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New drug shows promise for painful hand and foot psoriasis

NCT ID NCT03135548

Completed Disease control Sponsor: Boehringer Ingelheim Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a drug called spesolimab in 59 people with palmoplantar pustulosis (PPP), a painful skin condition causing pustules and plaques on the palms and soles. Participants received either low or high doses of spesolimab or a placebo for 12 weeks. The goal was to see if the drug could reduce skin symptoms and check for side effects. Results suggest spesolimab may help improve PPP symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Spesolimab
What this could lead to
If successful, this could lead to a new treatment option for palmoplantar pustulosis, reducing painful pustules and plaques on hands and feet.
What could go wrong
This is an early Phase 2 trial with only 59 participants. The drug may not work for everyone, and side effects are possible. More research is needed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

palmoplantar pustulosis psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSORIASIS

Contacts and locations

Locations

  • Aarhus University Hospital, Skejby

    Aarhus, 8200, Denmark

  • Bispebjerg og Frederiksberg Hospital

    København NV, 2400, Denmark

  • Charité - Universitätsmedizin Berlin

    Berlin, 10117, Germany

  • Dr. Irina Turchin PC Inc.

    Fredericton, New Brunswick, E3B 1G9, Canada

  • Gentofte Hospital

    Hellerup, 2900, Denmark

  • Hospital Ramón y Cajal

    Madrid, 28034, Spain

  • Hospital Santa Creu i Sant Pau

    Barcelona, 08026, Spain

  • Hospital Universitario Infanta Leonor

    Madrid, 28031, Spain

  • Innovaderm Research Inc.

    Montreal, Quebec, H2K 4L5, Canada

  • Karolinska Univ. sjukhuset

    Stockholm, 171 76, Sweden

  • Ospedale San Giovanni di Dio

    Cagliari, 09124, Italy

  • Pol. Universitario Tor Vergata

    Roma, 00133, Italy

  • Sahlgrenska US, Göteborg

    Gothenburg, 413 45, Sweden

  • TFS Trial Form Support GmbH

    Hamburg, 20537, Germany

  • Universitätsklinikum Frankfurt

    Frankfurt am Main, 60596, Germany

  • Universitätsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitätsklinikum Schleswig-Holstein, Campus Kiel

    Kiel, 24105, Germany

  • York Dermatology Clinic and Research Centre

    Richmond Hill, Ontario, L4C 9M7, Canada

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