Lichen sclerosus et atrophicus

This study tests a cream called delgocitinib for lichen sclerosus, a skin condition that causes itching, pain, and scarring in the genital area. About 652 adults with mild to severe disease will apply the cream twice daily for up to 52 weeks. Researchers will check if the cream i…

This study tests a fractional 2940 nm laser to treat lichen sclerosus lesions in 50 women aged 18 and older. The laser aims to reduce symptoms like itching, burning, and painful intercourse by removing damaged tissue and promoting healing. Researchers will check tissue samples 16…

This study tests whether adding a special radiofrequency treatment to standard steroid cream works better than steroid cream alone for women with vulvar lichen sclerosus, a chronic skin condition causing itching, pain, and discomfort. About 68 women of reproductive age will be ra…

This study tests whether methotrexate, a drug used for arthritis, can help women with severe vulvar lichen sclerosus that hasn't improved with standard steroid creams. Twelve women will receive weekly injections of methotrexate for 12 months. The goal is to see if symptoms and sk…

This study tests whether a fractional CO2 laser can reduce inflammation and symptoms like itching and pain in vulvar lichen sclerosus, a chronic skin condition. Forty women who have not been treated before will receive either standard clobetasol ointment or three laser sessions. …

This study compares a laser treatment (Monalisa Glide) to a standard steroid cream (clobetasol) for keeping vulvar lichen sclerosus under control. 120 women who have already completed 12 weeks of steroid treatment will receive either three laser sessions or continue using the cre…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study is testing a software tool called Belle.ai that uses artificial intelligence to help doctors diagnose common skin diseases. About 400 patients at dermatology clinics will have three photos taken of their skin condition. The AI will analyze the photos and suggest possib…

This study is testing a new gel dressing for women with vaginal atrophy, lichen sclerosus, or similar vulvar skin conditions. About 2000 adult women will use the gel and report their symptoms and quality of life over 12 months. The goal is to see if the gel safely reduces discomf…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study collects biological samples—like blood, skin biopsies, and swabs—from people with or at risk for skin diseases, as well as healthy volunteers. Researchers will use these samples to study the causes of skin conditions and explore potential treatments. Up to 700 particip…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This observational study will follow 300 men diagnosed with lichen sclerosus, a chronic skin condition affecting the genitals, for up to 10 years. Researchers will track how well routine treatments like circumcision work, monitor for disease recurrence or complications, and asses…

This study looks at how skin conditions related to cancer or cancer treatments affect the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to better understand these effects and improve trea…