New shot could stop painful swelling attacks in kids

NCT ID NCT05819775

Completed Disease control Sponsor: CSL Behring Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called Garadacimab in 22 children aged 2 to 11 with hereditary angioedema, a condition that causes sudden, painful swelling. The drug is given as a shot under the skin to prevent attacks. The study looked at safety and how well it works. It has already been completed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Garadacimab (a lab-made antibody given as a shot under the skin)
What this could lead to: If it works, this could give children with hereditary angioedema a new option to prevent painful swelling attacks.
What could go wrong: This is a small, completed study with only 22 children, so results may not apply to everyone. Side effects or lack of effectiveness are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hereditary angioedema hereditary angioedema with C1Inh deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEREDITARY ANGIOEDEMA (HAE)

Contacts and locations

Locations

AARA Research Center

Dallas, Texas, 75231, United States
Barzilai University Medical Center

Ashkelon, 7830604, Israel
Bernstein Clinical Research

Cincinnati, Ohio, 45236, United States
Campbelltown Hospital, Western Sydney University

Campbelltown, NSW 2560, Australia
Charité - Universitätsmedizin Berlin

Berlin, 12203, Germany
Donald S. Levy M.D.

Orange, California, 92868, United States
HZRM Hämophilie Zentrum Rhein Main GmbH

Frankfurt am Main, Hesse, 60596, Germany
Medical Research of Arizona

Scottsdale, Arizona, 85251, United States
Ottawa Allergy Research Corp

Ottawa, K1H1E4, Canada
PennState Health Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033, United States
Raffi Tachdjian MD, Inc.

Santa Monica, California, 90404, United States
Research Solutions of Arizona

Litchfield Park, Arizona, 85340, United States
Universitätsklinikum Frankfurt

Frankfurt am Main, 60590, Germany

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