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New PAH pill aims to delay worsening in large trial

NCT ID NCT03626688

Disease control Sponsor: United Therapeutics Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new oral drug called ralinepag in 687 adults with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. Participants took ralinepag or a placebo on top of their usual PAH medications. The main goal was to see if ralinepag could delay the first worsening event, such as hospitalization or death. The trial is complete, and results help understand if this add-on therapy improves disease control.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

687 people

The number who actually took part.

Started

Jan 2019

Finished

Dec 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. At least 18 years of age. 2. Evidence of a personally signed and dated informed consent form indicating that the subject has been informed of all pertinent aspects of the study prior to initiation of any study-related procedures. 3. Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures 4. Primary diagnosis of symptomatic PAH. 5. Has had a right heart catheterization (RHC) performed at or within 3 years prior to Screening (RHC will be performed during Screening if not available) that is consistent with the diagnosis of PAH. 6. Has WHO/ NYHA functional class II to IV symptoms. 7. If on PAH-specific background oral therapy, subject is on stable therapy with either an endothelin receptor antagonist (ERA) and/or a phosphodiesterase type 5 inhibitor (PDE5-I) or a soluble guanylate cyclase (sGC) stimulator. 8. Has a 6MWD of ≥150 meters. 9. If taking concomitant medications that may affect the clinical manifestations of PAH (eg, calcium channel blockers, diuretics, digoxin, or L arginine supplementation, beta blockers, angiotensin-converting enzyme inhibitors, or angiotensin II receptor blockers), must be on a stable dose for at least 30 days prior to the Baseline Visit and the dosage maintained throughout the study. The exception is that the dose of diuretics must be stable for at least the 10 days prior to Baseline. 10. Both male and female subjects agree to use a highly effective method of birth control throughout the entire study period from informed consent through to the 30-Day Follow-up Visit, if the possibility of conception exists. Eligible male and female subjects must also agree not to participate in a conception process during the study and for 30 days after the last dose of IMP. Eligible male subjects must agree not to participate in sperm donation for 90 days after the last dose of IMP. Exclusion Criteria: 1. For subjects with known HIV-associated PAH, a cluster designation 4 (CD4+) T-cell count \<200/mm3 within 90 days of Baseline. 2. Must not have 3 or more left ventricular dysfunction risk factors as defined in the study protocol. 3. Has evidence of more than mild lung disease on pulmonary function tests performed within 180 days prior to, or during Screening. 4. Has evidence of thromboembolic disease as determined by a V/Q lung scan or local standard of care diagnostic evaluation at or after diagnosis of PAH. 5. Current diagnosis of ongoing and clinically significant sleep apnea as defined by the Investigator. 6. Male subjects with a corrected QT interval using Fridericia's formula (QTcF) \>450 msec and female subjects with a QTcF \>470 msec on ECG recorded at Screening and analyzed by the central ECG laboratory. Subjects with evidence of intraventricular conduction delay, defined as a QRS interval greater than 110 msec, will be excluded if the QTcF is \>500 msec for both males and females. 7. Severe chronic liver disease (ie, Child-Pugh Class C), portal hypertension, cirrhosis or complications of cirrhosis/portal hypertension (eg, history of variceal hemorrhage, encephalopathy). 8. Confirmed active infection with hepatitis B virus (HBV) or hepatitis C virus (HCV). 9. Subjects with alanine aminotransferase or aspartate aminotransferase ≥3 times the upper limit of normal (ULN) or total bilirubin ≥2 × ULN at Screening. 10. Chronic renal insufficiency as defined by serum creatinine \>2.5 mg/dL or requiring dialysis at Screening. 11. Hemoglobin concentration \<9 g/dL at Screening. 12. Subjects treated with an IV or SC prostacyclin pathway agent (eg, epoprostenol, treprostinil, or iloprost) or activin signaling inhibitor for PAH at any time prior to Baseline (use in vasoreactive testing is permitted). 13. Subjects currently on or who were treated with an inhaled or oral prostacyclin pathway agent (iloprost, treprostinil, beraprost, or selexipag) for \>6 months or within 90 days prior to Baseline. 14. Subject has pulmonary veno-occlusive disease. 15. Malignancy diagnosed and/or treated within 5 years prior to Screening, with the exception of localized non-metastatic basal cell or squamous cell carcinoma of the skin or in-situ carcinoma of the cervix excised with curative intent. 16. Subject tests positive for amphetamine, cocaine, methamphetamine, methylenedioxymethamphetamine or phencyclidine in urine drug screen performed at Screening, or has a recent history (6 months) of alcohol or drug abuse. A subject will not be excluded due to a positive drug screen caused by prescribed medications. 17. Initiation or discontinuation of a cardio-pulmonary rehabilitation program based upon exercise within 90 days prior to Screening and/or planned during study participation. 18. Prior participation in any study of ralinepag or participation in another interventional clinical study with medicinal products within 30 days prior to Screening. Concurrent participation in registry or observational studies is allowed, as long as the subject can fulfill all other entry criteria and comply with all study procedures. 19. Any reason that, in the opinion of the Investigator or Medical Monitor, precludes the subject from participating in the study (eg, any previous or intercurrent medical condition) that may increase the risk associated with study participation or that would confound study analysis or impair study participation or cooperation. 20. Known hypersensitivity to ralinepag or any of the excipients. 21. Life expectancy \<12 months based on the Investigator's opinion. 22. Women who are pregnant, lactating or breast-feeding.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder connective tissue disorder Familial Primary Pulmonary Hypertension heritable pulmonary arterial hypertension hypertensive disorder lung disorder pulmonary arterial hypertension pulmonary hypertension respiratory system disorder vascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular diseases Connective tissue diseases Familial primary pulmonary hypertension Hypertension Hypertension, pulmonary Lung diseases PAH Pulmonary arterial hypertension Pulmonary hypertension Respiratory tract disease Vascular diseases

