Cardiovascular disorder

This study tests whether survodutide, a weekly injection for weight loss, is safe for the heart in people who are overweight or obese and have heart or kidney disease. About 5,500 adults will receive either survodutide or a placebo for up to 2 years, along with diet and exercise …

This study tests whether combining a shared decision-making checklist during doctor visits with mobile text reminders helps people with type 2 diabetes take their medications as prescribed. About 378 patients from community health centers in Michigan are taking part. The goal is …

This pilot study is testing a home-based virtual exercise program called Vivo Heart for older adults with cardiovascular disease. The program involves live, small-group sessions led by certified trainers, combining physical exercises with cognitive challenges to improve strength,…

This study tests whether a nurse-led smoking cessation program with free drugs and follow-up at healthy life centers helps heart patients quit smoking better than just giving them written information. About 221 daily smokers hospitalized for a heart event will be split into two g…

This study tests whether eating wild blueberry powder every day can lower blood pressure and improve blood vessel health in middle-aged and older men and postmenopausal women with slightly high blood pressure. Researchers will measure artery function and stiffness over time. The …

This study tests whether collecting and re-infusing unwashed shed blood during off-pump coronary artery bypass surgery can reduce the need for donor blood transfusions and lower complications. Fifty adults undergoing this surgery will have their shed blood returned via a special …

This Phase 2 trial tested the drug tovinontrine (CRD-750) against a placebo in 557 adults with chronic heart failure and reduced pumping ability. The goal was to see if the drug safely lowers a key heart stress marker called NT-proBNP over 12 weeks. The study is complete, and res…

This Phase 2 study tested the safety and effectiveness of tovinontrine, an experimental drug, compared to a placebo in 303 adults with chronic heart failure with preserved ejection fraction. The main goal was to see if tovinontrine could lower a key biomarker (NT-proBNP) in the b…

This study looks at whether a program called Heart Matters can help Black adults in rural eastern North Carolina lower their blood pressure. About 173 people with at least one heart disease risk factor (like high blood pressure or obesity) will take part. The program is led by co…

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This trial tests whether taking vitamin K2 (with vitamin D) every day can slow the progression of calcium buildup in the coronary arteries—a key risk factor for heart attacks. It enrolls 400 men and women with severe coronary calcification, who are randomly assigned to receive th…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This trial tests whether hydroxychloroquine, an anti-inflammatory drug, can reduce cardiovascular disease risk in people with chronic kidney disease (CKD). Participants with moderate-to-severe CKD will receive either hydroxychloroquine or a placebo for 18 months. Researchers will…

This trial tests whether a web-based program called PATH can help adults with obesity become more physically active and stick to recommended exercise levels. Participants are randomly assigned to either the PATH program, which includes personalized coaching and online resources, …

This trial tests a device called the Symphony Thrombectomy System in people with acute pulmonary embolism, a condition where blood clots block arteries in the lungs. The device is designed to restore blood flow by suctioning out or breaking up the clots. The study will check how …

This study tested a drug called pelacarsen in 422 Black/African American and Hispanic patients with high Lp(a) levels and existing heart disease. Lp(a) is a genetic risk factor for heart attacks and strokes. The goal was to see if pelacarsen could safely lower Lp(a) levels over 1…

This early-stage trial is testing a new gene therapy called AB-1002 in people with advanced heart failure (NYHA Class III). The therapy is given as a single infusion directly into the heart's blood vessels, aiming to deliver a gene that may help heart muscle pump more effectively…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study tested whether a physical activity program delivered by mail and website could improve the health of nearly 50,000 older women already in the Women's Health Initiative. The program included aerobic, balance, strength, and flexibility exercises, and encouraged reducing …

This study tested a procedure called renal denervation, which uses radiofrequency energy to calm overactive nerves in the kidneys, to see if it can safely lower blood pressure in people whose hypertension is not controlled by up to three medications. The study involved 337 partic…

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This trial tests whether a wearable ECG patch can help people recover better after heart surgery. Participants wear the MEMO Patch, which continuously records heart signals and activity, while completing a cardiac rehabilitation program that starts in the hospital and continues a…

This study tests a culturally appropriate education program called Indigenous SIPin to help Native American men reduce their intake of sugary drinks like soda and juice. The program includes classes and text messages, and involves 48 men from Native American athletic communities.…

This study tests an experimental drug called pelacarsen in people with very high levels of lipoprotein(a), a type of cholesterol linked to heart disease. Participants currently undergo weekly blood-filtering treatments (apheresis) to lower their Lp(a). The trial aims to see if ta…

This study tests whether a virtual environment (VE) can help minority men who have sex with men and are living with HIV adopt healthier behaviors to prevent cardiovascular disease. Participants use a computer-based virtual world to access educational quests and other features. Th…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This trial compares a generic extended-release tablet containing three diabetes drugs (empagliflozin, linagliptin, and metformin) to the brand-name Trijardy XR. The study involves 36 healthy adults who take a single dose of each version under fed conditions to see if the generic …

This study tests whether a 12-week vinyasa (flow) yoga program done at home via Zoom can improve heart health in people with high blood pressure. Thirty adults with elevated blood pressure will be split into two groups: one does yoga three times a week, the other continues their …

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This early-phase study tested a new drug called Kylo-11 in 71 healthy adults with high levels of Lp(a), a genetic risk factor for heart disease. The main goal was to check safety and how the drug moves through the body. Researchers gave single doses at different levels to see if …

This trial investigates whether replacing red or processed meat with pulses (like beans, lentils, and chickpeas) can improve markers of heart health and change the gut microbiome. Participants are adults aged 18-65 with unhealthy, sedentary lifestyles who eat at least three servi…

This study tested a new oral drug called ralinepag in 687 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took ralinepag or a placebo on top of their usual PAH medications. The main goal was to see if rali…

This completed study tested whether eating more fruits and vegetables or taking sodium bicarbonate (baking soda) tablets can slow the progression of chronic kidney disease and reduce heart risks in people with high blood pressure and kidney damage. 108 non-diabetic adults with st…

This study tested whether reducing dietary acid with fruits and vegetables or sodium bicarbonate (baking soda) can slow chronic kidney disease in people with high blood pressure. 153 participants were followed for 5 years to measure kidney function and heart risk markers. The goa…

This study tests whether a supplement made from seaweed, called rhamnan sulfate, can improve blood vessel function in middle-aged and older adults who have at least one risk factor for heart disease (like high blood pressure or obesity). Participants take the supplement or a plac…

This study tested whether bars made with polyunsaturated fatty acids could improve cholesterol and fat levels in people with metabolic syndrome. 60 adults aged 40-65 with high BMI and abnormal cholesterol took part. The goal was to see if these bars could help control dyslipidemi…

This study tested whether a stricter blood pressure goal (below 135/85) after a pregnancy complicated by high blood pressure is better than the usual care (below 150/100). About 60 new mothers were enrolled and followed for six months. The goal is to see if tighter control is pos…

