ATRIAL FIBRILLATION

This study tests whether a personalized catheter ablation method, which targets areas of low voltage in the heart, works better than the standard procedure for people with persistent atrial fibrillation (a type of irregular heartbeat). About 500 adults with persistent AFib will b…

This study tests a device called CLAAS that is placed in the heart to close off a small pouch (the left atrial appendage) in people with atrial fibrillation. The goal is to reduce the risk of stroke without needing lifelong blood thinners. The study involves 80 participants and u…

This study compares a new oral blood thinner, milvexian, to the standard drug apixaban in about 20,000 adults with atrial fibrillation (an irregular heartbeat). The goal is to see if milvexian is at least as good at preventing strokes and blood clots, while also checking for blee…

This study tests a single 30-minute IV infusion of HBI 3000 in 150 adults aged 18–80 who have had atrial fibrillation (irregular heartbeat) for 2 to 72 hours. The goal is to see if the drug can safely and quickly convert the heart back to normal rhythm. The trial first finds the …

This study tests a computer alert that reminds doctors to prescribe blood thinners for patients with atrial fibrillation, a heart condition that raises stroke risk. About 5,000 patients and their doctors are taking part. The goal is to see if the alert helps more patients start a…

This study tests a modified version of the Maze procedure, done at the same time as other heart surgery, to treat atrial fibrillation (an irregular heartbeat). The goal is to restore a normal rhythm and reduce stroke risk. About 151 adults with AFib who need heart surgery will ta…

This study tests whether using an insertable heart monitor to guide early treatment can reduce the amount of time people spend in atrial fibrillation (AFib) after a catheter ablation. About 120 adults with AFib will get a small monitor placed under their skin before or during the…

This study tests two heart procedures for people with persistent atrial fibrillation (AFib) and scarred heart tissue. Participants are randomly assigned to either standard vein isolation or standard isolation plus additional ablation of scarred areas. The goal is to see which app…

This study tests a new device that uses electrical pulses to treat atrial fibrillation (AFib), a common heart rhythm problem. About 25 people with AFib will receive this treatment to see if it is safe and can stop abnormal signals in the heart. The goal is to control the conditio…

This study tests whether adding extra ablation sites during a standard heart procedure for atrial fibrillation (AF) can lower the chance of AF coming back. About 400 adults with intermittent AF will be randomly assigned to receive either the standard ablation plus a drug to check…

This study is tracking how well a new procedure called Farapulse pulsed field ablation works for people with atrial fibrillation (an irregular heartbeat). Researchers will follow 10,000 patients for years to see if the procedure safely stops abnormal heart rhythms without major c…

This study compares the WATCHMAN FLX device, which closes off a part of the heart to prevent clots, with standard blood thinners (NOACs) in 3,000 people with non-valvular atrial fibrillation. The goal is to see if the device is as good as medication at preventing stroke and death…

This study looks at two ways to treat persistent atrial fibrillation in people aged 75 and older. One approach uses a pacemaker plus a procedure to block the heart's electrical signal (AV node ablation). The other uses a procedure to isolate the pulmonary veins. The goal is to se…

This study tests whether the blood thinner edoxaban can reduce the risk of stroke or blood clots in people with atrial fibrillation (an irregular heartbeat) who have already had a brain bleed. About 948 participants will take either edoxaban or no blood thinner (or just aspirin) …

This study observes over 600 people with atrial fibrillation who received the Amulet device to close a part of the heart called the left atrial appendage. The goal is to see how well the device prevents strokes and bleeding in everyday medical practice. Participants are followed …

This study tests a new system that uses short bursts of energy to fix irregular heartbeats (atrial fibrillation) in 300 people. The goal is to see if it safely restores a normal rhythm without needing lifelong medication. Participants have symptoms that haven't improved with drug…

This study compares two ways to prevent strokes in people with atrial fibrillation (an irregular heartbeat). One group gets a device called the Amulet that plugs a small pouch in the heart where clots can form. The other group takes standard blood-thinning medication (NOACs). The…

This study compares two blood thinners, dabigatran and warfarin, in 370 people with atrial fibrillation (irregular heartbeat) and moderate to severe mitral stenosis (narrowed heart valve). The goal is to see if dabigatran is as safe and effective as warfarin at preventing strokes…

This study collects information on the safety and effectiveness of a heart procedure for atrial fibrillation using the FARAPULSE system, which uses electrical pulses to treat abnormal heart rhythms. About 550 adults will be followed for one year after their standard-of-care ablat…

This study tests whether liraglutide, a medication that reduces fat and promotes weight loss, can shrink the fat deposits around the heart and help stabilize heart rhythm in people with atrial fibrillation (AFib). About 60 adults with AFib and a BMI of 27 or higher will receive l…