Contacts and locations

Locations

  • "Onasseio" Cardiosurgery Hospital, Hemodynamic Research and Interventional Cardiology Dept., 356, Syggrou Avenue

    Athens, Kallithea, 17674, Greece

  • AHEPA General Hospital of Thessaloniki, A' Cardiology Clinic, 1 St. Kyriakidi Street

    Thessaloniki, 54636, Greece

  • AKH Wien, Innere Med. II, Kardiologie, Währingergürtel 18-20

    Vienna, 1090, Austria

  • Allegheny General Hospital

    Pittsburgh, Pennsylvania, 15212, United States

  • Ascension Alexian Brothers

    Elk Grove Village, Illinois, 60007, United States

  • Ascension Texas Cardiovascular

    Austin, Texas, 78705, United States

  • Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza, Viale del Policlinico, 155

    Roma, Roma, 00161, Italy

  • Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia, S.C. di Cardiologia, Viale Luigi Pinto, 1

    Foggia, Foggia, 71100, Italy

  • Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo)

    Monza, 20900, Italy

  • Balcalı, Çukurova Üniversitesi Kardiyoloji ABD

    Adana, Saricam, 01330, Turkey (Türkiye)

  • Baylor University Medical Center

    Dallas, Texas, 75246, United States

  • Beijing Shijitan Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100038, China

  • Boston University Medical Center

    Boston, Massachusetts, 02118, United States

  • CE Dniprop RCC&C Center of Dniprop RC Dept of Card SI DMA of MOHU, Chair of Internal Medicine 3, 28, Knyazya Volodymyra Velykogo St.

