CONNECTIVE TISSUE DISEASES

This study tests whether stem cells from donated fat tissue can help people with lung scarring caused by autoimmune diseases like lupus or scleroderma. Sixteen adults will receive infusions and be monitored for safety and breathing improvements over nearly a year. The goal is to …

This study tests a new treatment called CD19-BCMA CAR-T cell therapy for people with connective tissue diseases like lupus, rheumatoid arthritis, and scleroderma. The therapy uses a patient's own immune cells, modified to target and calm the overactive immune system. The main goa…

This study looks at the long-term safety and effectiveness of belimumab in adults with lung scarring (interstitial lung disease) caused by scleroderma or other connective tissue diseases. About 514 people who finished a previous belimumab study will continue treatment for up to 3…

This study is testing whether a special MRI using 129 xenon gas can help doctors see and track changes in the lungs of people with pulmonary arterial hypertension (PAH), a serious condition where blood vessels in the lungs narrow. About 20 adults with PAH will have MRI scans alon…

This study looks at whether adding a simple microscope test of the tiny blood vessels at the base of the fingernails (capillaroscopy) can help doctors diagnose a type of lung disease linked to connective tissue disorders more quickly. About 48 adults newly diagnosed with intersti…

This study aims to find better ways to detect lung scarring (interstitial lung disease) early in people with autoimmune connective tissue diseases. Researchers will analyze tiny particles in the blood and use AI to examine lung scans from 200 participants. The goal is to identify…

This study tests a digital platform called the Genetics Navigator, designed to help patients and parents of children who are offered genetic testing. The goal is to see if using the platform reduces distress and improves the overall experience. About 170 adults will participate, …