This study compares three catheter ablation techniques for people with persistent atrial fibrillation (AFib), a heart rhythm problem lasting 3 months to 3 years. About 617 adults having their first ablation will be randomly assigned to one of three strategies. The goal is to see …

This study compares three different surgical ablation techniques (Cox-Maze IV, Tampa 2, and EnCompass) to treat atrial fibrillation, a common heart rhythm problem. About 220 adults with AFib who are already having heart surgery will be randomly assigned to one of the three method…

This study tests whether using a patient's gender, weight, and kidney function to calculate the first dose of the blood thinner heparin helps reach the right level faster than a standard dose based only on weight. About 145 adults with conditions like deep vein thrombosis, pulmon…

This study looks at 82 heart failure patients with atrial fibrillation who need a heart ablation and a pacemaker. It compares a newer pacing method (conduction system pacing) to the standard method (biventricular pacing) to see if the newer one works just as well or better at imp…

This study aimed to see if giving a short course of the heart medication amiodarone after non-bypass heart surgery could reduce the common complication of atrial fibrillation (irregular heartbeat). The researchers planned to enroll adults with normal heart rhythms before surgery,…

This study aimed to see if a device called LAmbre Plus could safely close off a small pouch in the heart (the left atrial appendage) in people with an irregular heartbeat (atrial fibrillation) who have a high risk of stroke. The goal was to reduce stroke risk without needing long…

This study tests whether using a personalized risk score (ABC-score) to guide treatment can lower the chance of stroke or death in people with atrial fibrillation, a common heart rhythm problem. About 3,900 participants were randomly assigned to either receive care guided by the …

This study tests whether aggressively managing risk factors (like high blood pressure, obesity, and diabetes) and avoiding triggers (like alcohol and smoking) can reduce the return of atrial fibrillation after a heart procedure called ablation. About 500 adults with AFib who are …

This study tests a new drug called Refralon in 175 adults with persistent atrial fibrillation or flutter. After doctors restore normal heart rhythm, participants take either a low or high dose of Refralon or a placebo daily for 6 months. The goal is to see if the drug can prevent…

This study follows over 1,100 people with atrial fibrillation who received a new treatment called FARAPULSE pulsed field ablation. The procedure uses electrical pulses to destroy tiny areas of heart tissue causing irregular rhythm. Researchers are watching for safety issues and h…

This study tests whether people with atrial fibrillation can take just one blood thinner or aspirin after getting a WATCHMAN FLX Pro device, instead of the usual two-drug plan. About 1,857 participants will be followed for 6 months to see if the simpler plans are as safe and effe…

This study tested whether a risk score based on health records can help find people with hidden atrial fibrillation (AF), a common heart rhythm problem that raises stroke risk. About 1,955 adults aged 30 and older with certain risk factors used a remote ECG monitor at home. The g…

This study tests whether a water-resistant, wireless ECG patch worn for 7 days can find more cases of hidden atrial fibrillation (an irregular heartbeat) in people who recently had a stroke or mini-stroke than the usual 24-hour Holter monitor. About 320 adults with no clear cause…

This study checks how well the Withings Move ECG watch detects atrial fibrillation (an irregular heartbeat) compared to a standard 12-lead ECG. About 234 adults will wear the watch and get a standard ECG to see if the watch's readings are accurate. The goal is to see if this wear…

This study tests whether an Apple Watch, worn over time, can catch atrial fibrillation (a common heart rhythm problem) early in people who are at high risk but haven't been diagnosed yet. About 2,000 participants from Mayo Clinic will use the watch for long-term monitoring. The g…

This study checks if a special blood pressure monitor (BPM Core) can correctly identify an irregular heartbeat called atrial fibrillation. Researchers compared the device's readings to a standard 12-lead ECG in 160 adults. The goal is to see if this easy-to-use home device can he…

This study tests whether the diabetes drug metformin, combined with lifestyle and risk factor changes, can reduce the amount of time people spend in atrial fibrillation (AFib). It includes 175 adults with pacemakers or defibrillators who have had at least one AFib episode lasting…

This study looks at whether closing a tiny sac in the heart (the left atrial appendage) during heart surgery can prevent strokes in people with atrial fibrillation. About 1500 adults having planned heart surgery are taking part. Doctors will compare those whose sac was closed to …

This study compares a standard heart procedure called pulmonary vein isolation (PVI) to a fake (sham) procedure in 262 people with atrial fibrillation. The goal is to see if the real procedure actually reduces symptoms and improves quality of life more than the placebo effect. Pa…