    Dnipro, 49070, Ukraine

  • CHRU de Lille - Hopital Cardiologique

    Lille, 59037, France

  • CHU Besançon - Hôpital Jean Minjoz

    Besançon, 25030, France

  • CHU Lyon - Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel, Service de Pneumologie, 59 Boulevard Pinel

    Bron, Rhone, 69677, France

  • CHU Nancy - Hôpital de Brabois Adultes, Pneumologie- Oncologie Médicale, Rue du Morvan

    Vandœuvre-lès-Nancy, Meurthe et Moselle, 54511, France

  • CHU de Brest - Hôpital de la Cavale Blanche

    Brest, 29609, France

  • CHU de Grenoble - Hôpital Albert Michallon, Clinique de Cardiologie, Boulevrad de la Chantourne

    Grenoble, Isere, 38048, France

  • CHU de Rouen - Hôpital Charles Nicolle

    Rouen, Seine Maritime, 76031, France

  • CHU de Saint-Etienne - Hopital Nord, Service de Medecine vasculaire et therapeutique, 81 Avenue A. Raimond

    Saint-Étienne-de-Montluc, Pays de la Loire Region, 42005, France

  • CHU de Strasbourg - Nouvel Hôpital Civil, Ctre de competence Hypertension Arterielle Pulmona, 1 place de l Hopital

    Strasbourg, Bas Rhin, 67091, France

  • CICUM San Miguel

    Guadalajara, Jalisco, 44160, Mexico

  • Cardiologia Palmero

    Caba, Buenos Aires F.D., 1425, Argentina

  • Carilion Clinic Pulmonary and Sleep Medicine

    Roanoke, Virginia, 24014, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Central Florida Pulmonary Group

    Orlando, Florida, 32803, United States

  • Centro Hospitalar Universitário Lisboa Norte, E.P.E. Hospital Pulido Valente

    Lisbon, 1769-001, Portugal

  • Centro Hospitalar de Santo António E.P.E.

    Porto, Porto District, 4099-001, Portugal

  • Centro Hospitalar e Universitário de Coimbra, E.P.E.

    Coimbra, 3000-075, Portugal

  • Chest Medicine Associates

    South Portland, Maine, 04106, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Cleveland Clinic Florida

    Weston, Florida, 33331, United States

  • Clinical Center Zemun. Clinic for internal medicine, Department of Cardiology

    Belgrade, 11080, Serbia

  • Clinical Center of Serbia, Koste Todorovica 8

    Belgrade, 11000, Serbia

  • Clinical Hospital Dubrava Zagreb, Avenija G.Šuška 6

    Zagreb, 10000, Croatia

  • Cliniques Universitaires de Bruxelles Hopital Erasme

    Brussels, 1070, Belgium

  • Communal Noncommercial Enterprise of Lviv Regional Council Lviv Clinical Hospital, Dept of Cardiology, D.Halytskyi Lviv NMU, Ch of Internal Medicine #1, 7, Chernihivska str.

    Lviv, 79010, Ukraine

  • Community Health Network Cancer Center North

    Indianapolis, Indiana, 46250, United States

  • Copenhagen University Hospital (Rigshospitalet)

    Copenhagen, 2100, Denmark

  • Dokuz Eylul Universitesi Tip Fakultesi, Mithatpasa caddesi Inciralti Balcova

    Izmir, 35340, Turkey (Türkiye)

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • East Carolina University

    Greenville, North Carolina, 27834, United States

  • Emory University Hospital

    Atlanta, Georgia, 30322, United States

  • Fiona Stanley Hospital

    Murdoch, Western Australia, 6150, Australia

  • Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35

    Milan, 20122, Italy

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100, Italy

  • Fundacion Favaloro

    Ciudad Autonoma Buenos Aires, Ciudad Autonoma Buenos Aires, C1093AAS, Argentina

  • Fundacion Respirar

    Ciudad Autonoma Buenos Aires, Ciudad Autonoma Buenos Aires, 1426, Argentina

  • Fuwai Hospital, Chinese Academy of Medical Sciences

    Beijing, 100037, China

  • Gachon University Hospital Gil Medical Center

    Incheon, Namdong-gu, 21565, South Korea

  • Gazi University Medical Faculty Hospital

    Ankara, 06560, Turkey (Türkiye)

