Diabetes Drug's hidden effect on heart fat revealed
NCT ID NCT04167761
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how a diabetes medicine called ertugliflozin affects fat tissue around the heart. Researchers took fat samples from 61 adults with type 2 diabetes and heart disease during heart surgery. They tested the fat in a lab to see if the drug improved how the fat cells work and reduced inflammation.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Early phase 1
The earliest testing in people: a first look at safety, in a very small group.
- Participants
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61 people
The number who actually took part.
- Started
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Jul 2020
- Finished
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Dec 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * patient at Stanford Cardiovascular Surgery clinic who is scheduled for cardiac bypass surgery or vascular surgery * history of Diabetes Mellitus Type 2 currently diet controlled, or on metformin or dpp4 inhibitors Exclusion Criteria: * allergy or intolerance to interventional medication * currently taking insulin, glp-1 inhibitors, or sulfonylureas
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Stanford University
Stanford, California, 94305, United States
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Other studies related to the condition(s) this trial covers.
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