PEDIATRIC CANCER

This early-phase study tests a new drug called CBA-1205, an antibody that targets a protein (DLK1) found on some cancer cells. The main goal is to check the drug's safety and find the right dose in about 66 adults with advanced solid tumors, including liver cancer and melanoma. P…

This study tests a combination of four drugs (cyclophosphamide, sorafenib, bevacizumab, and atezolizumab) in children and young adults with relapsed or hard-to-treat solid tumors. The goal is to find safe doses and see if the treatment shrinks tumors. The trial has two parts: fir…

This study tests whether the drug larotrectinib can make thyroid cancer cells more sensitive to radioactive iodine therapy. It includes children and adults with a specific genetic change (NTRK fusion) whose cancer has spread to the lungs. The goal is to see if this combination ca…

This study tests a laser treatment called LITT for children, teens, and young adults whose low-grade brain tumors have come back after prior therapy. About 40 participants will receive the laser procedure to heat and destroy tumor cells. The goal is to see if this approach can st…

This study tests a combination of three drugs (pucotenlimab, lenvatinib, and irinotecan) in children aged 2-18 with advanced hepatoblastoma that has relapsed or not responded to prior therapy. The goal is to see if this new mix can slow or stop the cancer. About 24 children will …

This study tests whether giving targeted drugs before radioactive iodine (RAI) can make thyroid cancer tumors absorb more RAI, potentially improving treatment. About 32 children and teens with metastatic differentiated thyroid cancer and specific genetic mutations will receive ta…

This study is testing a drug called lurbinectedin in people aged 10 and older whose solid tumors (like Ewing sarcoma) have come back or not responded to standard treatment. The goal is to see if the drug is safe and can shrink tumors or delay their growth. Participants must have …

This study tests whether giving a drug called selpercatinib for 6 months before radioactive iodine therapy can improve treatment outcomes in children, teens, and young adults (ages 2-25) with a specific genetic form of thyroid cancer (RET fusion). The goal is to make the cancer a…

This study looks at whether massage therapy can improve sleep for children aged 12 to 21 who are in the hospital for cancer treatment or a stem cell transplant. About 70 participants will either receive standard care or add massage therapy to their routine. Researchers will track…

This study tests whether a smartphone app called ARTCan can help young adults (ages 18-25) who survived childhood cancer feel better emotionally. Participants will use the app for 6 weeks to do art therapy activities and answer weekly surveys about their mood. The goal is to see …

This study tests a therapy called EASE for parents whose child has cancer. It aims to reduce traumatic stress symptoms over six months. About 306 parents will either get EASE plus their usual support or usual support alone. They will fill out questionnaires at several points to t…

This study tests whether guided imagery—a relaxation technique using mental images—can reduce nausea and vomiting caused by chemotherapy in children with cancer. About 40 children aged 7 to 18 will either receive guided imagery plus standard care or standard care alone. Researche…

This study looks at whether wearing virtual reality (VR) glasses can help children aged 4 to 10 with cancer feel less anxious and scared during a type of chemotherapy called intrathecal chemotherapy. About 20 children will either use VR glasses or receive no extra help. Researche…

This study tests whether an internet-based parent-child therapy program (I-PCIT) can help improve behavior in children aged 2-12 who have or had cancer. Parents of 300 children will be randomly assigned to start therapy right away or wait 5-6 months. The goal is to see if the pro…

This study explores whether a normal camping experience can help children with cancer feel better emotionally and socially. Up to 5,000 children aged 7-17, along with young adult counselors aged 18-25, will take part in a week-long camp. Researchers will interview families and ob…

This study looks at whether a structured exercise program (30 minutes, 5 days a week) can help children and young adults aged 2-25 who are newly diagnosed with cancer and undergoing chemotherapy. The goal is to see if exercise helps maintain physical function and improve quality …

This study tests a dissolvable film containing ondansetron to prevent vomiting caused by moderate-risk radiation therapy in children aged 1-14 with cancer. About 60 kids will receive the film and be monitored for how well it controls vomiting and any side effects. The goal is to …

This study looks at whether providing free, healthy frozen meals to families of children with cancer is practical and helpful. About 30 children aged 12-17 and their parents will take part. The goal is to see if families find the meals easy to use and acceptable during a child's …

This study tests whether a Snoezelen multisensory relaxation room can reduce anxiety in children aged 8 to 17 who are hospitalized for chemotherapy. Participants will compare their feelings during a chemo cycle without Snoezelen to a later cycle with 45-minute Snoezelen sessions …

