Hereditary skin disorder

This Phase 2 trial tested whether oral cimetidine (Tagamet), a common heartburn drug, can reduce light sensitivity in people with erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP). These genetic conditions cause severe pain from sunlight exposure. The study en…

This phase 3 study tested the drug bimekizumab in 133 Chinese adults with moderate to severe plaque psoriasis. Participants received either bimekizumab or a placebo for 16 weeks. The main goals were to see if bimekizumab could clear at least 90% of psoriasis (PASI90) and achieve …

This completed Phase 3 trial tested the drug guselkumab (Tremfya) in 211 people with skin of color who have moderate-to-severe plaque psoriasis or scalp psoriasis. Participants received either guselkumab or a placebo injection. The study measured how well the drug cleared skin le…

This study is testing how the drug guselkumab affects the immune system in people with two types of psoriasis: plaque and guttate. Twenty-five adults will receive guselkumab injections over 44 weeks. Researchers will measure changes in immune cells in the skin to understand how t…

This study tests whether adding a weight-loss drug (tirzepatide) to a standard psoriasis treatment (ixekizumab) helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 250 adults will receive either ixekizumab alone or both drugs together for…

This early-phase study tested the safety of rituximab, a drug that targets faulty white blood cells, in 7 adults with rare immune diseases like pulmonary alveolar proteinosis and severe candidiasis. Participants received several doses over 6 months and were monitored for 18 month…

This study investigates whether clascoterone cream 1%, an FDA-approved acne medication, works by reducing sebum (skin oil) production. Researchers will measure forehead oil levels and changes in skin bacteria in 40 participants aged 12 and older with mild to moderate acne. The go…

This phase 2 trial tested whether combining two drugs, romidepsin and lenalidomide, is safe and effective for people with peripheral T-cell lymphoma (PTCL) who haven't had treatment yet. PTCL is a rare blood cancer with no standard therapy, and current options like CHOP chemother…

This study looked at how a new oral medication (sebetralstat) works in the bodies of 11 teenagers aged 12 to 17 with hereditary angioedema (HAE) types I or II. The goal was to measure drug levels and timing in the blood. All participants were already in a larger HAE trial. The st…

This study looked at the long-term safety of an oral medication called KVD900 for treating swelling attacks in people with hereditary angioedema (HAE) types I or II. The trial enrolled 145 adolescents and adults who had already completed a previous study. Participants took KVD900…

This study tested a drug called Garadacimab in 22 children aged 2 to 11 with hereditary angioedema, a condition that causes sudden, painful swelling. The drug is given as a shot under the skin to prevent attacks. The study looked at safety and how well it works. It has already be…

This study tested the long-term safety and effectiveness of garadacimab, a monthly injection, for preventing attacks of hereditary angioedema (HAE) — a rare condition causing severe swelling. 171 people aged 12 and older who had frequent HAE attacks took part. The goal was to see…

This study tested a new oral medication, JNJ-77242113, for long-term control of moderate-to-severe plaque psoriasis. 227 adults who completed a previous 16-week study continued treatment for up to 36 more weeks. The goal was to see how well the drug kept skin clear over time.

This Phase 3 study tested an ointment called TMB-001 in 153 people aged 6 and older with X-linked or ARCI ichthyosis, conditions that cause dry, scaly, and cracked skin. Participants applied the ointment or a placebo daily for 12 weeks, with some continuing for maintenance. The g…

This completed trial tested whether adding vitamin D supplements to standard acne treatment (azithromycin and a topical retinoid) improves acne more than standard treatment alone. Fifty-eight people aged 13 to 40 with acne vulgaris took part. The main goal was to see if the combi…

This study tested two doses of bimekizumab, a drug that targets inflammation, in 41 adolescents aged 12 to 17 with moderate to severe plaque psoriasis. The main goals were to measure how the drug behaves in the body and to check its safety. Researchers also looked at how well it …

This phase 2 trial tested a drug called orticumab in 77 adults with moderate-to-severe psoriasis who also had cardiometabolic risks (like obesity and high cholesterol). The goal was to see if orticumab could safely reduce skin plaques and inflammation linked to heart disease. Par…

This phase 3 trial tested whether a new biologic called CMAB015 works as well as secukinumab (Cosentyx) for moderate-to-severe plaque psoriasis. 336 adults received either drug for up to 48 weeks. The main goal was to see if at least 75% of skin symptoms improved by week 12. The …

This early trial tested a new drug called navenibart in 29 people with hereditary angioedema (HAE), a condition that causes sudden, painful swelling attacks. Participants received one or two doses of the drug to check its safety and how well it might reduce attacks. The study is …

This study tested the long-term safety and effectiveness of donidalorsen, an injectable drug, in 20 people with hereditary angioedema (HAE), a condition that causes sudden, painful swelling attacks. Participants received different doses over 64 weeks. The main goal was to check f…

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This study tested special clothing made with Lumiton yarn that captures sunlight and turns it into red and near-infrared light, aiming to improve skin conditions like psoriasis, alopecia areata, and polymorphous light eruption. Eighteen adults with mild-to-severe forms of these c…

This study tested an oral tablet called JNJ-77242113 in 90 adults with moderate-to-severe plaque psoriasis. Participants were randomly assigned to receive the drug or a placebo for 16 weeks. The main goal was to see if the drug could improve psoriasis symptoms by at least 75% com…

This completed Phase 3 trial tested whether the experimental drug zasocitinib works better than the approved drug deucravacitinib for moderate-to-severe plaque psoriasis. Over 600 participants took one tablet and one capsule daily for 16 weeks. The main goal was to see how many a…

This completed phase 3 trial tested the drug guselkumab against a placebo in 338 adults with moderate plaque psoriasis covering only 2-15% of their body but including special sites like the scalp, face, or genitals. The goal was to see if guselkumab could clear or nearly clear ps…

This study tracked over 2,300 adults in Korea who were prescribed Skyrizi (risankizumab) for moderate to severe plaque psoriasis or psoriatic arthritis. Researchers monitored side effects and symptom changes for 52 weeks during routine doctor visits. The goal was to confirm the d…

This study tested Daxxin Psoriasis Shampoo in 41 adults with moderate scalp psoriasis. Participants used the shampoo 3 to 7 times a week for 6 weeks. The goal was to see if it reduced scalp redness, thickness, and scaling, and improved quality of life. Results showed most people …

This study tested whether a higher dose of the drug brodalumab works better than the standard dose for people with moderate-to-severe plaque psoriasis who weigh at least 120 kg. The trial involved 385 adults and lasted 52 weeks. The main goal was to see if more patients on the hi…

This study looked at 781 adults with moderate-to-severe plaque psoriasis and metabolic syndrome (a cluster of conditions like high blood pressure and obesity). Researchers wanted to see if adding a lifestyle intervention (diet and exercise) to the drug Secukinumab (Cosentyx) impr…

This study tested a drug called bimekizumab in 60 adults with moderate-to-severe plaque psoriasis who had not improved with other similar treatments. The drug works by blocking certain inflammatory substances in the body to reduce skin redness, scaling, and thickness. The main go…

