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Could a simple gas protect organs during surgery?

NCT ID NCT07638124

Knowledge-focused Sponsor: Alexander Averyanov Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers measured markers of blood vessel health, kidney and gut injury, and recovery time to see if the gas had any protective effect.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
inhaled nitric oxide gas
What this could lead to
If it works, this could point toward a simple way to protect the heart, kidneys, and gut during surgery.
What could go wrong
This is a very small pilot study with only 40 people. It was not designed to prove the treatment works, only to see if it is worth studying further.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Nov 2024

Finished

May 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years. * Documented cardiovascular disease, including at least one of the following: coronary artery disease, stable angina pectoris (II-III functional class), chronic heart failure (NYHA I-III), prior myocardial infarction, or cerebrovascular disease. * Revised Cardiac Risk Index (RCRI) ≥2 (moderate/high perioperative risk). * Scheduled for elective laparoscopic abdominal surgery (e.g., colorectal, gastric, hepatic resections) with expected duration \>120 minutes. * Ability to provide written informed consent. Exclusion Criteria: * Pregnancy or lactation. * Baseline methemoglobin level \>3%. * Known hypersensitivity or contraindication to inhaled NO. * Chronic intake of NO donors (e.g., nitroglycerin, isosorbide) or drugs known to increase methemoglobin (e.g., lidocaine, prilocaine, benzocaine). * Severe neutropenia (neutrophils \<500/mm³) or severe thrombocytopenia (platelets \<30,000/mm³). * Haemoglobin \<7 g/dl. * Severe renal failure (estimated GFR \<30 ml/min/1.73 m²). * Poorly controlled diabetes mellitus (HbA1c \>9% or frequent hypoglycaemia). * Significant electrolyte disorders (K⁺ \<3.0 or \>5.5 mmol/l; Na⁺ \<125 or \>155 mmol/l). * Any acute exacerbation of chronic disease on the day of surgery. * Need to convert to open laparotomy during surgery (exclusion from analysis). * Requirement for extracorporeal life support or other advanced organ support not compatible with protocol procedures. * Participation in another interventional clinical trial. * Withdrawal of consent by the patient at any point. * Development of an allergic or severe adverse reaction to the study intervention

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Laparoscopic abdominal surgeries

Contacts and locations

Locations

  • First Moscow State Medical University named after I.M. Sechenov (Sechenov University)

    Moscow, 119048, Russia

More trials for these conditions

Other studies related to the condition(s) this trial covers.