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New pill could stop painful swelling attacks in rare disease

NCT ID NCT04618211

Completed Symptom relief Sponsor: Pharvaris Netherlands B.V. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an oral medication called deucrictibant for quickly relieving swelling and pain attacks in people with hereditary angioedema (HAE) types I and II. 74 adults received either one of three doses of the drug or a placebo during an attack. The main goal was to see if symptoms like skin swelling, skin pain, and belly pain improved more with the drug than with placebo within 4 hours.

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Conditions

The condition(s) this trial relates to.

C1 inhibitor deficiency hereditary angioedema hereditary angioedema type 1 hereditary angioedema type 2 Hereditary Angioedema Types I and II hereditary angioedema with C1Inh deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

C1 ESTERASE INHIBITOR DEFICIENCY C1 INHIBITOR DEFICIENCY HEREDITARY ANGIOEDEMA HEREDITARY ANGIOEDEMA - TYPE 1 HEREDITARY ANGIOEDEMA - TYPE 2 HEREDITARY ANGIOEDEMA ATTACK HEREDITARY ANGIOEDEMA TYPE I HEREDITARY ANGIOEDEMA TYPE II HEREDITARY ANGIOEDEMA TYPES I AND II HEREDITARY ANGIOEDEMA WITH C1 ESTERASE INHIBITOR DEFICIENCY

Contacts and locations

Locations

  • Study site

    Birmingham, Alabama, 35209, United States

  • Study site

    Paradise Valley, Arizona, 85253, United States

  • Study site

    San Diego, California, 92122, United States

  • Study site

    Santa Monica, California, 90404, United States

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    Walnut Creek, California, 94598, United States

  • Study site

    Chevy Chase, Maryland, 20815, United States

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    St Louis, Missouri, 63141, United States

  • Study site

    Hershey, Pennsylvania, 17033, United States

  • Study site

    Sofia, Bulgaria

  • Study site

    Edmonton, Alberta, Canada

  • Study site

    Ottawa, Ontario, Canada

  • Study site

    Toronto, Ontario, Canada

  • Study site

    Montreal, Quebec, Canada

  • Study site

    Québec, Quebec, Canada

  • Study site

    Brno, Czechia

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    Hradec Králové, Czechia

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    Grenoble, France

  • Study site

    Montpellier, France

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    Paris, France

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    Berlin, Germany

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    Dresden, Germany

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    Frankfurt, Germany

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    Mainz, Germany

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    Ulm, Germany

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    Budapest, Hungary

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    Ashkelon, Israel

  • Study site

    Haifa, Israel

  • Study site

    Tel Aviv, Israel

  • Study site

    Monserrato, Italy

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    Naples, Italy

  • Study site

    Amsterdam, Netherlands

  • Study site

    Krakow, Poland

  • Study site

    Barcelona, Spain

  • Study site

    Madrid, Spain

  • Study site

    Brighton, United Kingdom

  • Study site

    London, United Kingdom