Drug combo shows promise for rare skin disease in kids
NCT ID NCT07151508
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested a combination of two immune-targeting drugs, secukinumab and dupilumab, in 15 children with severe Netherton syndrome, a rare genetic skin disorder. The goal was to see if the treatment could improve survival and control the disease. The children received weight-adjusted doses of both drugs for at least three months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- secukinumab and dupilumab (two biologic drugs that target different parts of the immune system)
- What this could lead to
- If this combination works well, it could offer a new treatment option to control the severe skin and immune symptoms of Netherton syndrome in children.
- What could go wrong
- This is a very small study (15 children) with no comparison group, so results may not apply to all patients. Biologic drugs can have side effects like infections or allergic reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology
Moscow, Russia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Experimental drug for rare skin disease fails to reach goal
- Scientists hunt for clues to ichthyosis in skin and blood
- Could arthritis drug humira ease rare skin disease?
- Microbiome study seeks clues in rare skin condition
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