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This completed pilot study tested whether eating watermelon can lower blood pressure in adults with pre-hypertension. 39 healthy overweight adults ate either 1 cup, 2 cups of watermelon, or a control (Italian ice) daily for 4 weeks. Researchers measured 24-hour blood pressure and…

This pilot study tested whether varenicline (Chantix) helps smokers with coronary heart disease quit better than the standard nicotine patch. Fifty motivated smokers who had a heart-related event were randomly assigned to one of the two treatments for 12 weeks. The main goal was …

This study looked at whether bread made from watermelon rind could improve heart health in 120 adults with mild to moderate heart issues. Participants were between 35 and 65 years old and had conditions like high blood pressure, unhealthy cholesterol levels, or pre-diabetes. The …

This completed study tested a new device called the Supernova stent retriever in 55 people with severe stroke caused by a large blood clot in the brain. The device is threaded through blood vessels to grab and remove the clot, restoring blood flow. Researchers measured how often …

This study tested a new device called the Vertex Pulmonary Embolectomy System in 10 people with pulmonary embolism (blood clots in the lungs). The device is threaded through a blood vessel to remove clots and relieve strain on the right side of the heart. Researchers measured cha…

This study compared two types of dialysis in 415 older adults (ages 65-90) with chronic kidney failure: online hemodiafiltration and conventional hemodialysis. The goal was to see which method is better tolerated and whether it reduces heart problems and other complications. Pati…

This study looked at whether a 16-week strength training program can prevent or reduce late effects like muscle loss, heart disease, and diabetes in adults who had a bone marrow transplant as children. 28 survivors and a matched control group participated. The goal was to see if …

This study tested whether using social networks (like family and friends) can help people at high risk for stroke stick to their medications and control risk factors after leaving the hospital. Researchers enrolled 720 patients and compared standard care with a social network-bas…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This completed Phase 4 trial tested the drug inclisiran (given as a shot under the skin) against a placebo in 1770 adults with high cholesterol who were already on cholesterol-lowering therapy. The goal was to see if inclisiran helps more people reach their LDL cholesterol target…

This study tested a digital quality improvement program to help doctors better manage LDL (bad) cholesterol in patients with heart disease. Over 1,400 adults with established cardiovascular disease participated. The program used smartphone tools to improve treatment and follow gu…

This study tested the drug evolocumab (Repatha) in 81 kidney transplant recipients with high cholesterol. The goal was to see if it could safely lower cholesterol levels, since standard statin drugs often cause side effects in these patients. The results could lead to a better wa…

This study tested whether drinking unsweetened soymilk every day can lower cholesterol in adults with high levels. Twenty-five participants drank two bottles (750 mL total) daily for 8 weeks. Researchers measured cholesterol and other health markers to see if the soymilk helped i…

This study tested a device that removes blood clots from the main lung arteries in 123 people with a sudden pulmonary embolism. The goal was to reduce strain on the right side of the heart and prevent serious complications like major bleeding or heart injury. Participants were ad…

This study tested a weight management program for young adult cancer survivors (ages 18-39) who have obesity and are within 5 years of finishing cancer treatment. The program combined healthy eating, physical activity, and symptom management to help reduce cardiovascular disease …

This phase 2 trial tested olpasiran, an injectable drug, in 281 adults with high lipoprotein(a) – a genetic risk factor for heart disease. Participants received either olpasiran or a placebo. The main goal was to see how much the drug lowered Lp(a) levels after 36 weeks. Results …

This study looked at how different amounts of aerobic exercise affect blood flow and fitness in 115 people with heart disease. Participants joined a cardiac rehab program and were monitored for changes in skin blood flow and oxygen use during exercise. The goal is to find the mos…

This study tested whether taking a daily probiotic drink called Goodbelly for 6 weeks could improve blood vessel function and reduce inflammation in 215 adults with heart disease or type 2 diabetes. Researchers measured blood markers and gut bacteria to see if the probiotic made …

This study tested whether a low dose of the blood thinner rivaroxaban (Xarelto) could reduce major heart problems like heart attacks and strokes in people with advanced chronic kidney disease or kidney failure on dialysis. About 1,753 participants were randomly assigned to receiv…

This study compared two exercise programs—periodized circuit training and conventional strength training—in 50 adults with type 2 diabetes. Over 6 weeks, researchers measured changes in heart and lung fitness, quality of life, and blood sugar control. The goal was to see which ap…

This completed study tested a device that uses ultrasound to calm overactive nerves near the kidneys (renal denervation) in 6 people with chronic heart failure. The goal was to see if it is safe and can improve heart function by reducing sympathetic nerve activity. Because it was…

This study tested whether a drug called sacubitril-valsartan (Entresto) can improve early signs of heart failure in people with HIV. The 39 participants had well-controlled HIV but showed subtle heart changes on scans. The goal was to see if the drug could reduce inflammation and…

This completed study tested two strategies to reduce bleeding and artery blockage after a common heart procedure. 451 patients received either a standard or lower dose of heparin and a different compression band. The goal was to see if the new approach could shorten recovery and …

This study tested a new drug called zilebesiran in 375 adults with high blood pressure that wasn't controlled by their current medications. Participants received either zilebesiran or a placebo as an add-on to their usual pills. The goal was to see if zilebesiran could lower bloo…

This study looked at whether a Mediterranean diet and increased physical activity could improve heart health in 150 breast cancer survivors taking hormone therapy. Participants received counseling on diet and exercise over three months. Researchers measured changes in waist size,…

This study tested whether daily text messages with specific behavior change techniques could help sedentary adults at risk for cardiovascular disease walk an extra 1,000 steps per day. Over 600 participants received messages focused on goal setting, action planning, self-monitori…

This large study in rural India trained village health workers to diagnose and treat common illnesses like high blood pressure, diarrhea, pneumonia, malaria, asthma, and COPD. Over 72,000 adults aged 16-60 from 80 tribal villages took part. The goal was to reduce deaths by at lea…

This completed trial tested a new, noninvasive device that uses focused ultrasound to destroy a small amount of fat around the kidney. The goal was to lower blood pressure in people with mild hypertension who were not taking medication. 79 participants were randomly assigned to r…

This study tested a virtual world-based cardiac rehabilitation program called 'Destination Cardiac Rehab' against traditional center-based rehab. Over 2,800 adults with heart conditions participated to see if the virtual program could match or beat in-person rehab in improving he…

This study tested a 12-week walking program for 140 chronic stroke survivors. The program combined robotic-assisted walking with regular walking exercises. The goal was to improve walking ability, help with weight management, and lower blood pressure. Researchers wanted to find t…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This study looked at whether a 12-week health coaching program could help adults with at least one heart disease risk factor (like high blood pressure, diabetes, or obesity) improve their lifestyle habits and health. 120 adults took part and received counseling on physical activi…

