New light therapy could zap stubborn acne without pills

NCT ID NCT05080764

Completed Disease control Sponsor: Biofrontera Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This study tests a treatment called photodynamic therapy (PDT) for adults with moderate to severe acne. A gel called Ameluz® is applied to the face, then activated with a special red light. The goal is to see if this combination reduces acne lesions better than a placebo. About 126 adults are taking part in this phase II trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ameluz® (BF-200 ALA) with red light photodynamic therapy
What this could lead to: If successful, this could offer a new, non-antibiotic treatment option for adults with stubborn moderate to severe acne.
What could go wrong: This is a mid-stage trial with only 126 participants, so results may not apply to everyone. Photodynamic therapy can cause temporary redness, swelling, and pain during treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acne Acne Vulgaris

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACNE VULGARIS

Contacts and locations

Locations

Austin Institute for Clinical Research Inc.

Pflugerville, Texas, 78660, United States
Clinical Research Center of the Carolinas

Charleston, South Carolina, 29407, United States
Cosmetic Laser Dermatology

San Diego, California, 92121, United States
DelRicht Research

Baton Rouge, Louisiana, 70809, United States
DermResearch PA

Austin, Texas, 78759, United States
Dermatology Associates PA of the Palm Beaches

Delray Beach, Florida, 33445, United States
First OC Dermatology

Fountain Valley, California, 92708, United States
ForCare Clinical Research

Tampa, Florida, 17033, United States
Skin Search of Rochester, Inc

Rochester, New York, 14623, United States

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