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Breathing settings during prostate surgery may protect your brain

NCT ID NCT06865027

Knowledge-focused Sponsor: University Hospital, Akershus Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 46 men having robot-assisted prostate surgery. Researchers tested two different carbon dioxide levels in the blood during surgery to see how they affect brain blood flow and pressure inside the skull. They also checked if these levels changed thinking skills the day after surgery. The goal is to find the safest way to manage breathing during this type of surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ventilation strategy (normocapnia or hypercapnia)
What this could lead to
If successful, this could help doctors choose the best ventilation strategy during surgery to protect brain function and reduce cognitive decline after prostate surgery.
What could go wrong
This is a small, completed study with only 46 participants, so results may not apply to all patients. It looks at short-term effects, not long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

46 people

The number who actually took part.

Started

Jan 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 to 80 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Males 55-80 years old, accepted by surgeon and attending anesthesiologist for RALP surgery. Exclusion Criteria: * Poorly controlled hypertension (resting BP \>165/90 on pre-study consult). * Emphysema of the lung. * Previous spontaneous pneumothorax. * Cerebrovascular disease. Including but not limited to previous SAH, EDH, SDH, hemorrhage from AVM, known AVM and stenosis in carotid or cerebral arteries. * Intracranial malignancy or metastases from primary cancer. * Significant cardiovascular disease (NYHA class III or IV). * Renal failure grade 4 or 5 (estimated GFR \<30). * Anatomical hinders for performing ultrasound of the right carotid artery or middle cerebral artery. * Primary language other than Scandinavian. * Diagnosed dementia of any subtype.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder intracranial hypertension Postoperative Cognitive Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebral perfusion pressure Circulation system Cognitive function Intracranial pressure

Contacts and locations

Locations

  • Akershus University Hospital

    Lørenskog, 1478, Norway

More trials for these conditions

Other studies related to the condition(s) this trial covers.