Smartphone mindfulness app tested to lower heart disease risk
NCT ID NCT06152185
First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times
Summary
This study tests whether a smartphone-based mindfulness training program can reduce stress and improve cardiovascular health in stressed adults aged 45 and older who are at risk for heart disease. About 106 participants will either use the app for 28 days or continue their usual routine. Researchers will measure changes in stress, blood pressure, and daily life reactions over three months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- mindfulness training app
- What this could lead to
- If it works, this could point toward a simple, low-cost way to lower stress and improve heart health in at-risk adults.
- What could go wrong
- This is a small, early feasibility study with only 106 participants. Results may not apply to everyone, and the app may not produce lasting changes in stress or blood pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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106 people
The number who actually took part.
- Started
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Feb 2024
- Finished
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Jun 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age 45 years or older * Fluent in English and proficient in reading English * Living in the Pittsburgh area for the next 5 months and available for study visits and activities during this period * High perceived stress (greater than or equal to 14 on the 10-item Perceived Stress Scale) * Diagnosed with hypertension by medical provider and, if medicated, blood pressure below 150/100, or if unmedicated, clinic blood pressure reading greater than or equal to 125/75 and less than 150/100 * Moderate-to-high cardiovascular disease risk, as indicated by hypertension and at least 1 of the following: * Diagnosed with diabetes by medical provider * Diagnosed with high cholesterol by medical provider * Current smoker by self-report (smoking or vaping every day or nearly every day) * Body Mass Index ≥30 * Android or iOS smartphone that meets study requirements * Participant otherwise able to meet study requirements Exclusion Criteria: * Clinical or symptomatic atherosclerotic disease, including ischemic heart disease, heart failure, angina, stroke, or atrial fibrillation * Two or more "night shift" episodes in the past month * Pregnancy * Typical alcohol consumption ≥15 drinks per week * Marijuana or hashish use \>9 of the past 30 days * Use of other controlled substances (e.g., cocaine, crack, heroin, meth, ecstasy) in the past 30 days * Current moderate-to-severe depressive symptoms (score ≥15 on PHQ-9) * Suicidal ideation (PHQ-9 item 9 score \>0) * Positive PTSD screen (traumatic event(s) endorsed and total score ≥3 on Primary Care PTSD screen for DSM-5) * Positive Bipolar Disorder screen (≥7 yes responses to item 1, yes to item 2, and moderate or serious on item 3 of Mood Disorder Questionnaire) * Positive screen for psychosis (≥1 on Two-Item Screen for Early Psychosis) * Regular systematic mind-body practice (e.g., yoga or meditation \>2 times/week) * Current participation in another clinical trial or in a study that uses smartphone software
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
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