Childhood radiation linked to thyroid cancer? new study aims to find out
NCT ID NCT07473518
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study follows children who had radiation therapy for cancer to see how often they develop thyroid nodules or thyroid cancer. Researchers will compare them to children who did not have radiation, looking for risk factors and genetic clues. The goal is to create better screening plans and possibly tailor treatments in the future.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to better, personalized screening guidelines for children who had radiotherapy, helping catch thyroid problems early.
- What could go wrong
- This is an observational study, not a treatment trial, so it won't directly change care yet. Results may take years and might not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 2,550 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2025
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
* Oncologic patients who underwent radiotherapy during childhood between January 1, 1999, and December 31, 2018, with a follow-up of at least 4 years at the Pediatric Unit of IRCCS AOU Bologna. * Subjects not exposed to radiotherapy and without specific risk factors for differentiated thyroid cancer (DTC), who had a thyroid ultrasound performed during childhood at the Nuclear Medicine Unit of IRCCS AOU Bologna between January 1, 1999, and December 31, 2018.
- Ages
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10 to 43 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
INCLUSION CRITERIA For the group of oncologic patients who underwent radiotherapy: * Radiotherapy for an oncologic condition performed between January 1, 1999, and December 31, 2018; * Age at the time of radiotherapy \< 18 years; * Follow-up of at least 4 years conducted at the Endocrine-Metabolic Diseases Program, Pediatric Unit, IRCCS AOU Bologna; * Obtained informed consent For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC: * No history of exposure to ionizing radiation; * No specific risk factors for DTC (autoimmune thyroiditis, familial forms, genetic syndromes); * Thyroid ultrasound performed between January 1, 1999, and December 31, 2018, at the Nuclear Medicine Unit of IRCCS AOU Bologna; * Age at the time of the thyroid ultrasound \< 18 years; * Obtained informed consent EXCLUSION CRITERIA: For the group of oncologic patients who underwent radiotherapy: * Patients transferred to another center before completing 4 years of follow-up after radiotherapy at the Pediatric Unit of IRCCS AOU Bologna, without having received a diagnosis of thyroid cancer. For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC: * None.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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UO Medicina Nucleare - IRCCS Azienda Ospedaliero-Universitaria di Bologna
RECRUITINGBologna, 40138, Italy
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UOC Pediatria - IRCCS Azienda Ospedaliero-Universitaria di Bologna
RECRUITINGBologna, 40138, Italy
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