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New procedure shows promise for Hard-to-Control high blood pressure

NCT ID NCT02439775

Disease control Sponsor: Medtronic Vascular Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tested a procedure called renal denervation, which uses radiofrequency energy to calm overactive nerves in the kidneys, to see if it can safely lower blood pressure in people whose hypertension is not controlled by up to three medications. The study involved 337 participants with high blood pressure. The main goal was to measure blood pressure changes six months after the procedure and check for serious side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

337 people

The number who actually took part.

Started

Jul 2015

Finished

Aug 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individual has office systolic blood pressure (SBP) ≥ 150 mmHg and \<180 mmHg and a diastolic blood pressure (DBP) ≥ 90 mmHg when receiving a medication regimen of one, two, or three antihypertensive medication classes. * Individual has 24-hour Ambulatory Blood Pressure Monitoring (ABPM) average SBP ≥ 140 mmHg and \< 170 mmHg. Exclusion Criteria: * Individual lacks appropriate renal artery anatomy. * Individual has estimated glomerular filtration rate (eGFR) of \<45. * Individual has type 1 diabetes mellitus or poorly-controlled type 2 diabetes mellitus. * Individual has one or more episodes of orthostatic hypotension. * Individual requires chronic oxygen support or mechanical ventilation other than nocturnal respiratory support for sleep apnea. * Individual has primary pulmonary hypertension. * Individual is pregnant, nursing or planning to become pregnant. * Individual has frequent intermittent or chronic pain that results in treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) for two or more days per week over the month prior to enrollment * Individual has stable or unstable angina within 3 months of enrollment, myocardial infarction within 3 months of enrollment; heart failure, cerebrovascular accident or transient ischemic attack, or atrial fibrillation at any time. * Individual works night shifts.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder hypertensive disorder vascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular diseases Hypertension Vascular diseases

Contacts and locations

Locations

  • Alfred Hospital

    Melbourne, Victoria, 3004, Australia

  • AnMed Health

    Anderson, South Carolina, 29621, United States

  • Aurora St. Luke's Medical Center

    Milwaukee, Wisconsin, 53215, United States

  • Baptist Medical Center Jacksonville

    Jacksonville, Florida, 32207, United States

  • Barnes-Jewish Hospital

    St Louis, Missouri, 63110, United States

  • Baylor Heart & Vascular Hospital

    Dallas, Texas, 75226, United States

  • Cardiff and Vale University Health Board - University Hospital of Wales

    Cardiff, United Kingdom

  • Cardiology Associates Research LLC

    Tupelo, Mississippi, 38801, United States

  • Centennial Medical Center

    Nashville, Tennessee, 37203, United States

  • Charleston Area Medical Center

    Charleston, West Virginia, 25304, United States

  • Clinique Pasteur

    Toulouse, France

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • Emory University Hospital Midtown

    Atlanta, Georgia, 30308, United States

  • Galway University Hospital

    Galway, Ireland

  • Hamilton Heath

    Hamilton, Ontario, Canada

  • Hattiesburg Clinic

    Hattiesburg, Mississippi, 39401, United States

  • Heart Center Research, LLC

    Huntsville, Alabama, 35801, United States

  • Herzzentrum Leipzig, Universitätsklinik

    Leipzig, 04289, Germany

  • Higashi Takarazuka Satoh Hospital

    Takarazuka, Hyōgo, Japan

  • Hippokration General Hospital of Athens

    Athens, 11527, Greece

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Imperial College Healthcare NHS Trust

    London, W12 0HS, United Kingdom

  • Iowa Heart Center

    West Des Moines, Iowa, 50266, United States

  • Jichi Medical University Hospital

    Shimotsuke, Tochigi, 329-0498, Japan

  • Klinikum Wels-Grieskirchen

    Wels, 4600, Austria

  • Memorial Hospital Jacksonville

    Jacksonville, Florida, 32216, United States

  • Minneapolis Heart Institute Foundation

    Minneapolis, Minnesota, 55407, United States

  • Mitsui Memorial Hospital

    Chiyoda City, Tokyo, 101-8643, Japan

  • Mount Sinai Medical Center

    New York, New York, 10029, United States

  • North Shore University Hospital

    Manhasset, New York, 11030, United States

  • Oregon Health & Science University Hospital

    Portland, Oregon, 97239, United States

  • Piedmont Heart Institute

    Atlanta, Georgia, 30309, United States

  • PinnacleHealth Cardiovascular Institute

    Harrisburg, Pennsylvania, 17011, United States

  • Providence Hospital

    Southfield, Michigan, 48075, United States

  • Royal Bournemouth Hospital

    Bournemouth, United Kingdom

  • Royal Devon & Exeter NHS Foundation Trust

    Exeter, EX2 5DW, United Kingdom

  • Royal Perth

    Perth, Australia

  • Saint Barnabas Medical Center

    Livingston, New Jersey, 07039, United States

  • Saiseikai Nakatsu Hospital

    Osaka, Japan

  • Sana Kliniken Lübeck

    Lübeck, 23560, Germany

  • Shonan Kamakura General Hospital

    Kamakura, Okamoto, Japan

  • St Joseph Mercy Oakland

    Pontiac, Michigan, 48341, United States

  • St. George Hospital

    Kogarah, Australia

  • St. Michael's Hospital

    Toronto, Ontario, Canada

  • Stanford Hospital and Clinics

    Stanford, California, 94305, United States

  • Tallahassee Research Institute

    Tallahassee, Florida, 32308, United States

  • The Miriam Hospital

    Providence, Rhode Island, 02906, United States

  • University General Hospital of Thessaloniki (AHEPA)

    Thessaloniki, 54621, Greece

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • University of Kentucky

    Lexington, Kentucky, 40536, United States

  • Universitäts-Herzzentrum Freiburg - Bad Krozingen GmbH

    Bad Krozingen, 79189, Germany

  • Universitätsklinikum Erlangen

    Erlangen, 91054, Germany

  • Universitätsklinikum des Saarlandes

    Homburg, 66421, Germany

  • Washington DC VA Medical Center

    Washington D.C., District of Columbia, 20422, United States

  • Weill Cornell Medical College/The New York Presbyterian Hospital

    New York, New York, 10021, United States

  • Yale New Haven Hospital

    New Haven, Connecticut, 06520, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.