This study looks at whether a program called PediRISE, which gives extra money to families, can help reduce financial stress for those caring for a child with cancer. About 40 families will be randomly assigned to either receive the PediRISE support or standard care. The main goa…

This study tests whether a computer model (machine learning) can help prevent vomiting in children being treated for cancer. About 1,332 children admitted to the hospital will have their risk of vomiting in the next 96 hours predicted daily. Pharmacists will then alert the medica…

This study follows children under 21 who have a genetic condition that raises their risk of developing cancer, along with their relatives. Researchers will collect medical information and samples over time to better understand how these cancers develop and how to spot them early.…

This study follows 500 Indian children with acute lymphoblastic leukemia (ALL) to see how their genes influence side effects from chemotherapy and how well they respond to steroids. Researchers will collect blood samples and track health outcomes over five years. The goal is to f…

This study involves 205 teens and young adults (ages 15-24) who have or survived childhood cancer. Researchers want to see if a simple screening questionnaire helps doctors and patients talk about sexual health issues. The goal is to make it easier for young survivors to get the …

This study is creating a large database of children with cancer in Africa. It will collect information on cancer types, stages, treatments, and outcomes. The goal is to help health authorities plan better cancer programs for children. No new treatments are being tested; this is p…

This study is for children and teens with cancer that has come back or not responded to standard treatments. Researchers will use advanced genetic testing of each child's tumor to select specific anticancer drugs that target the tumor's unique molecular features. The main goals a…

This study collects real-world data on innovative cancer drugs used in children, adolescents, and young adults (up to age 25) whose cancer has returned or not responded to standard therapy and who cannot join a clinical trial. Researchers will track safety and effectiveness of ta…

This study tests whether trained peer navigators can help Hispanic families enroll their children in cancer clinical trials and better understand the consent process. About 450 parents of Hispanic children with newly diagnosed cancer will be randomly assigned to receive either pe…

This study tests a new tool called Cancer Care Companion that helps parents of children with cancer communicate with doctors and manage care through their electronic health record. About 40 parents will use the tool and give feedback on how easy and helpful it is. The goal is to …

This study creates a registry of 500 children, teens, and young adults (ages 1-39) diagnosed with cancer. Researchers will collect health surveys, physical tests, and blood samples over time to understand how cancer and its treatment affect aging and quality of life. The goal is …

This study tests whether a special video and support program (VIDEO-PEDS) helps parents and doctors have better conversations about treatment goals for children with cancer. About 567 parents of children aged 0-12 with any type of cancer will take part. The goal is to see if the …

This study watches how children and their caregivers recover after major cancer surgery using smartwatches and questionnaires. It also looks at blood proteins and metabolites linked to stress. The goal is to find patterns that show how well a child is bouncing back, so doctors ca…

This study looks at how well the immune system works in children who have finished cancer treatment. It also tests giving vaccines earlier than usual, starting at 3 months after therapy ends. Researchers will compare a single booster shot to a full series of vaccines to see which…

This study watches how children and young adults with cancer improve their ability to move and do daily tasks while receiving physical therapy. Researchers will follow 249 patients across Italy, checking their progress monthly. The goal is to understand which rehab methods work b…

This study is for children with blood cancer who are getting the seasonal flu vaccine. Researchers want to see how strong their immune response is after vaccination. They will take blood samples at different times to measure antibodies and T-cells. The goal is to learn if the vac…

This study works with parents, interpreters, and doctors to create short educational videos in Spanish about key cancer topics. The goal is to help Spanish-speaking caregivers better understand their child's care and feel more supported. The project will test if these videos are …

This study looks at children who received radiation therapy for cancer to see how often they develop thyroid nodules or thyroid cancer. Researchers will track up to 2,550 participants to find risk factors and genetic clues that might predict who is most at risk. The goal is to cr…

This study looks at how parents of children with blood cancers or solid tumors cope with stress and how their coping style affects their child. Researchers will use questionnaires to understand the emotional resources and parent-child relationship. The goal is to create better ps…

This study tests whether a group of specialists from different hospitals can come up with new treatment strategies for children and young adults with cancer that is hard to cure. The team will review each patient's case and suggest a plan different from the one their own doctor h…

This study tests a questionnaire called QUOCCAS, filled out by patients and their caregivers, to see if it can accurately identify children and teens with cancer who may have an inherited cancer predisposition syndrome. About 205 participants will complete the questionnaire, give…

This study is creating a large collection of tumor samples and health information from children and young adults with cancer, as well as survivors and healthy volunteers. Researchers will analyze the genetic makeup of the tumors to find patterns and potential targets for new trea…