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18-Year sleep apnea study reveals hidden heart and brain risks

NCT ID NCT05077748

Knowledge-focused Sponsor: Chinese University of Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 202 people who were first checked for sleep apnea as children in 2003. Researchers want to see how their sleep apnea changed over 18 years and whether it is linked to heart problems or thinking difficulties. Participants will repeat sleep tests, blood pressure monitoring, heart scans, and thinking assessments. The goal is to understand the natural history of sleep apnea and its long-term effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal which childhood sleep apnea cases persist into adulthood and how they impact long-term heart and brain health.
What could go wrong
This is an observational follow-up, not a treatment trial. Results may not apply to all populations, and some participants may drop out over 18 years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

202 people

The number who actually took part.

Started

Oct 2021

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

In our current proposal, subjects from the 2003 cohort will be invited to join this follow-up study. Written consent will be obtained from the participants. The study protocol will be conducted in compliance with the Declaration of Helsinki. Ethics approval will be obtained from the Clinical Research Ethics Committee of the Joint Chinese University of Hong Kong - New Territories East Cluster.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Subjects participants from the 2003 cohort Exclusion Criteria: * Neuromuscular disease * Pathological central apnoea * Severe chronic lung disease with documented hypoxaemia or awake oxygen saturation \<92% * Chronic respiratory failure (unrelated to OSA) * Acquired upper airway disease/obstruction * Craniofacial abnormalities (e.g. secondary to trauma and malignancy) Other arrangement: * Subjects who have any respiratory illness within 2 weeks of the scheduled follow-up visit will have their assessment re-arranged until they have fully recovered. * Subjects taking medications that may affect sleep, upper airway patency or blood pressure (for example sedatives, stimulants, antihistamines, and cough medicine) within a week from recruitment will also be rescheduled to participate when they are free from medication use for at least 2 weeks. * Subjects with hypertension and are on anti-hypertensive therapy are allowed to continue on their medication and the information will be obtained and recorded during data collection.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Cognition Disorders cognitive disorder hypertensive disorder obstructive sleep apnea syndrome sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular complication Epidemiology Natural history Neurocognitive dysfunction Obstructive sleep apnea

Contacts and locations

Locations

  • Prince of Wales Hospital

    Hong Kong, 999077, China

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