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Eye scans may reveal hidden heart risks

NCT ID NCT05082402

Diagnosis Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or severity of blocked arteries in the neck, which is a key risk factor for heart attack and stroke.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Swept Source Optical Coherence Tomography Angiography (SS-OCTA)
What this could lead to
If successful, this could lead to a non-invasive eye scan that helps identify people at risk for cardiovascular disease, potentially enabling earlier detection.
What could go wrong
This is a small, completed study with only 42 participants. The results may not apply to everyone, and the eye scan is not yet proven to reliably predict heart disease.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

42 people

The number who actually took part.

Started

Aug 2021

Finished

Oct 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

These subjects were identified in the Northwestern Medicine Division of Vascular Surgery during their standard of care visit.

Ages

18 to 95 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects between 18 and 95 years of age * Able to participate in a clinical eye examination setting * Able to consent * Subjects receiving standard of care carotid duplex ultrasounds Exclusion Criteria: * Inability to get high quality imaging for any reason (ex. Dense cataract, media opacity) * Lack of capacity to provide informed consent * Subjects younger than 18 years of age or older than 95 years of age * History of stroke or acute loss of vision * Unable to participate in a clinical eye examination setting

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder retinal degeneration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular diseases Retina; change

Contacts and locations

Locations

  • Northwestern University/Northwestern Medical Group, Department of Ophthalmology

    Chicago, Illinois, 60611, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.