This Phase 3 study tested a drug called olezarsen in 1,478 people with very high triglycerides (a type of blood fat) and either heart disease or a high risk for it. Participants received either olezarsen or a placebo as a shot under the skin. The main goal was to see if olezarsen…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This completed early-phase trial tested whether switching HIV medications to doravirine (with emtricitabine and tenofovir alafenamide) could improve cholesterol and reduce early signs of artery hardening compared to staying on integrase inhibitors. Twenty-six adults with well-con…

This study tested a nurse-guided phone program for 500 recent stroke patients in Ghana to help them manage their blood pressure at home. The program included home blood pressure monitoring, medication reminders, and education on heart health. The goal was to see if this approach …

This early-stage study tested a single dose of an investigational drug called AMG 890 in 79 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease. The main goal was to check safety and how the drug moves through the body. Researchers measured side eff…

This study tested whether a smartphone app and regular phone calls could help people with heart or lung disease complete rehabilitation at home instead of going to a clinic. The program included exercise tracking, education, and counseling over 12 weeks. Researchers wanted to see…

This completed study tested whether a health behavior program designed with input from immigrant communities can improve diabetes management in first-generation immigrants with type 2 diabetes. Researchers compared the culture-sensitive program to standard care in 202 participant…

This study tested whether common blood pressure medications (ACE inhibitors or ARBs) could improve outcomes for high-risk COVID-19 patients. Researchers enrolled 372 adults with confirmed COVID-19 who were either over 40 (outpatients) or over 18 (hospitalized). The goal was to se…

This study tested two extra treatments for people on dialysis for kidney failure. One adds a special filter (hemoperfusion) to clean more toxins from the blood, aiming to reduce heart and brain complications. The other gives a steady sugar solution during dialysis to help patient…

This study tested a very small balloon catheter (Sapphire 3) in 170 people with severely blocked heart arteries (chronic total occlusions). The balloon was used to open the blockage before placing a stent. The main goal was to see if the device could be safely delivered, inflated…

This study tested whether monthly text messages with heart-health tips could help people who had a heart attack better control their risk factors and avoid future heart problems. 370 participants received either usual care or usual care plus text messages for one year. The goal w…

This completed study looked at whether moderate-dose statins work as well as high-dose statins in lowering 'bad' LDL cholesterol after a heart attack. 190 adults aged 25-85 took either a moderate or high dose of atorvastatin or rosuvastatin daily for 3 months. The goal was to see…

This study tested a drug called elranatamab in 39 Chinese patients with multiple myeloma that had stopped responding to at least three prior treatments. The drug works by helping the immune system attack cancer cells. The goal was to see if it could shrink tumors and control the …

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This study tested whether a Mediterranean diet that removes red and processed meat can lower LDL cholesterol and other heart disease risk factors. 157 adults with high cholesterol were assigned to either the special diet or standard heart-health advice for 8 weeks. Researchers me…

This study tested a drug called ziltivekimab in 264 people with advanced chronic kidney disease and high inflammation. Participants received monthly injections of either a placebo or one of three doses of ziltivekimab for six months. The goal was to see if the drug could safely l…

This study tested whether a Fitbit activity tracker combined with virtual health coaching could help people on weight loss medications (GLP-1/GIP) become more active. Fifteen participants wore a Fitbit and had up to six coaching sessions over 12 weeks. The main goal was to see if…

This study looked at the SAPIEN XT heart valve, which is placed through a thin tube (catheter) to fix a failed valve in the heart's right ventricle. Researchers wanted to confirm it is safe and works well. They enrolled 57 people with a narrowed or leaky heart valve conduit. The …

This study looked at whether taking beetroot juice (which is rich in nitrates) together with vitamin C could lower blood pressure and improve blood vessel health in overweight adults aged 50-75. Fifteen participants took either the combination, beetroot juice alone, or a placebo.…

This completed trial tested whether taking two blood thinners (clopidogrel and aspirin) for 12 months after a heart stent procedure is better than aspirin alone for people with multiple blocked coronary arteries. Over 8,000 patients were enrolled across 100 centers. The main goal…

This study looked at whether tildrakizumab, a drug already approved for psoriasis, can improve blood flow to the heart in people with moderate-to-severe psoriasis. 36 adults took the drug for 6 months, and researchers measured heart function using special scans. The goal was to s…

This study tested whether training healthcare teams to share tasks can help people living with HIV better control their high blood pressure. It involved 960 adults across 30 clinics. The approach included measuring blood pressure, providing lifestyle advice, and starting medicati…

This study tested whether an 8-week circuit exercise program could improve markers of inflammation in overweight young women. Twenty-two women aged 20-30 were randomly assigned to either the exercise program or their usual routine. The exercise group showed increases in a benefic…

This study tested whether a nurse-led program could help veterans with HIV lower their blood pressure and reduce their risk of heart disease. 305 veterans with HIV and high blood pressure took part. The program used video visits and care coordination to help manage blood pressure…

This study tested a program to help people with rheumatoid arthritis (RA) get their cholesterol checked and treated. Many RA patients are at higher risk for heart attacks and strokes but often miss out on proper screening. The program used peer coaches and educational materials t…

This study tested a new device called NEURESCUE in 6 adults experiencing in-hospital cardiac arrest. The device is a balloon catheter inserted through the leg artery that inflates to redirect blood flow to the heart and brain. The goal was to see if it could be deployed quickly a…

This study tested whether a chewing gum containing dietary nitrate (a natural compound found in leafy greens and beets) could improve gum health and heart health in adults with mild gum disease. Thirty participants were randomly assigned to use either the nitrate gum or a placebo…

This study looked at whether using a person's genetic information to choose their blood-thinning medication (clopidogrel or an alternative) leads to better outcomes after a heart procedure. 283 adults with chronic coronary artery disease who had a stent placed were split into two…

This study tested whether injecting donor stem cells into the leg muscles before amputation could prevent wound problems and reduce the need for more amputations. 81 people scheduled for leg amputation due to poor blood flow took part. The main goal was to check safety, not yet t…

This study looked at whether combining exercise with the diabetes drug metformin improves blood vessel function in adults with metabolic syndrome. 91 participants were assigned to different exercise intensities with or without metformin for 16 weeks. The goal was to see if the co…

This pilot study tested a device that stimulates the diaphragm in time with the heartbeat to see if it can improve heart function in people with heart failure. 35 participants with reduced ejection fraction received the implant. The study checked for safety and changes in heart s…

This study tested whether the Oxiris membrane, a filter used during heart-lung machine support, can reduce inflammation and improve blood flow in small blood vessels after heart surgery. 70 adults having elective heart surgery with a long bypass time took part. The membrane aims …

This study tested whether taking daily vitamin D3 and prebiotics (inulin) for six months could improve heart health markers in 190 adults with type 2 diabetes. Researchers measured blood sugar control, cholesterol, and gut bacteria changes. The goal is to find simple dietary ways…