This study tested a new drug called bimekizumab in 567 adults with moderate to severe plaque psoriasis. Participants received either bimekizumab, a placebo, or another active drug. The main goal was to see how well bimekizumab cleared skin lesions after 16 weeks. Results showed s…

This phase 3 study tested bimekizumab, a drug given by injection, against a placebo in 435 adults with moderate to severe plaque psoriasis. The main goal was to see how many people achieved at least 90% skin clearing after 16 weeks. The trial also looked at complete clearing and …

This study compares two already-approved drugs, risankizumab (injection) and deucravacitinib (pill), for adults with moderate plaque psoriasis. About 393 participants who haven't used biologics before will receive one of the treatments for up to 44 weeks. The goal is to see which…

This Phase 3 trial tested bimekizumab against secukinumab and placebo in 743 adults with moderate to severe plaque psoriasis. The main goal was to see how many patients achieved complete skin clearance (PASI100) at 16 weeks. Bimekizumab showed superior results compared to secukin…

This Phase 3 trial tested netakimab, a biologic drug given as a shot, against a placebo in 202 Chinese adults with moderate-to-severe plaque psoriasis. The main goal was to see if netakimab could improve skin symptoms by at least 75% (PASI75) or achieve clear/almost clear skin (s…

This study tested a new medicine called bimekizumab against an existing drug (adalimumab) in 478 adults with moderate to severe plaque psoriasis. The goal was to see if bimekizumab could clear more skin at 16 weeks. Participants received either bimekizumab or adalimumab, and then…

This study looked at the long-term safety and tolerability of bimekizumab in over 1,300 adults with moderate to severe plaque psoriasis. Participants who completed earlier studies received bimekizumab injections over several years. The main goal was to track side effects and see …

This study tested a new daily medicine called ESK-001 in 862 adults with moderate to severe plaque psoriasis. The goal was to see if it reduces psoriasis severity and is safe, comparing it to a placebo and an existing drug (apremilast). Participants took the medicine for 24 weeks…

This study tested whether a new daily pill, ESK-001, can safely reduce psoriasis severity in adults with moderate to severe plaque psoriasis. Over 900 participants took either ESK-001, a placebo (dummy pill), or an approved psoriasis drug (apremilast) for 24 weeks. Researchers me…

This study looked at whether non-surgical gum disease treatment could reduce inflammation and improve blood fat levels in young adults with severe periodontitis. Fifty participants (25 with gum disease and 25 healthy) were involved. Those with gum disease received deep cleaning a…

This Phase 2 trial tested whether Humira (adalimumab), a drug used for arthritis, can help people with Netherton syndrome, a rare genetic skin condition that causes severe inflammation, itching, and pain. Eleven patients received six injections over three months, followed by thre…

This study tested a drug called PF-06651600 in over 1,000 adults and teenagers with alopecia areata, a condition that causes patchy or complete hair loss. The goal was to see if the drug is safe and helps hair grow back over the long term. A smaller group also checked how well th…

This study tested a new ointment (LEO 90100) against a standard one (Daivobet) for stable plaque psoriasis in 604 Chinese adults. Participants applied the treatment for 4 weeks. The goal was to see if the new ointment could clear or nearly clear psoriasis patches better than the …

This study followed 48 people with hereditary angioedema (HAE) in Poland who were taking lanadelumab as part of a national drug program. Researchers tracked how many participants remained attack-free over 24 months, how many attacks still needed rescue treatment, and the severity…

This study tested a drug called alemtuzumab (Campath) as a first treatment for children with hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The goal was to see if it could help children survive until they could receive a stem cell transplan…

This study looked at how the drug afamelanotide (Scenesse) behaves in the bodies of 28 people with erythropoietic protoporphyria (EPP), a rare condition that causes severe pain on sun exposure. Researchers measured the drug's concentration in the blood after a single implant. The…

This Phase 2 trial tested the drug bimekizumab in 49 adults with moderate to severe plaque psoriasis. Participants received either bimekizumab or a placebo, and researchers measured how well the drug cleared skin and how long it stayed in the body. The goal was to see if bimekizu…

This study tested a new dual laser treatment for vulvar lichen sclerosus, a chronic skin condition causing discomfort. 66 participants were randomly assigned to receive either laser therapy or standard steroid cream. The goal was to see if the laser works as well as the cream, po…

This study tested whether psoriasis patients who are stable on biologic drugs (IL17 or IL23 inhibitors) can safely reduce their dose without their skin condition getting worse. Researchers enrolled 244 adults with plaque psoriasis who had been on a normal dose for at least 6 mont…

This Phase 3 trial tested a drug called imsidolimab in 45 adults with generalized pustular psoriasis (GPP), a rare and severe skin condition that causes painful pustules. Participants received either a single intravenous dose of imsidolimab (750 mg or 300 mg) or a placebo. The ma…

This completed Phase 1 trial compared a generic tretinoin gel (0.04%) to the brand-name RETIN-A MICRO for treating acne vulgaris. Over 1,000 participants aged 12 to 40 with mild to moderate acne applied the gel daily for 12 weeks. The goal was to see if the generic version works …

This study looked at whether QLETLI, a biosimilar of adalimumab, is safe and effective for children and teens aged 4 to 17 with severe plaque psoriasis. A total of 80 participants were followed for 24 weeks. The main goal was to see how much their psoriasis symptoms improved, mea…

This study tested whether platelet-rich plasma (PRP) can improve tendon healing in people with a torn rotator cuff. Forty adults having arthroscopic repair surgery were split into two groups: one received PRP during surgery, the other did not. Researchers compared tendon tissue s…

This observational study followed 331 adults with moderate-to-severe plaque psoriasis who were treated with tildrakizumab (Ilumetri) as part of their routine care. Researchers tracked how much the skin cleared and how quality of life improved over up to two years. The goal was to…

This small early-phase trial tested an experimental drug called rigosertib in just 2 people with a rare blistering skin disease (recessive dystrophic epidermolysis bullosa) who also had advanced skin cancer. The goal was to see if the drug could shrink tumors and whether it was s…

This study tested the drug risankizumab (Skyrizi) in 214 adults with moderate to severe genital or scalp psoriasis. Participants received either the drug or a placebo for 16 weeks, then all received the drug. The goal was to see if it could clear or nearly clear the skin in these…

This study tested an experimental drug called JNJ-77242113 in 255 adults with moderate-to-severe plaque psoriasis. The goal was to see if different doses could clear at least 75% of skin symptoms after 16 weeks compared to a placebo. Participants had psoriasis for at least 6 mont…

This study tested a drug called pegcetacoplan in 124 adults and teens with two rare kidney diseases (C3G and IC-MPGN). The goal was to see if the drug could reduce protein in the urine, a sign of kidney damage. Participants received either the drug or a placebo twice a week for 2…

This early-stage trial tests a new drug called SHR-1139 in healthy volunteers and people with moderate-to-severe plaque psoriasis. The main goal is to check safety and how the body handles the drug. A total of 64 participants will receive either the drug or a placebo, with doses …

