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Heart patients get Double-Duty blood thinners in massive trial

NCT ID NCT04624854

Disease control Sponsor: Harbin Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This completed trial tested whether taking two blood thinners (clopidogrel and aspirin) for 12 months after a heart stent procedure is better than aspirin alone for people with multiple blocked coronary arteries. Over 8,000 patients were enrolled across 100 centers. The main goal was to see if the combination reduces major heart problems like heart attack, stroke, or death.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Clopidogrel and aspirin
What this could lead to
If it works, this could confirm that combining clopidogrel with aspirin for 12 months after stenting lowers the risk of heart attack, stroke, or death in people with multiple blocked arteries.
What could go wrong
This is a completed Phase 4 trial, so results are available, but the open-label design may introduce bias. The benefit must be weighed against a higher bleeding risk from dual antiplatelet therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

8,250 people

The number who actually took part.

Started

Oct 2020

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The enrolled subjects must meet all of the following criteria: 1. Aged 18-75 years old (inclusive). 2. Patients with MVD who underwent DES implantation for 12 months. 3. Patients have been treated with aspirin and can tolerant of aspirin at doses of 75-150 mg/day as maintenance therapy during the study period. 4. Patients have signed informed consent. Exclusion Criteria: \- Subjects who meet any one of the following criteria are excluded from the study: 1. Planned to use of ADP receptor blockers (eg, clopidogrel, ticagrelor, and ticlopidine), dipyridamole, or cilostazol. 2. Contraindication to ADP receptor blockers or aspirin. 3. Planned to use anticoagulants during the study period. 4. Planned coronary, cerebrovascular, or peripheral arterial revascularization during the study period. 5. Planned major cardiac or non-cardiac surgery during the study period. 6. Concomitant oral or intravenous therapy with CYP2C19 medium or strong inhibitors. 7. Known severe liver disease(ALT/AST is 3 times above normal). 8. Subjects with renal failure who required or anticipated dialysis during the study period. 9. Platelet count \<50×10\^9/L. 10. Patients with: * A history of intracranial bleed or ischemic stroke at any time. * A central nervous system tumor or intracranial vascular abnormality (eg, aneurysm, arteriovenous malformation) at any time. * Intracranial or spinal cord surgery within 5 years. 11. Pregnancy or lactation or planned to pregnant during the study period. 12. Life expectancy \< 1 year. 13. Any condition which in the opinion of the investigator would make it unsafe or unsuitable for the patient to participate in this study (eg, active malignancy other than squamous cell or basal cell skin cancer). 14. Concern for inability of the patient to comply with study procedures and/or followup (eg, alcohol or drug abuse). 15. Participation in another clinical study and did not reach the major endpoint. 16. Involvement in the planning and/or conduct of the study.

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Conditions

The condition(s) this trial relates to.

acute coronary syndrome Arterial Occlusive Diseases arteriosclerosis disorder cardiovascular disorder coronary artery disorder Coronary Disease heart disorder myocardial ischemia vascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute coronary syndrome Arterial occlusive diseases Arteriosclerosis Cardiovascular diseases Coronary artery disease Coronary disease Heart diseases Myocardial ischemia Syndrome heart disease Vascular diseases

Contacts and locations

Locations

  • Affiliated Hospital of Chengde Medical University

    Chengde, Hebei, 067000, China

  • Affiliated Hospital of Zunyi Medical University

    Zunyi, Guizhou, 563003, China

  • Affiliated Pizhou Hospital of Xuzhou Medical University

    Pizhou, Jiangsu, 221300, China

  • Baoqing County People's Hospital

    Shuangyashan, Heilongjiang, 155600, China

  • Beidahuang Industry Group General Hospital

    Harbin, Heilongjiang, 150088, China

  • Cangzhou Central Hospital

    Cangzhou, Hebei, 061014, China

  • Central Hospital of Dalian University of Technology (Dalian municipal central hospital )

