New shot cuts swelling attacks in rare disease over long term
NCT ID NCT04739059
First seen Jan 26, 2026 · Last updated May 09, 2026 · Updated 12 times
Summary
This study tested a drug called garadacimab (CSL312) for long-term prevention of hereditary angioedema (HAE) attacks, which cause painful swelling. 171 people aged 12 and older received regular injections. The goal was to see if the drug is safe and reduces attack frequency over time.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AARA Research Center
Dallas, Texas, 75231, United States
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Allergy & Asthma Clinical Research
Walnut Creek, California, 94598, United States
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Amsterdam UMC, location AMC
Amsterdam, 1105, Netherlands
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Auckland City Hospital
Grafton, Auckland, 1023, New Zealand
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Barzilai University Medical Center
Ashkelon, 7830604, Israel
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Bernstein Clinical Research Center, LLC
Cincinnati, Ohio, 45236, United States
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Campbelltown Hospital / Western Sydney University
Campbelltown, New South Wales, 2560, Australia
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Charité - Universitätsmedizin Berlin
Berlin, 10117, Germany
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Clinical Research Center of Alabama
Birmingham, Alabama, 35209, United States
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Clover Hospital
Kanagawa, Kugenumaishigami, Fujisawa-shi, 251-0025, Japan
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Donald S. Levy M.D.
Orange, California, 92868, United States
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Fiona Stanley Hospital, Department of Clinical Immunology
Murdoch, Western Australia, 6150, Australia
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Gordon Sussman Clinical Research
Toronto, Ontario, M3B 3S6, Canada
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HZRM Haemophilie Zentrum Rhein Main GmbH
Mörfelden-Walldorf, 64546, Germany
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Hospital Gregorio Marañón, Servicio de Alergia
Madrid, 28007, Spain
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Hospital Universitari General de La Vall d'Hebron
Barcelona, 8035, Spain
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Institute for Asthma and Allergy PC
Chevy Chase, Maryland, 20815, United States
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Johannes Gutenberg-Universität KöR, Hautklinik und Poliklinik der Universitätsmedizin, Clinical Research Center
Mainz, 55131, Germany
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Juntendo University Hospital
Tokyo, Hongo Bunkyo-ku, 113-8431, Japan
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Koga Community Hospital
Shizuoka, Daikakuji Yaizu-shi, 425-0088, Japan
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Little Rock Allergy & Asthma Clinic
Little Rock, Arkansas, 72205, United States
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Local Incorporated Administrative Agency Osaka City Hospital Organization Osaka City General Hospital
Miyakojima-ku, Osaka-shi, 534-0021, Japan
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McMaster University
Hamilton, Ontario, L8N 3Z5, Canada
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Medical Research of Arizona
Scottsdale, Arizona, 85251, United States
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Mie University Hospital
Mie, Edobashi, Tsu-shi, Edobashi, Tsu-shi, Japan
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Montreal Clinical Research Institute
Montreal, Quebec, H2W 1R7, Canada
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NRC Institute of Immunology FMBA Russia
Moscow, 115522, Russia
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National Hospital Organization Disaster Medical Center
Tokyo, Midoricho, Tachikawa-shi, 190-0014, Japan
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Ottawa Allergy Research Corp
Ottawa, Ontario, K1H 1E4, Canada
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PennState Health Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033, United States
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Raffi Tachdjian MD, Inc.
Santa Monica, California, 90404, United States
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Research Solutions of Arizona
Litchfield Park, Arizona, 85340, United States
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Saga University Hospital
Saga, Nebeshima, Saga-shi, 849-8501, Japan
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Saitama Medical Center
Saitama, Kamoda Kawagoe-shi, 350-8550, Japan
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Saiyu Soka Hospital
Saitama, Matsubara Soka-shi, 340-0041, Japan
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Semmelweis Egyetem Altalanos Orvostudományi Kar Belgyógyászati és Hematológiai Klinika
Budapest, 1088, Hungary
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St. Marianna University School of Medicine Hospital
Kanagawa, Kawasaki-shi, 216-8511, Japan
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Taichung Veterans General Hospital
Taichung, 407, Taiwan
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The Alfred Hospital
Melbourne, Victoria, 3004, Australia
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The University of Hong Kong, Queen Mary Hospital
Hong Kong, Hong Kong
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University Hospital Motol
Prague, 150 06, Czechia
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University hospital St. Anna Ustav klinicke imunologie a alergologie, Fakultní nemocnice u sv. Anny v Brně
Brno, 65691, Czechia
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University of Alberta - Research Transition Facility
Edmonton, Alberta, T6G 2B7, Canada
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Universitätsklinikum Frankfurt
Frankfurt, 60590, Germany
Conditions
Explore the condition pages connected to this study.