This study tested whether adding metformin, a common diabetes drug, to cyclosporine works better for psoriasis than cyclosporine alone. Thirty-two adults with moderate to severe psoriasis took part. Researchers measured skin improvement, body surface area affected, and quality of…

This study tested whether people with moderate-to-severe plaque psoriasis who achieve complete skin clearance after 20 weeks of guselkumab (Tremfya) can maintain that control with injections every 16 weeks instead of every 8 weeks. About 880 participants were enrolled, and the ma…

This study reviewed medical records of 115 Chinese people with hereditary angioedema (HAE) to see how well two approved drugs work in real life. One drug, lanadelumab, is used to prevent attacks, and the other, icatibant, treats sudden attacks. Researchers measured attack rates a…

This study tested the acne cream Winlevi in 10 people with darker skin tones (Fitzpatrick types IV, V, VI). The goal was to see how well it cleared or nearly cleared acne after 16 weeks. Acne is very common, but there is little research focused on skin of color, so this study hel…

This study tested a drug called bitopertin in 75 adults with erythropoietic protoporphyria (EPP), a rare condition that causes severe pain from sunlight exposure. The goal was to see if the drug is safe and can lower levels of a harmful substance in the blood. Participants receiv…

This study tested a higher dose (10 mg/kg every 8 weeks) of the drug TA-650 in 51 adults with psoriasis who had initially improved on the standard dose of Remicade but later lost that benefit. The goal was to see if the increased dose could again reduce skin symptoms. Participant…

This study tested a gel called SGX302, which is activated by visible light, on 15 people with mild-to-moderate plaque psoriasis. The goal was to see if it could clear or nearly clear skin lesions over 18 weeks. The treatment is applied to the skin and then exposed to light, aimin…

This study tested the drug apremilast (Otezla) in 203 Chinese adults with moderate to severe plaque psoriasis. Participants took either apremilast or a placebo pill twice daily for 16 weeks. The main goal was to see if more people on apremilast achieved at least a 75% improvement…

This study followed 42 children aged 6 to 17 with moderate to severe plaque psoriasis in China who were treated with Cosentyx® (secukinumab) for up to 52 weeks. The goal was to see how safe and effective the drug is in real-world settings. Researchers tracked side effects and mea…

This study looked at the long-term safety and effects of the drug apremilast in 160 children aged 6 to 17 with moderate to severe plaque psoriasis. Participants who had already completed one year of treatment could continue taking the drug for up to 208 weeks (about 4 years). The…

This completed trial tested two different cumulative doses of the acne drug Roaccutane (120 mg/kg vs 150 mg/kg) in 91 people with severe cystic acne. Researchers measured how well each dose reduced acne lesions and severity, and tracked whether acne returned within a year. The go…

This Phase 3 trial tested a new drug called JS005 in 747 adults with moderate-to-severe plaque psoriasis. JS005 is an antibody that blocks IL-17A, a protein that drives inflammation in psoriasis. The study compared JS005 to a placebo to see if it could improve skin clearance, mea…

This study tested whether a generic tapinarof cream works as well as the brand-name VTAMA® cream for adults with plaque psoriasis. 560 participants used either the generic cream, the brand-name cream, or a placebo for 12 weeks. The goal was to see if the generic version is equall…

This early study tested a cream called SXR1096 on 9 people with Netherton syndrome, a rare inflammatory skin disease. The cream aims to block certain enzymes that cause skin problems. Participants applied the cream and a placebo to different skin areas for one month to check safe…

This phase 2 clinical trial tested an experimental oral drug called D-2570 in 161 adults with moderate-to-severe plaque psoriasis. Participants were randomly assigned to one of three doses of D-2570 or a placebo for 12 weeks. The main goal was to see how many people achieved at l…

This small study tested whether a short course of HIV drugs (emtricitabine and tenofovir) could reduce inflammation in people with plaque psoriasis. Only 8 people took part, and the main goal was to see changes in certain markers in skin biopsies. The study is complete, but resul…

This study tested whether tofacitinib, a drug already approved for arthritis, is safe and helpful for immune-related skin conditions in people with Down syndrome. 47 adolescents and adults with Down syndrome and skin issues like eczema or psoriasis took the drug. Researchers chec…

This completed study tested whether applying a dextrose (sugar) gel with ultrasound, called phonophoresis, can improve mild to moderate acne. 115 people aged 18 to 30 with acne took part. The goal was to see if this approach reduces acne lesions and severity.

This study tested two treatments for lichen sclerosus, a chronic skin condition causing itching and pain. 246 women received either a non-ablative CO2 laser treatment or a steroid cream (clobetasol) for three months. The goal was to see which works better at reducing symptoms lik…

This large study looked at whether taking daily vitamin D or fish oil supplements could lower the risk of developing autoimmune diseases (like rheumatoid arthritis), reduce signs of inflammation in the blood, and ease chronic knee pain. Over 25,000 adults without prior cancer or …

This study tested the long-term safety of a daily pill called ASC40 (Denifanstat) in 240 people with moderate to severe acne who had already completed a previous phase 3 trial. Participants took the drug once daily for up to 40 weeks, with regular blood tests and checkups to moni…

This study looked at whether tildrakizumab, a drug already approved for psoriasis, can improve blood flow to the heart in people with moderate-to-severe psoriasis. 36 adults took the drug for 6 months, and researchers measured heart function using special scans. The goal was to s…

This completed pilot study tested whether filtering inflammatory molecules from the blood using a device called Efferon CT can help people with severe psoriasis. Sixty adults with moderate to severe plaque psoriasis received the treatment, which involves circulating blood through…

This phase 2 trial tested an experimental drug called BMS-986322 in 109 adults with moderate-to-severe plaque psoriasis. Participants received either the drug or a placebo for 12 weeks. The main goal was to see if the drug could significantly reduce psoriasis skin symptoms (measu…

This study tested an oral medication called deucrictibant for quickly treating attacks of hereditary angioedema (HAE), a condition causing sudden, painful swelling. The trial involved 134 adolescents and adults with HAE types 1, 2, or 3. Participants took either the drug or a pla…

This study tested an experimental oral drug called TAK-279 in 1,108 adults with moderate-to-severe plaque psoriasis. Participants received either TAK-279, a placebo, or an approved psoriasis drug (apremilast) for up to 69 weeks. The main goal was to see if TAK-279 could clear or …

This study tested three types of chemical peels—50% glycolic acid, 30% salicylic acid, and modified Jessner's—on 90 adults with mild to moderate facial acne and post-acne dark spots. Participants received one type of peel, and doctors measured improvements in acne severity and pi…

This phase 2a study tested an experimental drug called ASKP1240 in 60 adults with moderate to severe plaque psoriasis. Participants received either the drug or a placebo intravenously. The main goals were to check safety, how the drug moves through the body, and early signs of ef…