This study tested a device called MitraClip, which is a small clip placed through a tube in a vein to repair a leaky mitral valve in the heart. The trial included 304 people with severe mitral regurgitation and heart failure. Half got the clip plus standard medical care, and half…

This study tested a device called the Cordella™ Heart Failure System in 15 people with advanced heart failure. The system includes a small sensor implanted in the lung artery that measures pressure, sending data to doctors remotely. The goal was to see if it is safe and accurate,…

This study tests whether a simpler device called pOpmètre can accurately measure arterial stiffness in children aged 4 to 8. Arterial stiffness is an important sign of heart and blood vessel health. The standard device, Sphygmocor, is harder to use in children. If pOpmètre works …

This study explores whether a heart ultrasound taken during exercise on a special bicycle can detect subtle heart changes in young people who finished cancer treatment months or years earlier. It aims to see if this test is practical and acceptable for survivors aged 10 to 25, an…

This study is testing whether an AI platform called Okaya can accurately detect fatigue and depression in people with heart conditions. Participants will complete standard questionnaires and an AI assessment that analyzes facial and vocal features. The goal is to see if the AI ma…

This study tests whether a new device called VicorderCS can measure blood pressure accurately. The device uses a standard arm cuff and is designed to be faster and more portable than older models. Researchers will compare its readings to those taken with a traditional stethoscope…

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This completed study looked at 313 children to see if blood tests and advanced heart scans could help detect congenital heart disease earlier and predict which children might need surgery. Researchers compared children with heart defects to healthy controls using blood biomarkers…

This pilot study tested whether special magnifying goggles (Frenzel lenses) and a step-by-step diagnostic algorithm help emergency doctors better detect nystagmus—a telltale eye movement—in patients with sudden vertigo. The goal is to improve diagnosis of stroke versus benign inn…

This study compared two types of heart scans—CT and PET—to see if CT can measure blood flow to the heart as accurately as PET, which is the current gold standard. Researchers enrolled 20 adults with suspected coronary artery disease. Each participant received both a CT scan and a…

This study tested whether a simple checklist and blood test (the YEARS algorithm) can safely rule out pulmonary embolism (a blood clot in the lungs) in people with active cancer, compared to the standard approach of doing a CT scan on everyone. About 700 cancer patients with susp…

This study tested a new tool called the Cardiovascular Integrated Risk Tool (CVD IRT) in GP surgeries to see if it could be easily used during routine NHS Health Checks. Over 800 people aged 45-64 took part. The goal was to see if the tool works in real-world primary care and if …

Researchers at Ankara University are testing whether a five-week nursing education program, supported by virtual reality, can improve heart health behaviors in sixth-grade students. The study enrolls about 90 to 100 children from two middle schools in Ankara, Turkey. One group re…

This large study tested whether taking daily cocoa extract (a source of flavanols) or a standard multivitamin could lower the risk of heart disease and cancer in over 21,000 older adults. Participants took the supplements or placebos for several years, and researchers tracked hea…

This study looks at whether eating two portions of fish per week or taking omega-3 supplements can improve blood vessel health and raise omega-3 levels in young adults aged 18 to 30. Participants with low omega-3 levels and little fish intake will be assigned to one of four group…

This pilot study tested whether ready-to-eat meals based on the DASH diet could help lower blood pressure and reduce heart disease risk. Twenty adults ate the prepackaged meals daily for 4 weeks while researchers monitored their blood pressure and weight. The goal was to see if a…

This large observational study followed over 135,000 Chinese women aged 40-70 to see if eating soy food reduces the risk of heart attacks and fatal heart disease. Researchers tracked participants' soy intake and heart health over time. The study aims to provide clues about diet a…

This study tested whether giving pregnant women in India, Guatemala, Peru, and Rwanda a clean-burning liquefied petroleum gas (LPG) stove and free fuel for 18 months could improve health outcomes for their babies. Over 3,600 households participated, with half receiving the LPG st…

This study tested a 1-year online program designed to help adults aged 40-70 who are at risk for heart disease become more physically active. Participants either received a fitness tracker plus online coaching and goal-setting sessions, or just a fitness tracker with standard act…

This completed trial in Singapore tested whether telling people their 'heart age' and giving them a behavior-change app (HOPE-CVD) could lower their risk of heart disease. Over 1,100 adults aged 30-74 with at least a 5% risk were split into four groups, each receiving different l…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This completed study tested a 6-month program that taught nutrition and exercise to mothers and their children (ages 7-12) in the Yaqui Valley, Mexico. The goal was to improve lifestyle habits and prevent food insecurity, malnutrition, and related health problems like heart disea…

This study tested a family-focused lifestyle program designed to help rural Hispanic and non-Hispanic adults lower their risk for heart disease and type 2 diabetes. Over 500 participants took part in a culturally tailored program that encouraged healthy eating, physical activity,…

This study tested a digital health program that combines online tools and phone coaching to help adults adopt healthier habits and prevent heart disease. Over 2,600 participants used the program for at least one year. Researchers measured changes in cardiovascular risk, physical …

This study tested an 8-week digital lifestyle program called MYCardio-PEER for low-income adults at risk of heart disease. Participants received weekly videos and infographics on healthy eating and exercise, plus group chats with peer leaders. The goal was to see if the program i…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This large phase 3 trial tested whether a daily statin (pitavastatin) can reduce the risk of heart attacks, strokes, and other cardiovascular events in adults with HIV who are on antiretroviral therapy. Over 7,700 participants from multiple countries took either the statin or a p…

Researchers are testing whether a multimedia self-learning program can prepare patients for open heart surgery as well as traditional physical therapist instruction. The program uses a 2D animated video to teach breathing exercises, coughing, ankle pumping, and moving in bed. The…

This trial tests whether a digital cognitive behavioral therapy (CBT) app called Daylight can reduce anxiety and improve health behaviors in adults who have had a heart event, such as a heart attack or stroke, and also experience significant anxiety. Participants will either use …

This study tests whether a smartphone-based mindfulness training program can reduce stress and improve cardiovascular health in stressed adults aged 45 and older who are at risk for heart disease. About 106 participants will either use the app for 28 days or continue their usual …

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This completed trial tested an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. 474 couples attended weekly group sessions focused on communication, emotional support, and heart health. The goal was to see if the program improve…

This study tested two methods of giving the drug adenosine to people with a rapid heart rhythm called supraventricular tachycardia (SVT). 131 adults in the emergency room received the drug either through one syringe or two syringes. The goal was to see which method restored a nor…

This study tested whether a 20-minute session of nurse-led spiritual care, including prayer and relaxation techniques, could help heart surgery patients feel less anxious and have more stable blood pressure and heart rate before their operation. 248 adults in Indonesia took part.…

