ATRIAL FIBRILLATION

This study tests a wrist-worn device called CardiaCare RR2 that stimulates the median nerve to calm irregular heart rhythms after catheter ablation for atrial fibrillation (AF). About 34 adults who have had AF ablation will use the device daily for six months. Half will receive a…

This study is tracking over 1,100 people with atrial fibrillation who are treated with the FARAPULSE system, a device that uses electrical pulses to destroy tiny areas of heart tissue causing the irregular rhythm. The goal is to see how well it works and how safe it is in everyda…

This registry tracks 550 people with atrial fibrillation who are treated with the FARAPULSE pulsed field ablation system, using a special catheter and mapping technology. The goal is to see how safe and effective the procedure is in real-world settings over one year. Researchers …

This study tests whether people with atrial fibrillation who receive a WATCHMAN FLX Pro device can safely take just one blood thinner or aspirin instead of the usual two-drug plan. About 1,857 participants are being followed for six months to compare rates of death, stroke, major…

This study tests whether a personalized catheter ablation approach, guided by mapping low-voltage areas in the heart, works better than standard ablation for people with persistent atrial fibrillation (AFib). About 510 adults with persistent AFib will be randomly assigned to rece…

This large study is testing whether a device called WATCHMAN FLX, which closes off a small pouch in the heart, can be a safe and effective alternative to daily blood thinners (NOACs) for preventing strokes in people with non-valvular atrial fibrillation. The trial involves 3,000 …

This study compares a new oral blood thinner, milvexian, to the standard apixaban in about 20,000 adults with atrial fibrillation (an irregular heartbeat). The goal is to see if milvexian is at least as good at preventing strokes and blood clots, while also checking for major ble…

This registry is following 10,000 people with atrial fibrillation who are getting a procedure called pulsed field ablation using the Farapulse system. The goal is to see how well it stops irregular heart rhythms and how safe it is in everyday medical practice. Researchers will tr…

This study compares three catheter ablation techniques for people with persistent atrial fibrillation (AF), a heart rhythm disorder. About 617 adults having their first ablation will be randomly assigned to one of three groups: isolating the pulmonary veins alone, adding ablation…

This study tests a new device system that uses pulsed electric fields to treat atrial fibrillation, a common heart rhythm problem. About 300 people with symptomatic, recurrent atrial fibrillation will receive the procedure. The goal is to see if it safely and effectively restores…

This study tests whether adding the weight-loss drug liraglutide and a lifestyle program to standard catheter ablation can reduce fat around the heart and improve outcomes for people with atrial fibrillation (AF). About 60 adults with AF and a BMI of 27 or higher will take liragl…

This study compares two catheter ablation techniques for atrial fibrillation (AF), a condition where the heart beats irregularly. One method uses a standard approach with a drug called adenosine to find missed spots, while the other adds an extra ring of ablation without the drug…

This study tests whether a newer pacing method (conduction system pacing) is as good as or better than standard biventricular pacing in heart failure patients with atrial fibrillation who need a heart ablation. About 82 participants will be randomly assigned to one of the two pac…

This study compares three different surgical ablation techniques (Cox-Maze IV, Tampa 2, and EnCompass alone) to treat atrial fibrillation, a common heart rhythm problem. About 220 adults with AFib who are already having heart surgery will be randomly assigned to one of the three …

This study tests whether a tailored exercise and education program, given before and after a first-time atrial fibrillation ablation, can improve heart fitness and quality of life compared to standard care. About 107 adults scheduled for ablation will be randomly assigned to eith…

This study tests whether a new drug called Refralon, taken as a tablet once or twice daily, can prevent atrial fibrillation or flutter from returning after normal heart rhythm has been restored. About 175 adults with persistent AFib will receive either Refralon or a placebo for 6…

This study tests whether a computer alert in doctors' charts can help more atrial fibrillation patients get blood thinners to prevent strokes. About 5,094 patients and their doctors are involved. The alert fires during visits if a patient has high stroke risk but isn't on blood t…

This study compares two approaches—short-term anticoagulation (stronger blood thinners) versus antiplatelet therapy (milder blood thinners)—to prevent clots on a device placed in the heart's left atrial appendage. The trial involves 510 adults who have had this procedure. The goa…

This study tests whether a nurse practitioner-led team can improve care for adults with two or more chronic conditions like heart failure, diabetes, or kidney disease. Participants are randomly assigned to either the nurse-led team or usual care. The team reviews medications to e…

This study tests whether the blood thinner edoxaban can prevent strokes in people with atrial fibrillation (an irregular heartbeat) who have already survived a brain bleed. About 948 participants will receive either edoxaban or non-anticoagulant therapy (like aspirin or no blood …

This study is testing a new device called CLAAS that is implanted in the heart to close off a small pouch (the left atrial appendage) where blood clots often form in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing long-term blood thinners…

