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A bike ride could reveal hidden heart risks in young cancer survivors

NCT ID NCT05261256

Diagnosis Sponsor: Technical University of Munich Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This study explores whether a heart ultrasound taken during exercise on a special bicycle can detect subtle heart changes in young people who finished cancer treatment months or years earlier. It aims to see if this test is practical and acceptable for survivors aged 10 to 25, and to compare their results with healthy peers. The goal is to find a way to catch heart problems early, before symptoms appear.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Exercise stress echocardiography (a heart ultrasound performed during exercise on a special bike)
What this could lead to
If feasible, this approach could enable earlier detection of heart problems in childhood cancer survivors, potentially guiding timely interventions to protect heart health.
What could go wrong
This is a small feasibility study, not a proof of effectiveness. It may show the test is impractical or poorly tolerated, and results may not generalize to all survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

40 people

The number who actually took part.

Started

Feb 2022

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants with a history of pediatric cancer will be recruited during appointments in follow-up care at two departments for pediatric cancer in Munich. Healthy peers will be recruited within social environment of participants with a history of cancer (siblings, close friends) and within schools and sport clubs.

Ages

10 to 25 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria for all participants: * Aged between 10 and 25 years * Body height of ≥1,40m (required for performing the examination on the semi supine bicycle ergometer) * Signed informed assent (minor participant) and consent (legal guardian and full-aged participant) Additional inclusion criteria for participants following cancer treatment: * Completion of acute cancer treatment with anthracyclines and/or chest radiation * End of treatment 12 months and five years ago (± three months) * Medical approval for study participation Additional inclusion criteria for healthy control subjects: \- Appropriate as matched pair with respect to age and gender Exclusion Criteria: * Known cardiovascular diseases (incoherent with cardiotoxic treatment) * Inability to follow study instructions (e.g., mental retardation, language) * Acute orthopedic injury (e.g., bone fracture) or orthopedic impairments that preclude examination on a bicycle ergometer (e.g., instable prosthetic device) All participants receive a basic physical and cardiological examination at rest as part of the study protocol to ensure capability before performing the exercise stress echocardiography.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder childhood malignant neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular diseases Pediatric cancer

Contacts and locations

Locations

  • Institute of Preventive Pediatrics, Department of Sport and Health Sciences, Technical University of Munich, Germany

    Munich, 80992, Germany

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