New pill could stop swelling attacks in hereditary angioedema
NCT ID NCT06343779
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested an oral medication called deucrictibant for quickly treating attacks of hereditary angioedema (HAE), a condition causing sudden, painful swelling. The trial involved 134 adolescents and adults with HAE types 1, 2, or 3. Participants took either the drug or a placebo at the start of an attack to see if it shortened time to symptom relief. The goal is to offer a convenient, on-demand pill option for managing HAE attacks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- deucrictibant (oral soft capsule)
- What this could lead to
- If successful, this could provide a convenient, on-demand oral treatment to quickly relieve swelling attacks in people with hereditary angioedema.
- What could go wrong
- This is a completed Phase 3 trial, but results are not yet published. The drug may not prove significantly better than placebo, and side effects are possible. It is not a cure—patients would still need ongoing management.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Birmingham, Alabama, 35209, United States
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Paradise Valley, Arizona, 85258, United States
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Little Rock, Arkansas, 72205, United States
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San Diego, California, 92122, United States
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Santa Monica, California, 90404, United States
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Walnut Creek, California, 94598, United States
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Colorado Springs, Colorado, 80907-6231, United States
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Chevy Chase, Maryland, 20815, United States
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Boston, Massachusetts, 02115, United States
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Detroit, Michigan, 48202, United States
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St Louis, Missouri, 63141, United States
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Hershey, Pennsylvania, 17033, United States
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Dallas, Texas, 75231, United States
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Buenos Aires, B1629AHJ, Argentina
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Salta, 4400, Argentina
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Campbelltown, New South Wales, 2560, Australia
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Box Hill, 3128, Australia
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Graz, 8036, Austria
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Linz, 4021, Austria
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Vienna, 1090, Austria
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Paraná, 80810-100, Brazil
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Ribeirão Preto, 14048-900, Brazil
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Salvador, 41950-640, Brazil
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Santo André, 09060-870, Brazil
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São Paulo, 05403-000, Brazil
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Sofia, 1431, Bulgaria
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Sofia, 1680, Bulgaria
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Edmonton, Alberta, T6G 1Z1, Canada
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Bogotá, 00, Colombia
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Bogotá, 111221, Colombia
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Bogotá, 111711, Colombia
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Medellín, 050021, Colombia
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Brno, 602 00, Czechia
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Lille, 59037, France
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Paris, 75571, France
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Berlin, 12203, Germany
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Frankfurt am Main, 60590, Germany
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Frankfurt am Main, 60596, Germany
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Lübeck, 23538, Germany
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Hong Kong, Hong Kong
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Budapest, 1088, Hungary
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Dublin, D08 A978, Ireland
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Catania, 95124, Italy
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Milan, 20138, Italy
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Milan, 20097, Italy
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Padova, 35128, Italy
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Palermo, 90146, Italy
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Roma, 00133, Italy
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Chiba, 260-8677, Japan
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Hiroshima, 730-8518, Japan
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Kanagawa, 216-8511, Japan
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Osaka, 569-8686, Japan
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Tokyo, 113-8431, Japan
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Amsterdam, 1105 AZ, Netherlands
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Skopje, 1000, North Macedonia
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Krakow, 31-503, Poland
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San Juan, 00918, Puerto Rico
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San Juan, 00927, Puerto Rico
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Sângeorgiu de Mureş, 547530, Romania
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Riyadh, 11471, Saudi Arabia
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Singapore, 308433, Singapore
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Cape Town, 7700, South Africa
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Daegu, 41944, South Korea
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Seoul, 03080, South Korea
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Barcelona, 08035, Spain
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Barcelona, 08907, Spain
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Lund, 22185, Sweden
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Ankara, 06203, Turkey (Türkiye)
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Istanbul, 34093, Turkey (Türkiye)
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Izmir, 35100, Turkey (Türkiye)
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Bristol, BS10 5NB, United Kingdom
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Camberley, GU16 7UJ, United Kingdom
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Cambridge, CB2 0QQ, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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London, E1 2ES, United Kingdom
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Plymouth, PL6 8DH, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New oral option may offer relief for hereditary angioedema attacks
- Can a new injection tame hereditary swelling attacks?
- Could a simple pill shield HAE patients from Procedure-Triggered attacks?
- Teens with rare swelling disorder get new drug tested
- New daily pill aims to stop HAE attacks, but trial cut short
- New drug shows promise for controlling rare swelling disorder