This study tests whether intensive lifestyle changes—like treating sleep apnea, cutting alcohol, exercising, losing weight, and managing blood pressure—can stop atrial fibrillation (AF) from coming back after a heart procedure called catheter ablation. About 509 people with AF wh…

This study tests if a device that closes a small pouch in the heart (left atrial appendage) is safer and more effective than long-term blood thinners for preventing strokes in people with atrial fibrillation. About 2,650 participants with AFib and high stroke risk are randomly as…

This pilot study was designed to test a new, more targeted way to perform ablation for atrial fibrillation (AFib). Instead of burning a wide area around the pulmonary veins, doctors would use special mapping technology to precisely target the heart muscle sleeves causing the abno…

This study compares dabigatran (Pradaxa) to warfarin for preventing strokes in 370 people with both atrial fibrillation and moderate-to-severe mitral stenosis. Participants are randomly assigned to one of the two blood thinners. The goal is to see if dabigatran is as good as or b…

This study tests whether adding ablation of scarred heart tissue to standard pulmonary vein isolation helps people with persistent atrial fibrillation stay free of irregular heartbeats. Two hundred participants will be randomly assigned to one of two ablation procedures. The main…

This pilot study tests a new device that uses special electrical pulses (coherent sine-burst electroporation) to treat atrial fibrillation, a common heart rhythm problem. The device aims to isolate the pulmonary veins, which are often the source of the abnormal signals. The study…

This study tests a modified Maze procedure done during heart surgery to treat atrial fibrillation, a common heart rhythm problem. About 151 adults with AFib scheduled for heart surgery will receive the procedure, which uses heat or cold to create scar lines in the heart and close…

This study tests a single 30-minute IV infusion of HBI 3000 in 150 adults with atrial fibrillation that started within the last 3 days. The goal is to safely convert the heart back to normal rhythm. The trial first finds the best dose, then compares it to a placebo in a blinded f…

This study tests whether using a patient's gender, weight, and kidney function to calculate the starting dose of the blood thinner heparin gets patients to the right level faster than the standard flat rate. About 145 adults with blood clots, atrial fibrillation, or mechanical he…

This study was designed to test a device called LAmbre Plus, which is implanted to seal off a small pouch in the heart where clots can form in people with atrial fibrillation. The goal was to see if it could safely prevent strokes in patients with large or irregularly shaped hear…

This study tests whether using an implantable heart monitor (or a wearable patch) to detect atrial fibrillation early after catheter ablation can reduce the total time spent in AF. About 120 people with paroxysmal or persistent AF will be monitored for 15 months. The goal is to s…

This study observes over 600 people with atrial fibrillation who received the Amulet device to close a part of the heart called the left atrial appendage. The goal is to see how well the device prevents strokes and bleeding in everyday medical practice. Participants are followed …

This study compares two procedures for people aged 75 and older with persistent atrial fibrillation (an irregular heartbeat). One group gets a pacemaker plus ablation of the heart's electrical node, while the other gets pulmonary vein isolation using cryoenergy. The goal is to se…

This study tests whether using a personalized risk score (ABC-score) to guide treatment can lower the chance of stroke or death in people with atrial fibrillation, a common heart rhythm problem. About 3,900 participants are randomly assigned to either standard care or treatment b…

This study looks at better ways to find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 337 participants will use either a wearable patch for 72 hours or a handheld device three times a day to monitor their heart rhythm. The goal is to s…

This study tests whether a water-resistant, wireless ECG patch worn for 7 days can detect more cases of hidden atrial fibrillation (a heart rhythm problem that raises stroke risk) than the usual 24-hour Holter monitor. Researchers will enroll 320 adults who recently had a stroke …

This study was designed to test a new portable ECG recorder called Hativ P30, which uses artificial intelligence to analyze heart rhythms. Researchers planned to compare its readings to a standard 12-lead ECG in adults, including those with and without arrhythmias. However, the s…

This study is testing whether a smart blood pressure cuff called the Withings BPM Core can accurately detect atrial fibrillation, a common heart rhythm problem. Researchers will compare the device's single-lead ECG readings to a standard 12-lead ECG in 160 adults. If it works wel…

This study checks how well the Withings Move ECG watch can detect atrial fibrillation (an irregular heartbeat) compared to a standard 12-lead ECG. About 234 adults will wear the watch and get a standard ECG to see if the watch's automatic reading is accurate. The goal is to see i…

This study tests whether an Apple Watch, worn over a long period, can catch early signs of atrial fibrillation (a type of irregular heartbeat) in people who are at high risk but haven't been diagnosed yet. About 2,000 participants who had a previous ECG and a high AI risk score w…

This study is testing whether a new risk score can help find people who have atrial fibrillation (an irregular heartbeat) but don't know it yet. About 1,955 adults at higher risk will use a remote ECG monitor at home. The goal is to see if the risk score correctly identifies who …

This study tests whether closing the left atrial appendage—a small sac in the heart where blood clots often form—during planned heart surgery can prevent strokes in people with atrial fibrillation. About 1500 patients having coronary bypass or valve surgery are included. The goal…