This study tested an inhaled medication called RT234 in 14 adults with pulmonary arterial hypertension (PAH), a condition where blood pressure in the lungs is dangerously high. The goal was to see if the drug could quickly lower lung blood pressure during a heart catheterization …

This study looked at whether a whole-body progressive resistance training program could improve blood vessel function and muscle strength in postmenopausal women. Thirty-two women aged 55 to 70 who were at least one year past menopause took part. Researchers measured changes in a…

This study looked at whether a 12-week virtual exercise program could help women with cardiac implantable electronic devices (CIEDs) improve their physical fitness, quality of life, and mental health. Twenty women took part, doing either high-intensity interval training (HIIT) or…

This study tested whether a 3-month yoga program could improve physical and mental health in adults over 65 who had recently finished cardiac rehab. Participants attended yoga twice a week. Researchers measured balance, muscle strength, anxiety, and mood. The goal was to see if y…

This study tested whether a short, 15-minute brain-training task (evaluative conditioning) could help heart attack survivors exercise at a higher intensity during cardiac rehab. Twenty-four patients were split into two groups: one received training linking physical activity with …

This early study tested a new way to deliver a substance that helps blood vessels relax, potentially lowering blood pressure. Fourteen healthy adults took a mixture placed under the tongue. Researchers measured changes in blood pressure and related chemicals in the blood to see i…

This study tested a 9-week internet-based cognitive behavioral therapy (CBT) program designed to reduce stress, anxiety, and depression in people with stable heart disease. 215 adults with heart disease and elevated stress or mood symptoms took part. The program was personalized …

This study looked at whether a 12-week program of aerobic and strength exercises could improve heart health and fitness in women who finished treatment for endometrial cancer. Thirty-three survivors in remission took part. They received exercise equipment and a Fitbit, and had he…

This study tested whether adding virtual reality (VR) driving simulations to standard cardiac rehabilitation helps heart surgery patients feel less anxious and depressed. Sixty adults recovering from heart surgery took part. The results suggest VR can improve emotional well-being…

This study tested whether applying mild electrical stimulation to the skin over the spinal cord could help regulate blood pressure in veterans with spinal cord injury who have chronically low blood pressure. Ten participants with injuries at or above T6 received stimulation at di…

This study compared two medications, norepinephrine and phenylephrine, for treating low blood pressure during spinal anesthesia in C-sections. 46 women were randomly given one of the two drugs when their blood pressure dropped. Both drugs worked well, but norepinephrine kept the …

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

This study looked at how certain gene variations affect the health of blood vessels in 178 healthy adults. Participants had an ultrasound and a short-acting medication to measure blood flow. The goal was to learn more about genetic risks for heart disease, not to provide treatmen…

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

This study looked at how blood vessel stiffness affects organs like the heart, brain, kidneys, and gut in people with Williams Syndrome (WS) or supravalvular aortic stenosis (SVAS). Researchers compared 159 participants (ages 3–85) with these conditions to healthy volunteers over…

This study checked how well over 5,000 heart patients follow their prescribed medicine routine. Researchers asked patients about their medication habits and any side effects. The goal was to understand how many patients do not take their medicines as directed.

This study is testing whether following a Mediterranean-style diet based on U.S. dietary guidelines improves heart health more when combined with weight loss. Researchers will provide all meals for 70 adults with obesity or excess body fat for eight weeks. Participants will be sp…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study collected DNA, tissue, and medical history from 305 people with Williams syndrome or supravalvar aortic stenosis (SVAS), as well as their family members and healthy volunteers. The goal was to create a resource for future research to understand why symptoms vary so muc…

This long-running study follows over 12,000 people from the Gila River Indian Community in Arizona to understand why type 2 diabetes develops and how it leads to complications. Participants receive regular check-ups every two years, including blood tests and physical exams. The g…

This study looked at 20 people with CADASIL, a rare genetic disease that damages brain arteries and causes migraines, strokes, and dementia. Researchers used blood tests, skin biopsies, eye exams, and brain scans to learn more about how the disease works. The goal was to better u…

This large observational study looks at health records from general practitioners in Naples to estimate how common insulin resistance is in the local population. It also examines whether people with insulin resistance have a higher rate of cardiovascular disease compared to those…

This study is looking at whether peripheral artery disease (PAD) is linked to lower levels of regenerative cells in the blood. Researchers will compare blood samples from adults with PAD to those without the condition, measuring the number of certain progenitor cells and markers …

This pilot study explored whether combining lifestyle changes, risk factor management, medications, and supplements could improve movement, thinking, and immune function in aging adults. 23 sedentary adults aged 50-70 took part. The main goal was to see if the study methods were …

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This study follows adults receiving maintenance hemodialysis for end-stage kidney disease to develop a model that predicts the risk of dying from cardiovascular disease. Researchers will track routine lab results, including how often blood phosphate levels stay in a target range,…

This study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70. The goal was to learn how these tissues change over tim…

This study looked at markers of inflammation, blood clotting, and blood vessel function in 310 HIV-infected adults and healthy volunteers. Researchers collected blood samples to understand how these markers relate to HIV and risks like heart disease or stroke. The goal was to gat…

This large observational study is investigating whether nitrate, nitrite, and phosphate—compounds found naturally in food and water and used as additives—are linked to chronic diseases like gastrointestinal cancers, heart disease, and respiratory conditions. Researchers will foll…

This trial investigates whether genetic variations in the CES1 gene influence how the body responds to the blood thinners clopidogrel and aspirin. Healthy Amish adults will take clopidogrel for a week, then a single dose of aspirin, with blood tests measuring platelet function be…

This study looks at whether getting a yearly LDL cholesterol test could help cancer survivors avoid serious heart problems like heart attacks and strokes. Researchers will analyze health records from over a million cancer survivors in Korea, comparing those who had the test with …

This study looks at how mental stress affects the heart in men and women who have had a heart attack within the past 8 months. Participants undergo a stress challenge and are followed for up to 3 years to see if stress-induced changes in the heart are linked to future heart probl…

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This observational study investigates whether levels of certain enzymes (ACE and ACE2) in saliva and blood are linked to the severity of gum disease in adults with cardiovascular disease. Researchers will compare these enzyme levels across different stages of gum disease—from gin…

This study will assess the diet, heart health, body composition, mental wellbeing, and physical performance of 600 U.S. Army soldiers. Researchers aim to gather detailed data on nutrition and health, similar to a national survey but tailored for the military. The goal is to bette…

This study investigates whether women who had high blood pressure during pregnancy (hypertensive disorders) show differences in brain health in midlife compared to those with normal pregnancies. Participants undergo MRI scans, blood tests, cognitive assessments, and sleep monitor…

This study looks at how aging changes the way older adults respond to exercise. Researchers will have 26 people who previously completed a structured exercise program do a 6-month aerobic workout. They will measure changes in insulin sensitivity and heart fitness to see if age af…

