection around a nerve cluster in the neck, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (irregular heartbeat) in the first week after surgery. About 450 adults scheduled for bypass will …

This trial tests whether two heart medications, metoprolol and amiodarone, can prevent new-onset atrial fibrillation (AFib) in people who develop minor rhythm issues after transcatheter aortic valve replacement (TAVR). About 198 participants will be randomly assigned to one of th…

This study tests whether a telemedicine program, led by village doctors and supported by wearable devices and remote specialists, can prevent heart failure in older adults (65-80) with atrial fibrillation living in rural China. About 1,268 participants will be assigned to either …

This study tests whether the sedative drug dexmedetomidine can prevent new-onset atrial fibrillation (a fast, irregular heartbeat) in the days after mitral valve surgery. Researchers will randomly give 140 adults either the drug or a placebo during and after surgery. The goal is …

This study tests whether an electronic alert in doctors' computers can increase the use of blood thinners to prevent strokes in people with atrial fibrillation (an irregular heartbeat). About 2,500 high-risk patients who are not currently on blood thinners will take part. The goa…

This study compares apixaban alone versus apixaban plus clopidogrel for 30 days in people who have had a stroke and have both atrial fibrillation and atherosclerosis. About 586 participants will be randomly assigned to one of the two treatments. The goal is to see if the combinat…

This study tests an experimental medicine called BAY 3670549 in 360 adults with atrial fibrillation (an irregular heartbeat). Participants receive a single IV dose of the drug or a placebo to see if it can restore normal heart rhythm without needing an electrical shock procedure.…

This study compares deep sedation using a combination of three drugs (dexmedetomidine, remimazolam, and remifentanil) to standard general anaesthesia for patients undergoing a procedure to treat atrial fibrillation (an irregular heartbeat). The goal is to see if deep sedation can…

This study tests whether starting with a higher shock energy (360 J) is better than a standard 200 J for restoring normal heart rhythm in people with atrial fibrillation. About 400 adults will be randomly assigned to one of three groups, including a personalized approach based on…

This study tests whether giving lidocaine through an IV can reduce diaphragm twitching and coughing during a procedure called pulse field ablation for atrial fibrillation. Sixty adults with AFib will be randomly assigned to receive lidocaine or a placebo (saline). The goal is to …

This study tests an investigational nasal spray called etripamil for people with atrial fibrillation (AFib) who experience episodes of dangerously fast heart rate. About 750 adults will be randomly assigned to use either the real spray or a placebo at home when symptoms start. Th…

This study will collect real-world information on the VERAFEYE system, a device that creates 3D images of the heart during procedures to treat atrial fibrillation (an irregular heartbeat) and to close the left atrial appendage (a small pouch in the heart). About 50 adults will ta…

This study will collect ECG recordings from 600 people using the HeartBeam 3-Lead ECG recorder. The goal is to build a database of heart rhythm information for future research and regulatory use. Participants will have their ECG taken as part of routine care, and their de-identif…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and AI tools to understand why some patients respond well to treatment while others do not. The goal is to find better…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This pilot study tests a web-based decision aid for Black and White patients with atrial fibrillation who need to choose whether to take blood thinners to prevent strokes. The tool explains risks and benefits and asks about personal preferences. The study will check if the tool i…

This study aims to see if artificial intelligence can predict serious heart rhythm problems, like atrial fibrillation, after high-risk surgeries. Researchers will record ECGs from 300 adults before surgery and analyze over 200 heart cycle parameters to find the best prediction me…

This study tests a new software module that analyzes heart signals during a procedure called pulsed field ablation, used to treat atrial fibrillation. The goal is to see if the software can accurately tell doctors when the targeted heart veins are fully isolated. One hundred adul…

This study will follow 500 people with dual-chamber pacemakers to see how the pacemaker's programming affects the development of permanent atrial fibrillation (AF), a common heart rhythm problem. Researchers will track AF episodes, quality of life, hospitalizations, and deaths ov…

This study tests a small, sticky patch that records heart rhythms in hospitalized patients who need continuous monitoring. The patch sends data to a central system for real-time alerts and later review. Researchers want to see if it helps doctors make faster decisions about treat…

This study will follow 1,100 people with atrial fibrillation who have a pulsed field ablation procedure. The goal is to find out which patient traits and procedure details make a repeat ablation more likely. Researchers will track heart rhythm problems and side effects for one ye…