  • Golden Jubilee National Hospital

    Glasgow, West Dunbartonshire, G81 4DY, United Kingdom

  • Gottsegen György Országos Kardiovaszkuláris Intézet

    Budapest, Budapest, 1096, Hungary

  • Groupement Hospitalier Sud - Hôpital Bicêtre

    Le Kremlin-Bicêtre, Val de Marne, 94275, France

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangdong, 510080, China

  • HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás

    Goiânia, Goiás, 74605-020, Brazil

  • Hadassah Ein Kerem Medical Center, Kiryat Hadassah

    Jerusalem, 9112001, Israel

  • Hospital Britanico de Buenos Aires

    Ciudad Autonoma Buenos Aires, Ciudad Autonoma Buenos Aires, 1280, Argentina

  • Hospital Clinic de Barcelona, C/ Villarroel, 170

    Barcelona, 08036, Spain

  • Hospital Garcia de Orta, E.P.E

    Almada, 2805-267, Portugal

  • Hospital Italiano

    Ciudad Autonoma Buenos Aires, Buenos Aires, C1181ACH, Argentina

  • Hospital Italiano de Cordoba

    Córdoba, X5004BAL, Argentina

  • Hospital PROVINCIAL "Dr. Jose Maria Cullen"

    Santa Fe, Santa Fe Province, 3000, Argentina

  • Hospital Privado Centro Medico de Cordoba S.A

    Córdoba, Córdoba Province, X5016KEH, Argentina

  • Hospital Sao Lucas da PUC-RS

    Porto Alegre, R.S, 90610-000, Brazil

  • Hospital Sao Paulo

    São Paulo, São Paulo, 04037-002, Brazil

  • Hospital Universitari Vall d'Hebron, Respiratory Dept., Passeig Vall d'Hebron,119-129, Neumologia

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, Madrid, 28041, Spain

  • Hospoital Universitari i Politecnic La Fe

    Valencia, Valencia, 46026, Spain

  • Hôpital Nord - CHU Marseille

    Marseille, 13015, France

  • IRCC Ospedale Policlinico San Martino

    Genova, Genova, 16132, Italy

  • Imperial College Healthcare NHS Trust

    London, W12 0HS, United Kingdom

  • Indiana University School of Medicine

    Indianapolis, Indiana, 46202, United States

  • Institut Universitaire de Cardiologie et de Pneumologie de Quebec

    Québec, Quebec, G1V 4G5, Canada

  • Institute for Pulmonary Diseases of Vojvodina, Put Dr Goldmana 4

    Kamenitz, 21204, Serbia

  • Instituto Nacional de Cardiologia Dr Ignacio Chavez Rivera

    Mexico City, Mexico City, 14080, Mexico

  • Instituto Nacional de Ciencias Médicas y Nutricion Dr. Salvador Zubiran

    Mexico City, Mexico City, 14080, Mexico

  • Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa

    Belo Horizonte, Minas Gerais, 30441-070, Brazil

  • Instituto de Cardiologia de Corrientes

    Corrientes, Corrientes Province, Argentina

  • Instituto de Investigaciones Clinicas Mar del Plata

    Mar del Plata, Buenos Aires, 7600, Argentina

  • Instituto do Coracao

    São Paulo, São Paulo, 05403-000, Brazil

  • Institutul Inimii "Niculae Stancioiu" Cluj-Napoca, Cardiologie, Str. Motilor nr. 19-21

    Cluj-Napoca, 400001, Romania

  • Institutul de Pneumoftiziologie "Marius Nasta", Sos. Viilor nr. 90, Sector 5

    Bucharest, 050159, Romania

  • Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C.C. Iliescu", Sos. Fundeni nr. 258