This study looks at whether showing nutrition information on menus—especially through a digital app with augmented reality—helps customers choose healthier meals. About 240 adults dining at two Hispanic restaurants in Texas will try three menu types: a standard menu, a paper menu…

This study explores whether a web-based gamification app can improve nursing students' knowledge and skills in cardiopulmonary resuscitation (CPR). About 86 students will use the app, which includes practice questions, a timer, and a leaderboard to track scores. Researchers will …

This study uses French national health data to compare the risk of major heart problems—like heart attack, stroke, and death—in people with Takayasu arteritis versus similar people without the disease. It also looks at how steroid use may affect these risks. The goal is to better…

This study tests a multi-component behavioral intervention to find the minimum number of weeks needed to help adults on statin therapy increase their daily walking by 2,000 steps. Participants wear a Fitbit to track steps and receive techniques like goal setting, action planning,…

This completed study looked at 260 patients with ischemic cardiomyopathy (a weak heart due to blocked arteries) who had heart surgery. The goal was to develop a personalized approach to choose the best type of surgery and predict risks and outcomes. Researchers used imaging, bloo…

This completed study from France looked at health records of 2 million adults to see if having pneumonia increases the chance of later heart problems like heart attacks, strokes, or heart failure. Researchers compared people who had pneumonia with similar people who did not. The …

This study followed 380 people who had COVID-19 pneumonia for one year after they left the hospital. Researchers used heart ultrasounds, lab tests, and CT scans to check for heart problems. The goal was to understand how COVID-19 affects the heart over time.

This study looked at 50 trained to elite female athletes to understand how not getting enough energy (low energy availability) might harm their hearts. Researchers measured heart disease risk factors and checked DNA changes that could be linked to these risks. The goal was to lea…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This study tested whether helping people sleep longer (through sleep hygiene and extending sleep time) could lower their blood pressure during sleep. 66 adults who slept less than 7 hours per night took part. Researchers measured blood pressure during sleep and awake periods at t…

This study looked at how a diabetes medicine called ertugliflozin affects fat tissue around the heart. Researchers took fat samples from 61 adults with type 2 diabetes and heart disease during heart surgery. They tested the fat in a lab to see if the drug improved how the fat cel…

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This early-stage study tested a new drug called Vitalangio1 in 627 healthy adults aged 18–55 to see if it is safe and how the body processes it. Participants took either the drug or a placebo, and some took it with or without food to see how that affects absorption. The study doe…

This study looked at 46 men having robot-assisted prostate surgery. Researchers tested two different carbon dioxide levels in the blood during surgery to see how they affect brain blood flow and pressure inside the skull. They also checked if these levels changed thinking skills …

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study tested whether an educational website helps people who stopped taking statins due to muscle pain make informed decisions about restarting. Nearly 900 participants were randomly assigned to use the website or receive usual care. The goal was to see if the website increa…

This study followed 268 adults with end-stage kidney disease on dialysis. Each participant wore a Holter heart monitor for 7 days to track irregular heartbeats. Researchers then looked for links between those heart patterns and serious outcomes like sudden cardiac death, heart at…

This pilot study looked at whether adding genetic risk information to standard heart disease counseling or health coaching helps people make healthier choices. 31 adults at risk for heart disease participated. The goal was to see if this approach is practical and can improve diet…

This completed study followed over 7,200 heart patients in Tunisia to see how well they stick to their heart medications after a heart attack or procedure. Researchers simply observed and recorded data without giving any new treatment. The goal is to understand real-world medicat…

This completed study looked at 115 people with inflammatory bowel disease (IBD) to see if their condition raises the risk of atherosclerosis, a hardening of the arteries that can lead to heart attacks and strokes. Researchers measured artery stiffness and thickness, and tracked h…

This study checked if certain blood markers can predict serious heart events like heart attack or death within a year after a stent procedure. Researchers measured two types of cells related to blood vessel health in 170 adults scheduled for a stent. The goal was to see if these …

This study followed 241 adults hospitalized with the flu to see how the infection impacts the heart. Researchers tracked heart complications like new or worsening heart failure, heart attacks, and cardiac arrest. The goal was to better understand the link between influenza and he…

This study looked at whether exercise training can improve physical capacity and heart function in adults who survived Hodgkin lymphoma after chemotherapy and chest radiation. Forty survivors took part in fitness tests and heart monitoring. The goal was to see if exercise could r…

This study looked at why some people improve their aerobic fitness more than others with exercise. Researchers had 21 healthy men do short, intense cycling workouts and measured changes in fitness and certain muscle signals called myokines. The goal was to see if low responders h…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study looked at 99 people with high heart risk to understand how a protein called CETP affects plaque buildup in arteries. Researchers measured CETP activity, artery thickness, and calcium scores. The goal was to learn more about heart disease, not to test a new treatment.

This study tested a school football program called '11 for Health' in 254 Pakistani children aged 8-14. The program included football skills and health lessons over 11 weeks. Researchers measured fitness, health knowledge, and well-being before and after the program, comparing pa…

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This study looked at whether taking short, regular walks during long periods of sitting can lower blood sugar and cholesterol after meals—key risk factors for Type 2 diabetes and heart disease. Researchers compared the effects in normal-weight and overweight/obese South Asian adu…

This study tested a tool built into electronic health records that prompts doctors to discuss heart health with cancer survivors during routine visits. Researchers enrolled 645 survivors of breast, prostate, colorectal, endometrial, and lymphoma cancers across 12 clinics. The goa…

This completed study from Penn State University looked at how a strict 4-week ketogenic diet (very low carb, high fat) affects blood cholesterol and heart health in 25 healthy adults. Researchers compared people with a healthy BMI to those with obesity to see if the diet raises '…

This study examined how conditions like diabetes, smoking, heart disease, and osteoporosis affect the health of dental implants. Researchers looked at 93 people with 314 implants that had been in place for at least three years. They found that these systemic factors can influence…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study tested new ways to make genetic counseling more helpful for people from all backgrounds. Over 1,000 adults completed surveys and allowed their counseling sessions to be recorded. The goal was to see if different counseling methods lead to better experiences, especially…

This study tested a program called GRACE that helps primary care patients assess their risk for diseases like heart disease, cancer, and liver disease using family health history. Researchers enrolled 245 patients from five clinics, including low-resource settings, to see how man…

This study looked at whether a special audit and feedback tool could help elementary schools in Oakland follow physical education laws better. The goal was to increase students' physical activity and reduce health inequalities. Researchers worked with 35 schools that serve mostly…

This study tested whether replacing sitting with standing or walking during daily life could improve blood sugar levels in South Asian adults who are overweight or obese. Eighteen participants followed two regimens: one with more sitting and one with less sitting. The goal was to…

This study tested whether teaching people about healthy lifestyles—through workshops or digital messages—could improve their cardiovascular health and help with food insecurity. It involved 460 participants from vulnerable populations. The goal was to see if better health knowled…