This study tested an oral drug called BCX4161 to prevent attacks of hereditary angioedema (HAE), a condition that causes sudden, painful swelling. Over 12 weeks, 110 adults with HAE took either a low dose, high dose, or placebo pill. Researchers tracked how many swelling attacks …

This completed study followed 2759 adults with moderate to severe plaque psoriasis to see how well risankizumab works compared to other commonly used biologic drugs. Researchers measured skin clearance and how long patients stayed on treatment. The goal was to understand real-wor…

This study tested a new oral medication, SAR441566, in 221 adults with moderate to severe plaque psoriasis. Participants received either the drug or a placebo for 12 weeks. The main goal was to see if the drug could reduce psoriasis severity by at least 75%. Results will help det…

This study tested an oral medication called deucravacitinib against a placebo in 154 adults with moderate-to-severe scalp psoriasis. The main goal was to see if more people achieved clear or almost clear scalp skin after 16 weeks of treatment. This is a disease-control study, mea…

This pilot study tested higher-than-standard doses of risankizumab in 20 adults with moderate-to-severe plaque psoriasis. The goal was to see if higher doses could better reduce certain skin immune cells (resident memory T cells) and improve skin clearance. The study was complete…

This Phase 3 study tested an experimental oral drug called TAK-279 in 693 adults with moderate-to-severe plaque psoriasis. Participants received either TAK-279, an approved treatment (apremilast), or a placebo for up to 61 weeks. The main goal was to see if TAK-279 reduces skin p…

This study monitored 52 Japanese patients with generalized pustular psoriasis (GPP) who received spesolimab for acute symptoms. Researchers tracked side effects and disease activity in everyday clinical settings, not a controlled lab environment. The goal was to see how well the …

This program in China gave a single infusion of spesolimab to 39 people with a severe skin condition called generalized pustular psoriasis (GPP) during a flare-up. Participants had no other treatment options available. The goal was to control the flare and monitor for side effect…

This study tested four different doses of an experimental drug (BI 655130) against a placebo in 152 adults with moderate to severe palmoplantar pustulosis (PPP), a skin condition causing painful pus-filled blisters on the palms and soles. The main goal was to see which dose best …

This study tested a drug called spesolimab in 59 people with palmoplantar pustulosis (PPP), a painful skin condition causing pustules and plaques on the palms and soles. Participants received either low or high doses of spesolimab or a placebo for 12 weeks. The goal was to see if…

This phase 2 trial tested an oral drug called LY3972406 in 33 adults with moderate-to-severe plaque psoriasis. The study compared the drug to a placebo to see if it could reduce skin symptoms. Results will help determine if larger studies are warranted.

This study tested a single dose of spesolimab in 53 people with generalized pustular psoriasis (GPP) experiencing a moderate-to-severe flare. The drug aims to quickly clear skin pustules. Results showed that more patients receiving spesolimab had no visible pustules after one wee…

This study tested a combination of two acne treatments—Winlevi (a hormone-blocking cream) and adapalene 0.3% gel—to see how well they work together in real-life use. Twenty people with acne used both treatments for 16 weeks. The main goal was to see how many achieved clear or alm…

This study tested an oral drug called upadacitinib (RINVOQ) against a placebo and an injected drug (adalimumab/Humira) in 1705 people with active psoriatic arthritis who had not responded well to standard non-biologic treatments. The goal was to see if upadacitinib reduces joint …

This Phase 2 trial tested a drug called imsidolimab (ANB019) in 123 people with moderate to severe acne. The drug is a lab-made antibody designed to reduce inflammation. Researchers measured how much facial acne lesions decreased over 12 weeks compared to a placebo. The goal is t…

This study tested a drug called imsidolimab in 8 adults with generalized pustular psoriasis (GPP), a rare and severe skin condition. The drug is an antibody that targets inflammation. Researchers measured how well it worked using skin scores and other health markers. The goal was…

This phase 2 trial tested a monthly injection called imsidolimab (ANB019) in 59 adults with palmoplantar pustulosis, a chronic skin condition causing painful, pus-filled blisters on the palms and soles. The study compared the drug to a placebo to see if it could reduce the severi…

This phase 3 trial tested whether Bmab 1200, a biosimilar of the drug Stelara, works as well as Stelara for people with moderate to severe plaque psoriasis. 384 adults received either Bmab 1200 or Stelara over 40 weeks. The main goal was to see how much psoriasis symptoms improve…

This phase 3 study tested upadacitinib, an oral anti-inflammatory drug, in 642 adults with active psoriatic arthritis who had not responded well to at least one biologic treatment. Participants received either 15 mg or 30 mg of upadacitinib daily or a placebo. The main goal was t…

This study tested an experimental oral drug called LY4100511 (DC-853) in 222 adults with moderate-to-severe plaque psoriasis. Participants were randomly assigned to receive different doses of the drug or a placebo. The main goal was to see how well the drug clears skin and whethe…

This study tested whether a mobile game could help children aged 11-14 with chronic kidney failure better manage their condition. 68 children were split into two groups: one used the game, the other received standard education. Researchers measured changes in BMI, blood pressure,…

This completed study observed over 1,000 people with psoriasis who were prescribed OTEZLA (apremilast) for the first time. Researchers tracked side effects, symptom improvement, and quality of life over several years. The goal was to see how well the drug works in real-world sett…

This study tested a combination of two immune-targeting drugs, secukinumab and dupilumab, in 15 children with severe Netherton syndrome, a rare genetic skin disorder. The goal was to see if the treatment could improve survival and control the disease. The children received weight…

This study followed 140 people with hereditary angioedema (HAE) who were already taking lanadelumab. Researchers compared the number of swelling attacks during treatment to the number before starting the drug. Participants reported their symptoms via a smartphone app and during c…

This study tested whether an artificial intelligence tool called Legit Health Plus can help doctors track the severity of chronic skin conditions like acne, psoriasis, and eczema from a distance. 160 participants used a smartphone app for 6 months to take photos of their skin and…

This completed study tested whether an AI device could help 16 doctors (10 general practitioners and 6 dermatologists) more accurately diagnose 13 different skin conditions, including melanoma, psoriasis, and acne. The doctors reviewed 29 medical images, first giving a diagnosis …

This study tested whether an artificial intelligence (AI) tool could help primary care doctors diagnose skin conditions more accurately. Nine doctors reviewed 30 images of various skin problems, first giving their own diagnosis and then a final diagnosis after seeing the AI's sug…

This study tested a new type of microscope called SECM to see if it can take clear pictures of pigmented skin lesions like moles. Sixteen healthy adults with moles on their forearms had their skin imaged with both a standard dermatoscope and the SECM device. The goal was simply t…

This study tested whether a monthly injection of spesolimab can prevent flare-ups of generalized pustular psoriasis (GPP), a rare and severe skin condition. 123 people aged 12 to 75 with clear or nearly clear skin joined the trial. They received either one of three doses of speso…

This study tests two different numbing creams—one with lidocaine/prilocaine and another with lidocaine/tetracaine—against a placebo to see which works best for pain during Q-switched 532nm laser treatment for age spots (lentigines) and skin rejuvenation. Women aged 25 to 65 with …

This study compared two painkillers, oliceridine and morphine, in 252 adults undergoing laparoscopic colorectal surgery. The goal was to see if oliceridine causes less nausea and vomiting after surgery. Patients used a pump to control their pain medicine for up to 3 days after th…

This study tested a cream made from green tea extract (Veregen) on 6 people with lamellar ichthyosis, a rare genetic condition that causes severe dry, scaly skin. Participants applied the cream to one side of their body and a standard moisturizer to the other for 4 weeks. The goa…

This study tested a self-guided online program for people with psoriasis. 348 adults were split into two groups: one got the app plus their regular treatment, the other got regular treatment alone. The main goal was to see if the app improved quality of life over 12 months.