    Dalian, Liaoning, 116089, China

  • Central Hospital of Yongcheng

    Shangqiu, Henan, 476610, China

  • Central South University Xiangya School of Medicine Affiliated Haikou Hospital

    Haikou, Hainan, 570208, China

  • Dancheng County People's Hospital

    Zhoukou, Henan, 477150, China

  • Daqing People's Hosipital

    Daqing, Heilongjiang, 163316, China

  • Dazhou Central Hospital

    Dazhou, Sichuan, 635099, China

  • First Affiliated Hospital of Dalian Medical University

    Dalian, Liaoning, 116011, China

  • First Affiliated Hospital of Xinjiang Medical University

    Ürümqi, Xinjiang, 830054, China

  • First People's Hospital of Fuzhou

    Fuzhou, Jiangxi, 344000, China

  • First People's Hospital of Shangqiu

    Shangqiu, Henan, 476005, China

  • Fuzhou University Affiliated Provincial Hospital

    Fuzhou, Fujian, 350001, China

  • General Hospital of Ningxia Medical University - Cardiovascular and Cerebrovascular Hospital

    Yinchuan, Ningxia, 750002, China

  • Guangdong Provincial People's Hospital

    Zhongshan, Guangdong, 510080, China

  • Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University)

    Haikou, Hainan, 570311, China

  • Harbin 242 Hospital

    Harbin, Heilongjiang, 150066, China

  • Harrison International Peace Hospital

    Hengshui, Hebei, 053000, China

  • Hegang Hekuang Hospital

    Hegang, Heilongjiang, 154100, China

  • Heilongjiang Provincial Hospital

    Harbin, Heilongjiang, 150030, China

  • Hongqi Hospital Affiliated to Mudanjiang Medical University

    Mudanjiang, Heilongjiang, 157011, China

  • Hulunbuir People's Hospital

    Hulunbuir, Inner Mongolia, 021008, China

  • Inner Mongolia Autonomous Region People's Hospital

    Hohhot, Inner Mongolia, 010017, China

  • Jiamusi Central Hospital

    Jiamusi, Heilongjiang, 150086, China

  • Jiansanjiang Hospital of Beidahuang Group

    Jiamusi, Heilongjiang, 156300, China

  • Jilin Central General Hospital

    Jilin City, Jilin, 132011, China

  • Jilin Hospital of Chinese and Western Medicine

    Jilin City, Jilin, 132012, China

  • Jixi Jikuang Hospital

    Jixi, Heilongjiang, 158100, China

  • Jixi People's Hospital

    Jixi, Heilongjiang, 158100, China

  • Kaifeng Central Hospital

    Kaifeng, Henan, 475001, China

  • Mishan People's Hospital

    Mishan, Heilongjiang, 158300, China

  • Mudanjiang Cardiovascular Hospital

    Mudanjiang, Heilongjiang, 157011, China

  • Mudanjiang City Second People's Hospital

    Mudanjiang, Heilongjiang, 157000, China

  • Mudanjiang First People's Hospital

    Mudanjiang, Heilongjiang, 157011, China

  • Mudanjiang Hospital of Beidahuang Group

    Mudanjiang, Heilongjiang, 158322, China

  • Nanyang First People's Hospital

    Nanyang, Henan, 473004, China

  • Nenjiang People's Hospital

    Heihe, Heilongjiang, 161400, China

  • People's Hospital of Daxing'anling Region

    Xing'anling, Heilongjiang, 165000, China

  • People's Hospital of Hegang City

    Hegang, Heilongjiang, 154100, China

  • People's Hospital of Xinjiang Uygur Autonomous Region

    Ürümqi, Xinjiang, 830001, China

  • Pingquan County Hospital

    Chengde, Hebei, 067500, China

  • Puyang People's Hospital

    Puyang, Henan, 457000, China

  • Qilu Hospital of Shandong University

    Jinan, Shandong, 250063, China

  • Qiqihar Jianhua Hospital

    Qiqihar, Heilongjiang, 161000, China

  • Shaanxi Provincial People's Hospital

    Xi'an, Shaanxi, 710068, China

  • Shandong Healthcare Group Feicheng Hospital

    Feicheng, Shandong, 271608, China

  • Shandong Second Provincial General Hospital

    Jinan, Shandong, 250031, China

  • Shuangcheng People's Hospital

    Harbin, Heilongjiang, 150100, China

  • Shuangyashan Mining Group Hospital

    Shuangyashan, Heilongjiang, 155100, China

  • Shuangyashan People's Hospital