This study looked at whether fatty liver disease can be an early warning sign for heart disease, separate from known risk factors. Researchers measured blood markers of blood vessel damage in 63 people aged 50-69 who were already at high risk for heart problems. The goal was to b…

This study looked at whether wearing an activity monitor (like a Fitbit) after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Researchers tracked motivation, length of hospital stay, and readmission rates in 12 adults who had car…

This study tested whether giving heart attack patients remote monitoring devices to use at home could reduce the need for hospital readmissions. 337 participants with high cardiovascular risk took part. The goal was to see if telemedicine could safely provide necessary diagnostic…

This study looked at how over 1,600 people's bodies react to different breakfasts, like whole grain vs. refined grain and high-fat vs. high-carb. Researchers measured blood sugar, fats, and other markers after meals to understand why responses vary. The goal is to pave the way fo…

This study worked with 42 Cherokee citizens to design a program that strengthens community connections and shares cultural knowledge. The goal was to see if this approach could help lower blood pressure and improve mental well-being. The project had two phases: first gathering he…

This study looked at over 1,600 people with giant cell arteritis, a condition that inflames blood vessels and raises heart risks. Researchers compared tocilizumab and methotrexate to see which better prevents heart attacks, strokes, or death. Using French health data, they analyz…

This study looked at health records of over 2,000 people with HIV from racial and ethnic minority groups to see if seeing a heart specialist (cardiologist) helps prevent heart disease. Researchers tracked who visited a cardiologist and for how long, up to 5 years. The goal is to …

This study looked at what happens when active older adults (55+) reduce their physical activity for just 3 days. Researchers measured changes in blood sugar after meals and blood vessel function, comparing them to younger adults. The goal was to see how quickly inactivity can aff…

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and their mood to understand why weight gain happens. The goal is to use this information to design better programs that help people wi…

This study checked in on 5 adults with Fabry disease who had been taking enzyme replacement therapy (ERT) since childhood for about 15 years. Researchers measured kidney function and heart health to see how well the long-term treatment worked. The goal was to gather follow-up dat…

This completed study followed 200 adults who had COVID-19 to see if the virus causes long-term heart problems or mental health issues. Participants wore health-tracking devices and answered surveys about anxiety, depression, and substance use. The goal was to better understand th…

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This study examined 404 adults aged 40-59 to see if a diagonal crease on the earlobe, known as Frank's sign, is more common in smokers. Researchers took ear photos and recorded medical histories. The goal was to see if this simple, non-invasive sign could help doctors quickly ide…

This study tested whether a theory-based motivational letter mailed six months in advance could increase attendance at a one-year post-cardiac rehabilitation check-up. Researchers compared 102 adults who received the letter to those who got usual care. The goal was to see if a si…

This study looked at 485 patients who had coronary artery bypass surgery to see if a computer method called fuzzy logic could better predict who is at risk of dying. Fuzzy logic is a way to handle uncertain information, similar to how doctors think. The goal is to create a tool t…

This study looked at why African Americans were more likely to get sick and die from COVID-19. Researchers examined how genetics, environment, and social factors like neighborhood and income might affect heart health after infection. The 431 participants, all African Americans fr…

This study worked with Black adults aged 55 and older who have type 2 diabetes to understand why they sit for long periods and how to help them sit less. Researchers used interviews and activity monitors to learn about the social and personal factors that lead to prolonged sittin…

This study looked at how social factors like income, housing, and stress, along with depression, affect blood vessel health in low-income racial and ethnic minority adults. Researchers measured depression, anxiety, stress, and social needs using questionnaires. The goal was to un…

This study tested whether reducing ultra-processed foods (UPF) can improve blood vessel function in middle-aged adults, a key factor in heart disease. Seventeen participants ate either a diet with no UPF or one with high UPF for six weeks. Researchers measured changes in artery f…

This study looked at how reducing inflammation might lower heart disease risk in people with rheumatoid arthritis. Researchers measured heart blood flow in 74 patients before and after treatment with certolizumab, a drug that fights inflammation. The goal was to see if better con…

This completed study tested a web-based tool called PedsBP CDS that helps doctors identify and manage high blood pressure in children aged 6-17. The tool was used in 45 primary care clinics across three rural states, involving over 41,000 youth. The goal was to see if the tool im…

This completed study tested whether artificial intelligence could analyze CT scans of the heart to better predict who is at risk for heart attacks or death. Researchers looked at data from 2190 patients with coronary artery disease. The goal was to create a risk score that goes b…

This study tested whether teaching dialysis staff and providing support to patients could reduce episodes of dangerously low blood pressure during treatment. Over 1,400 patients across multiple clinics took part. The goal was to make dialysis sessions safer and more stable.

This study looked at how different diet compositions affect the number of calories people burn and their risk for chronic diseases like diabetes and heart disease after losing weight. Over 200 adults with overweight or obesity followed a weight-loss phase, then a weight-maintenan…

This study looked at whether online referrals from doctors to the WIC food program help more pregnant women sign up. About 240 pregnant women on public insurance or uninsured took part. Some got usual care, others got a direct digital referral, and some also spoke with a dietitia…

This completed study looked at 80 childhood cancer survivors who had received high doses of anthracycline chemotherapy. Researchers used cardiac MRI and blood tests to find early signs of heart damage that standard tests might miss. The goal was to see if these advanced methods c…

This study looked at how well a daily low-dose aspirin works in people who have both immune thrombocytopenia (low platelets) and heart disease. Only 4 adults took part. Researchers measured platelet function after aspirin to see if the standard dose is enough to prevent blood clo…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study looked at 320 adults who had heart surgery to see how well two different risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers calculated each patient's scores before surgery and compared them to what actually happened. The goal…

This completed study examined blood samples from 40 adults to see if high levels of lipoprotein (a), a type of cholesterol, are linked to fewer or different blood vessel repair cells. Participants with high Lp(a) were compared to those with normal levels. The goal was to better u…

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study gathered information from 100 people undergoing a standard heart procedure called left atrial appendage closure. Researchers used the data to test a software tool that measures heart structures from echocardiograms. No new treatments or procedures were given—only routi…

This study had two parts. First, researchers held focus groups with Arab women in East Jerusalem to understand their health literacy needs. Then, they tested a 4-session workshop designed to improve how these women communicate with their doctors and learn about heart disease. Abo…

This completed study looked at 70 breast cancer survivors to see how their physical activity levels relate to heart disease risk. Participants wore a special armband for a week to track activity, and researchers measured their heart risk using standard scores. The goal was to gat…

This study tested a worksite wellness program designed to reduce stress and improve cardiovascular health among long-term care workers. 159 staff and residents participated. The program included health promotion and safety education, and researchers also looked at whether healthi…