This study tests whether a daily skincare routine using Cetaphil cleansers and moisturizers can improve skin symptoms and quality of life for people with mild-to-severe plaque psoriasis. Participants apply the products to one side of their body while continuing their usual prescr…

This study tested a drug called MT-7117 in 165 adults and adolescents (ages 12-75) with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP), conditions that cause severe pain from sunlight exposure. The goal was to see if the drug could delay the first symptoms o…

This study tested whether the drug deucravacitinib can improve quality of life for adults with moderate-to-severe plaque psoriasis. 180 participants received either the drug or a placebo. The main goal was to see if more people on the drug reported no or minimal impact of their s…

This study compared two therapies—myofeedback and neuromuscular electrical stimulation—to see which better improves arm and hand function in children aged 6 to 14 who have one-sided weakness (hemiplegia) after brain tumor surgery. Forty-five children participated, and researchers…

This study tested a gel containing dapsone (7.5%) against a placebo gel in 100 adults with mild-to-moderate acne. Participants applied the gel once daily for 8 weeks, and researchers tracked changes in acne lesions, skin oil, redness, and quality of life. The goal was to see if t…

This study tested two strengths of a topical isotretinoin ointment (TMB-001) in 34 people aged 9 and older with congenital ichthyosis, a rare genetic skin condition causing severe scaling. The main goal was to see if the ointment could reduce scaling by at least 50% compared to a…

This pilot study tested whether rimegepant (Nurtec), a drug used for migraines, can reduce chronic abdominal pain in people with irritable bowel syndrome (IBS). Thirty-nine adults with non-constipation IBS took either the drug or a placebo for 28 days. Researchers measured change…

This early-phase study tested a medicated foam called ARQ-154 (roflumilast) in 22 children aged 2 to 12 with scalp and body psoriasis. The goal was to see how much of the drug enters the bloodstream and whether it is safe. Researchers monitored side effects and skin reactions ove…

This study tested a laser device (NIRA Laser M2.1) on 120 adults aged 35 and older to see if it could safely reduce full-face wrinkles. Some participants also used a topical cream after the laser. Wrinkle improvement was judged by experts looking at before-and-after photos, and p…

This study looked at whether aerobic exercise and virtual reality games could improve functional capacity, activity, and participation in children aged 6-10 living in care facilities. Sixty-three children were split into groups: one did aerobic exercise, one played VR games, and …

This completed study tested a moisturizing medical device called RL3020-DP0364 (Dexeryl) in 40 adults with stable mild plaque psoriasis, dry skin, and itching. Participants applied the cream to their whole body (except head) for about a month. The main goal was to see if it reduc…

This study compared a new tapinarof cream to an already-approved one (Vtama®) for treating plaque psoriasis, a skin condition causing red, scaly patches. 575 adults with mild to moderate psoriasis used one of the creams or a placebo for a set time. The goal was to see if the new …

This study looked at how a prescription lotion (IDP-118) works in children aged 4 to 16 with moderate to severe plaque psoriasis. Researchers measured how much of the drug enters the bloodstream and whether it affects the body's stress hormone system (HPA axis). The goal was to c…

This study looked at whether intermittent fasting (eating only during certain hours) can reduce disease severity and improve quality of life for people with psoriasis and psoriatic arthritis. Sixty overweight adults were randomly assigned to either follow an intermittent fasting …

This Phase 3 study tested the drug tildrakizumab in 99 adults with moderate to severe nail psoriasis. Participants received either the drug or a placebo for 28 weeks to see if it improved nail appearance and reduced pain. The trial is complete, and results may help determine if t…

This study tested a cream made from plant compounds (total coumarins) in 88 adults with mild-to-moderate psoriasis. Participants applied the cream or a placebo for several weeks. The goal was to see if the cream safely reduces skin redness, scaling, and thickness better than a pl…

This study tested whether a smartphone-based cognitive behavioral therapy (CBT) program could help adults with psoriasis who also have depression symptoms. 30 participants used the app for 8 weeks with guidance from a coach. The goal was to see if people would engage with the pro…

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration form of adalimumab (AVT-02). Researchers measured injection site pain and how well patients stuck with their treatment over 180 days…

This study tested a dark spot corrector serum along with two different skincare routines in 48 women with moderate age spots. Over 16 weeks, doctors checked if the spots got lighter, smaller, or less noticeable. The goal was to see if the treatment was safe and effective for impr…

This study tested whether a cream made from icariin, a plant compound, can improve acne and reduce acne scars. Twenty-five adults applied the cream or a control solution to their face twice daily for two months. The goal was to see if it lowers the number of pimples and scars and…

This study tested whether cannabidiol (CBD) can reduce severe itching in 10 children with a rare genetic skin condition called epidermolysis bullosa. The children took CBD syrup three times a day for a month. Researchers measured itch, pain, sleep, and quality of life before and …

This study looked at whether using finger puppets, video games, or stress balls can help reduce fear and improve emotional behavior in children aged 4-6 who need inhaler therapy. 120 children participated, and researchers measured their fear levels, emotional responses, and paren…

This early-stage study tested a new drug called CAN10, an antibody that blocks a protein involved in inflammation. Researchers gave single doses to 80 healthy adults and repeated doses to people with mild to moderate plaque psoriasis to see if it is safe and how the body processe…

This study tested an experimental drug called TQH3906 in 209 adults with moderate to severe plaque psoriasis. The goal was to see if it could safely clear skin patches and improve symptoms over 12 weeks. Researchers measured how much skin improved using standard psoriasis scores.