    Bucharest, 022328, Romania

  • Instiuto Nacional del Torax

    Providencia, Santiago de Chile, 7500691, Chile

  • Integris Baptist Medical Center

    Oklahoma City, Oklahoma, 73112, United States

  • Irmandade da Santa Casa de Misericórdia de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90035-074, Brazil

  • Istituto Mediterraneo Trapianti e Terapie a Alta Specializzazione (IRCCS-ISMETT)

    Palermo, PA, 90127, Italy

  • Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California, 90027, United States

  • Keck Hospital of USC

    Los Angeles, California, 90033, United States

  • Kentuckiana Pulmonary Research Center

    Louisville, Kentucky, 40202, United States

  • Krakowski Szpital Specjalistyczny im. Jana Pawla II, Oddział Kliniczny Chorób Serca i Naczyń z Pododdziałem Intensywnego Nadzoru Kardiologicznego, Pradnicka 80

    Krakow, 31-202, Poland

  • LA Biomedical Research Institute Harbor-UCLA Medical Center

    Torrance, California, 90502, United States

  • LHSC - Victoria Hospital

    London, Ontario, N6A 5W9, Canada

  • Linköping Universitetssjukhuset

    Linköping, 58185, Sweden

  • Loma Linda University Medical Center

    Loma Linda, California, 92354, United States

  • MHAT "Sveta Anna" Sofia AD

    Sofia, Sofia, 1750, Bulgaria

  • MHAT - "National Heart Hospital" EAD, 65, Konyovitza Str.

    Sofia, 1309, Bulgaria

  • Macquarie University

    Macquarie, New South Wales, 2109, Australia

  • Marmara Universitesi Istanbul Pendik Egitim ve Arastirma Hastanesi

    Istanbul, 34899, Turkey (Türkiye)

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Medical College of Wisconsin/Froedtert Hospital

    Milwaukee, Wisconsin, 53226, United States

  • Medizinische Universität Innsbruck

    Innsbruck, 6020, Austria

  • Meir Medical Center, 59 Tshernichovski st.

    Kfar Saba, 4428164, Israel

  • Memorial Hermann Hospital

    Houston, Texas, 77030, United States

  • Mersin Üniversitesi Tip Fakültesi Ciftlikköy Kampüsü

    Mersin, Yenisehir, 33343, Turkey (Türkiye)

  • Mount Sinai School of Medicine

    New York, New York, 10029, United States

  • NYU Langone Medical Center

    New York, New York, 10016, United States

  • NZOZ Europejskie Centrum Zdrowia, ul. Borowa 14/18

    Otwock, 05-400, Poland

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Heart Centre

    Singapore, 169609, Singapore

  • National Jewish Health

    Denver, Colorado, 80206, United States

  • National Taiwan University Hospital

    Taipei, Taipei, 10002, Taiwan

  • National University Hospital

    Singapore, Singapore, 119074, Singapore

  • Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • Nepean Hospital

    Kingswood, New South Wales, 2751, Australia

  • Norrlands Universitetssjukhus, Hjärtcentrum

    Umeå, 90185, Sweden

  • Ochsner Medical Center

    New Orleans, Louisiana, 70121, United States

  • Ordensklinikum Linz GmbH - Elisabethinen, Fadingerstrasse 1

    Linz, 4020, Austria

  • Oregon Clinic-Pulmonary West

    Portland, Oregon, 97225, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Osmangazi Uni Medical Faculty

    Eskişehir, Odunpazari, 26040, Turkey (Türkiye)

  • Pecsi Tudomanyegyetem, Szivgyogyaszati Klinika, Ifjusag u. 13.