    Shuangyashan, Heilongjiang, 155100, China

  • Songyuan Central Hospital

    Songyuan, Jilin, 138001, China

  • Tangshan Central Hospital

    Tangshan, Hebei, 063099, China

  • The 7th People's Hospital of Zhengzhou

    Zhengzhou, Henan, 450016, China

  • The Affiliated Taian City Centeral Hospital of Qingdao University

    Tai’an, Shandong, 271099, China

  • The Baoquanling Hospital of Beidahuang Group

    Hegang, Heilongjiang, 154211, China

  • The Fifth Affiliated Hospital of Qiqihar Medical College, Daqing Longnan Hospital.

    Daqing, Heilongjiang, 163001, China

  • The Fifth Hospital of Xiamen

    Xiamen, Fujian, 361101, China

  • The Fifth People's Hospital of Jinan

    Jinan, Shandong, 250022, China

  • The First Affiliated Hospital of Chongqing Medical University

    Chongqing, Chongqing Municipality, 400042, China

  • The First Affiliated Hospital of Jiamusi University

    Jiamusi, Heilongjiang, 154002, China

  • The First Affiliated Hospital of Nanyang Medical College

    Nanyang, Henan, 473007, China

  • The First Affiliated Hospital of Qiqihar Medical University

    Qiqihar, Heilongjiang, 161006, China

  • The First Affiliated Hospital of University of South China

    Hengyang, Hunan, 421001, China

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, 450052, China

  • The First Hospital of Harbin

    Harbin, Heilongjiang, 150010, China

  • The First Hospital of Jilin University

    Changchun, Jilin, 130021, China

  • The First Hospital of Suihua City

    Suihua, Heilongjiang, 152053, China

  • The First Hospital of Yichun City

    Yichun, Heilongjiang, 153000, China

  • The First People's Hospital of Lianyungang

    Lianyungang, Jiangsu, 222002, China

  • The Fourth Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, 150001, China

  • The Fourth People's Hospital of Jinan

    Jinan, Shandong, 250031, China

  • The Hongxinglong Hospital of Beidahuang Group

    Shuangyashan, Heilongjiang, 155811, China

  • The People's Hospital of Yongcheng

    Yongcheng, Henan, 476600, China

  • The Second Affiliated Hospital of Hainan Medical University

    Haikou, Hainan, 570311, China

  • The Second Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, 150086, China

  • The Second Affiliated Hospital of Xingtai Medical College

    Xingtai, Hebei, 054000, China

  • The Second Hospital of Harbin

    Harbin, Heilongjiang, 150056, China

  • The Second Hospital of Hebei Medical University

    Shijiazhuang, Hebei, 052306, China

  • The Second Hospital of Jilin University

    Changchun, Jilin, 130041, China

  • The Second People's Hospital of Liaocheng

    Liaocheng, Shandong, 252699, China

  • The Third Affiliated Hospital of Qiqihar Medical University

    Qiqihar, Heilongjiang, 161000, China

  • The Third Betune Hospital of Jilin University

    Changchun, Jilin, 130033, China

  • The Third Hospital of Shijiazhuang

    Shijiazhuang, Hebei, 052360, China

  • The Third Xiangya Hospital of Central South University

    Changsha, Hunan, 410013, China

  • Tianjin Chest Hospital

    Tianjin, Tianjin Municipality, 300222, China

  • Tianjin Medical University General Hospital

    Tianjin, Tianjin Municipality, 300052, China

  • Tieli Medical Service Community Central Hospital

    Yichun, Heilongjiang, 152500, China

  • Xinqiao Hospital, Army Medical University

    Chongqing, Chongqing Municipality, 400037, China

  • Xinxiang Second People's Hospital

    Xinxiang, Henan, 453099, China

  • Yichang Central People's Hospital

    Yichang, Hubei, 443000, China

  • Yichun Forestry Central Hospital

    Yichun, Heilongjiang, 153000, China

  • Zhongda Hospital, Southeast University

    Nanjing, Jiangsu, 210009, China

  • Zhongshan Hospital Wusong Branch, Fudan University

    Shanghai, Shanghai Municipality, 200032, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.