This study tested a drug called sebetralstat in 36 children aged 2 to 11 with hereditary angioedema (HAE) types I or II, a condition that causes sudden, painful swelling. The goal was to see if the drug is safe and how well it works to relieve attacks. The trial was open-label, m…

This study tested an experimental drug called SCD-044 in 263 adults with moderate to severe plaque psoriasis. Participants received either the drug or a placebo to see if it could improve skin symptoms like redness and scaling. The main goal was to measure how many people achieve…

This study tested two ways to inject a cortisone medicine (triamcinolone acetonide) to treat genital lichen sclerosus, a skin condition causing itching, pain, and discomfort in women. Twenty women who did not improve with standard creams received injections either by a traditiona…

This study looked at two different ways to use light therapy (photodynamic therapy) for treating port-wine stains—a type of birthmark—in 33 children aged 3 to 12. One group got a lower-power light for a longer time, and the other got a higher-power light for a shorter time. Both …

This study tested whether the diabetes drug metformin can treat moderate to severe facial acne as well as the antibiotic doxycycline. Sixty-eight people aged 12 to 40 took either metformin twice daily or doxycycline once daily for 12 weeks. Researchers counted pimples and used a …

This study tested whether adding ear acupressure to a standard acne gel (adapalene) helps clear pimples better than the gel alone. Researchers enrolled 64 people with mild to moderate acne and compared the combination to the gel-only group. The goal was to see if the combo reduce…

This study tested a cream made from andaliman fruit extract on 40 adults with seborrheic keratosis, harmless skin growths on the face. Participants applied the cream daily for 12 weeks, and researchers checked for changes in the growths using a special camera. The goal was to see…

This early-phase study tested deucravacitinib, an oral drug, for treating nail psoriasis. The goal was to see if it improves nail appearance and symptoms. Only one person took part, and researchers measured changes in nail psoriasis severity over 48 weeks. Because it's so small, …

This study tested a drug called MT-7117 in 184 people aged 12 to 75 with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP), rare conditions that cause severe pain from sunlight. The goal was to see if the drug could delay the first signs of sun sensitivity (bur…

This phase 2 trial tested a drug called MT-7117 in 102 adults with erythropoietic protoporphyria (EPP), a rare condition that causes severe pain from sunlight. Participants took either a low dose, high dose, or placebo daily for 16 weeks. The goal was to see if the drug could inc…

Pfizer completed a Phase 1 study testing a new topical drug called PF-07905428 for acne. The study included 52 healthy volunteers and people with moderate to severe acne, who applied the drug daily for 14 or 28 days. The main goal was to check safety and side effects, not to see …

This study tested a facial moisturizer in 47 people with mild to moderate acne over 4 weeks. Researchers checked skin dryness, redness, and overall appearance, and participants reported how their skin felt. The goal was to see if the moisturizer is gentle and helpful for acne-pro…

This study tested two stress and symptom management programs for adults with neurofibromatosis (NF1, NF2, or schwannomatosis). The programs were delivered through live videoconferencing over 8 weekly sessions. Researchers measured changes in quality of life and emotional well-bei…

This study tested whether a low-FODMAP diet—which limits certain carbohydrates that can cause gas and bloating—can reduce symptoms and improve quality of life in people with irritable bowel syndrome (IBS). 183 adults with IBS were split into two groups: one received education on …

This study tested a drug called icatibant (Icanticure) in 5 adults with a rare condition that causes sudden, painful swelling attacks. The goal was to see how quickly the drug relieved symptoms and if it was safe. Participants received the injection for free during an acute attac…

This study tested an oral medication called deucrictibant for quickly relieving swelling and pain attacks in people with hereditary angioedema (HAE) types I and II. 74 adults received either one of three doses of the drug or a placebo during an attack. The main goal was to see if…

This study looked at whether taking probiotics can reduce a protein in the blood linked to acne inflammation. Researchers measured this protein in 50 adults with mild to moderate acne before and after probiotic treatment. The goal was to see if probiotics could help ease acne sym…

This study tested whether a numbing cream (ropivacaine) can reduce severe pain during bath and dressing changes in children and young adults with epidermolysis bullosa, a rare genetic skin condition. Ten participants applied the cream before dressing changes and reported their pa…

This study tested whether an 8-week ketogenic or Mediterranean diet could reduce inflammation in 26 adults with obesity, psoriasis, and psoriatic arthritis. Participants followed one of the two diets, and researchers measured skin severity (PASI score) and joint activity (DAPSA s…

This study looked at whether children with year-round allergic rhinitis can use a nasal steroid spray only when symptoms bother them, instead of every day. Sixty-eight children aged 6 to 18 were randomly assigned to either daily use or as-needed use of fluticasone furoate spray. …

This study in Japan looked at 32 children (ages 2 to under 18) with hereditary angioedema who received Firazyr injections for acute attacks. Researchers tracked side effects and how quickly symptoms resolved over 3 months. The goal was to gather real-world safety and effectivenes…

This Phase 2 trial tested a new acne gel called IDP-126 against a standard gel (Epiduo Forte) and a placebo gel in 686 people aged 12 and older with moderate to severe acne. Participants applied the gel once daily for 12 weeks. Researchers measured changes in acne lesion counts a…

This study tested a cream called MC2-25 to see if it can safely reduce itching in women with vulvar lichen sclerosus, a skin condition that causes discomfort. 33 women used either the active cream or a placebo for 12 weeks. The main goal was to measure how much the worst itching …

This study tested a 12-week online program called Immune Strength for people with psoriasis or psoriatic arthritis. The program provided tips on stress, sleep, nutrition, and exercise, plus one-on-one email coaching from a wellness professional. Researchers wanted to see if this …

This study tested a new drug called AX-158 in 31 adults with mild to moderate plaque psoriasis. Participants took either AX-158 or a placebo daily for 28 days, then were monitored for another 30 days. The main goal was to see if the drug is safe and tolerable, with some early che…

This study followed 291 adults with mild-to-moderate scalp psoriasis who were prescribed a cream containing calcipotriene and betamethasone (Wynzora®). Researchers measured how satisfied patients were with the treatment, its effect on quality of life, and how well it worked in re…

This early-stage trial tested a new oral drug called SAR441566 in 38 adults with mild to moderate psoriasis. Participants took the drug or a placebo twice daily for 4 weeks. The main goal was to check safety and tolerability, while also looking at changes in skin lesion severity.…

This study tested whether a shot of platelet-rich plasma (PRP) from a person's own blood works better than a common steroid shot for shoulder arthritis pain. Fifty adults with mild to moderate shoulder osteoarthritis received either a PRP or steroid injection. Researchers measure…

This pilot study tested whether cooling the skin with a device (the Zeltiq System) could safely reduce sebum production in 11 young men with acne. The treatment was applied to the upper back, and sebum levels were measured before and after. The goal was to see if a 30% reduction …

This pilot study tested a portable device called Spincare that sprays a nanofiber dressing onto wounds in people with recessive dystrophic epidermolysis bullosa (RDEB), a rare genetic condition causing fragile, blistering skin. Six participants with at least six chronic or recurr…

This study looked at whether people with mild-to-moderate psoriasis prefer using Wynzora cream over Enstilar foam. Thirty adults who had previously used Enstilar foam tried Wynzora cream for four weeks. Researchers used questionnaires to measure preference, treatment satisfaction…

This study looks at rare genetic disorders where the body can't make cholesterol properly, which can cause birth defects and learning problems. Researchers collect blood, urine, and tissue samples from affected people and their families to learn more about these conditions. The g…

This completed study followed 945 people, mostly children and young adults with severe eczema or related allergic conditions, along with their relatives. Researchers observed how these diseases progress over up to a year, using tests like allergy skin pricks, blood draws, and lun…

