New hope for Tough-to-Treat psoriasis: guselkumab targets sensitive areas

NCT ID NCT06039189

Completed Disease control Sponsor: Janssen Research & Development, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed phase 3 trial tested the drug guselkumab against a placebo in 338 adults with moderate plaque psoriasis covering only 2-15% of their body but including special sites like the scalp, face, or genitals. The goal was to see if guselkumab could clear or nearly clear psoriasis at these tricky spots by week 16. Results are available and may help guide treatment for this specific group.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Guselkumab (Tremfya)

What this could lead to

If successful, this could confirm guselkumab as a treatment option for people with moderate psoriasis that affects small body areas but includes sensitive spots like the scalp or genitals.

What could go wrong

This is a completed phase 3 trial, so results are available. However, the benefit may not apply to all patients, and side effects like infections or allergic reactions are possible with guselkumab.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MODERATE PLAQUE PSORIASIS

Contacts and locations

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Locations

Accellacare Research of Cary

Cary, North Carolina, 27511, United States
Acclaim Dermatology

Sugar Land, Texas, 77479, United States
Apex Dermatology Mayfield Heights

Mayfield Heights, Ohio, 44124, United States
Arlington Center for Dermatology

Arlington, Texas, 76011, United States
Atlanta Biomedical Clinical Research

Atlanta, Georgia, 303331, United States
Bare Dermatology

Dallas, Texas, 75235, United States
Beacon Dermatology

Calgary, Alberta, T3E 0B2, Canada
Bellair Dermatology

Bellaire, Texas, 77401, United States
Bexley dermatology research

Bexley, Ohio, 43209, United States
Brunswick Dermatology Center

Fredericton, New Brunswick, E3B 1G9, Canada
CCA Medical Research Corporation

Ajax, Ontario, L1S7K8, Canada
Cahaba Research Inc

Birmingham, Alabama, 35244, United States
California Dermatology & Clinical Research Institute

Encinitas, California, 92024, United States
Canadian Dermatology Center

Toronto, Ontario, M3B 0A7, Canada
Center for Clinical Studies

Houston, Texas, 77004, United States
Clinical Science Institute

Santa Monica, California, 90404, United States
Darst Dermatology

Charlotte, North Carolina, 28277, United States
DermAssociates, PC

Rockville, Maryland, 20850, United States
DermCare, LLC

Quincy, Massachusetts, 02169, United States
Dermatology and Laser Center of Charleston

Charleston, South Carolina, 29414, United States
Dermatrials Research

Hamilton, Ontario, L8N 1Y2, Canada
Dr Wei Jing Loo Medicine Professional Corporation

London, Ontario, N6H 5L5, Canada
Dr. Chih ho Hong Medical

Surrey, British Columbia, V3R 6A7, Canada
Enverus Medical

Surrey, British Columbia, V3V 0C6, Canada
FACET Dermatology

Toronto, Ontario, M4E 2Y9, Canada
First OC Dermatology

Fountain Valley, California, 92708, United States
Florida Academic Dermatology Centers

Coral Gables, Florida, 33134, United States
Frontier Derm Partners CRO, LLC

Mill Creek, Washington, 98102, United States
Glick Research Institute

Margate, Florida, 33063, United States
Henry Ford Medical Center

West Bloomfield, Michigan, 48322, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10003, United States
JRB Research Inc

Ottawa, Ontario, K1H 7X3, Canada
K. Papp Clinical Research Inc.

Waterloo, Ontario, N2J 1C4, Canada
Kindred Hair and Skin Center

Columbia, Maryland, 21045, United States
Lawrence J Green MD LLC

Rockville, Maryland, 20850, United States
Markowitz Medical OptiSkin

New York, New York, 10128, United States
Menter Dermatology Research Institute

Dallas, Texas, 75246, United States
Metro Boston Clinical Partners

Brighton, Massachusetts, 02135, United States
Miami VA Healthcare System

Miami, Florida, 33124, United States
Modern Research Associates PLLC

Dallas, Texas, 75231, United States
Nashville Skin: Comprehensive Dermatology Center

Nashville, Tennessee, 37212, United States
North York Research Inc

North York, Ontario, M2M 4J5, Canada
Palmetto Clinical Trial Services, LLC

Fountain Inn, South Carolina, 29644, United States
Piedmont Plastic Surgery and Dermatology

Huntersville, North Carolina, 28078, United States
Practice Wang

Riverside, California, 92505, United States
Progressive Clinical Research

San Antonio, Texas, 78229, United States
Rehlen, Bartlow, Goodman and Baron Dermatology Group

Santa Ana, California, 92701, United States
Rejuvenation Dermatology Clinic Edmonton Downtown

Edmonton, Alberta, T5J 3S9, Canada
Remington Davis Inc

Columbus, Ohio, 43215, United States
Research Toronto

Toronto, Ontario, M4W 2N2, Canada
Revival Research

Doral, Florida, 33122, United States
SimcoDerm Medical and Surgical Dermatology Centre

Barrie, Ontario, L4M 7G1, Canada
Suzanne Bruce and Associates - The Center for Skin Research

Houston, Texas, 77056-4132, United States
Tennessee Clinical Research Center

Nashville, Tennessee, 37215, United States
Texas Dermatology and Laser Specialists

San Antonio, Texas, 78218, United States
The Centre de recherche Saint-Louis

Québec, Quebec, G1W 4R4, Canada
Therapeutics Clinical Research

San Diego, California, 92123, United States
Toronto Research Centre

Toronto, Ontario, M3H 5Y8, Canada
Tory P Sullivan M D PA

North Miami Beach, Florida, 33162, United States
Total Dermatology

Birmingham, Alabama, 35203, United States
TrueBlue Clinical Research

Brandon, Florida, 33511, United States
University of Conn Health Center

Farmington, Connecticut, 06030, United States
Winnipeg Clinic

Winnipeg, Manitoba, R3C 0N2, Canada
Wiseman Dermatology Research Inc.

Winnipeg, Manitoba, R3M 3Z4, Canada