Psoriasis patients may cut drug doses without Flare-Ups, study finds

NCT ID NCT04340076

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 26 times

Summary

This study tested whether people with stable psoriasis could safely reduce their dose of IL17 or IL23 inhibitor drugs without causing flare-ups. 244 adults with well-controlled psoriasis were randomly assigned to either dose reduction or standard care. The goal was to see if lower doses kept the skin clear (PASI ≤ 5) for at least 12 months. The results help guide personalized treatment plans that may reduce side effects and costs.

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Contacts and locations

Locations

  • AZ Maria Middelares

    Ghent, Belgium

  • AZ St Lucas

    Ghent, Belgium

  • Amphia Hospital

    Breda, Netherlands

  • Bravis hospital

    Bergen op Zoom, Netherlands

  • CHU Liege

    Liège, Belgium

  • Catharina hospital

    Eindhoven, Netherlands

  • Dermatologie Maldegem

    Maldegem, Belgium

  • Erasmus MC

    Rotterdam, Netherlands

  • Ghent University Hospital

    Ghent, 9000, Belgium

  • Maastricht UMC

    Maastricht, Netherlands

  • Máxima Medisch Centrum

    Veldhoven, Netherlands

  • Radboudumc

    Nijmegen, 6500HB, Netherlands

  • Slingeland hospital

    Doetinchem, Netherlands

  • UCL Saint Luc

    Leuven, Belgium

  • ULB Erasme

    Brussels, Belgium

  • UMC Groningen

    Groningen, Netherlands

  • UMC Utrecht

    Utrecht, Netherlands

  • UZ Leuven

    Leuven, Belgium

  • Ziekenhuisgroep Twente

    Almelo, Netherlands

Conditions

Explore the condition pages connected to this study.