    Pécs, 7624, Hungary

  • Peter Lougheed Centre

    Calgary, Alberta, T1Y 6J4, Canada

  • Piedmont Healthcare Pulmonary and Critical Care Research

    Austell, Georgia, 30106, United States

  • Premium Clinic Wrocław CM, Podwale 83/17

    Wroclaw, 50-414, Poland

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Rabin Medical Center-Beilinson Campus, Pulmonary Institute, 39 Jabotinsky St Ground floor

    Petah Tikva, 4941492, Israel

  • Ronald Reagan UCLA Medical Center

    Los Angeles, California, 90024, United States

  • Royal Brompton Hospital

    London, SW3 6NP, United Kingdom

  • Royal Free London NHS Foundation Trust, Pond Street

    London, Greater London, NW3 2QG, United Kingdom

  • Royal Hobart Hospital

    Hobart, Tasmania, 7000, Australia

  • Royal Prince Alfred Hospital

    Camperdown, New South Wales, 2050, Australia

  • SBPA Research LLC

    Santa Barbara, California, 93105, United States

  • SI F.H.Yanovskyi National Institute of Phthisiology and Pulmonology of NAMSU, Clinical and Functional Dept, 10, Amosova St.

    Kyiv, 03680, Ukraine

  • SMBD Jewish General Hospital d/b/a Jewish General Hospital

    Montreal, Quebec, H3T1E2, Canada

  • Sahlgrenska Universitetssjukhuset

    Gothenburg, 41345, Sweden

  • Samsung Medical Center

    Seoul, Gangnam-gu, 06351, South Korea

  • Sanatorio Parque

    Rosario, Santa Fe Province, 2000, Argentina

  • Sanatorio de la Trinidad Mitre

    Buenos Aires, Buenos Aires, C1039AAO, Argentina

  • Schwarzwald-Baar Klinikum

    Donaueschingen, 78166, Germany

  • Sentara Cardiovascular Research Institute

    Norfolk, Virginia, 23507, United States

  • Seoul National University Hospital

    Seoul, Jongno-gu, 03080, South Korea

  • Shanghai Pulmonary Hospital

    Shanghai, Shanghai Municipality, 200443, China

  • Spectrum Health Medical Group

    Grand Rapids, Michigan, 49546, United States

  • Spitalul Clinic de Boli Infectioase si Pneumoftiziologie "Dr. Victor Babes" Timisoara, Str. Gheorghe Adam nr. 13

    Timișoara, 300310, Romania

  • St Vincent's Hospital Melbourne

    Fitzroy, Victoria, 3065, Australia

  • St Vincent's Hospital Sydney

    Darlinghurst, New South Wales, 2010, Australia

  • St. Joseph's Hospital and Medical Center

    Phoenix, Arizona, 85013, United States

  • St. Vincent Medical Group, Inc.

    Indianapolis, Indiana, 46260, United States

  • Stanford Healthcare

    Stanford, California, 94305, United States

  • Statcare Pulmonary Consultants

    Knoxville, Tennessee, 37919, United States

  • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ Családorvosi Intézet és Rendelő

    Szeged, Csongrád-Csanád, Hungary, Hungary

  • Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu, Oddzial Kardiologii - F, ul. Dluga 1/2

    Poznan, 61-848, Poland

  • Tel Aviv Sourasky Medical Center, 6 Weizmann St.

    Tel Aviv, 6423906, Israel

  • Temple University

    Philadelphia, Pennsylvania, 19140, United States

  • The Alfred Hospital

    Melbourne, Victoria, 3004, Australia

  • The Lady Davis Carmel Medical Center, 7 Michal st.