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

This study looks at how isotretinoin, a vitamin A-based acne medication, affects eye structures and tear production in people with severe cystic acne. Participants receive standard treatment and undergo eye exams, including dry eye tests and advanced imaging, before and during th…

This study tests whether wearable sensors and digital home tasks can track changes in movement, speech, and falls in people with ALS. About 20 participants will wear neck and wrist sensors and complete speech and handwriting tests over 48 weeks. The goal is to see if these digita…

This study followed 55 people with dental implants for 5 years to see if their history of gum disease (aggressive, chronic, or none) affected implant health. Participants received regular dental cleanings. Researchers measured bone loss, gum inflammation, and implant survival. Th…

This study looked at how the drug adalimumab affects gene activity in the skin of people with chronic plaque psoriasis. Researchers compared skin samples from normal, non-lesional, and lesional areas before and after treatment. The goal was to understand the immune changes that h…

This study looked at people with three rare genetic conditions—xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD)—that affect the body's ability to repair DNA. Researchers examined 709 participants to understand how these defects relate to cancer ri…

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This study investigates people with oculocutaneous albinism who have no known genetic cause for their condition. Researchers use advanced DNA analysis techniques to search for new or hidden mutations. The goal is to improve diagnosis and understanding of this inherited condition.

This study tested whether AI-generated educational material on acne could teach medical students as well as standard human-written material. 190 first- and second-year medical students were split into three groups: one read AI-generated content, one read content from the Turkish …

This completed study looked at inherited disorders common in Amish and Mennonite populations. Researchers collected medical histories, blood or cheek swab samples from 157 participants to find the genes behind these conditions. They also built a computer database of family trees …

This completed study enrolled 377 individuals and families with a high risk of breast or ovarian cancer due to known or suspected genetic factors. Researchers collected medical records, questionnaires, and biological samples to better understand the disease's natural history and …

This study looked for a new gene that causes hereditary lipodystrophy, a rare disease where people lose body fat and often develop diabetes and heart problems. Researchers studied DNA and cells from 2 patients who had the disease but no known genetic cause. The goal was to find t…

This study looked at how four different drinks—two prebiotic sodas, regular Coca-Cola, and Diet Coke—affect hunger, blood sugar, insulin, and appetite hormones in healthy men aged 18-40. Ten participants visited the lab four times, each time drinking one of the beverages in a ran…

This study looked at 24 adults with moderate-to-severe plaque psoriasis to understand how a single injection of risankizumab (Skyrizi) changes immune cells in the skin. The goal was to learn why some patients stay clear of psoriasis for up to 66 weeks without further treatment. R…

This pilot study tested whether time-restricted feeding (eating all daily calories between 8am and 2pm, then fasting for 18 hours) could reduce inflammation in men with mild to moderate psoriasis. 27 participants (including healthy volunteers) stayed at the clinic for 4.5 days, w…

This study looked at whether a food safety training program helps food service employees improve their knowledge, attitudes, and practices around safe food handling. About 200 adult workers took part, and the training covered personal hygiene and safe food preparation. The goal w…

This study looked at whether specialized training for nurses on how to care for children with a rare, severe skin condition called epidermolysis bullosa (EB) can reduce their stress and anxiety. The study involved 19 nurses and nursing assistants at a hospital in France. Research…

This study tested a school program called SocLaLola that uses a comic book to teach children aged 8-11 about pain. The goal was to see if it improves kids' understanding of pain and reduces their fear of moving. Eighty-two students from two primary schools took part. The program …

This pilot study tested a nurse-led educational program for people with psoriasis. Twenty-four participants received extra education sessions over six weeks, alongside standard care. The goal was to see if the program was feasible and could improve disease knowledge, self-managem…

This completed French survey of 300 hereditary angioedema (HAE) patients and their caregivers aimed to understand the challenges of using on-demand treatments for HAE attacks. Researchers collected data on attack frequency, severity, treatment delays, hospitalizations, and the fi…

This study looked at skin samples from 170 people with psoriasis, atopic dermatitis (eczema), or healthy skin to understand how a protein called Lyn is involved in inflammation. Researchers measured Lyn activity and related enzymes in both affected and unaffected skin. The goal w…

This completed study looked at 52 adults with plaque psoriasis who had been on biologic drugs for at least one year. Researchers used questionnaires to measure treatment satisfaction, quality of life, depression, and personality type. The goal was to find out which clinical and p…

This study tested a new questionnaire called DermCLCI-p to see if it accurately measures the long-term life impacts of moderate-to-severe psoriasis. 154 adults starting the medication risankizumab filled out the 30-question survey over 28 weeks. The goal was to validate the tool …

This study looked at how standing on a vibrating platform affects spinal reflexes in 15 healthy adults. Participants stood in different positions with or without vibration while researchers measured electrical signals from a leg muscle. The goal was to understand how vibration ch…

This study followed 60 heart transplant patients for one year to see if levels of a harmless virus called TTV in the blood are linked to infections or organ rejection. Researchers took monthly blood samples alongside routine care. The goal is to find a new way to monitor transpla…

This study looked at why children with hereditary epidermolysis bullosa (a rare condition causing fragile skin and painful blisters) often do not take prescribed opioid painkillers before baths and bandage changes. Researchers interviewed 10 children and their parents to understa…

This study tested whether removing a wound dressing just 6 hours after facial skin surgery is better than keeping it covered for 7 days. 144 adults with benign skin lesions like moles or cysts were randomly assigned to one of the two methods. Researchers checked for swelling, red…

This study looked at how skin cells from 30 people with recessive dystrophic epidermolysis bullosa (RDEB) grow and repair wounds. RDEB is a rare genetic condition that causes fragile skin and painful blisters. Researchers took small skin samples to study the cells in a lab, aimin…

This completed study created a French national registry for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected medical and genetic information from 28 patients to better understand these conditions and estimate how many people are affecte…

This study tested whether an artificial intelligence (AI) tool could help doctors diagnose rare and tricky skin conditions like generalized pustular psoriasis (GPP). Fifteen doctors, including both general practitioners and dermatologists, looked at 100 skin images. They first ga…

This study looked at how a genetic test that checks 25 genes linked to hereditary cancers is used in clinics. Over 1,500 people with a personal or family history of cancer took part. Researchers collected blood samples and had participants fill out questionnaires over five years …

This study aimed to create and test a decision aid for people with psoriasis or psoriatic arthritis who are starting or switching treatments. Researchers worked with 37 patients and their doctors to design a tool that supports shared decision-making. The goal was to help patients…

This study followed over 2,300 adults with moderate to severe plaque psoriasis to see how safe and effective secukinumab is in everyday medical practice. Researchers recorded side effects and how well the drug cleared skin symptoms. The goal was to gather real-world evidence, not…

This completed registry study in Japan looked at how doctors treat palmoplantar pustulosis (PPP), a skin condition causing pus-filled blisters on hands and feet. Researchers collected data from 276 patients' medical records and clinic visits to understand which treatments are use…

