Could a common arthritis drug ease a devastating skin condition?
NCT ID NCT07352917
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether methotrexate, a drug used for arthritis, can help women with severe vulvar lichen sclerosus that hasn't improved with standard steroid creams. Twelve women will receive weekly injections of methotrexate for 12 months. The goal is to see if symptoms and skin changes get better.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- methotrexate
- What this could lead to
- If it works, this could point toward a new treatment option for women with severe vulvar lichen sclerosus who do not respond to standard creams.
- What could go wrong
- This is a very small pilot study with only 12 participants, so results may not apply broadly. Methotrexate can cause side effects like nausea, liver issues, and increased infection risk.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for VULVAR LICHEN SCLEROSUS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
DermoCentro
RECRUITINGSão José dos Campos, São Paulo, 12245760, Brazil
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Laser zaps away lichen sclerosus symptoms in new trial
- Laser treatment could offer new hope for chronic skin condition
- Can a daily drink ease vaginal dryness in lichen sclerosus?
- New combo treatment tested for painful skin condition
- Laser may offer new hope for women with chronic vulvar condition
- New study tests PRP against standard creams for chronic vulvar condition