Acne drug dose showdown: which roaccutane dose works best?
NCT ID NCT07228481
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed trial tested two different cumulative doses of the acne drug Roaccutane (120 mg/kg vs 150 mg/kg) in 91 people with severe cystic acne. Researchers measured how well each dose reduced acne lesions and severity, and tracked whether acne returned within a year. The goal was to find the most effective dose with the fewest side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
isotretinoin (Roaccutane)
What this could lead to
If successful, this could help doctors choose the best Roaccutane dose to clear cystic acne with fewer side effects and lower relapse rates.
What could go wrong
This is a small, completed Phase 4 trial with only 91 participants. Results may not apply to all acne types, and higher doses may increase side effects without better outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.