This study follows 202 people who were first checked for sleep apnea as children in 2003. Researchers want to see how their sleep apnea changed over 18 years and whether it is linked to heart problems or thinking difficulties. Participants will repeat sleep tests, blood pressure …

This study tested whether giving Medicaid patients with stage 2 cardiovascular-kidney-metabolic syndrome (CKMS) access to healthy food through Instacart vouchers and food banks, plus nutrition counseling, is practical and engaging. Over 24 weeks, researchers measured how many peo…

This study looked at nearly 242,000 adults with type 2 diabetes to compare different glucose-lowering medications and their effects on heart health. The goal was to help patients and doctors choose the best treatment based on age, sex, race, and kidney function. The main focus wa…

This study looked at how two types of trans fats—one from milk and one from processed oils—affect heart disease risk. 46 healthy adults ate special foods containing either type of fat for a period, and researchers measured changes in their cholesterol and other blood markers. The…

This completed study followed 6,000 adults who had COVID-19 symptoms and were tested for the virus. Participants completed online surveys every 3 months for 18 months to track long-term health issues like fatigue, brain fog, and heart problems. The goal was to better understand t…

This study looked at how stress, behavior, and social factors affect weight loss and heart health in people from disadvantaged backgrounds. 15 adults with overweight or obesity took part. Researchers measured weight, waist size, and heart health over time to understand what helps…

This study tested an indoor air pollution intervention called AIRWISE in 20 adults aged 55 and older with heart disease. Participants received personal air cleaners, a color-changing air quality monitor, and educational materials. The goal was to see if they would use these tools…

This study looked at whether silent myocardial ischemia (reduced blood flow to the heart without chest pain) increases the risk of heart problems or death in people with coronary heart disease. Researchers followed participants for one to three years. The goal was to better under…

This completed study looked at whether digital data like social media posts and online searches can help predict heart disease risk and healthcare use. Researchers analyzed language from Facebook, Twitter, and other platforms from 781 adults aged 30-74. The goal was to find patte…

This study tested whether a brain-healthy version of soul food, called the MIND+SOUL diet, is practical and well-liked by older African Americans at risk for heart disease and cognitive decline. Twenty-nine participants aged 55 and older took cooking classes and received dietary …

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This study tested a way to give veterans their genetic test results that show a higher risk for heart disease. 112 veterans took part. The goal was to see if sharing this information helps them lower their cholesterol and improve their health. The study focused on developing the …

This study looked at how long-term lack of sleep affects heart health and weight in women. Researchers compared premenopausal and postmenopausal women to see if sleep loss raises blood pressure, blood sugar, and belly fat. The goal was to understand if sleep is more important for…

This study looked at health records from over 386,000 adults with type 2 diabetes and moderate heart disease risk. Researchers compared four common second-line diabetes drugs to see which ones were linked to fewer heart attacks, strokes, and other complications. They also asked p…

This study used national health survey data to estimate how many US adults with high cholesterol might be eligible for a new drug called inclisiran. Researchers also calculated how many heart attacks and strokes could be prevented over 10 years if these patients took the drug. Th…

This study tested whether changing the type of fat in milk (by changing cows' diets) could affect heart health in 107 healthy adults. Researchers measured cholesterol and other blood fats after people consumed different milk fats. The goal was to understand how natural trans fats…

This study looked at how certain heart-related proteins change in the blood of 26 adults with end-stage kidney disease during two types of dialysis. The goal was to understand the patterns of these proteins, which may help doctors better monitor heart health in dialysis patients.…

This study aimed to find out if certain genes make people more likely to die suddenly from a heart problem. Researchers looked at the DNA of 2,500 people to see if specific gene variations were linked to sudden cardiac death. No treatments or interventions were given; the goal wa…

This study looked at whether web-based childbirth education helps pregnant women bond with their baby and feel less fear about giving birth. 120 pregnant women in Turkey took part. The researchers measured attachment and fear levels using questionnaires. The goal was to see if on…

This completed study looked at 1,000 heart attack patients to understand why some have no standard risk factors like smoking, high blood pressure, or diabetes. Researchers compared these 'SMuRF-less' patients to those with risk factors, examining their medical history, lab tests,…

This study looks at whether eating whole eggs (which contain cholesterol) helps people aged 50-69 gain more muscle from resistance training compared to eating only egg whites. Thirty-six participants will either do weight training or remain sedentary for 12 weeks while consuming …

This study looked at whether tiny cell parts called mitochondria contribute to higher blood pressure and worse blood vessel health in Black adults. Researchers gave 31 middle-aged and older adults a supplement called MitoQ or a placebo for 8 weeks. The goal was to understand the …

This small study looked at whether drinking a KETO5 XOGenius beverage every day could improve markers of heart health, thinking skills, and body measurements like weight and waist size. Six healthy adults aged 18 to 50 took part. The goal was to gather early information, not to t…

This early-phase trial tested the safety and how the body processes an inhaled form of vardenafil (RT234) in 31 healthy adults. Participants received single and multiple doses of the drug via an inhaler or as a pill. The study is complete and focused on side effects and drug leve…

This study tested whether taking a high-dose fish oil supplement (E-EPA) for one month changes how LDL ('bad' cholesterol) clumps together in 68 healthy adults. Researchers measured blood fats and LDL stickiness before, during, and after the supplement period. The goal was to und…

This study followed 277 male runners who took part in a 2009 study to see how years of ultra-endurance running affect the heart and body. Researchers measured heart function and blood markers over a decade. The goal is to learn about the long-term effects of extreme exercise on h…

This completed study looked at whether the amount of energy people burn through daily activity is linked to body weight and diabetes risk. Researchers measured activity levels in 2500 Black adults from Ghana, South Africa, Seychelles, Jamaica, and the US. They tracked weight chan…

This study tested whether a whole-food plant-based diet, compared to a standard North American diet, can lower LDL cholesterol in 50 adults with heterozygous familial hypercholesterolemia (HeFH). Participants followed each diet for 28 days in a crossover design. Researchers also …

This study looked at how to make school-based physical activity and nutrition programs work better for children in Texas. Researchers tested different support methods—like mentoring, extra resources, and contests—to see which helped schools deliver these programs most effectively…

This completed study followed over 18,000 Taiwanese Buddhists to see if a vegetarian diet is linked to a lower risk of chronic diseases like dementia, depression, heart disease, stroke, gout, cataracts, gallstones, and urinary tract infections. Researchers compared health records…

This study checked if newer psoriasis drugs (IL17/23 inhibitors) also improve artery stiffness, a sign of heart disease. Researchers followed 66 people with moderate-to-severe psoriasis for a year, measuring pulse wave velocity (PWV) and other markers. The goal was to see if thes…

This study looked at 362 adults who had a heart attack to understand why they waited before going to the hospital. Researchers collected information on symptoms, travel time, and other barriers. The goal is to find patterns that can help doctors and communities reduce delays and …