This study looks at whether cooling the esophagus (the tube connecting the mouth to the stomach) during a heart procedure called ablation can help people with atrial fibrillation (an irregular heartbeat). About 312 adults with this condition will be followed for up to a year to s…

This study looks at whether a tailored exercise and education program, given before and after a first-time atrial fibrillation (AF) ablation, can improve heart fitness and quality of life. About 107 adults scheduled for AF ablation will be split into two groups: one gets the extr…

This study looks at whether adding online group weight loss classes to standard cardiac rehab helps people with atrial fibrillation (AFib) and obesity lose at least 10% of their body weight. Losing this much weight may reduce or even eliminate AFib symptoms. About 120 adults with…

This study looks at two methods for treating atrial fibrillation (an irregular heartbeat) using a balloon catheter that delivers radiofrequency energy. About 60 adults with this condition will be randomly assigned to one of two approaches: one guided by a 3D mapping system (CARTO…

This study reviewed medical records from French health insurance to see how doctors prescribe blood thinners (like apixaban or warfarin) to atrial fibrillation patients who also have a high risk of stomach bleeding. Researchers looked at which treatments were used and whether pat…

This study looks at whether a new type of ECG (called wavECG) can help predict which patients will develop an irregular heartbeat (atrial fibrillation) after open-heart surgery. Researchers will follow 353 adults having heart surgery for the first time. The goal is to improve pre…

This study looks at whether sending cardiologists regular emails about quality goals can improve how often they prescribe key medications for heart failure and atrial fibrillation. About 7000 patients will be included. The goal is to see if this simple feedback method increases t…

This study aims to detect hidden episodes of atrial fibrillation (AF) in 1,200 acutely ill patients aged 50 and older who are at risk for stroke. Participants will be monitored with devices to catch short AF episodes that standard tests might miss. The data will be used to create…

This study aimed to find blood markers that could help doctors better diagnose and treat atrial fibrillation, a common heart rhythm problem. Researchers planned to test samples from 266 patients to see if certain markers could predict disease burden or treatment success. However,…

This study looks at whether people with atrial fibrillation (an irregular heart rhythm) experience temporary changes in thinking, memory, or focus during an episode. Researchers will test 600 participants using tablet-based games that measure cognitive skills, comparing their per…

This study aims to uncover the genetic factors behind atrial fibrillation, a common heart rhythm disorder. Researchers will collect blood samples and health data from 1,300 adults—both those with and without the condition—to build a gene bank. The goal is to better understand why…

This study follows 50 people with chronic lymphocytic leukemia who are starting treatment with acalabrutinib or zanabrutinib. Participants use wearable devices at home to monitor their heart rhythm and blood pressure. The goal is to learn how often these drugs cause high blood pr…

This study follows 5,000 adults with persistent atrial fibrillation (a type of irregular heartbeat) in Southwest China for up to 5 years. Researchers will collect information on patients' health, treatments, and outcomes to learn what works best for managing the condition. The go…

This study looks at whether a small device placed under the skin (an implantable cardiac monitor) can find hidden atrial fibrillation in people with heart failure who are at high risk for stroke. About 477 participants will either get the monitor or standard care. The goal is to …

This study looks at 1,400 women who had a stroke with no known cause. Researchers want to see if using a small heart monitor for a long time can find hidden irregular heartbeats (atrial fibrillation) and if blood thinners can then prevent another stroke. The goal is to understand…

This study tests whether watching storytelling videos can help African American and Black patients with atrial fibrillation (an irregular heartbeat) start and continue taking blood thinners to prevent strokes. About 80 adults who are not currently on blood thinners but should be …

This study looks at whether insulin resistance (when the body doesn't respond well to insulin) can predict how well a heart procedure called pulsed field ablation works for people with atrial fibrillation (an irregular heartbeat). About 120 non-diabetic patients having their firs…

This study collects data and blood samples from over 2,400 people with atrial fibrillation who are scheduled for a heart ablation procedure. Researchers hope to find clinical and genetic clues that predict whether the ablation will work. The goal is to better select patients for …

This study aimed to compare a new, more precise ablation technique for atrial fibrillation with the standard approach. It planned to enroll people with symptomatic atrial fibrillation that did not respond to medication. However, the study was withdrawn before any participants wer…

This study follows 186 adults in Europe undergoing a heart procedure (catheter ablation) for atrial fibrillation, using an AI software to guide treatment. The goal is to see how well the AI works in everyday practice, including safety, long-term heart rhythm control, and healthca…

This study aims to classify people with atrial fibrillation (AFib) into groups based on the electrical patterns in their hearts, using computer simulations. Researchers hope this will lead to more targeted treatments. About 91 adults with AFib will have their heart activity measu…