This study looked at a specific immune pathway (PGE2/IL22/IL17) in people with eczema to see if it plays a role in the disease. Researchers collected skin and blood samples from 38 participants, including those with eczema, psoriasis, and healthy volunteers. The goal was to ident…

This study looked at gene activity in immune cells from 30 people with hereditary angioedema and healthy volunteers. The goal was to see if certain receptors on monocytes are linked to inflammation and blood vessel problems. No treatment was given; the study was purely observatio…

This study looked at 173 Chinese patients to see if their skin type (based on the Baumann Skin Type system) affects how well they heal and scar after facial surgery for benign growths like moles or cysts. Researchers checked wound healing at 7 days and scar quality at 90 days usi…

This completed study aimed to find out how many patients with a certain set of symptoms actually have acute hepatic porphyria (AHP), a rare metabolic disorder. Researchers enrolled 150 adults aged 18 to 60 who had severe abdominal pain along with neurological symptoms like limb w…

This completed study tracked 132 children with obstructive sleep apnea who had their tonsils removed. Researchers recorded how many had breathing problems after surgery, especially those with other health issues. The goal was to create a simple flowchart to help doctors decide wh…

This completed study looked at skin samples from 40 people with psoriasis to understand how certain immune cells (CD4+ T cells) and a protein called S100A7 behave in psoriatic skin. Researchers used special staining techniques to measure these components. The goal was to learn mo…

This study tested an artificial intelligence algorithm designed to help primary care doctors decide whether a patient with a skin condition really needs to see a dermatologist. Researchers enrolled 200 adults with skin problems and had their doctors take photos of the affected ar…

This study tested a mobile health tool called CAARE to help children under 12 and their caregivers cope with emotional and behavioral challenges after a traumatic injury. Researchers measured changes in distress, PTSD symptoms, depression, and quality of life in 54 participants. …

This study followed 88 people with hereditary angioedema (HAE) types I or II who already use icatibant for sudden attacks. Participants filled out diaries for 48 hours after each attack to report symptom changes, severity, and anxiety levels. The goal was to gather real-world inf…

This study looked at fatigue in 33 adults with psoriatic arthritis or psoriasis. Researchers used questionnaires to measure tiredness and see how it relates to disease severity and treatments. The goal was to better understand fatigue and its impact on quality of life.

This study examined 152 people with hereditary ichthyosis to find out how common eye problems are. Participants received a full eye exam, including tests for dry eye, corneal shape, and vision. The goal was to detect hidden issues like keratoconus, which can lead to vision loss i…

This study looked at how the body processes cortisol in people with a rare genetic condition called familial partial lipodystrophy type 2 (FPL2). The goal was to see if increased activity of a certain enzyme (11β-HSD1) contributes to the severe metabolic problems seen in this dis…

This study tested two different ways to remove leftover glue from teeth after braces are taken off. 142 people who had braces or clear aligners were split into two groups: one used a special ultrasonic tool, the other used a polishing bur. Researchers checked plaque, bleeding, le…

This study followed 150 children aged 2 to 12 who have a port wine stain on a leg. Researchers tracked how the stain changes as the child grows, and whether it leads to problems like blood vessel issues or bone growth differences. The goal was to learn more about the condition an…

This study looked at how skin blood flow and nerve sensitivity differ in psoriasis plaques compared to healthy skin. Twenty adults with psoriasis on their back received mild electrical currents to deliver vasodilators (acetylcholine, sodium nitroprussiate, or plain water) into bo…

This study examined how the COVID-19 pandemic impacted skin allergy visits among healthcare workers. Researchers analyzed records from 341 healthcare workers who visited skin clinics before and after the pandemic. The goal was to understand if increased use of masks, gloves, and …

This study looked at how children with Noonan syndrome process energy and sugar. Researchers measured insulin sensitivity in 20 children with the condition to see if they have unique metabolic traits. The goal was to better understand the disease, not to test a new treatment.

This study involved 20 adults with psoriasis to see how Hemay005 tablets affect the way the body processes another drug called midazolam. Researchers also checked for heart rhythm changes and measured inflammation markers. The goal was to gather safety and drug interaction data, …

This study looked at Netherton syndrome, a rare genetic skin condition, to better understand how it affects the body and immune system. Researchers studied 18 people with the disease, measuring immune markers in the blood and tracking skin changes. The goal was to find new target…

This completed Phase 1 study tested how the psoriasis drug Hemay005 is processed by the body in people with mild or moderate kidney impairment compared to those with normal kidneys. 26 adults took a single dose, and researchers measured drug levels in the blood to see if kidney f…

This completed study followed 127 adults with moderate to severe plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, or non-radiographic axial spondyloarthritis who were already taking or starting secukinumab. Researchers observed them for two years to see how long the…

This study followed 133 people with PPNAD (a rare adrenal gland disorder) or Carney Complex (a related genetic condition) for three years. The goal was to better understand the symptoms and genetic causes of these diseases, not to test a new treatment. Participants had yearly che…

This study tested different doses of oliceridine, a painkiller, to find the amount that best prevents sudden rises in blood pressure and heart rate when a breathing tube is placed during anesthesia. Researchers enrolled 58 adults having elective surgery and adjusted doses based o…

This study interviewed 20 adults aged 30 and older with congenital ichthyosis, a rare genetic skin condition. Researchers asked about pain, social life, work, and finances to learn how the disease affects overall well-being. The goal was to gather insights, not to test a treatmen…

This study followed 240 adults in Taiwan with moderate-to-severe plaque psoriasis to see how well risankizumab works compared to other biologics in real-world settings. Participants received their prescribed treatment and were monitored for about 2 years. The main goal was to mea…

This completed Phase 1 trial in 18 healthy women aged 18–40 tested whether taking the experimental psoriasis drug HS-10374 changes how the body absorbs and clears the birth control pill Yasmin. Participants took Yasmin alone and then again after a course of HS-10374. Researchers …

This study looked at how trouble regulating body temperature affects sleep in people with hypohidrotic ectodermal dysplasia (HED), a condition that limits sweating. Researchers compared sleep quality, skin temperature, and melatonin levels in 22 HED patients and healthy volunteer…

This study checked if newer psoriasis drugs (IL17/23 inhibitors) also improve artery stiffness, a sign of heart disease. Researchers followed 66 people with moderate-to-severe psoriasis for a year, measuring pulse wave velocity (PWV) and other markers. The goal was to see if thes…

This study tested whether digital photographs can reliably measure psoriasis severity compared to in-person exams. Thirty-four adults with plaque psoriasis had their skin assessed both ways. The goal was to see if remote scoring could be as accurate as face-to-face evaluation.

This completed study examined whether people with psoriasis have worse gum health and how it affects their daily lives. Researchers compared 226 adults with and without psoriasis through oral exams and questionnaires. The goal was to understand if the chronic skin condition also …

This completed study looked at 100 adults with moderate-to-severe psoriasis to see how two common biologic drugs, Secukinumab and Adalimumab, affect bone density. Researchers measured bone mineral density in the spine and hip over time. The goal was to understand if these treatme…