PEDIATRIC CANCER

This study is testing whether a drug called larotrectinib can make radioactive iodine therapy more effective for people with advanced thyroid cancer that has spread to the lungs and has a specific genetic change (NTRK fusion). Participants will take larotrectinib for six months, …

This study aims to find the best way to restore vaccine protection in children who have finished cancer treatment. It compares giving a single booster shot versus restarting a full vaccine series. The goal is to help these young survivors rebuild their immune defenses against ser…

This is the first human study of an experimental antibody drug called CBA-1205 for people with advanced solid tumors that haven't responded to standard treatments. The trial will test the drug's safety and find the right dose in 66 adults and children with various cancers includi…

This study is for children and young adults with advanced thyroid cancer that has spread to the lungs. Researchers want to see if taking new 'targeted' drugs for about a month makes the cancer absorb radioactive iodine better. If it works, this could help doctors use a standard t…

This European trial is testing whether personalized treatments can help children and teenagers whose cancers have returned or not responded to standard therapies. Doctors analyze the unique genetic changes in each child's tumor and match them to specific drugs designed to target …

This study is testing a new combination of three drugs—an immunotherapy, a targeted therapy, and a chemotherapy—for children and teenagers with advanced hepatoblastoma, a type of liver cancer, that has come back or hasn't responded to standard treatments. The goal is to see if th…

This study is testing a new combination of four medicines for children and young adults (under 30) whose solid tumors have come back or haven't responded to standard treatments. The first part checks if the drug mix is safe and finds the right dose. The second part sees how well …

This study is testing a drug called lurbinectedin to see if it is safe and can control tumors in children and adults (age 10+) whose Ewing sarcoma or related cancers have come back after initial treatment. The drug is designed to target specific genetic changes that drive these t…

This study is testing if a drug called selpercatinib can make a standard thyroid cancer treatment (radioactive iodine) work better for children and young adults. It focuses on patients aged 2-25 with a specific genetic change (RET fusion) in their cancer. The goal is to see if ta…

This study is testing whether delivering healthy, frozen meals to families of children undergoing cancer treatment is a practical and helpful support. It will involve 30 families to see if the meal service is easy to use and well-liked by both parents and children. The goal is to…

This study is testing a questionnaire for families to fill out, called QUOCCAS, to see if it can accurately identify children with cancer who might have an inherited risk for the disease. It will compare the questionnaire's results to standard doctor assessments and genetic testi…

This study is looking at whether a special week-long camping experience can improve the quality of life and self-esteem of children with cancer. Researchers will observe and interview kids aged 7-17 who are in treatment or recently finished, as well as young adult counselors, bef…

This study is testing whether a structured exercise program helps children and young adults (ages 2-25) who are newly diagnosed with cancer and undergoing treatment. Researchers want to see if exercising 30 minutes, five days a week helps maintain physical function and improves q…

This study tests whether a computer model can predict which children in the hospital for cancer treatment are most likely to vomit in the next four days. If the model flags a child as high-risk, pharmacists will alert the medical team so they can start preventive anti-nausea medi…

This study is testing whether a special therapy program called EASE can help parents of children recently diagnosed with cancer cope with traumatic stress. Researchers will compare parents who receive the EASE program plus usual care against those who receive only usual care. The…

This study is testing if a special dissolving film containing the drug ondansetron can safely prevent vomiting in children (aged 1-14) who are receiving radiation therapy for cancer. It aims to find a better way to manage this common and distressing side effect. The trial will in…

This study is testing whether a relaxation technique called guided imagery can help reduce nausea and vomiting in children receiving chemotherapy for cancer. Researchers will compare children who receive guided imagery plus standard care to those who receive standard care alone. …

This study is testing whether a smartphone app can deliver art therapy to help young adults who survived childhood cancer. Fifteen participants aged 18-25 will use the app for six weeks, completing weekly art prompts and surveys about their mood. The main goal is to see if this d…

This study is testing whether a financial support program called PediRISE can be successfully offered to families of children with cancer who are facing financial hardship. It will enroll 40 low-income families, who will be randomly assigned to either receive the PediRISE program…

This study aims to understand how physical and motor rehabilitation helps children, teens, and young adults with cancer regain their strength and movement. Researchers will observe 249 patients across Italy who are already receiving standard rehab care, tracking their progress mo…

This study aims to find the best way to monitor children who had radiotherapy for cancer, as they have a higher risk of developing thyroid problems later. Researchers will follow over 2,500 people to see how often thyroid nodules or cancer occur, identify risk factors, and study …

This study aims to collect tumor samples and health information from children and young adults with cancer, as well as survivors and healthy volunteers. The goal is to build a large database to understand how genetic changes in tumors relate to patient outcomes. Researchers will …

This study aims to better understand why some children are born with a high genetic risk for cancer. Researchers will follow children with these inherited conditions and their family members over time, collecting health information and samples. The goal is to learn how these cond…

This study aims to understand how children and their families recover from the stress of major cancer surgery. Researchers will have children and a caregiver wear smartwatches, answer questionnaires, and provide extra blood samples during routine draws to look for patterns linked…

This study aims to create and test Spanish-language educational videos about pediatric cancer topics. Researchers are partnering with Spanish-speaking parents, medical interpreters, and doctors to develop these videos. The goal is to see if these videos can help improve knowledge…

This project is creating a large registry to collect information on children with cancer in French-speaking African countries. It aims to track how many children are diagnosed, what treatments they receive, and their health outcomes. The data will help local health authorities be…

This study is testing a program called COMPRENDO, which uses trained peer guides to help Hispanic parents understand and decide about joining cancer treatment trials for their children. It compares this support to standard care to see if it helps more families participate in rese…

This study is testing a new digital tool called the Cancer Care Companion. It's designed to help parents of children recently diagnosed with cancer communicate better with their medical team and manage their child's care. Researchers want to see if parents find the tool easy to u…

This study is testing a new approach to help children and young adults whose cancers are considered incurable or not responding well to standard treatments. A special team of doctors from different hospitals will review each patient's case to see if they can suggest new, personal…

This study aims to understand how well the seasonal flu vaccine protects children being treated for blood cancers like leukemia. Researchers will follow 150 young patients for a year, taking small blood samples to measure their immune response after vaccination. The goal is to se…

This study aims to learn more about how COVID-19 affects children and young adults, particularly those with cancer. Researchers will collect samples from participants who have tested positive for the virus to understand their symptoms, how their immune system responds, and how lo…

This study aims to understand how a child's genes might influence their risk of severe side effects and how well they respond to standard leukemia treatment. Researchers will observe about 550 Indian children with acute lymphoblastic leukemia (ALL) to find genetic markers linked …