    Haifa, 3436212, Israel

  • The Methodist Hospital Research Institute

    Houston, Texas, 77030, United States

  • The Newcastle upon Tyne Hospitals NHS Foundation Trust, Sir William Leech Lung Research Centre

    Newcastle upon Tyne, Tyne and Wear, NE7 7DN, United Kingdom

  • The Ohio State University Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • The Prince Charles Hospital

    Chermside, Queensland, 4032, Australia

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • Thoraxklinik-Heidelberg Zentrum für Pulmonale Hypertonie

    Heidelberg, Baden-Wurttemberg, 69126, Germany

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • UCSD Health Sciences

    La Jolla, California, 92037, United States

  • UNESP-Faculdade de Medicina da Universidade Estadual Paulista Campus Botucatu

    Botucatu, São Paulo, 18618-687, Brazil

  • UT Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • UZ Leuven, UZ Leuven Campus Gasthuisberg, Herestraat 49

    Leuven, 3000, Belgium

  • Uludag Universitesi Tip Fakültesi, Gorukle Kampusu

    Bursa, 16059, Turkey (Türkiye)

  • Unidad de Investigacion Clinica en Medicina, S.C.

    Monterrey, N.L., 64718, Mexico

  • Universitaetsklinikum Carl Gustav Carus TU Dresden

    Dresden, 01307, Germany

  • Universitaetsklinikum Hamburg-Eppendorf

    Hamburg, 20246, Germany

  • Universitaetsklinikum des Saarlandes, Innere Medizin V, IMED, Kirrberger Strasse 100, Gebäude 41

    Homburg, Saarland, 66424, Germany

  • Universitaetsmedizin der Johannes-Gutenberg-Universitaet Mainz, Zentrum für Kardiologie I, Centrum für Thrombose und Hämostase (CTH), Langenbeckstrasse 1

    Mainz, Rhineland-Palatinate, 55131, Germany

  • University Clinic for Pulmonary Diseases, Jordanovac 104

    Zagreb, 10000, Croatia

  • University General Hospital Attikon

    Chaïdári, 12462, Greece

  • University General Hospital of Alexandroupolis

    Alexandroupoli, 68100, Greece

  • University Health Network-Toronto General Hospital

    Toronto, Ontario, M5G 2N2, Canada

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

  • University of Arizona

    Tucson, Arizona, 85724, United States

  • University of California Davis Medical Center

    Sacramento, California, 95817, United States

  • University of California, Irvine

    Orange, California, 19103, United States

  • University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

  • University of Cincinnati-Medical Science Building

    Cincinnati, Ohio, 45267, United States

  • University of Colorado Hospital

    Aurora, Colorado, 80045, United States

  • University of Florida

    Gainesville, Florida, 32610, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242, United States

  • University of Maryland Medical Center

    Baltimore, Maryland, 21201, United States

  • University of Miami

    Miami, Florida, 33136, United States

  • University of New Mexico

    Albuquerque, New Mexico, 87131, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of Virginia Medical Center

    Charlottesville, Virginia, 22908, United States

  • Universitätsklinikum Leipzig, Medizinische Klinik II, Pneumologie

    Leipzig, Saxony, 04103, Germany

  • Universitätsmedizin Greifswald

    Greifswald, Mecklenburg-Vorpommern, 17475, Germany

  • Uniwersytecki Szpital Kliniczny w Bialymstoku, Klinika Kardiologii z Oddzialem Intensywnego Nazdoru Kardiologicznego, M. Sklodowskiej 24a

    Bialystok, 15-276, Poland

  • VA Greater Los Angeles Healthcare System

    Los Angeles, California, 90073, United States

  • VU Medisch Centrum, De Boelelaan 1117

    Amsterdam, 1081 HV, Netherlands

  • Vermont Lung Center

    Colchester, Vermont, 05446, United States

  • Vseobecna fakultni nemocnice v Praze, II. interni klinika kardiologie a angiologie VFN a 1. LF UK, U nemocnice 2

    Prague, 128 08, Czechia

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Weill-Cornell-New York Presbyterian Hospital

    New York, New York, 10021, United States

  • Westmead Hospital

    Sydney, New South Wales, 2145, Australia

  • Winthrop Hospital

    Mineola, New York, 11501, United States

  • Xiangya Hospital Central South University

    Changsha, Hunan, 410008, China

  • Århus Universitetshospital

    Aarhus, 8200, Denmark

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