This study tests whether the diabetes drug metformin, combined with lifestyle changes like diet and exercise, can reduce episodes of atrial fibrillation (an irregular heartbeat) in people with pacemakers or defibrillators. About 175 participants will take metformin or a placebo a…

This study tests a simpler deep-sedation method for people having a heart procedure called pulsed-field ablation to treat atrial fibrillation (an irregular heartbeat). The goal is to see if the new sedation approach is safe and makes patients more comfortable. About 40 adults wil…

This study tests whether adding group weight-loss classes to standard cardiac rehabilitation helps people with atrial fibrillation and obesity lose at least 10% of their body weight. About 120 adults will take part, with half getting the extra classes. The goal is to see if this …

This study compares a common heart procedure called pulmonary vein isolation (PVI) to a fake (sham) version to see if it truly reduces symptoms of atrial fibrillation. About 262 people with symptomatic AF will be randomly assigned to receive either the real procedure or a sham pr…

This study follows 100 ICU patients who developed new atrial fibrillation (AF) during their stay. Using a chest-worn heart monitor, researchers track whether AF returns after leaving the ICU and up to 3 months after hospital discharge. The goal is to understand who might need lon…

This study looks at two methods for treating atrial fibrillation (an irregular heartbeat) using a special balloon catheter. The goal is to see if using a 3D mapping system (CARTO) makes the procedure faster and safer than using X-ray guidance alone. About 60 adults with paroxysma…

This study aimed to validate several blood biomarkers (like NT-proBNP and IL-6) to help doctors assess atrial fibrillation burden and track treatment effectiveness. Researchers planned to analyze samples from 266 patients before and after treatment. However, the study was withdra…

This study is a registry that collects information and blood samples from over 2,400 people with atrial fibrillation who are scheduled for a heart procedure called ablation. The goal is to learn which patients benefit most from the procedure and to better understand what causes a…

This study checks if insulin resistance (when your body doesn't use insulin well) can predict whether a heart procedure called pulsed field ablation will work for people with atrial fibrillation (an irregular heartbeat). About 120 non-diabetic patients having their first ablation…

This study tests whether watching storytelling videos can help African American and Black patients with atrial fibrillation (an irregular heartbeat) start and continue taking blood thinners to prevent strokes. About 80 adults who are not currently on blood thinners but have a hig…

This study tests whether a small device placed under the skin can detect hidden atrial fibrillation (an irregular heartbeat) in people with heart failure who are at high risk for stroke. About 477 participants either received the implant or standard care. The goal is to see if th…

This study watches 50 people with chronic lymphocytic leukemia (CLL) who are starting a type of drug called a BTK inhibitor. These drugs can cause high blood pressure and irregular heartbeats. Participants will use a wearable device at home to track their heart rhythm and blood p…

This study follows 5,000 adults in Southwest China with persistent atrial fibrillation (a type of irregular heartbeat) for up to 5 years. Researchers will collect information on patients' health, treatments, and outcomes to learn which approaches work best and why. The goal is to…

This study follows 186 adults with atrial fibrillation who are having a heart ablation procedure. Doctors use an AI software to guide the treatment, and researchers track how well it works and any side effects over two years. The goal is to see if the AI helps improve outcomes an…

This study looks at whether a special type of ECG (called wavECG) can predict atrial fibrillation, a common irregular heartbeat after open-heart surgery. Researchers will follow 100 patients having their first heart surgery, using wavECG and echocardiograms to see who develops at…

This study tests whether sending cardiologists regular emails about quality goals helps them prescribe recommended medications for heart failure and atrial fibrillation. Researchers will track prescribing rates for 7,000 patients. The goal is to see if simple feedback can improve…

This study looks at whether actively cooling the esophagus during a common heart procedure (ablation for atrial fibrillation) helps improve outcomes and reduce side effects. Researchers will follow 312 adults with symptomatic atrial fibrillation who are already scheduled for abla…

This study looks at whether people with atrial fibrillation (AF) have temporary drops in thinking skills during an AF episode. Researchers will test 600 patients using tablet-based games that measure memory, attention, and decision-making while in AF and again after their heart r…

This study follows 1,400 women who had a stroke with no known cause. Researchers use a small implantable heart monitor to check for hidden atrial fibrillation, an irregular heartbeat that can cause strokes. The goal is to see if detecting this condition and using blood thinners c…

This study uses a wireless patch to monitor the heart rhythms of 1,200 patients at high risk for atrial fibrillation (AF), a common heart rhythm problem that raises stroke risk. Participants are adults over 50 with certain acute conditions like heart failure or sepsis, but no kno…

This study aims to uncover the genetic roots of atrial fibrillation, a common heart rhythm disorder. Researchers are collecting blood samples and health data from 1,300 adults—some with the condition and some without—to compare their DNA. The goal is to identify genetic variants …